DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu2 and Eef1a2

DIOPT Version :9

Sequence 1:	NP_610288.1	Gene:	mEFTu2 / 35681	FlyBaseID:	FBgn0033184	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_031932.1	Gene:	Eef1a2 / 13628	MGIID:	1096317	Length:	463	Species:	Mus musculus

Alignment Length:	458	Identity:	116/458 - (25%)
Similarity:	201/458 - (43%)	Gaps:	97/458 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RELPHCNVGTIGHVDHGKTTLTA------------AITRIQSQ-----KGLAEYLSYDQIDRAPE 100
            :|..|.|:..|||||.||:|.|.            .|.:.:.:     ||..:|...  :|:...
Mouse     3 KEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWV--LDKLKA 65

  Fly   101 EKARGITINACHIGYSTTERTYAHTDCPGHADYIKNMISGASQMDGAILVVAATDGQMP------ 159
            |:.|||||:.....:.||:......|.|||.|:|||||:|.||.|.|:|:|||..|:..
Mouse    66 ERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKN 130

  Fly   160 -QTREHLLLAKQVGIQRIIVFINKADLV-----DQEVLELVEIEMREMLSDFGFDGVNSPVI--- 215
             |||||.|||..:|::::||.:||.|..     ::...|:|: |:...:...|::....|.:
Mouse   131 GQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVK-EVSAYIKKIGYNPATVPFVPIS 194

  Fly   216 --CGSALL-------------ALREDKSEFGVPSIEKLLEQCDSYIPTPQRDISSPFILPIDNAF 265
              .|..:|             ..|::.:..||    .|||..|:.:| |.|....|..||:.:.:
Mouse   195 GWHGDNMLEPSPNMPWFKGWKVERKEGNASGV----SLLEALDTILP-PTRPTDKPLRLPLQDVY 254

  Fly   266 TVPGRGTVVVGTIKRGTIPRNADADLLGFNQ-NLKTSISDIQIFRKSVPQAQAGENVGALLRGIK 329
            .:.|.|||.||.::.|.:   ....::.|.. |:.|.:..:::..:::.:|..|:|||..::.:.
Mouse   255 KIGGIGTVPVGRVETGIL---RPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVS 316

  Fly   330 ISAVERGMLLCATGSED---ISNHFEGSMYLLSRAEGGRV----KPMLSKYIQQLFSQTWNVPAR 387
            :..:.||. :|.....|   .:..|...:.:|:..  |::    .|::..:...:..:...:..:
Mouse   317 VKDIRRGN-VCGDSKADPPQEAAQFTSQVIILNHP--GQISAGYSPVIDCHTAHIACKFAELKEK 378

  Fly   388 ID------IVPSEAMLMPGEHGQVRVTLLRKMVMTPGQ--------------AFTIRENGATVAT 432
            ||      :..:...|..|:...|.        |.||:              .|.:|:...|||.
Mouse   379 IDRRSGKKLEDNPKSLKSGDAAIVE--------MVPGKPMCVESFSQYPPLGRFAVRDMRQTVAV 435

  Fly   433 GMV 435
            |::
Mouse   436 GVI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu2	NP_610288.1	PRK00049	53..437	CDD:234596	116/458 (25%)
		EF_Tu	56..249	CDD:206671	73/239 (31%)
		EFTU_II	257..343	CDD:293898	20/86 (23%)
		mtEFTU_III	347..437	CDD:294005	18/113 (16%)
Eef1a2	NP_031932.1	PTZ00141	1..460	CDD:185474	116/458 (25%)
		G1. /evidence=ECO:0000250	14..21		5/6 (83%)
		G2. /evidence=ECO:0000250	70..74		3/3 (100%)
		G3. /evidence=ECO:0000250	91..94		1/2 (50%)
		G4. /evidence=ECO:0000250	153..156		2/2 (100%)
		G5. /evidence=ECO:0000250	194..196		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840