Protein Alignment didum and MYO4

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_009373.1
• Gene: MYO4 / 851204
• SGDID: S000000027
• Length: 1471
• Species: Saccharomyces cerevisiae
• Alignment Length: 1622
• Identity: 520/1622 - (32%)
• Similarity: 803/1622 - (49%)
• Gaps: 271/1622 - (16%)

  Fly     6 MLYAQGAKIWVPHADLVWESATL-EESYRKGAGFLKICTDSGKLKEVKLKA-----DGSDLPPLR 64
            |.:..|.|.|.||.:..|....: :..:.:|...|::..:.|:...::..:     |...||.||
Yeast     1 MSFEVGTKCWYPHKEQGWIGGEVTKNDFFEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLR 65

  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAY 128
            ||.||...:||||||||:||.|||.::.|:...| ||||.||:|:|.||:.::. ||...:|:.|
Yeast    66 NPPILESTDDLTTLSYLNEPAVLHAIKKRYMNGQ-IYTYSGIVLIAANPFDKVDHLYSREMIQNY 129

  Fly   129 RGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESE--- 190
            ......:||||:||:|||||..:..|..|.:::|||||||||||||||.|||||:|..|.:.
Yeast   130 SSKRKDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGE 194

  Fly   191 ---TQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252
               :|:|.::||::||||||||||||||||||||||:.::||.....:   :|:.:.||||||||
Yeast   195 VEMSQIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTI---RGSKIRTYLLEKSR 256

  Fly   253 VVYQAQGERNYHIFYQLCAARSK--YPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMT 315
            :|||.:.|||||||||:.....:  ..||.|.....:.:.|.||.|.|..:.:|.::..|..|::
Yeast   257 LVYQPETERNYHIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAGIDEAREYKITTDALS 321

  Fly   316 VLGFSIQQIADIVKILAGILHLGNIQVSKKFNE---GSEEEDSDSCDIFHNDIHLQITADLLRVS 377
            ::|.:.:....|.|||||:||:|||::....|:   .|||:            :|||..:||.:.
Yeast   322 LVGINHETQLGIFKILAGLLHIGNIEMKMTRNDASLSSEEQ------------NLQIACELLGID 374

  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKS-----LNNGS 437
            ..:..:|::.::|.:.:|.::...:...|..|||::||.||:.||.::|..:||:     |:...
Yeast   375 PFNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQD 439

  Fly   438 KQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDN 502
            ...||||:|||||||.||.|||||||||||||||||:|||||||||||||:||.|.|:.|:|.||
Yeast   440 HVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDN 504

  Fly   503 QPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPH---FEKPRFGTTSFFIKHFSD 564
            ||||||||::||:|.|||||.|:|.|||||||.||....||.|.   |.|||||.|.|.:.|::.
Yeast   505 QPCIDLIENKLGILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFGQTKFIVSHYAV 569

  Fly   565 TVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGR 629
            .|||:|.||:|||||:||.....|...:...:.||::...|:.:   |.|
Yeast   570 DVEYEVEGFIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRS---DDA--------------- 616

  Fly   630 KQQGNDTRRRVVPSK--QHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKI 692
            .::.|..::.::|::  |.:.|:||.|::||..|::.:::|..||:||||||.:|..::::...:
Yeast   617 PEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMV 681

  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL---------VYRSKLDKNDMKLSCRNIVM 748
            :.||||||||||:|||.|||||||.:.:|..||.||         :|...|.|..:...|::|:.
Yeast   682 LSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILD 746

  Fly   749 KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQ 813
            ..|.|..||:.|||:|||:||.:||||::|.|...:...|:|..:|...||.|:|:..:.|...|
Yeast   747 ATISDSAKYQIGNTKIFFKAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQ 811

  Fly   814 KHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLR-HSISGIQTYARGML----ARNKF 873
            ...|..|.|.|.....:.||.::|....|. |.:|.|.|.. ..|..:|...:..|    ...||
Yeast   812 SQIRSLLVRTRVDHELKTRAAILLQTNIRA-LWKREYYRAAIGQIIKLQCTCKRKLILDSVNRKF 875

