DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and Gspt2

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001102789.1	Gene:	Gspt2 / 501582	RGDID:	1563213	Length:	632	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	130/492 - (26%)
Similarity:	196/492 - (39%)	Gaps:	159/492 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GLRELPHCNVGTIGHVDHGKTT-------LTAAITRIQSQKGLAE---------YLSYDQIDRAP 99
            |..:..|.||..|||||.||:|       ||..:.|...:|...|         |||: .:|...
  Rat   201 GAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSW-ALDTNQ 264

  Fly   100 EEKARGITINACHIGYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMP----- 159
            ||:.:|.|:......:.|.::.:...|.|||..::.|||.||||.|.|:||::|..|:..
  Rat   265 EERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEK 329

  Fly   160 --QTREHLLLAKQVGIQRIIVFINKAD--LVD--QEVLELVEIEMREMLSDFGFDGVNSP----- 213
              |||||.:|||..|::.:||.|||.|  .||  .|..|..:.::...|...||    ||
  Rat   330 GGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGF----SPKKDIH 390

  Fly   214 -VICGSALLALREDKSEF-----GVPSIEKLLEQCDSYIPTPQRDISSPFILPIDNAFTVPGRGT 272
             :.|.....|..:::|:|     |:|.|..|    || :|...|.|..|..|||.:.:  ...||
  Rat   391 FMPCSGLTGANIKEQSDFCPWYTGLPFIPYL----DS-LPNFNRSIDGPIRLPIVDKY--KDMGT 448

  Fly   273 VVVGTIKRGTI---------PRNADADLLGFNQNLKTSISDIQIFRKSVPQAQA-----GENVGA 323
            ||:|.::.|:|         |.....::||.       :||         .|:.     |||:..
  Rat   449 VVLGKLESGSIFKGQQLVMMPNKHSVEVLGI-------VSD---------DAETDFVAPGENLKI 497

  Fly   324 LLRGIKISAVERGMLLCATGSEDISNHFEGSMYLLSRAEGGRVKPMLSKYIQQLFSQTWNVPARI 388
            .|:||:...:..|.:||...               :....||               |::|  :|
  Rat   498 RLKGIEEEEILPGFILCEPN---------------NLCHSGR---------------TFDV--QI 530

  Fly   389 DIVPSEAMLMPGEHG---------QVRVTLLRKMV-------------------------MTPGQ 419
            .|:..::::.||.:.         :|.:|.|..:|                         .|.|.
  Rat   531 VIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGT 595

  Fly   420 -------------AFTIRENGATVATGMVTQRLPSLD 443
                         .||:|:.|.|:|.|.|.:.:|..|
  Rat   596 ICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	127/482 (26%)
		EF_Tu	56..249	CDD:206671	77/230 (33%)
		EFTU_II	257..343	CDD:293898	25/99 (25%)
		mtEFTU_III	347..437	CDD:294005	22/136 (16%)
Gspt2	NP_001102789.1	PAM2	54..71	CDD:284542
		TEF1	205..629	CDD:227581	127/483 (26%)
		EF1_alpha	209..425	CDD:206670	75/225 (33%)
		eRF3_II	434..514	CDD:293906	24/97 (25%)
		eRF3_C_III	521..627	CDD:294003	22/122 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930