DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XIC

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_172349.2	Gene:	XIC / 837394	AraportID:	AT1G08730	Length:	1538	Species:	Arabidopsis thaliana

Alignment Length:	1833	Identity:	523/1833 - (28%)
Similarity:	819/1833 - (44%)	Gaps:	374/1833 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILV 70
            :|::.|:.:|....::.|....:|   :.....:.|...:||    |:.|..|.:.|....|...
plant    13 VLHSIGSHVWFEDPEVAWIDGEVE---KINGQEVVIQATTGK----KVTAKLSKIYPKDVEAPAG 70

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMG 134
            |.:|:|.||||||||||.||::|: |...||||.|.||:||||:..:| :|...:::.|:|..:|
plant    71 GVDDMTKLSYLHEPGVLQNLKIRY-ELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPLG 134

  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---SESETQVERK 196
            :|.||:||:|:.||..:..|..:.||:||||||||||.:.|..|||.|.:||   :|..| ||::
plant   135 ELSPHVFAVADVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGRT-VEQQ 198

  Fly   197 VLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGER 261
            ||.|:|::||||||||.||:||||||||.::.|..|..:   .||.:.|||||:|||...:..||
plant   199 VLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQGRI---SGAAIRTYLLERSRVCQISDPER 260

  Fly   262 NYHIFYQLCAA-RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325
            |||.||.|||| :.:..:..|.|...|.:||.....|:..:|||..:..|.:||.::|.|.::..
plant   261 NYHCFYLLCAAPQEEIEKYKLGHPKTFHYLNQSKCFELVGISDAHDYLATRRAMDIVGISEKEQE 325

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
            .|.:::|.|||:|||.    |.:|.|.:.|...| ..:..||:..|:||......|...|..|.:
plant   326 AIFRVVAAILHIGNID----FTKGKEVDSSVPKD-EKSKFHLKTAAELLMCDLKALEDALCKRVM 385

  Fly   391 ESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFE 455
            .:..|.:......::|..:||.|||.:|::||.::|..:|||:...:...|.||||||||||:|:
plant   386 ITPEEVIKRSLDPQSAVTSRDGLAKTVYSRLFDWLVDKINKSIGQDANSRSLIGVLDIYGFESFK 450

  Fly   456 VNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLDLL 519
            .|||||||||:.||||||.|||||||:|||||.||.|.|:.|:|.|||..:||||.:. |::.||
plant   451 TNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEAIDWSYIEFVDNQDVLDLIEKKPGGIVALL 515

  Fly   520 DEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKE 584
            ||.|..||.:.|::|.||.........|.||:...|.|.:.|::..|.|....||:||:|.|..|
plant   516 DEACMFPKSTHETFANKLYQTFKTHKRFIKPKLSRTDFAVAHYAGEVLYQSELFLDKNKDYVIPE 580

  Fly   585 LTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKT 649
            ...:|..|     |....:.....|..:::|||..                            .:
plant   581 HQDLLGAS-----KCPFVVGLFPPLPEETSKSSKF----------------------------SS 612

  Fly   650 VGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPS 714
            :||:|:..|..|:.||:.|.|||:||:|||:......:|...|:||||..||||.:|||.||:|:
plant   613 IGSRFKLQLQQLMETLNCTEPHYIRCVKPNNLLKPAIFENVNIMQQLRCGGVLEAIRISCAGYPT 677

  Fly   715 RWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIV----MKWIQDEDKYRFGNTQIFFRAGQVAFLE 775
            |..:.:|..|:.||...:.....|.|::|:.|:    :|      .|:.|.|::|.||||:|.|:
plant   678 RKPFFEFINRFGLLSPAALEGNFDEKVACQKILDNMGLK------GYQIGKTKVFLRAGQMAELD 736

  Fly   776 QVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY 840
            ..||.:.......:|..:|....:::|:.::|....:|...||.|:.:....:|...|.:.:.|.
plant   737 ARRAEVLSSAAKKIQRRIRTHQAQKRFIVLRKATISLQAICRGRLSCKHYDNLRREAAAVKIQKN 801

  Fly   841 ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI 905
            .|....|:.|.:|..:...:||..|.|.||.:|...:....|..:|...|...|...|:|.:..:
plant   802 GRRHYSRKSYKKLHVASLVVQTGLRAMAARKQFRFRKQTKAATIVQAQWRCHRAISYYKKLKNGV 866

  Fly   906 IICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKH-KTSEI 969
            ::.|...|..||:|:.:::|..|:....::.....||.|:..:..|:....|...:|:. ||.||
plant   867 VLSQTRWRGRLAKRELRKLKMAARETGALKEAKDMLEKKVEELTYRVQLEKRSRGDLEEAKTQEI 931

