DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and MYH13

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_003793.2 Gene:MYH13 / 8735 HGNCID:7571 Length:1938 Species:Homo sapiens


Alignment Length:1888 Identity:482/1888 - (25%)
Similarity:844/1888 - (44%) Gaps:444/1888 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYR 129
            ||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::.|||
Human    81 NPPKFDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYR 144

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV---GGSESET 191
            |....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||.:   |..:.||
Human   145 GKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKET 209

  Fly   192 Q-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLE 249
            |       :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.|||||
Human   210 QPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIETYLLE 271

  Fly   250 KSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAEQFNET 310
            ||||.:|...||:||||||:.:  :|.|||:   |...:.|.|..:. |...:..:.|:|:...|
Human   272 KSRVTFQLSSERSYHIFYQIMS--NKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLAT 334

  Fly   311 VQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD--- 372
            ..|:.:||||.::...|.|:...::|.||::..:|..|  |:.:.|..::          ||   
Human   335 DNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEV----------ADKAG 387

  Fly   373 -LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNG 436
             |:.:::.::.:.|...:::..||||....:::....:..||||.:|.|:|.::|..:|:.|:..
Human   388 YLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTK 452

  Fly   437 SKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-Y 500
            ..:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .
Human   453 QPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGM 517

  Fly   501 DNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTTSF 557
            |...||:|||..:|:..:|:|||..||.:|.|:..||    :||.|   :|:||:    .....|
Human   518 DLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN---NFQKPKPAKGKAEAHF 579

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622
            .:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:.:       ....|::...||.
Human   580 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFS-------NYAGAETGDSGGS 637

  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687
               ..|.|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.|.....
Human   638 ---KKGGKKKGSSF-----------QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVM 688

  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMK 749
            :...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...::..
Human   689 DHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRIL-NASAIPEGQFIDSKNASEKLLNS 752

  Fly   750 WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814
            ...|.:::|||||::||:||.:..||::|   .:|.:|::.|.                    |.
Human   753 IDVDREQFRFGNTKVFFKAGLLGLLEEMR---DEKLVTLMTST--------------------QA 794

  Fly   815 HARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDH 879
            ..||||.|...:||.|.|..:...:|.     .|.::.::|           ....|.|      
Human   795 VCRGYLMRVEFKKMMERRDSIFCIQYN-----IRSFMNVKH-----------WPWMNLF------ 837

  Fly   880 YRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENK 944
               .:|:..::.|.|.:.....:.:                |:|.|.|   ::..|.:...||.|
Human   838 ---FKIKPLLKSAEAEKEMATMKED----------------FERTKEE---LARSEARRKELEEK 880

  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQD--KDKLIEALNKQL 1007
            ::|:.|..::|.               |:::.|.:..::||.:     |:.  |.|::      |
Human   881 MVSLLQEKNDLQ---------------LQVQSETENLMDAEER-----CEGLIKSKIL------L 919

  Fly  1008 EAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RNQED 1065
            ||:..|..:.|||......|.:::|:....:...|:|.||::      ::..|:|..|: :|..:
Human   920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984

  Fly  1066 RMLAEIDN--------RELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQ 1122
            .|.|..:|        :.|.||:|:.:.|.:|.|::           ..|...::|:     ..|
Human   985 EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK-----------VNGLIKINAK-----LEQ 1033

  Fly  1123 NEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKLS 1183
            ..||:     :.:|:..:                   |||:.||..|:|    .|:.||..:.|.
Human  1034 QTDDL-----EGSLEQEK-------------------KLRADLERAKRKLEGDLKMSQESIMDLE 1074

  Fly  1184 SRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKA 1248
            :..:..|:..:..|.|:...:.:.:.:|:. |::...:|.||.|:...|:||:  ..|..::.| 
Human  1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVH-SLQFQKKIKELQARIEELEEEI--EAEHTLRAK- 1135

  Fly  1249 VLLQQSQSMRSLEPESLQMRGNDVNELME----AFHSQKLINRQLESE-------LKAITEEHNS 1302
            :..|:|...|.||         :::|.:|    |..:|..:|::.|:|       |:..|.:|.:
Human  1136 IEKQRSDLARELE---------EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

  Fly  1303 -----------KLVEMTQEIERLNNEKDELQKVMFESIDEFED--SNVDTLRQNDRYLRRELQKA 1354
                       .:.|:.::|:.|...|.:|:|...|...|.:|  ||::.|.::...:.|..:..
Human  1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV 1256

  Fly  1355 VAQFLLVQ----------EELKLANAKLKAYRQDGGQLEHKIE--------------------EE 1389
            ..||..::          .:|.:..|:|:.   ..|:|.|::|                    ||
Human  1257 EDQFSEIKAKDEQQTQLIHDLNMQKARLQT---QNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318

  Fly  1390 MIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI---LQRLLSALTP-----RTVVGLLP 1446
            :.|.....|.|........|.|::...|::....:..:.   |||.||....     ||      
Human  1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT------ 1377

  Fly  1447 GFPAYLIFMCIRY-TDLTNADDDVRELLSKFVIQIKK--------------MHRTPHPIENRVIW 1496
                       :| ||.....:::.|...|...::::              :.:|...::..|..
Human  1378 -----------KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED 1431

  Fly  1497 LVNSI-----TLLNLMKQYGDVDEYVKFNTEKQNQQQLK-----------NFNLFEYRRVILDLI 1545
            |:..:     ....|.|:..:.|:.:....:|.::.|.:           :..||:.|       
Human  1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR------- 1489

  Fly  1546 VNLYQALIMQIQGL-------------LDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597
             |.|:.::.|::.|             |..:|.....|..|.::.::..........:       
Human  1490 -NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV------- 1546

  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMII 1662
                 |.:::.|.|||                                           |...|:
Human  1547 -----ALEEVEGSLEH-------------------------------------------EESKIL 1563

  Fly  1663 RYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSY 1727
            |..:...:  |:| ::...|:.....:.|:.:  .|:::.:.:|::.| ....|....|::.|..
Human  1564 RVQLELSQ--VKS-ELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLD-AEIRSRNDALRLKKKM 1622

  Fly  1728 KLDDYESEI----TNVFLEKLTEKLNARQMQKSNS-----DEFTIDQKFIQPFKVVFRYSDIKLE 1783
            :.|..|.||    :|..:.:..:.|...|.|..:|     |....::...:...:|.|.:.:.||
Human  1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687

  Fly  1784 DIE 1786
            ::|
Human  1688 ELE 1690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 275/742 (37%)
MYSc_Myo5 84..767 CDD:276831 264/712 (37%)
IQ 900..922 CDD:197470 0/21 (0%)
GBP_C <971..1086 CDD:303769 31/131 (24%)
coiled coil 1049..1068 CDD:293879 4/25 (16%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/119 (24%)
Myo5_CBD 1424..1792 CDD:271254 64/424 (15%)
MYH13NP_003793.2 Myosin_N 36..73 CDD:280832
Myosin_head 88..770 CDD:278492 268/724 (37%)
MYSc_Myh13 100..770 CDD:276887 264/712 (37%)
Actin-binding. /evidence=ECO:0000250 659..681 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 761..775 9/13 (69%)
Myosin_tail_1 850..1927 CDD:279860 185/1028 (18%)
RILP-like <1273..1399 CDD:304877 27/145 (19%)
TMPIT 1744..>1837 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1917..1938
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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