DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and MYO18B

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_011528760.1	Gene:	MYO18B / 84700	HGNCID:	18150	Length:	2610	Species:	Homo sapiens

Alignment Length:	1760	Identity:	392/1760 - (22%)
Similarity:	679/1760 - (38%)	Gaps:	474/1760 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEMLYAQGAKIWVPHADLVWESATL---EESYRKGAGFLKICTDSGK-LKEVKLKADGSDLPPLR 64
            |:..| :..|:|:...|....:..|   |.:....||.:::..|:.| :.||     ..:.....
Human   549 EDRWY-EAEKVWLAQKDGFTLATVLKPDEGTADLPAGRVRLWIDADKTITEV-----DEEHVHRA 607

  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRA-- 127
            ||..|....||.:|..::|..||:.|..|: :.|:::|..|..|:.:.|      .|||:..|
Human   608 NPPELDQVEDLASLISVNESSVLNTLLQRY-KAQLLHTCTGPDLIVLQP------RGPSVPSAGK 665

  Fly   128 -YRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-ESE 190
             .:|...| |..||.::|:.||..|..:..:.||:..|.||||||...:..:.:...:.|| :..
Human   666 VPKGRRDG-LPAHIGSMAQRAYWALLNQRRDQSIVALGWSGAGKTTCCEQVLEHLVGMAGSVDGR 729

  Fly   191 TQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVY 255
            ..|| |:.|:..::.|||:.....:.:::||.....|.| |..|  .:..|.:.|.|||||||..
Human   730 VSVE-KIRATFTVLRAFGSVSMAHSRSATRFSMVMSLDF-NATG--RITAAQLQTMLLEKSRVAR 790

  Fly   256 QAQGERNYHIFYQLCAARSKYPELVLD-------HQ--DKFQF-LNMGGAPEIERVSDAEQFNET 310
            |.:||.|:.:|.|:.|.      |.||       ||  |...| :.:...|| ::...|..|.:.
Human   791 QPEGESNFLVFSQMLAG------LDLDLRTELNLHQMADSSSFGMGVWSKPE-DKQKAAAAFAQL 848

  Fly   311 VQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE---------------GSEEEDSDSCDI 360
            ..||.:||.|..:...:.::||.|.|||.....|...:               |.|.|:.::...
Human   849 QGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVGRKQFMRFEWANYAAEALGCEYEELNTATF 913

  Fly   361 FHNDIHLQITADLLRVSADDLRRW----------LLMRKIESVNEYVLIPNSIEAAQAARDALAK 415
            .|   ||:   .:::.......||          |.|..::.|                 :.:|.
Human   914 KH---HLR---QIIQQMTFGPSRWGLEDEETSSGLKMTGVDCV-----------------EGMAS 955

  Fly   416 HIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFET------FEVNSFEQFCINYANEKLQQQ 474
            .:|.:||..:|.::|:|.::.....:.|.|:|..||:.      ....:||:.|.|||:|:||..
Human   956 GLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELCHNYAHERLQLL 1020

  Fly   475 FNQHVFKLEQEEYLKEGI-------------TWTMIDFYDNQ----PCIDLIESRLGVLDLLDEE 522
            |.|..|....:.|.:||:             |..::|...:|    |.....:...|:..:||||
Human  1021 FYQRTFVSTLQRYQEEGVPVQFDLPDPSPGTTVAVVDQNPSQQVRLPAGGGAQDARGLFWVLDEE 1085

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPRFGT--------------TSFFIKHFSDTVEYDVNGF 573
            ..:...||.....:|...      |||...||              ...|.:...|.|.||:.|:
Human  1086 VHVEGSSDSVVLERLCAA------FEKKGAGTEGSSALRTCEQPLQCEIFHQLGWDPVRYDLTGW 1144

  Fly   574 LEKNRDTVSK-ELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTR 637
            |.:.:..:|. :..|||.:|..         ||:.:|....||...:...|....|..||... |
Human  1145 LHRAKPNLSALDAPQVLHQSKR---------EELRSLFQARAKLPPVCRAVAGLEGTSQQALQ-R 1199

  Fly   638 RRVVP-------SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPND--------------- 680
            .|:|.       :...||...||.:..:.:|.|.:..:..|::.|:.||.
Human  1200 SRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPPPQ 1264

  Fly   681 ---DK------VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL--VYRSKL 734
               ||      :|......::  ||....:||.:|:...|:........|..::|:|  ....||
Human  1265 PGRDKPGAGGPLALDIPALRV--QLAGFHILEALRLHRTGYADHMGLTRFRRQFQVLDAPLLKKL 1327

  Fly   735 DKNDMKLSCRNIVMKWIQDEDKYR----FGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRR 795
            ......:..|..|.:.::..|..:    .|::|:|.:||.::.||:.|..|..:.|.:.|:..:.
Human  1328 MSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQAACKG 1392

