DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and Tufm

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_766333.1	Gene:	Tufm / 233870	MGIID:	1923686	Length:	452	Species:	Mus musculus

Alignment Length:	409	Identity:	208/409 - (50%)
Similarity:	300/409 - (73%)	Gaps:	10/409 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RLLATSADKNPAPGLRELPHCNVGTIGHVDHGKTTLTAAITRIQSQKGLAEYLSYDQIDRAPEEK 102
            |.||..|.|.   .:|:.||.||||||||||||||||||||:|.::.|.|::..|::||.||||:
Mouse    41 RGLAVEAKKT---YVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEER 102

  Fly   103 ARGITINACHIGYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMPQTREHLLL 167
            ||||||||.|:.|||..|.||||||||||||:||||:|.:.:||.||||||.||.||||||||||
Mouse   103 ARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLL 167

  Fly   168 AKQVGIQRIIVFINKADLV-DQEVLELVEIEMREMLSDFGFDGVNSPVICGSALLALREDKSEFG 231
            |||:|::.::|::||||.| |.|::||||:|:||:|::||:.|..:|||.||||.||.:...|.|
Mouse   168 AKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEQRDPELG 232

  Fly   232 VPSIEKLLEQCDSYIPTPQRDISSPFILPIDNAFTVPGRGTVVVGTIKRGTIPRNADADLLGFNQ 296
            |.|::|||:..|:|||.|.||:..||:||:::.:::|||||||.||::||.:.:..:.:|||.|:
Mouse   233 VKSVQKLLDAVDTYIPVPTRDLDKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECELLGHNK 297

  Fly   297 NLKTSISDIQIFRKSVPQAQAGENVGALLRGIKISAVERGMLLCATGSEDISNHFEGSMYLLSRA 361
            |::|.::.|::|.||:.:|:||:|:|||:||:|...:.||:::...||.......|..:|:||:.
Mouse   298 NIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIQPHQKVEAQVYILSKE 362

  Fly   362 EGGRVKPMLSKYIQQLFSQTWNVPARIDIVPSEAMLMPGEHGQVRVTLLRKMVMTPGQAFTIREN 426
            ||||.||.:|.::..:||.||::..|:.:.|.:.:.||||..::.:.|.:.|::..||.||:|:.
Mouse   363 EGGRHKPFVSHFMPVMFSLTWDMACRVILPPGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDG 427

  Fly   427 GATVATGMVTQRLPSLDLP 445
            ..|:.||:||      |:|
Mouse   428 NKTIGTGLVT------DVP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	200/384 (52%)
		EF_Tu	56..249	CDD:206671	125/193 (65%)
		EFTU_II	257..343	CDD:293898	36/85 (42%)
		mtEFTU_III	347..437	CDD:294005	32/89 (36%)
Tufm	NP_766333.1	PRK00049	47..439	CDD:234596	203/400 (51%)
		EF_Tu	56..250	CDD:206671	125/193 (65%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	64..71		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	105..109		3/3 (100%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	126..129		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	181..184		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	219..221		1/1 (100%)
		EFTU_II	258..344	CDD:293898	36/85 (42%)
		mtEFTU_III	347..439	CDD:294005	33/97 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0050
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002097
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43721
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910