DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XIA

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_171954.1	Gene:	XIA / 839480	AraportID:	AT1G04600	Length:	1730	Species:	Arabidopsis thaliana

Alignment Length:	1889	Identity:	531/1889 - (28%)
Similarity:	875/1889 - (46%)	Gaps:	330/1889 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GAKIWVPHADLVWESATLEESYRKGAGFLKICTD-SGKLKEVKLK---ADGSDLPPLRNPAILVG 71
            |:.:||...|..|....:||...:     :|..: |||....||.   ....:.|.|       |
plant    10 GSHVWVEDPDDAWIDGEVEEVNSE-----EITVNCSGKTVVAKLNNVYPKDPEFPEL-------G 62

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGD 135
            .:|:|.|:||||||||.||:.|:...: ||||.|.||:|:||:..:| |||...::.|:|.|.|:
plant    63 VDDMTKLAYLHEPGVLLNLKCRYNANE-IYTYTGNILIAVNPFKRLPHLYGSETMKQYKGTAFGE 126

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG-SESE-TQVERKVL 198
            |.||.||:|:.||.|:..|..:.:|:||||||||||.|.|..|:|.|.:|| :||| ..||::||
plant   127 LSPHPFAVADSAYRKMINEGVSQAILVSGESGAGKTESTKMLMQYLAYMGGRAESEGRSVEQQVL 191

  Fly   199 ASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNY 263
            .|:|::||||||||.||:||||||||.::.| :|.|  .:.||.:.|||||:|||...:..||||
plant   192 ESNPVLEAFGNAKTVRNNNSSRFGKFVEIQF-DQRG--RISGAAIRTYLLERSRVCQVSDPERNY 253

  Fly   264 HIFYQLCAARSKYPE-LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |.||.||||..:..| ..|.....|::||......::.:.|::::..|.:||.|:|.:.::...|
plant   254 HCFYMLCAAPEQETERYKLGKPSTFRYLNQSNCYALDGLDDSKEYLATRKAMDVVGINSEEQDGI 318

  Fly   328 VKILAGILHLGNIQVSK-KFNEGSEEEDSDSCDIFHNDIHLQITADLL----RVSADDLRRWLLM 387
            .:::|.|||||||:.:| :.:|.||.:|..|      ..||::.|:|.    :...|.|.:.:::
plant   319 FRVVAAILHLGNIEFAKGEESEASEPKDEKS------RFHLKVAAELFMCDGKALEDSLCKRVMV 377

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFE 452
            .:.||:.: .|.|:|   |...||||||.:|:|||.::|..:|.|:.........||||||||||
plant   378 TRDESITK-SLDPDS---AALGRDALAKIVYSKLFDWLVTKINNSIGQDPNSKHIIGVLDIYGFE 438

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVL 516
            :|:.|||||||||..||||||.|||||||:|||||.||.|.|:.|:|.|||..:||||.:. |::
plant   439 SFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYTKEEIDWSYIEFIDNQDVLDLIEKKPGGII 503

  Fly   517 DLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            .||||.|..|:.:.:::|.||.........|.||:...|.|.|.|::..|.|....||:||:|.|
plant   504 ALLDEACMFPRSTHDTFAQKLYQTFKNHKRFGKPKLAQTDFTICHYAGDVTYQTELFLDKNKDYV 568

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ..|...:||.|:.|....:     ...|..:|:|:|..
plant   569 VGEHQALLSSSDCSFVSSL-----FPPLPEESSKTSKF--------------------------- 601

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             .::||||::.|.||:.:|..|.|||:||:|||:......:|...|:.|||..||:|.:|||.||
plant   602 -SSIGSQFKQQLQSLLESLSTTEPHYIRCVKPNNLLKPDIFENINILHQLRCGGVMEAIRISCAG 665

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQ 776
            :|:|..:.:|..|:::|...:.....|...:|:.::.|  .|...::.|.|::|.||||:|.::.
plant   666 YPTRKPFNEFLTRFRILAPETTKSSYDEVDACKKLLAK--VDLKGFQIGKTKVFLRAGQMAEMDA 728

  Fly   777 VRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYA 841
            .||.:......|:|..|..:..|::||.:|.....||...||.:||...:.||...|.|.:.|.|
plant   729 HRAEVLGHSARIIQRNVLTYQSRKKFLLLQAASTEIQALCRGQVARVWFETMRREAASLRIQKQA 793

  Fly   842 RGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNII 906
            |.::|:..|..|..|...|||..|...||.:....:.....:.||..:|..|..:.|.:.::..|
plant   794 RTYICQNAYKTLCSSACSIQTGMRAKAARIELQLRKKRRATIIIQSQIRRCLCHQRYVRTKKAAI 858

  Fly   907 ICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISV 971
            ..|...|..:|||:.:.:|..||....:::....|||       :::||   .||
plant   859 TTQCGWRVKVARRELRNLKMAAKETGALQDAKTKLEN-------QVEEL---TSN---------- 903

  Fly   972 LKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWR 1036
                |||:|.:..|.:..|:      :.||||...|   .|.|:||                  |
plant   904 ----LELEKQMRMEIEEAKS------QEIEALQSVL---TDIKLQL------------------R 937

  Fly  1037 QENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEEL 1101
            ...|...::|.::..:..:.::..|:.::....||.:      .|.|::|.::          |:
plant   938 DTQETKSKEISDLQSVLTDIKLQLRDTQETKSKEISD------LQSALQDMQL----------EI 986