  Fly   970 SVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQT 1034
                  |:||.:.|           :..|.::..|..|..||:...:..||    ....|.:.|.
plant   932 ------LKLKSSFE-----------EMRKKVDETNALLLKEREAAKKAAEE----APPVIKETQI 975

  Fly  1035 WRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDK----EVIENENF 1095
            ..::.:::....:|:    ::.:|...|::.|  |:...|:..|| |.:::||    |..|.:..
plant   976 LVEDTKKIELMTEEL----ESVKVTLENEKQR--ADDAVRKFEEA-QESLEDKKKKLEETEKKGQ 1033

  Fly  1096 MLKEELSRLTAGSFSLHARKASNASSQNE--DDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLV 1158
            .|:|.|:|:        ..|.||..|:|:  .....:.|.|.....|...:|.:.   ::|..|.
plant  1034 QLQESLTRM--------EEKCSNLESENKVLRQQAVSMAPNKFLSGRSRSILQRG---SESGHLA 1087

  Fly  1159 VKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVE-----NEKLRSEYDQLRTSIKH 1218
            |..||.|  :...|.:          .|:..      ||:|.:     |||.:...|.|..||
plant  1088 VDARSNL--DLHSHSI----------NHRDP------SEVEDKPQKSLNEKQQENQDLLIRSI-- 1132

  Fly  1219 GVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQK 1283
                    .||...|.  .|....||..|.:|     ..||.|.|    |.:..:.:::.
plant  1133 --------VQHLGFQG--NRPITACIIYKCLL-----QWRSFEVE----RTSVFDRIIQT----- 1173

  Fly  1284 LINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLR 1348
             |...:|      |:::|:.|.                          :..||..||
plant  1174 -IGHAIE------TQDNNNTLA--------------------------YWLSNTSTL-------- 1197

  Fly  1349 RELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQN 1413
                     .||:|..||.:.|...|.:               |.:|:      .|.:..:.||:
plant  1198 ---------LLLLQRTLKASGAAGMAPQ---------------RRRSS------SATLFGRMSQS 1232

  Fly  1414 PQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVI 1478
            .:|                   ..|...:.::.|...             ...|..|::.:|:..
plant  1233 FRG-------------------APPGVNLAMINGAAG-------------GGADTFRQVEAKYPA 1265

  Fly  1479 QIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILD 1543
            .:.|...|.:                 :.|.||    .::.|.:|:
plant  1266 LLFKQQLTAY-----------------VEKIYG----MIRDNLKKE------------------- 1290

  Fly  1544 LIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSI-GASSSPEHGGGPA---- 1603
                     |..:.||.             ||..|     .|||:.: |||.|.   |..|
plant  1291 ---------ISPLLGLC-------------IQAPR-----TSRASLVKGASRSV---GNTAAQQA 1325

  Fly  1604 ----WKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRY 1664
                |:.::..|.:|....:...:.:....::|.|:..||.....|.|:||.:.|.:..|..::.
plant  1326 LIAHWQGIVKSLTNFLNTLKSNNVPSFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKA 1390

  Fly  1665 NIGCIEDWVRSKKMSNDVL-TALAPLNQVSQ----LLQSRKSEQDVQTIC-DLCTSLSTAQVLKV 1723
            .:..:|.|  ..|.:|:.. ::...|..:.|    |:..:|.::.:..|. |||..||..|:.::
plant  1391 GLSELEHW--CFKATNEYAGSSWDELKHIRQAIGFLVVHQKPKKTLDEISHDLCPVLSIQQLYRI 1453

  Fly  1724 MKSYKLDDYESE------ITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI-- 1780
            ...|..|.|.:.      |.|:.: .:||..|     .:.|:.|.:|.....||.|    .|:
plant  1454 STMYWDDKYGTHSVSPDVIANMRV-LMTEDSN-----NAVSNSFLLDDDSSIPFSV----DDLSK 1508

  Fly  1781 -----KLEDIELP 1788
                 ::.|||.|
plant  1509 SMEKFEIADIEPP 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	298/722 (41%)
		MYSc_Myo5	84..767	CDD:276831	282/692 (41%)
		IQ	900..922	CDD:197470	6/21 (29%)
		GBP_C	<971..1086	CDD:303769	22/114 (19%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	26/113 (23%)
		Myo5_CBD	1424..1792	CDD:271254	74/393 (19%)
XIC	NP_172349.2	Myosin_N	19..56	CDD:280832	7/43 (16%)
		MYSc	71..739	CDD:214580	297/716 (41%)
		MYSc_Myo11	84..728	CDD:276835	282/692 (41%)
		Rabaptin	726..>1055	CDD:281520	89/364 (24%)
		MyosinXI_CBD	1119..1504	CDD:271259	110/595 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20100
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830