DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and Eefsec

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_075547.1	Gene:	Eefsec / 65967	MGIID:	2137092	Length:	583	Species:	Mus musculus

Alignment Length:	301	Identity:	92/301 - (30%)
Similarity:	148/301 - (49%)	Gaps:	30/301 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NVGTIGHVDHGKTTLTAAITRIQSQKGLAEYLSYDQIDRAPEEKARGITIN---ACHI------- 113
            |||.:||:|.|||.|..|::...|...         .|:.|:.:.||||::   :|.:
Mouse     9 NVGVLGHIDSGKTALARALSTTASTAA---------FDKQPQSRERGITLDLGFSCFVVPLPGAE 64

  Fly   114 -GYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMPQTREHLLLAKQVGIQRII 177
             |.|.|.......||||||..|:.:|.||..:|..:||:..|.|...|:.|.|::. |:..|:::
Mouse    65 PGSSDTLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIG-QIACQKLV 128

  Fly   178 VFINKADLV----DQEVLELVEIEMREMLSDFGFDGVNSPVICGSALLALREDKSEFGVPSIEKL 238
            |.:||.||:    .|..::.:..:|::.|.:..|.|  :|:|..:|.....|.........|.:|
Mouse   129 VVLNKIDLLAEGKRQAAIDKMTKKMQKTLENTKFRG--APIIPVAAKPGGPEAPETEAPQGISEL 191

  Fly   239 LEQCDSYIPTPQRDISSPFILPIDNAFTVPGRGTVVVGTIKRGTIPRNADADLLGFNQNLKTSIS 303
            :|...|.|..|.||.|.||::.:|:.|::.|:|||:.|||..|||......::...  .:...:.
Mouse   192 IELLKSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGTISLGDSVEIPAL--KVVKKVK 254

  Fly   304 DIQIFRKSVPQAQAGENVGALLRGIKISAVERGMLLCATGS 344
            .:|:|...|..|..|:.:|..:.......:||| |:||..|
Mouse   255 SMQMFHTPVTSAMQGDRLGICVTQFDPKLLERG-LVCAPES 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	92/301 (31%)
		EF_Tu	56..249	CDD:206671	61/204 (30%)
		EFTU_II	257..343	CDD:293898	25/85 (29%)
		mtEFTU_III	347..437	CDD:294005
Eefsec	NP_075547.1	SelB_euk	8..197	CDD:206676	59/199 (30%)
		GTP_EFTU	8..195	CDD:278438	59/197 (30%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	14..21		4/6 (67%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	46..50		3/3 (100%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	78..81		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	132..135		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	171..173		0/1 (0%)
		SelB_II	210..292	CDD:293897	24/84 (29%)
		eSelB_III	297..437	CDD:294009
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..390
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..562
		Nuclear localization signal. /evidence=ECO:0000255	534..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870