DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYO1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_011888.1 Gene:MYO1 / 856418 SGDID:S000001065 Length:1928 Species:Saccharomyces cerevisiae


Alignment Length:1988 Identity:530/1988 - (26%)
Similarity:885/1988 - (44%) Gaps:415/1988 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 TDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRF-CERQIIYTYCGI 106
            |:...|.:|::    ||:.|: ||:......:::.|::|:||.||:||..|: |:  :||||.|:
Yeast    53 TEVSNLVQVRI----SDVFPV-NPSTFDKVENMSELTHLNEPSVLYNLEKRYDCD--LIYTYSGL 110

  Fly   107 ILVAINPYAEMPLYGPSIIRAYRG------------HAMGDLEPHIFALAEEAYTKLERENCNLS 159
            .|||||||..:.||....|..|..            ::...|.|||||:|||||..|..|..:.|
Yeast   111 FLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQS 175

  Fly   160 IIVSGESGAGKTVSAKYAMRYFAA-----------VGGSESETQVERKVLASSPIMEAFGNAKTT 213
            |:|:||||||||.:.|..::|.|:           |.||......|.|:|.|:||:|:||||:|.
Yeast   176 ILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTV 240

  Fly   214 RNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAA--RSKY 276
            ||:||||||||.|:.| |:.|:  :.||.:..|||||||:|:|...||||||||||.:.  .|:.
Yeast   241 RNNNSSRFGKFIKIEF-NEHGM--INGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSEL 302

  Fly   277 PELVLDHQD--KFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGN 339
            ..|.|..::  .::.|:......|..::|.|.|.|.:.|:.::|||..||..|.:::|.||.:||
Yeast   303 KNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGN 367

  Fly   340 IQ-VSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSI 403
            |: ||.:..:.|          |.||:  ......|.|...|.:..:|..:.::..|:|....:.
Yeast   368 IEFVSDRAEQAS----------FKNDV--SAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNS 420

  Fly   404 EAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYAN 468
            :.|:...:||::::|.:||.|||.::||:|::||...::||:|||.|||.||.|||||.||||.|
Yeast   421 QQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTN 485

  Fly   469 EKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESR---LGVLDLLDEECRMPKGS 529
            |||||.||.|:|.|||.|||||.|.|..||: .|.|..||||||:   .|||.|||||..:||.:
Yeast   486 EKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKST 550

  Fly   530 DESWAGKLIGKCNK-FPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESN 593
            |||:..|||...:: ...|::.|. ...|.:||::..|||.|.|:|.||:|.::..|..:||.|.
Yeast   551 DESFYSKLISTWDQNSSKFKRSRL-KNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQ 614

  Fly   594 MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHR--KTVGSQFQE 656
            ..:..::...|        ..|||:.|          .:.|.:.:.|..|.:..  ||..|:.:|
Yeast   615 NDIISKLFQPE--------GEKSSSAG----------VEANISNQEVKKSARTSTFKTTSSRHRE 661

  Fly   657 SLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDF 721
            ...:|::.|.:|.||:||||.||:.|....:....|:.|||..||||.:|::..|:|:|..:.:|
Yeast   662 QQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEF 726

  Fly   722 YMRYQLL--------VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVR 778
            :.||::|        .:.||| |...|.:|..::.....|...|:.|||::||:||.:|.||   
Yeast   727 FQRYRILYPENSTTTTFSSKL-KASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLE--- 787

  Fly   779 ANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARE----RTQKMREARA-GLILS 838
                                :::.:::..::..:....|||..|:    ..||:::.|. |....
Yeast   788 --------------------KQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFR 832

  Fly   839 KYAR-----GWLCRRRYLRLR----------------HSISGIQTYARGMLARNKFHAMRDHYRA 882
            .|.|     .|.  ..::|::                ..|:.::...:.|.::.||...::....
Yeast   833 LYNRLVKEDPWF--NLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTV 895

  Fly   883 VQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE-----------AKTISHMEN 936
            .:::. .:..|.:.....|:...::.:........:::|..:.:|           |:.:.....
Yeast   896 NELEN-TQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQ 959

  Fly   937 KYMGLENKIISMQQRIDELNRDNSNLKHKTSEI-----------SVLKMKLELKKTLEAEFKNVK 990
            |..||:..|...:..:::|:..|:.|..:.|::           |::|   |.|..||.|.|.:|
Yeast   960 KIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIK---ESKLKLENEIKRLK 1021

  Fly   991 AACQDKDKLIEALNKQL---EAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDM 1052
            .....|::.|::.|.:|   |.:.|.|:..||:|.:..   :|:.|:...||.:||.: :|....
Yeast  1022 DVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIA---MSRLQSLVTENSDLRSK-NENFKK 1082

