DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and MYO3

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_012793.2	Gene:	MYO3 / 853729	SGDID:	S000001612	Length:	1272	Species:	Saccharomyces cerevisiae

Alignment Length:	1512	Identity:	379/1512 - (25%)
Similarity:	628/1512 - (41%)	Gaps:	375/1512 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRV 92
            ::|..::.|...|...|:.|.||                   ||.:|||.||.:.:..:..||:.
Yeast    13 VKEPKKRSAKIKKATFDANKKKE-------------------VGISDLTLLSKISDESINENLKK 58

  Fly    93 RFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCN 157
            || :..|||||.|.:|:::||:.::.:|..:::.:|:|....::.||:||:||..|..|:..|.|
Yeast    59 RF-KNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNEN 122

  Fly   158 LSIIVSGESGAGKTVSAKYAMRYFAAVGGSESET--QVERKVLASSPIMEAFGNAKTTRNDNSSR 220
            ..:|:|||||||||.:||..|:|.||...|.||:  :::..|||::|::|:||.|||.||:||||
Yeast   123 QCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSR 187

  Fly   221 FGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC-AARSKYPELV-LDH 283
            .||:.::.|.:|....   ...:..|||||.|||.|.:.|||:|||||.. .|...|.::. :..
Yeast   188 HGKYLEIKFNSQFEPC---AGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQM 249

  Fly   284 QDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE 348
            .:::.:....|....:.:.|.:.:..|::||..:|...::...|.::||.||.:|||...:. .|
Yeast   250 PEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIEN-EE 313

  Fly   349 GSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESV------NEYVLIPNSIEAAQ 407
            |:.:....|...|        .|.||:|.|..|.:.|:.|.:::.      :.|.:..|.::|.
Yeast   314 GNAQVGDTSVTDF--------VAYLLQVDASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQAT- 369

  Fly   408 AARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQ 472
            |.||||||.||..||.:||..:|.||.........||:|||||||.||.|||||.||||.|||||
Yeast   370 AVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQ 434

  Fly   473 QQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR--LGVLDLLDEECRM----PKGSDE 531
            |.|.|...|.|||.|.:|.|.||.|.::||:...||||::  .|:|..:::....    ...:|:
Yeast   435 QIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQ 499

  Fly   532 SWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL 596
            ::|.:| ...|..|:||   .....|.|||::..|.||:||..:||:|.:.|:|.:::..:..:.
Yeast   500 AFAQRL-NLFNSNPYFE---LRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTF 560

  Fly   597 AKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASL 661
            ...:.. :::|                          .|::||       ..|.|.:..:|...|
Yeast   561 LSTIFP-DDVD--------------------------KDSKRR-------PPTAGDKIIKSANEL 591

  Fly   662 ISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQ 726
            :.||....|.|:|.||||..|....::..:::.|::..|:.|.|||..|||..|..:..|..|:.
Yeast   592 VETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFY 656

  Fly   727 LLV--------YRSKLDKND-MKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF-LEQVRANL 781
            ||.        |....|..: :||..|:.::    .|.:::.|.|.:|.:..:..| ||.:|...
Yeast   657 LLSPDCSYAGDYTWDGDTLEAVKLILRDAMI----PEKEFQLGVTSVFIKTPESLFALEDMRDKY 717

  Fly   782 RKKYITIVQSVVRRFVYRR--QFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGW 844
            .......:|...|||:.||  ..::||:.|                   ||.:.|
Yeast   718 WYNMAARIQRAWRRFLQRRIDAAIKIQRTI-------------------REKKGG---------- 753

  Fly   845 LCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQ 909
               .:|::||       .|...:||..|             :|.....|..||:.   .:.:.|.
Yeast   754 ---NKYVKLR-------DYGTKLLAGKK-------------ERRSMSLLGYRAFM---GDYLSCN 792

  Fly   910 AAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKM 974
                             |:||......:.:|:::|::.
Yeast   793 -----------------ESKTKGSYIRRQVGIKDKVVF--------------------------- 813

  Fly   975 KLELKKTLEAEFKNVKAACQDKDKLIEALNKQL--EAERDEKMQLLEENGHAQEEWISQKQTW-- 1035
                         ::|..|         |:.:.  .|:|.:|:            :|..|:|:
Yeast   814 -------------SIKGEC---------LHSKFGRSAQRLKKV------------FILTKKTFYI 844

  Fly  1036 ---RQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEI------DNRELNEAYQRAIKDKEVIE 1091
               .:|...::...|..||:.|..:|:..|.:|..:..|      .:..:|..::..:..:....
Yeast   845 IGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKL 909

  Fly  1092 NENFMLKEELSRLTAGSFSLHAR--KASNASSQNEDDV---GYASAKNTLDINRPPDLLSK-NYS 1150
            ||..|:|      ...:...|.:  |.....|:..|..   |.....:|:.:.|.....|| |..
Yeast   910 NEKIMIK------VGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKSNKK 968

  Fly  1151 YNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTS 1215
            ..:...|..|   .::.:|.|||          |.||.|. |.|......:.:.|.|:
Yeast   969 PKNPGGLSGK---PIKSKKSKHK----------STHKHTH-SHRSHRDAAKKQPLPSQ------- 1012

  Fly  1216 IKHGVEINELNAQHAALQEEVRRRREECIQLK--AVLLQQSQSMRSLEPESLQMRGNDVNELMEA 1278
                ..:|.|:....|.|.....:.::.:.:|  |:...:..|..|.:|.|
Yeast  1013 ----KPVNPLSLAATAAQAAYNPKPDKTVPIKSSAIPAAKVSSKHSSKPSS-------------- 1059

  Fly  1279 FHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV------------------- 1324
              .:|:..::..|..|:.:.:.|...:..::.:|:   .|:.|::.
Yeast  1060 --KEKVAVKKASSSHKSSSAKQNQVSMPPSKGVEK---NKEPLKETTATATANIPIPPPPPPMGQ 1119

  Fly  1325 ----MFESIDEFEDSNVDT---LRQND-RYLRRELQK--AVAQFLLVQEELKLANAKLKAYR--- 1376
                .||:..:|..|...:   |::.| .::.|:...  ::|:.|...:|..:..|.:..|:
Yeast  1120 PKDPKFEAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTR 1184

  Fly  1377 ----------------QDGGQLEHKIEEEMIRNKSNGT---SADVGANVTKQKSQNPQGLMKFHS 1422
                            |...|:::.|.     :...|.   ||.||.  |.....||.|..
Yeast  1185 NTVPVAATGAVNDVTNQKSSQIDNTIS-----SAQEGVQFGSATVGP--TSDNQSNPVGTF---- 1238

  Fly  1423 SDLDKILQRLLSALTPR 1439
            ||      .|.|||..|
Yeast  1239 SD------GLASALAAR 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	247/738 (33%)
		MYSc_Myo5	84..767	CDD:276831	237/707 (34%)
		IQ	900..922	CDD:197470	1/21 (5%)
		GBP_C	<971..1086	CDD:303769	19/127 (15%)
		coiled coil	1049..1068	CDD:293879	6/18 (33%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	17/110 (15%)
		Myo5_CBD	1424..1792	CDD:271254	6/16 (38%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	379/1512 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910