Protein Alignment didum and MYO2

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1869
• Identity: 581/1869 - (31%)
• Similarity: 907/1869 - (48%)
• Gaps: 395/1869 - (21%)

  Fly     6 MLYAQGAKIWVPHADLVWESA-TLEESYRKGAGFLKICTDSGKLKEVKLKADGSD----LPPLRN 65
            |.:..|.:.|.||.:|.|..| .::..:..|...|::..:..::..|..|...:|    ||.|||
Yeast     1 MSFEVGTRCWYPHKELGWIGAEVIKNEFNDGKYHLELQLEDDEIVSVDTKDLNNDKDQSLPLLRN 65

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEM-PLYGPSIIRAYR 129
            |.||....|||:||||:||.|||.::.|:.:.. ||||.||:|:|.||:..: .||...:|:||.
Yeast    66 PPILEATEDLTSLSYLNEPAVLHAIKQRYSQLN-IYTYSGIVLIATNPFDRVDQLYTQDMIQAYA 129

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESET--- 191
            |...|:||||:||:|||||..::.:..|.:|:|||||||||||||||.|||||:|....|.|
Yeast   130 GKRRGELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQH 194

  Fly   192 -----QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKS 251
                 :.|:|:||::||||||||||||||||||||||:.::||.....::   ||.:.|||||:|
Yeast   195 QVEMSETEQKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSII---GARIRTYLLERS 256

  Fly   252 RVVYQAQGERNYHIFYQLCA---ARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313
            |:|||...||||||||||.|   |::| .||.|.....:.::|.||..:|..:.||:::..||.|
Yeast   257 RLVYQPPIERNYHIFYQLMAGLPAQTK-EELHLTDASDYFYMNQGGDTKINGIDDAKEYKITVDA 320

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378
            :|::|.:.:....|.||||.:||:|||::.|..|:.|...|         :.:|::..:||.:.|
Yeast   321 LTLVGITKETQHQIFKILAALLHIGNIEIKKTRNDASLSAD---------EPNLKLACELLGIDA 376

  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNN---GSKQC 440
            .:..:|:..::|.:.:|.::...:...|..|:|::||.||:.||.::|..:|..|.|   ..:..
Yeast   377 YNFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLCNPAVNDQIS 441

  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPC 505
            ||||||||||||.||.|||||||||||||||||:|||||||||||||:||.|.|:.|:|.|||||
Yeast   442 SFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPC 506

  Fly   506 IDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPH---FEKPRFGTTSFFIKHFSDTVE 567
            |||||::||:|.|||||.|:|.||||||..||....:|.|.   |.|||||.|.|.:.|::..|.
Yeast   507 IDLIENKLGILSLLDEESRLPAGSDESWTQKLYQTLDKSPTNKVFSKPRFGQTKFIVSHYALDVA 571

  Fly   568 YDVNGFLEKNRDTVSKELTQVLSESN--------MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVV 624
            |||.||:||||||||....:||..|.        ..|.|....|||...|.::
Yeast   572 YDVEGFIEKNRDTVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELE------------ 624

  Fly   625 ISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWET 689
             .||.|:.|      .:.:...:.|:||.|::||..|::|:::|..||:||||||.||.|::::.
Yeast   625 -QAGSKKPG------PIRTVNRKPTLGSMFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDN 682

  Fly   690 AKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLD---------KNDMKLSCRN 745
            ..::.||||||||||:|||.|||||||.:.:|.:||.:|:...:.|         :.|:....:.
Yeast   683 LMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKM 747

  Fly   746 IVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810
            |:...::|:.||:.|||:|||:||.:|:||::|:|.....|.::|..:|...||:|:|:|.:.|.
Yeast   748 ILDATVKDKSKYQIGNTKIFFKAGMLAYLEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIK 812

  Fly   811 GIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHA 875
            .:|.:.:|::.|:|.....:.....:|....||...|.....:..:|:.:|...|..|.:.:...
Yeast   813 YLQNNIKGFIIRQRVNDEMKVNCATLLQAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQ 877

  Fly   876 MRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMG 940
            ..::..||.||..||....|..:.:.:::.::.|:.|||..|:||.|::||:||:::|::.....
Yeast   878 EHEYNAAVTIQSKVRTFEPRSRFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAKSVNHLKEVSYK 942

