DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and eRF3

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	118/460 - (25%)
Similarity:	189/460 - (41%)	Gaps:	121/460 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HCNVGTIGHVDHGKTTLTAAITRIQSQKGLAE-------------------YLSYDQIDRAPEEK 102
            |.||..|||||.||:|:..   :|.|..|:.:                   |||: .:|...||:
  Fly   195 HVNVVFIGHVDAGKSTIGG---QIMSLTGMVDKRTLEKYEREAREKSRESWYLSW-ALDTNQEER 255

  Fly   103 ARGITINACHIGYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMP-------Q 160
            .:|.|:......:.|..:.:...|.|||..::.|||.||:|.|.|:||::|..|:..       |
  Fly   256 DKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQ 320

  Fly   161 TREHLLLAKQVGIQRIIVFINKAD----LVDQEVLELVEIEMREMLSDFGFDGVNSPVI--C-GS 218
            ||||.:|||..|::.::|.:||.|    ..||......:.::...|...||:.......  | |.
  Fly   321 TREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGL 385

  Fly   219 ALLALREDKSE----------FGVPSIEKLLEQCDSYIPTPQRDISSPFILPIDNAFTVPGRGTV 273
            :...|::...|          | :|.|::|        |:..|....|||:||.:.:  ...|||
  Fly   386 SGYGLKDQIPETLCPWYRGPAF-IPFIDEL--------PSLNRKSDGPFIMPIVDKY--KDMGTV 439

  Fly   274 VVGTIKRGTIPRNADADLLGFNQNL-----KTSISDIQIFRK--SVPQAQAGENVGALLRGIKIS 331
            |:|.::.||..:         .|||     :|.::..|:|..  .|.....||||...|:||:..
  Fly   440 VMGKVESGTARK---------GQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEE 495

  Fly   332 AVERGMLLCATGSEDISNH------FEGSMYLLSRAEGGRVKPMLSKYIQQLFSQTWNVPARIDI 390
            .|..|.:||     |.:|.      |:..:.:|..          ...|...:|...::....:.
  Fly   496 DVSPGFVLC-----DAANPIKTGKIFDAQVVILEH----------KSIICAGYSAVMHIHCAAEE 545

  Fly   391 VPSEAML-----MPGEHGQVR--------VTLLR------------KMVMTPGQAFTIRENGATV 430
            |..:|::     ..|:..:.|        |.::|            |:....|: ||:|:...|:
  Fly   546 VTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGR-FTLRDENKTI 609

  Fly   431 ATGMV 435
            |.|.|
  Fly   610 AIGKV 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	118/460 (26%)
		EF_Tu	56..249	CDD:206671	66/234 (28%)
		EFTU_II	257..343	CDD:293898	29/92 (32%)
		mtEFTU_III	347..437	CDD:294005	20/120 (17%)
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	118/460 (26%)
		EF1_alpha	197..416	CDD:206670	64/231 (28%)
		eRF3_II	424..505	CDD:293906	30/96 (31%)
		eRF3_C_III	511..617	CDD:294003	19/115 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840