  Fly   796 FVYRRQF--LRIQKV-INGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSI 857
            |:.|::|  |:|::: ...|||:...:||                   .:.|    .:.:|   :
Human  1393 FLSRQEFKKLKIRRLAAQCIQKNVAVFLA-------------------VKDW----PWWQL---L 1431

  Fly   858 SGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFK 922
            ..:|......:...:..|..:..                             ..:||.|  .|.:
Human  1432 GSLQPLLSATIGTEQLRAKEEEL-----------------------------TTLRRKL--EKSE 1465

  Fly   923 RMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEA--E 985
            :::.|.:..:.:      ||:||.       :|..|.::.:.| .:::...::.|..:.|:|  |
Human  1466 KLRNELRQNTDL------LESKIA-------DLTSDLADERFK-GDVACQVLESERAERLQAFRE 1516

  Fly   986 FKNVKAACQDKDKLIEALNKQLEAERDEKMQL--LEEN--GHAQEEWISQKQTWRQENEELRR-- 1044
            .:.:|:..:...|.:..:||||| |..:|:||  ||.|  |.| :||..:....:.|||.||:
Human  1517 VQELKSKHEQVQKKLGDVNKQLE-EAQQKIQLNDLERNPTGGA-DEWQMRFDCAQMENEFLRKRL 1579

  Fly  1045 -QIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGS 1108
             |.:|.:|    :|:..|.:.::.|.     ||..||..|.|...       .||.:...||.
Human  1580 QQCEERLD----SELTARKELEQKLG-----ELQSAYDGAKKMAH-------QLKRKCHHLTC-- 1626

  Fly  1109 FSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKH- 1172
                                        |:.....||....|.|...           |:|||.
Human  1627 ----------------------------DLEDTCVLLENQQSRNHEL-----------EKKQKKF 1652

  Fly  1173 -----KVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKH-GVEINELNAQHAA 1231
                 :.|.|...:...|.|.|:          ||..:|.|..||:..:|. ..|.::|..|...
Human  1653 DLQLAQALGESVFEKGLREKVTQ----------ENTSVRWELGQLQQQLKQKEQEASQLKQQVEM 1707

  Fly  1232 LQEEVRR------RREECI--------QLKAVLLQ----QSQSMRSLEP-ESLQMRGNDVNELME 1277
            ||:..|.      ..|.|:        :|::..|:    |||...:::. |.|:.|.....|.|:
Human  1708 LQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQQKIQSQQENTIKQLEQLRQRFELEIERMK 1772

  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIER-------LNNEKDELQKVMFESIDEFEDS 1335
            ..|.:.  ....|.||:.:.:....:|.::..::|:       :.:||.:|:.::....|:....
Human  1773 QMHQKD--REDQEEELEDVRQSCQKRLHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGHR 1835

  Fly  1336 NVDTLRQNDRYLRRELQKAVA-----QFLL----------VQEELKLANAKLKAYRQDGGQLEHK 1385
            :.|.    ::.|||:|::..|     |.||          .:|||:..:::|:       |.|.|
Human  1836 DFDV----EKRLRRDLRRTHALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLE-------QSEAK 1889

  Fly  1386 IEEEMIRNKSNGTSADVGA------NVTKQKSQNPQGL--MKFHSSDLDKILQRLLSALTPRTVV 1442
            .||.:...|.  .:||:.:      |:|:.||...:.|  ::|..:||   |:|
Human  1890 CEEALKTQKV--LTADLESMHSELENMTRNKSLVDEQLYRLQFEKADL---LKR----------- 1938

  Fly  1443 GLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK-----------------FVIQIKKMHRTPHPI 1490
                               :....||:.||:.|                 ..:|:::..:..|.:
Human  1939 -------------------IDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKL 1984

  Fly  1491 EN-------RVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNL 1548
            :.       |:.:|..|.....::.:...|...::..||.| :.|:|.|.:         |::.|
Human  1985 QEQLQVAQMRIEYLEQSTVDRAIVSRQEAVICDLENKTEFQ-KVQIKRFEV---------LVIRL 2039

  Fly  1549 YQALI 1553
            ..:||
Human  2040 RDSLI 2044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	205/826 (25%)
		MYSc_Myo5	84..767	CDD:276831	194/796 (24%)
		IQ	900..922	CDD:197470	4/21 (19%)
		GBP_C	<971..1086	CDD:303769	38/123 (31%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	29/128 (23%)
		Myo5_CBD	1424..1792	CDD:271254	25/154 (16%)
MYO18B	XP_011528760.1	Glutenin_hmw	<114..542	CDD:281191
		MYSc	608..1376	CDD:214580	205/827 (25%)
		MYSc_Myo18	627..1364	CDD:276837	194/796 (24%)
		Smc	1457..>2133	CDD:224117	156/731 (21%)
		GBP_C	<1723..1818	CDD:303769	18/96 (19%)
		coiled coil	1789..1803	CDD:293879	1/13 (8%)
		RILP-like	1923..>2020	CDD:304877	17/129 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910