  Fly   941 LENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK 1005
            ||||:|.:.|.:....::|   |..|..|..|::::|....|:...:|:|     |:.||:..|:
Yeast   943 LENKVIELTQNLASKVKEN---KEMTERIKELQVQVEESAKLQETLENMK-----KEHLIDIDNQ 999

  Fly  1006 QLEAERDEKMQ-LLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLA 1069
            :   .:|.::| .:|.|..:.|:.:...|.   |.|::.:|.||:.:.:|. ::.:..|..:.|.
Yeast  1000 K---SKDMELQKTIENNLQSTEQTLKDAQL---ELEDMVKQHDELKEESKK-QLEELEQTKKTLV 1057

  Fly  1070 EIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDV--GYASA 1132
            |         ||....|   ::||...||||::||.. :.||.....|........||  |.||.
Yeast  1058 E---------YQTLNGD---LQNEVKSLKEEIARLQT-AMSLGTVTTSVLPQTPLKDVMGGGASN 1109

  Fly  1133 KNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE 1197
            .|.:.:.      :.:.|.||                          :.|.||..|:..:..:..
Yeast  1110 FNNMMLE------NSDLSPND--------------------------LNLKSRSTPSSGNNHIDS 1142

  Fly  1198 LEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEP 1262
            |.|:.|              :||...::|       ||:.|           ||:.::.:.....
Yeast  1143 LSVDRE--------------NGVNATQIN-------EELYR-----------LLEDTEILNQEIT 1175

  Fly  1263 ESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFE 1327
            |.| ::|.:|.:...|....|                                      :.|::.
Yeast  1176 EGL-LKGFEVPDAGVAIQLSK--------------------------------------RDVVYP 1201

  Fly  1328 SIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR 1392
                                        |:.|::                        :..||.|
Yeast  1202 ----------------------------ARILII------------------------VLSEMWR 1214

  Fly  1393 NKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCI 1457
                                  .||.|...|.|.::|..:...:|......|:|....:|.
Yeast  1215 ----------------------FGLTKQSESFLAQVLTTIQKVVTQLKGNDLIPSGVFWLA---- 1253

  Fly  1458 RYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD----EYVK 1518
                      :||||.|                  .|::.:|||......|. |..|    |||.
Yeast  1254 ----------NVRELYS------------------FVVFALNSILTEETFKN-GMTDEEYKEYVS 1289

  Fly  1519 FNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGM 1583
            ..||.::     :|....|         |:|...:.::|..|..|.:.|::.::.:.      |.
Yeast  1290 LVTELKD-----DFEALSY---------NIYNIWLKKLQKQLQKKAINAVVISESLP------GF 1334

  Fly  1584 RSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA---------------EQIFH 1633
            .:..||                   |.|...:...:.:.:|:...               .::||
Yeast  1335 SAGETS-------------------GFLNKIFANTEEYTMDDILTFFNSIYWCMKSFHIENEVFH 1380

  Fly  1634 ----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQ 1694
                .||.::.|:..|.|:::.:...|:.|:.:.||:..:|:|.::..:: |....|..|.|.::
Yeast  1381 AVVTTLLNYVDAICFNELIMKRNFLSWKRGLQLNYNVTRLEEWCKTHGLT-DGTECLQHLIQTAK 1444

  Fly  1695 LLQSRK-SEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLE----------KLTEKL 1748
            |||.|| :.:|:..:..:|.||:.||:.|::..|::.||||.|....|.          .|:...
Yeast  1445 LLQVRKYTIEDIDILRGICYSLTPAQLQKLISQYQVADYESPIPQEILRYVADIVKKEAALSSSG 1509

  Fly  1749 NARQMQKSNSDEFTIDQ--KFIQPFKVVFRYSDIKLEDIE--LPSHLNL 1793
            |..:..:.:|..|...:  .|..||.::   ...|.:.:|  :|:.|:|
Yeast  1510 NDSKGHEHSSSIFITPETGPFTDPFSLI---KTRKFDQVEAYIPAWLSL 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	330/717 (46%)
		IQ	900..922	CDD:197470	7/21 (33%)
		SMC_prok_B	<942..1365	CDD:274008	80/425 (19%)
		Myo5_CBD	1424..1792	CDD:271254	83/405 (20%)
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	580/1868 (31%)