DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and ATM2

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001078755.1	Gene:	ATM2 / 835516	AraportID:	AT5G54280	Length:	1220	Species:	Arabidopsis thaliana

Alignment Length:	1122	Identity:	372/1122 - (33%)
Similarity:	578/1122 - (51%)	Gaps:	196/1122 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KIWVPHADLVWESATLEES-------YRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILV 70
            ::|...::..|:...::.:       ....|..:|:.|:              :|.| .||.||.
plant   164 RVWCRVSNGQWQLGKIQSTSADTSLVMLSTANVVKVSTE--------------ELFP-ANPDILE 213

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..||..||||:||.||:|||||:.: .:||:..|.:|:|:||:..:.:||..:|.||:...|.
plant   214 GVEDLIQLSYLNEPSVLYNLRVRYLQ-DVIYSKAGPVLIAVNPFKNVEIYGNDVISAYQKKVMD- 276

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
             .||::|:|:.||.::.||..|.|:|:|||||||||.:||:||:|.||:||  ....||.::|.:
plant   277 -APHVYAVADAAYDEMMREEKNQSLIISGESGAGKTETAKFAMQYLAALGG--GSCGVEYEILKT 338

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :.|:||||||||:||.|||||||..::.| :.||.  :.||.:.|:||||||||....|||:|||
plant   339 TCILEAFGNAKTSRNANSSRFGKLIEIHF-SAMGK--ICGAKLETFLLEKSRVVQLFNGERSYHI 400

  Fly   266 FYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIV 328
            ||:|||..|..  ..|.|....::.:|:......|..|.||::|::.::|..::....:......
plant   401 FYELCAGASPILKERLKLKTASEYTYLSQSDCLTIAGVDDAQKFHKLLEAFDIVQIPKEHQERAF 465

  Fly   329 KILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD--------LLRVSADDLRRWL 385
            .:||.:|.|||:                |..:..|:.|:::.||        |:..:.::|...|
plant   466 ALLAAVLWLGNV----------------SFRVTDNENHVEVVADEAVANAAMLMGCNTEELMVVL 514

  Fly   386 LMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNG-SKQCSFIGVLDIY 449
            ..||:::..:.:....::..|...||.:||.|||.||.::|..:|.:|..| |:....|.:||||
plant   515 STRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQINIALEVGKSRTGRSISILDIY 579

  Fly   450 GFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-L 513
            |||:|:.|||||||||||||:|||.||:|:||||||||.::||.||.::|.|||.|:||||.: :
plant   580 GFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGIDWTKVEFVDNQECLDLIEKKPI 644

  Fly   514 GVLDLLDEECRMPKGSDESWAGKLIG--KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEK 576
            |:|.|||||...||.:|.::|.||..  |.|.....|:.|    :|.:.|::..|.||.||||||
plant   645 GLLSLLDEESNFPKATDLTFANKLKQHLKTNSCFKGERGR----AFRVNHYAGEVLYDTNGFLEK 705

  Fly   577 NRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVV 641
            |||.:..:|..:||..:..|.|...|                           |.:|. :::.::
plant   706 NRDPLPADLINLLSSCDCQLLKLFST---------------------------KMRGK-SQKPLM 742

  Fly   642 PSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVR 706
            .|....:|||::|:..|..|::.|..|:||::||||||..::...:|...::||||.|||||.||
plant   743 LSDSTNQTVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPRVYEEDLVLQQLRCCGVLEVVR 807

  Fly   707 ISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQV 771
            ||.:|:|:|..:.:|..||..|:...|:.::.:.:|.. ::.::....:.|:.|.|:::.|.||:
plant   808 ISRSGYPTRLTHQEFAGRYGFLLSDKKVAQDPLSVSIA-VLKQYDVHPEMYQVGYTKLYLRTGQI 871

  Fly   772 AFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLI 836
            ...|    :.|||   ::|.:|                 |:|||.||:|:|...|.||  :..|:
plant   872 GIFE----DRRKK---VLQGIV-----------------GLQKHFRGHLSRAYFQNMR--KVTLV 910

  Fly   837 LSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFH------AMRDHYRAV-QIQRFVRGALA 894
            |..|.||...||.:          .|.|       |||      |..|...|| .:|..|||.||
plant   911 LQSYIRGENARRLF----------DTEA-------KFHADSVSEASTDELSAVIHLQSAVRGWLA 958

  Fly   895 RRAY-----QKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYM------GLENKIISM 948
            |:.:     ||..||:..        .::||..|..:|.|.|. :|...:      .|:.:|:..
plant   959 RKHFNSMQRQKELRNVAT--------KSKRKAGRRISEDKDIP-LEQPQVQPTSMSDLQKRILKS 1014

  Fly   949 QQRIDELNRDNSNLKHKTSEISV------LKMKLELKKTLEAEFKNVK--AACQDKDKLIEALNK 1005
            :..:.:...:|:.|:.:..:...      :||| .:::|.:.:..:::  .|...|....|::..
plant  1015 EAALSQKEEENTALREQLRQFEERWSEYDIKMK-SMEETWQKQMSSLQMSLAAARKSLAAESITG 1078

  Fly  1006 QLEAERDEKMQLLEENGHAQEEWIS----------QKQTWRQENEELRRQIDEIIDMAKNAEVNQ 1060
            |....:|..   :...|:..|:.:|          .|.| .....|||  |.|:     |..:|.
plant  1079 QAGGRQDTS---ISPFGYDSEDTMSTGTPGVRTPTNKFT-NGNTPELR--IREL-----NGSLNA 1132

  Fly  1061 RNQEDRMLAEIDNRELN 1077
            .|   .:..|.|.|.||
plant  1133 VN---HLAREFDQRRLN 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	284/726 (39%)
		MYSc_Myo5	84..767	CDD:276831	268/696 (39%)
		IQ	900..922	CDD:197470	5/21 (24%)
		GBP_C	<971..1086	CDD:303769	27/125 (22%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	1/1 (100%)
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
ATM2	NP_001078755.1	MYSc	208..879	CDD:214580	284/731 (39%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	268/696 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820