  Fly   874 HAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKY 938
            ..|    .||.||.::|....:..|:..:|:.|:.|:|:|..||||::..::.|.:..:...:..
Yeast   876 MLM----AAVIIQSYIRSYGHKTDYRTLKRSSILVQSAMRMQLARRRYIVLQKEVEERNIRASYG 936

  Fly   939 MGL--------ENKIISMQQRIDELNR-------DNSNLKHKTSE-----ISVLKMKLELKKTLE 983
            :||        .:.|::::...|...|       |.||:..|..:     ::....|:...|||:
Yeast   937 IGLLEEAIEFKNSFILNLEMLNDSYTRLTQLLQGDLSNIPSKQRQEYETIVNGYNDKISKLKTLQ 1001

  Fly   984 AEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDE 1048
            .|..|   ....|:.|.|...||....:.....|....|:.......:.::.:||...:...|.:
Yeast  1002 VEIMN---TLNKKNALKERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMKQELAFIENVIAQ 1063

  Fly  1049 IIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDK--EVIENE--NFMLKEELSRLTAGSF 1109
            ......:|     |:.|::      :.|..|.|: :|.|  .||..|  |..|.|.|..|..  :
Yeast  1064 DFTTTYSA-----NKNDKV------KGLGIAGQQ-VKPKLVNVIRRESGNPDLLELLMDLNC--Y 1114

  Fly  1110 SLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV 1174
            :|...:            ||....|..::| ..::|...:......|.:|:...:::..|...||
Yeast  1115 TLEVTE------------GYLKKVNVTEVN-GDNVLGPIHVITTVVSSLVRNGLLIQSSKFISKV 1166

  Fly  1175 LQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGV----EINELNAQHAALQEE 1235
            |                      |.||:..:....|:   ::..|:    .::.|.| .||.|:.
Yeast  1167 L----------------------LTVESIVMSLPKDE---TMLGGIFWLSNLSRLPA-FAANQKT 1205

  Fly  1236 VRRRR--EECIQLKAVLLQQSQSMRSLEPESLQMRGNDV-NELMEAFHSQKLINRQLESELKAIT 1297
            :....  :|..:|..:.|                  ||: ||.::.|  .|:.:..|...:|
Yeast  1206 LYEANGGDEKDKLTLIYL------------------NDLENETLKVF--DKIYSTWLVKFMK--- 1247

  Fly  1298 EEHNSKLVEMTQEI--ERL-NNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFL 1359
              |.|..:|:...:  |:| .|..||....:|..::||:                   ..:.:|.
Yeast  1248 --HASAHIEIFDMVLNEKLFKNSGDEKFAKLFTFLNEFD-------------------AVLCKFQ 1291

  Fly  1360 LVQE-ELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSS 1423
            :|.. ..|:.|..||       .|...:..::|               ||..:.|.:     :..
Yeast  1292 VVDSMHTKIFNDTLK-------YLNVMLFNDLI---------------TKCPALNWK-----YGY 1329

  Fly  1424 DLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADD--------------DVRELLS 1474
            ::|:.::||:|...|| :..:.|.....:..:.|....::|.::              .::.:|.
Yeast  1330 EVDRNIERLVSWFEPR-IEDVRPNLIQIIQAVKILQLKISNLNEFKLLFDFWYALNPAQIQAILL 1393

  Fly  1475 KFVIQIKKMHRTPHPIENRVIWLVNSITLLN----------LMKQYGDVDEYVKFNTEKQNQ 1526
            |:....|.....|:.|.|   :|.|.|...|          |..|:.....:::::|....|
Yeast  1394 KYKPANKGEAGVPNEILN---YLANVIKRENLSLPGKMEIMLSAQFDSAKNHLRYDTSAITQ 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	321/713 (45%)
		IQ	900..922	CDD:197470	9/21 (43%)
		SMC_prok_B	<942..1365	CDD:274008	85/449 (19%)
		Myo5_CBD	1424..1792	CDD:271254	23/127 (18%)
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	519/1621 (32%)