  Fly  1102 SRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILE 1166
            ..|:.|                              :....||.::|....:|.|   .|::.::
plant   987 EELSKG------------------------------LEMTNDLAAENEQLKESVS---SLQNKID 1018

  Fly  1167 EEKQKHKVLQEQYIKLSSR----HKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNA 1227
            |.::|:    |:..|:|..    ..|..|...:.:||.||:||::    |.:|::.  :|:||:.
plant  1019 ESERKY----EEISKISEERIKDEVPVIDQSAIIKLETENQKLKA----LVSSMEE--KIDELDR 1073

  Fly  1228 QHAALQEEVRRRREECI----QLKAVLLQQSQSMR----SLEPESLQMRGNDVNELMEAFHSQKL 1284
            :|......:..:.:|.:    ::.:.|..:::.::    |||.:..:...|..:|..|.    |.
plant  1074 KHDETSPNITEKLKEDVSFDYEIVSNLEAENERLKALVGSLEKKINESGNNSTDEQEEG----KY 1134

  Fly  1285 INRQLESELKAITEE---HNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRY 1346
            |.::     :::||:   .|.::.::..|.:.||:....|:|.:.|:..::|:::        |.
plant  1135 ILKE-----ESLTEDASIDNERVKKLADENKDLNDLVSSLEKKIDETEKKYEEAS--------RL 1186

  Fly  1347 LRRELQKAV-AQFLLVQEELKLANAKLKAYRQDGGQLEH-KIEEEMIRNKSNGTSADV---GANV 1406
            ....|::|: |:..|:  :||.:..:|:....|....|. :.::.::.:.|...|..|   ||..
plant  1187 CEERLKQALDAETGLI--DLKTSMQRLEEKVSDMETAEQIRRQQALVNSASRRMSPQVSFTGAPP 1249

  Fly  1407 TKQKSQNPQ--------GLMKFHSSDLDK----ILQRLLSALTPRTVVGLLPGFP--AYLIFMCI 1457
            .:...|.|.        |...|..|.:::    .:..||..::..  :|...|.|  |..|:.|:
plant  1250 LENGHQEPLAPIPSRRFGTESFRRSRIERQPHEFVDVLLKCVSKN--IGFSHGKPVAALTIYKCL 1312

  Fly  1458 RYTDLTNADDD--VRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQ----------- 1509
            ....:..|:..  ...::..|...|:......|    ...||.|:.|||.|:::
plant  1313 MRWKIFEAEKTSIFDRIVPVFGSAIENQEDDNH----LAYWLTNTSTLLFLLQRSLRQQSSTGSS 1373

  Fly  1510 ----------YGDVDEYVKFNTEKQN------QQQLKNFNLFEYRRVILDLIVNLY--------- 1549
                      :|.:.:..: :|...|      ||....:....:::.:...:..:|
plant  1374 PTKPPQPTSFFGRMTQGFR-STSSPNLSTDVVQQVDARYPALLFKQQLTAYVETMYGIIRENVKR 1437

  Fly  1550 ---QALIMQIQGLLDPKIVPAILN----------------------NDEIQRGRQAHGMRS---- 1585
               ..|...||.|.:.....:::|                      :.|....:::.|.:|
plant  1438 EVSSLLSSCIQSLKESSCDSSVVNSPSKSSEENLPAKSSEENSPKKSSEENSPKESSGDKSPQKL 1502

  Fly  1586 ------RATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVAL 1644
                  ........||.|:....:|:.:|..|.:....::...:.....:::|.|...:|.....
plant  1503 SDDNSPSKEGQAVKSSEENSPASSWQSIIEFLNYILITWKKNYVPLFLVQKMFSQTFQYINVQLF 1567

  Fly  1645 NCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQ----LLQSRKS--EQ 1703
            |.|:|..:.|....|:.::..:..:|.|. |:.....|.::...|....|    |:...||  ..
plant  1568 NSLLLEREYCTVNMGIKVKAGLDELESWC-SQATEEFVGSSWDELKHTRQAVVLLVTEPKSTITY 1631

  Fly  1704 DVQTICDLCTSLSTAQVLKVMKSYK-LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKF 1767
            |..|| :||:.|||.|:.::....| .||.:..::...:..|...|.   .:..||..|.:|...
plant  1632 DDLTI-NLCSVLSTEQLYRICTLCKDKDDGDHNVSPEVISNLKLLLT---NEDENSRSFLLDDDS 1692

  Fly  1768 IQPF 1771
            ..||
plant  1693 SIPF 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	295/722 (41%)
		MYSc_Myo5	84..767	CDD:276831	282/692 (41%)
		IQ	900..922	CDD:197470	6/21 (29%)
		GBP_C	<971..1086	CDD:303769	23/114 (20%)
		coiled coil	1049..1068	CDD:293879	1/18 (6%)
		coiled coil	1077..1086	CDD:293879	2/8 (25%)
		JAKMIP_CC3	<1190..1299	CDD:292653	24/116 (21%)
		Myo5_CBD	1424..1792	CDD:271254	76/434 (18%)
XIA	NP_171954.1	Myosin_N	11..47	CDD:280832	10/40 (25%)
		MYSc	59..727	CDD:214580	297/723 (41%)
		MYSc_Myo11	75..719	CDD:276835	282/692 (41%)
		SPEC	869..1036	CDD:295325	51/270 (19%)
		TACC	974..1189	CDD:282818	52/290 (18%)
		MyosinXI_CBD	1278..1699	CDD:271259	76/431 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830