  Fly  1053 AKNAEVNQ-RNQEDRML---AEIDNR-----------------------ELNEA----------- 1079
            .|.|..|| :|:|..:|   .:|||.                       ||.|.           
Yeast  1083 EKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNY 1147

  Fly  1080 ---------YQRAIKDKE------VIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGY 1129
                     :||..|::|      ::|:.|....:||....:...||: :..:...|.|..:...
Yeast  1148 QKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISLN-QYLNKRISGNSVETNI 1211

  Fly  1130 ASAKNTLDINRPP----DLLSKNY---------------SYNDSTSLVVKLR--------SILEE 1167
            :|.:.:...:..|    |::.|.|               ...:..:|:.:||        |..|:
Yeast  1212 SSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFED 1276

  Fly  1168 EKQK------HKVLQEQ--YIKLSS------RHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKH 1218
            :|.|      .|::|:.  .|.|.|      .:.|.::| .:::|.:|.:.|:.:.| :.|...:
Yeast  1277 QKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKES-DINKLMLEVDYLKRQLD-IETRAHY 1339

  Fly  1219 GVE--INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPE----SLQMRGN------- 1270
            ..|  |:.|:::...:|.|......:..:||  .....:.::|||.:    .|:.|.|       
Yeast  1340 DAENAISALHSKFRKIQGESSLSSSDIYKLK--FEASEERVKSLEDKLKTMPLRDRTNLPVGDII 1402

  Fly  1271 ----DVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMT--------------QEIERLNN- 1316
                .:::..|.....||.|.:|:.    |..|.|.||.::|              ::::||.. 
Yeast  1403 KNRDSISKYEEEIRYYKLENYKLQE----ILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKD 1463

  Fly  1317 -EKDELQKVMFESI-----DEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAY 1375
             |..|.||.:..|.     .:||:. :|.|:.|:..||..:. |:.|   .:|::|...:.::..
Yeast  1464 LESTERQKELLSSTIKQQKQQFENC-MDDLQGNELRLREHIH-ALKQ---AEEDVKNMASIIEKL 1523

  Fly  1376 RQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPR 1439
            :....|.|..| |.||.||.|     |:....|..:.:..|.:.|..|.||..:.:| |||:..|
Yeast  1524 KTQNKQKEKLIWEREMERNDS-----DMQLQETLLELKRVQDVKKILSDDLAHLKER-LSAVEDR 1582

  Fly  1440 TVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVN--SIT 1502
            :                 :|||..|...:......|....:||...|   ::.::....|  ...
Yeast  1583 S-----------------QYTDEINRLKEELNCSLKAETNLKKEFAT---LKYKLETSTNDSEAK 1627

  Fly  1503 LLNLMKQYGDVDEYVK----FNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPK 1563
            :.:|:||   :|.|.|    .|.|| :...|....|::           .|:||..:.:. |..|
Yeast  1628 ISDLLKQ---LDHYTKVVEMLNNEK-DAISLAEKELYQ-----------KYEALNTECES-LKGK 1676

  Fly  1564 IVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA 1628
            ||.......|::..........:.::...|||.:..     |::..::::..:..|         
Yeast  1677 IVSLTKIKQELESDLNQKTDALQISNAALSSSTQKN-----KEITEKIKYLEETLQ--------- 1727

  Fly  1629 EQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVS 1693
                              |.:..:....|....::.:....:|....:|..|      ..|.:.:
Yeast  1728 ------------------LQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKN------IDLYEEN 1768

  Fly  1694 QLLQSRKSEQDVQ------TICDLCTS---LSTAQVLKVMKSYKLD-DYESEITNVFLEKLTEKL 1748
            |.||...::..:|      .:.|....   ||....|:.|.|.:.| .||....|..||:..|:|
Yeast  1769 QTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLERAVEEL 1833

  Fly  1749 NARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIE 1786
            ..:..|:  :|...:..|....|:......:.::.|:|
Yeast  1834 QTKNSQQ--TDVIELANKNRSEFEEATLKYEAQISDLE 1869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 294/756 (39%)
MYSc_Myo5 84..767 CDD:276831 283/726 (39%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 40/164 (24%)
coiled coil 1049..1068 CDD:293879 6/19 (32%)
coiled coil 1077..1086 CDD:293879 3/28 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/125 (20%)
Myo5_CBD 1424..1792 CDD:271254 70/379 (18%)
MYO1NP_011888.1 COG5022 2..1691 CDD:227355 495/1768 (28%)
Smc 1534..>1890 CDD:224117 82/418 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.