DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and MYO1

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_011888.1 Gene:MYO1 / 856418 SGDID:S000001065 Length:1928 Species:Saccharomyces cerevisiae


Alignment Length:1988 Identity:530/1988 - (26%)
Similarity:885/1988 - (44%) Gaps:415/1988 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 TDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRF-CERQIIYTYCGI 106
            |:...|.:|::    ||:.|: ||:......:::.|::|:||.||:||..|: |:  :||||.|:
Yeast    53 TEVSNLVQVRI----SDVFPV-NPSTFDKVENMSELTHLNEPSVLYNLEKRYDCD--LIYTYSGL 110

  Fly   107 ILVAINPYAEMPLYGPSIIRAYRG------------HAMGDLEPHIFALAEEAYTKLERENCNLS 159
            .|||||||..:.||....|..|..            ::...|.|||||:|||||..|..|..:.|
Yeast   111 FLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQS 175

  Fly   160 IIVSGESGAGKTVSAKYAMRYFAA-----------VGGSESETQVERKVLASSPIMEAFGNAKTT 213
            |:|:||||||||.:.|..::|.|:           |.||......|.|:|.|:||:|:||||:|.
Yeast   176 ILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTV 240

  Fly   214 RNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAA--RSKY 276
            ||:||||||||.|:.| |:.|:  :.||.:..|||||||:|:|...||||||||||.:.  .|:.
Yeast   241 RNNNSSRFGKFIKIEF-NEHGM--INGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSEL 302

  Fly   277 PELVLDHQD--KFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGN 339
            ..|.|..::  .::.|:......|..::|.|.|.|.:.|:.::|||..||..|.:::|.||.:||
Yeast   303 KNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGN 367

  Fly   340 IQ-VSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSI 403
            |: ||.:..:.|          |.||:  ......|.|...|.:..:|..:.::..|:|....:.
Yeast   368 IEFVSDRAEQAS----------FKNDV--SAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNS 420

  Fly   404 EAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYAN 468
            :.|:...:||::::|.:||.|||.::||:|::||...::||:|||.|||.||.|||||.||||.|
Yeast   421 QQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTN 485

  Fly   469 EKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESR---LGVLDLLDEECRMPKGS 529
            |||||.||.|:|.|||.|||||.|.|..||: .|.|..||||||:   .|||.|||||..:||.:
Yeast   486 EKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKST 550

  Fly   530 DESWAGKLIGKCNK-FPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESN 593
            |||:..|||...:: ...|::.|. ...|.:||::..|||.|.|:|.||:|.::..|..:||.|.
Yeast   551 DESFYSKLISTWDQNSSKFKRSRL-KNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQ 614

  Fly   594 MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHR--KTVGSQFQE 656
            ..:..::...|        ..|||:.|          .:.|.:.:.|..|.:..  ||..|:.:|
Yeast   615 NDIISKLFQPE--------GEKSSSAG----------VEANISNQEVKKSARTSTFKTTSSRHRE 661

  Fly   657 SLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDF 721
            ...:|::.|.:|.||:||||.||:.|....:....|:.|||..||||.:|::..|:|:|..:.:|
Yeast   662 QQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEF 726

  Fly   722 YMRYQLL--------VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVR 778
            :.||::|        .:.||| |...|.:|..::.....|...|:.|||::||:||.:|.||   
Yeast   727 FQRYRILYPENSTTTTFSSKL-KASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLE--- 787

  Fly   779 ANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARE----RTQKMREARA-GLILS 838
                                :::.:::..::..:....|||..|:    ..||:::.|. |....
Yeast   788 --------------------KQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFR 832

  Fly   839 KYAR-----GWLCRRRYLRLR----------------HSISGIQTYARGMLARNKFHAMRDHYRA 882
            .|.|     .|.  ..::|::                ..|:.::...:.|.::.||...::....
Yeast   833 LYNRLVKEDPWF--NLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTV 895

  Fly   883 VQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE-----------AKTISHMEN 936
            .:::. .:..|.:.....|:...::.:........:::|..:.:|           |:.:.....
Yeast   896 NELEN-TQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQ 959

  Fly   937 KYMGLENKIISMQQRIDELNRDNSNLKHKTSEI-----------SVLKMKLELKKTLEAEFKNVK 990
            |..||:..|...:..:::|:..|:.|..:.|::           |::|   |.|..||.|.|.:|
Yeast   960 KIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIK---ESKLKLENEIKRLK 1021

