DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XIB

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_171912.2	Gene:	XIB / 839246	AraportID:	AT1G04160	Length:	1500	Species:	Arabidopsis thaliana

Alignment Length:	1815	Identity:	521/1815 - (28%)
Similarity:	798/1815 - (43%)	Gaps:	403/1815 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQN 73
            |.|:.:||...|..|....:.|.   ....:|:...|||...||    .|::.|....|...|..
plant     8 AVGSHVWVEDPDEAWLDGEVVEI---NGDQIKVLCASGKQVVVK----DSNIYPKDVEAPASGVE 65

  Fly    74 DLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGDLE 137
            |:|.|:||||||||.||:.|: :...||||.|.||:|:||:..:| ||...::..|:|.::|:|.
plant    66 DMTRLAYLHEPGVLQNLQSRY-DINEIYTYTGSILIAVNPFRRLPHLYSSHMMTQYKGASLGELS 129

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ---VERKVLA 199
            ||.||:|:.||.::..|..:.||:||||||||||.|.|..|||.|.:||..:.|:   ||:|||.
plant   130 PHPFAVADAAYRQMVNEGVSQSILVSGESGAGKTESTKLLMRYLAFMGGRGAATEGRTVEQKVLE 194

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.:|:||||||||.::.| :|.|  .:.||.:.|||||:|||...:..|||||
plant   195 SNPVLEAFGNAKTVKNNNSSRFGKFVEIQF-DQSG--RISGAAIRTYLLERSRVCQVSDPERNYH 256

  Fly   265 IFYQLCAARSKYPELVLDHQDKFQ--------FLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321
            .||.||||    ||   :...||:        :||.....:::.::|||:::.|.:||.|:|.|.
plant   257 CFYMLCAA----PE---EDAKKFKLGDPKIYHYLNQSKCIQLDAMNDAEEYHATKKAMDVVGISS 314

  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDS---DSCDIFHNDIHLQITADLLRVSADDLRR 383
            ::...|.:::|.|||||||:    |.:|:|.:.|   |....|    ||:..|:||..:...|..
plant   315 EEQDAIFRVVASILHLGNIE----FAKGTEIDSSIPRDEKSWF----HLKTAAELLMCNEKSLED 371

  Fly   384 WLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDI 448
            .|..|.:.:.:|.:......|||..:||||||.:|::||.::|..:|.|:.........||||||
plant   372 SLCKRIMATRDETITKTLDPEAALLSRDALAKVMYSRLFDWLVEKINTSIGQDPDSKYLIGVLDI 436

  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL 513
            ||||:|:.|||||||||..||||||.|||||||:|||||.||.|.|:.|:|.|||..:||||.:.
plant   437 YGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYKKEEINWSYIEFVDNQDILDLIEKKP 501

  Fly   514 -GVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKN 577
             |::.||||.|..|:.:.|::|.||.........|.||:...:.|.|.|::..|.|....||:||
plant   502 GGIIALLDEACMFPRSTHETFAQKLYQTYKNHKRFTKPKLARSDFTICHYAGDVTYQTELFLDKN 566

  Fly   578 RDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP 642
            :|.|..|...:|:.|..|....:......|
plant   567 KDYVIAEHQALLNASTCSFVANLFPPVSDD----------------------------------- 596

  Fly   643 SKQHR-KTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVR 706
            |||.: .::|::|::.|.||:..|:.|.|||:||||||:......:|...::||||..||:|.:|
plant   597 SKQSKFSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPNNLLKPGIFENQNVLQQLRCGGVMEAIR 661

  Fly   707 ISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMK-LSCRNIVMKWIQDEDKYRFGNTQIFFRAGQ 770
            ||.||:|:|..:.:|..|:.::. ...||||..: .:|:.::.|  ...:.|:.|.:::|.||||
plant   662 ISCAGYPTRKHFDEFLNRFGIIA-PQVLDKNSNEPAACKKLLDK--AGLEGYQIGKSKVFLRAGQ 723

  Fly   771 VAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGL 835
            :|.|:..|..:..:..:|:|..||.::.::.|::::.....||...||||||...:.||...|.|
plant   724 MADLDTRRTEILGRSASIIQRKVRSYLAQKTFIQLRISATQIQAVCRGYLARSIYEGMRREAAAL 788

  Fly   836 ILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQK 900
            .:.:..|.:|.|:.|..|..:...||...|||::|.:....|....|..||...|..|||..|:|
plant   789 KIQRDLRKFLARKAYTELFSATILIQAGMRGMVSRKELCLRRQTKAATIIQTRCRVYLARLHYRK 853

  Fly   901 RRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK 965
            .::..|..|.|.|..:||::.|.:|..|:....::.....||.::..:..|:....|..::|:
plant   854 LKKAAITTQCAWRGKVARKELKNLKMAARETGALQEAKNKLEKQVEELTWRLQLEKRMRTDLE-- 916

