DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and gspt1

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001003992.1	Gene:	gspt1 / 445485	ZFINID:	ZDB-GENE-040822-36	Length:	564	Species:	Danio rerio

Alignment Length:	466	Identity:	127/466 - (27%)
Similarity:	199/466 - (42%)	Gaps:	101/466 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PAPGLRELPHCNVGTIGHVDHGKTT-------LTAAITRIQSQKGLAE---------YLSYDQID 96
            |.|...:..|.||..|||||.||:|       ||..:.:...:|...|         |||: .:|
Zfish   130 PPPDAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVEKRTLEKYEREAKEKNRETWYLSW-ALD 193

  Fly    97 RAPEEKARGITINACHIGYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMP-- 159
            ...||:.:|.|:......:.|.::.:...|.|||..::.|||.||||.|.|:||::|..|:..
Zfish   194 TNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETG 258

  Fly   160 -----QTREHLLLAKQVGIQRIIVFINKADLVDQEV---LELVEIEMREMLSDF----GFDGVNS 212
                 |||||.:|||..|::.:||.|||.|  |..|   |:..| |.:|.|..|    ||    :
Zfish   259 FEKGGQTREHAMLAKTAGVKHLIVLINKMD--DPTVNWSLDRYE-ECKEKLVPFLKKVGF----N 316

  Fly   213 P------VICGSALLALREDKSEF-----GVPSIEKLLEQCDSYIPTPQRDISSPFILPIDNAFT 266
            |      :.|.....|..::.|:.     |:|.|..|    || :|...|....|..|||.:.:
Zfish   317 PKKDIHFMPCSGLTGANLKESSDLCPWYTGLPFIPHL----DS-LPIFSRSSDGPLRLPIVDKY- 375

  Fly   267 VPGRGTVVVGTIKRGTIPRNADADLLGFNQNLKTSISDIQIFRKSVPQAQA--GENVGALLRGIK 329
             ...||||:|.::.|:|   |.|..|....|..| :..:.:....|....|  |||:...|:||:
Zfish   376 -KDMGTVVLGKLESGSI---AKAQQLIMMPNRHT-VEVLSLLSDDVETEYAGPGENLKLRLKGIE 435

  Fly   330 ISAVERGMLLCATGSEDISNH---FEGSMYLLSRAEGGRVKPMLSKYIQQLFSQTWNVPARIDIV 391
            ...:..|.:||  .:|::.:.   |:..:.::..          ...|...::...::...|:.|
Zfish   436 EEEILPGFILC--NAENLCHSGRTFDAQIVIIEH----------KSIICPGYNAVLHIHTCIEEV 488

  Fly   392 PSEAML-----MPGEHGQVRVTLLRK------MVMTPGQ-------------AFTIRENGATVAT 432
            ...|::     ..||..:.|...:::      .:...|.             .||:|:.|.|:|.
Zfish   489 QISALICLVDKKTGEKSKTRPRFVKQDQVCIARLRAAGTICLETFKDFPQMGRFTLRDEGKTIAI 553

  Fly   433 GMVTQRLPSLD 443
            |.|.:.:|..|
Zfish   554 GKVLKLVPEKD 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	123/453 (27%)
		EF_Tu	56..249	CDD:206671	77/233 (33%)
		EFTU_II	257..343	CDD:293898	26/87 (30%)
		mtEFTU_III	347..437	CDD:294005	17/116 (15%)
gspt1	NP_001003992.1	PAM2	<32..44	CDD:284542
		TEF1	138..561	CDD:227581	123/453 (27%)
		EF1_alpha	141..358	CDD:206670	75/229 (33%)
		eRF3_II	366..447	CDD:293906	27/88 (31%)
		eRF3_C_III	453..559	CDD:294003	17/115 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930