  Fly   991 AACQDKDKLIEALNKQL---EAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDM 1052
            .....|::.|::.|.:|   |.:.|.|:..||:|.:..   :|:.|:...||.:||.: :|....
Yeast  1022 DVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIA---MSRLQSLVTENSDLRSK-NENFKK 1082

  Fly  1053 AKNAEVNQ-RNQEDRML---AEIDNR-----------------------ELNEA----------- 1079
            .|.|..|| :|:|..:|   .:|||.                       ||.|.           
Yeast  1083 EKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNY 1147

  Fly  1080 ---------YQRAIKDKE------VIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGY 1129
                     :||..|::|      ::|:.|....:||....:...||: :..:...|.|..:...
Yeast  1148 QKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISLN-QYLNKRISGNSVETNI 1211

  Fly  1130 ASAKNTLDINRPP----DLLSKNY---------------SYNDSTSLVVKLR--------SILEE 1167
            :|.:.:...:..|    |::.|.|               ...:..:|:.:||        |..|:
Yeast  1212 SSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFED 1276

  Fly  1168 EKQK------HKVLQEQ--YIKLSS------RHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKH 1218
            :|.|      .|::|:.  .|.|.|      .:.|.::| .:::|.:|.:.|:.:.| :.|...:
Yeast  1277 QKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKES-DINKLMLEVDYLKRQLD-IETRAHY 1339

  Fly  1219 GVE--INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPE----SLQMRGN------- 1270
            ..|  |:.|:::...:|.|......:..:||  .....:.::|||.:    .|:.|.|       
Yeast  1340 DAENAISALHSKFRKIQGESSLSSSDIYKLK--FEASEERVKSLEDKLKTMPLRDRTNLPVGDII 1402

  Fly  1271 ----DVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMT--------------QEIERLNN- 1316
                .:::..|.....||.|.:|:.    |..|.|.||.::|              ::::||.. 
Yeast  1403 KNRDSISKYEEEIRYYKLENYKLQE----ILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKD 1463

  Fly  1317 -EKDELQKVMFESI-----DEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAY 1375
             |..|.||.:..|.     .:||:. :|.|:.|:..||..:. |:.|   .:|::|...:.::..
Yeast  1464 LESTERQKELLSSTIKQQKQQFENC-MDDLQGNELRLREHIH-ALKQ---AEEDVKNMASIIEKL 1523

  Fly  1376 RQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPR 1439
            :....|.|..| |.||.||.|     |:....|..:.:..|.:.|..|.||..:.:| |||:..|
Yeast  1524 KTQNKQKEKLIWEREMERNDS-----DMQLQETLLELKRVQDVKKILSDDLAHLKER-LSAVEDR 1582

  Fly  1440 TVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVN--SIT 1502
            :                 :|||..|...:......|....:||...|   ::.::....|  ...
Yeast  1583 S-----------------QYTDEINRLKEELNCSLKAETNLKKEFAT---LKYKLETSTNDSEAK 1627

  Fly  1503 LLNLMKQYGDVDEYVK----FNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPK 1563
            :.:|:||   :|.|.|    .|.|| :...|....|::           .|:||..:.:. |..|
Yeast  1628 ISDLLKQ---LDHYTKVVEMLNNEK-DAISLAEKELYQ-----------KYEALNTECES-LKGK 1676

  Fly  1564 IVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA 1628
            ||.......|::..........:.::...|||.:..     |::..::::..:..|         
Yeast  1677 IVSLTKIKQELESDLNQKTDALQISNAALSSSTQKN-----KEITEKIKYLEETLQ--------- 1727

  Fly  1629 EQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVS 1693
                              |.:..:....|....::.:....:|....:|..|      ..|.:.:
Yeast  1728 ------------------LQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKN------IDLYEEN 1768

  Fly  1694 QLLQSRKSEQDVQ------TICDLCTS---LSTAQVLKVMKSYKLD-DYESEITNVFLEKLTEKL 1748
            |.||...::..:|      .:.|....   ||....|:.|.|.:.| .||....|..||:..|:|
Yeast  1769 QTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLERAVEEL 1833

  Fly  1749 NARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIE 1786
            ..:..|:  :|...:..|....|:......:.::.|:|
Yeast  1834 QTKNSQQ--TDVIELANKNRSEFEEATLKYEAQISDLE 1869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 283/726 (39%)
IQ 900..922 CDD:197470 1/21 (5%)
SMC_prok_B <942..1365 CDD:274008 121/568 (21%)
Myo5_CBD 1424..1792 CDD:271254 70/379 (18%)
MYO1NP_011888.1 COG5022 2..1691 CDD:227355 495/1768 (28%)
Smc 1607..>1901 CDD:440809 58/322 (18%)

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