  Fly   966 TSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEA-LNKQLEAER--DEKMQLLEENGHAQEE 1027
                       |.||...|::::.....|:|.|..|| |.|:.||.:  .|.:.:::|.....:|
plant   917 -----------EAKKQENAKYESSLEEIQNKFKETEALLIKEREAAKTVSEVLPIIKEVPVVDQE 970

  Fly  1028 WISQKQTWRQENEELRR-------QIDEII-DMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR-- 1082
             :.:|.|  .|||:|:.       :|||.. ::.:.|.::|...:..:.||....:|..|.||
plant   971 -LMEKLT--NENEKLKGMVSSLEIKIDETAKELHETARISQDRLKQALAAESKVAKLKTAMQRLE 1032

  Fly  1083 -AIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLS 1146
             .|.|.|.  .:..||::.:......|.:.|                            ||....
plant  1033 EKISDMET--EKQIMLQQTILNTPVKSVAGH----------------------------PPTATI 1067

  Fly  1147 KNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQ 1211
            ||......|:|                                |:.|        ||
plant  1068 KNLENGHRTNL--------------------------------ENQF--------NE-------- 1084

  Fly  1212 LRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELM 1276
                    ||:|. ||..:|.:.:               |:...::.....|::   |....:.:
plant  1085 --------VEVNG-NAGKSAAERQ---------------LENVDTLIDCVKENI---GFSNGKPI 1122

  Fly  1277 EAFHSQKLIN--RQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDT 1339
            .||...|.:.  :..||              |.|...:||..        |..|..|.||.|
plant  1123 AAFTIYKCLLHWKCFES--------------EKTSAFDRLIE--------MIGSAIENEDDN--- 1162

  Fly  1340 LRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGA 1404
                 .:|...|....|...|:|:.||.|.|                                ||
plant  1163 -----GHLAYWLTNTSALLFLLQKSLKPAGA--------------------------------GA 1190

  Fly  1405 NVTKQ----KSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLP---GFPAYLIFMCIRYTDL 1462
            ..:|:    .|...:..:.|.||      ..|.:|.....:..:.|   .:||.|.
plant  1191 TASKKPPITTSLFGRMALSFRSS------PNLAAAAEAAALAVIRPVEAKYPALLF--------- 1240

  Fly  1463 TNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQ 1527
                   ::.|:.:|.:|..|.|.                  ||.|:
plant  1241 -------KQQLAAYVEKIFGMIRD------------------NLKKE------------------ 1262

  Fly  1528 QLKNFNLFEYRRVILDLIVNLYQALI-MQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIG 1591
                                 ..||| |.||.   |:          |.:|    |::..|.|:|
plant  1263 ---------------------LSALISMCIQA---PR----------ISKG----GIQRSARSLG 1289

  Fly  1592 ASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMW 1656
            ..|...|     |:.:|..|.......:...:.....::|..|...|:.....|.|:||.:.|.:
plant  1290 KDSPAIH-----WQSIIDGLNSLLAILKDNYVPLVLIQKIHTQTFSFVNVQLFNSLLLRKECCTF 1349

  Fly  1657 ETGMIIRYNIGCIEDWV-RSKKMSNDVLTALAPLNQVSQLL----QSRKSEQDVQTICDLCTSLS 1716
            ..|..::..:..:|.|. :..:.:......|..:.|....|    :.|.|..|:  :.|||..||
plant  1350 SNGEFVKSGLAELELWCGQVNEYAGPSWDELKHIRQAVGFLVIHQKYRVSYDDI--VHDLCPILS 1412

  Fly  1717 TAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSN---SDEFTIDQKFIQPFKV 1773
            ..|:.::...|..|.|.   |....:::...:.|...::||   |:.|.:|.....||.:
plant  1413 VQQLYRICTLYWDDCYN---TRSVSQEVISSMRALMTEESNDADSNSFLLDDNSSIPFSI 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	296/730 (41%)
		MYSc_Myo5	84..767	CDD:276831	281/700 (40%)
		IQ	900..922	CDD:197470	7/21 (33%)
		GBP_C	<971..1086	CDD:303769	34/128 (27%)
		coiled coil	1049..1068	CDD:293879	2/19 (11%)
		coiled coil	1077..1086	CDD:293879	4/11 (36%)
		JAKMIP_CC3	<1190..1299	CDD:292653	18/110 (16%)
		Myo5_CBD	1424..1792	CDD:271254	67/362 (19%)
XIB	NP_171912.2	Myosin_N	11..48	CDD:280832	9/39 (23%)
		MYSc	57..731	CDD:214580	296/730 (41%)
		MYSc_Myo11	76..720	CDD:276835	281/700 (40%)
		IQ	830..852	CDD:197470	8/21 (38%)
		Tropomyosin	877..1053	CDD:278679	45/193 (23%)
		MyosinXI_CBD	1097..1470	CDD:271259	101/559 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830