Protein Alignment didum and MYA2

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001190465.1
• Gene: MYA2 / 834412
• AraportID: AT5G43900
• Length: 1565
• Species: Arabidopsis thaliana
• Alignment Length: 1814
• Identity: 516/1814 - (28%)
• Similarity: 805/1814 - (44%)
• Gaps: 400/1814 - (22%)

  Fly    11 GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDL 75
            |:.:||...|..|...   |..:.....:|:...|||....|:    |:..|....|...|.:|:
plant    70 GSFVWVEDPDEAWIDG---EVVQVNGDEIKVLCTSGKHVVTKI----SNAYPKDVEAPASGVDDM 127

  Fly    76 TTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGDLEPH 139
            |.|:||||||||.||..|: :...||||.|.||:|:||:..:| ||...::..|:|.::|:|.||
plant   128 TRLAYLHEPGVLQNLHSRY-DINEIYTYTGSILIAVNPFRRLPHLYSSHMMAQYKGASLGELSPH 191

  Fly   140 IFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG--SESETQVERKVLASSP 202
            .||:|:.||.::..:..:.||:||||||||||.|.|..|||.|.:||  :.....||:|||.|:|
plant   192 PFAVADAAYRQMINDGVSQSILVSGESGAGKTESTKLLMRYLAYMGGRAAAEGRSVEQKVLESNP 256

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            ::||||||||.||:||||||||.::.| ::.|  .:.||.:.|||||:|||...:..|||||.||
plant   257 VLEAFGNAKTVRNNNSSRFGKFVEIQF-DEKG--RISGAAIRTYLLERSRVCQVSDPERNYHCFY 318

  Fly   268 QLCAA-RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            .|||| :....:..|:...|:.:||.....|::.::|||:::.|.:||.|:|.|.::...|..::
plant   319 MLCAAPQEDVKKFKLEEPKKYHYLNQSKCLELDSINDAEEYHATRRAMDVVGISTEEQDAIFSVV 383

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDS----DSCDIFHNDIHLQITADLL----RVSADDLRRWLLMR 388
            |.|||:|||:.:|     .||.||    |...:|    ||:..|:||    :...|.|.:.:::.
plant   384 AAILHIGNIEFAK-----GEEIDSSIPKDDKSLF----HLKTAAELLSCDEKALEDSLCKRIMVT 439

  Fly   389 KIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFET 453
            :.|::.: .|.|   |||..:||||||.:|::||.::|..:|.|:.........||||||||||:
plant   440 RDETITK-TLDP---EAATLSRDALAKVMYSRLFDWLVDKINSSIGQDHDSKYLIGVLDIYGFES 500

  Fly   454 FEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLD 517
            |:.|||||||||..||||||.|||||||:|||||.||.|.|:.|:|.|||..:||||.:. |::.
plant   501 FKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYKKEEINWSYIEFVDNQDILDLIEKKPGGIIA 565

  Fly   518 LLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            ||||.|..|:.:.|::|.||.........|.||:...:.|.|.|::..|.|....||:||:|.|.
plant   566 LLDEACMFPRSTHETFAQKLYQTFKTHKRFTKPKLARSDFTICHYAGDVTYQTELFLDKNKDYVI 630

  Fly   583 KELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHR 647
            .|...:|:.|:.|....:......|                                   |||.:
plant   631 AEHQALLNSSSCSFVASLFPPMSDD-----------------------------------SKQSK 660

  Fly   648 -KTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             .::|::|::.|.||:..|:.|.|||:||||||:......:|...|:||||..||:|.:|||.||
plant   661 FSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPNNLLKPGIFENENILQQLRCGGVMEAIRISCAG 725

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDK-----YRFGNTQIFFRAGQV 771
            :|:|..:.:|..|:.:|.....:..:|...:|:.::       ||     |:.|.|::|.||||:
plant   726 YPTRKHFDEFLARFGILAPEVLVKNSDDPAACKKLL-------DKVGLEGYQIGKTKVFLRAGQM 783

  Fly   772 AFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLI 836
            |.|:..|..:..:..:|:|..||.::.::.|:.::.....||...||||||...:.||...|.|.
plant   784 ADLDTRRTEVLGRSASIIQRKVRSYLAKKSFIVLRNSAKQIQSVCRGYLARSVYEGMRREAAALK 848

  Fly   837 LSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKR 901
            :.:..|.:|.|:.|..|..:...:|...|||:||.:....|....|:.||.:.||.|||..|:|.
plant   849 IQRDLRRFLARKAYTELYSAAVSVQAGMRGMVARKELCFRRQTKAAIIIQTWCRGYLARLHYRKL 913

  Fly   902 RRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKT 966
            ::..|..|.|.|..:||.:.:::|..|:....::    ..:||   ::::::||.
plant   914 KKAAITTQCAWRSKVARGELRKLKMAARETGALQ----AAKNK---LEKQVEELT---------- 961

  Fly   967 SEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWIS 1030
                   .:|:|:|.:..:.:..|.  |:..|...:|.: ||:.:..|.:.:.|
plant   962 -------WRLQLEKRIRTDLEEAKK--QESAKAQSSLEELQLKCKETEALLIKE----------- 1006

  Fly  1031 QKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENF 1095
                     .|..::|.|...:.|  |:...:||                   :.||  |.|||.
plant  1007 ---------REAAKKIAETAPIIK--EIPVVDQE-------------------LMDK--ITNENE 1039

  Fly  1096 MLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAK--NTLDINRPPDLLSKNYSYNDSTSLV 1158
            .||..:|.|                   |..:|....|  .|..|::  |.|::..   ::.|.:
plant  1040 KLKSMVSSL-------------------EMKIGETEKKLQETTKISQ--DRLNQAL---EAESKL 1080

  Fly  1159 VKLRS--------ILEEEKQKHKVLQEQYIKLSSR----HKPTEDSFRVSELEVENE-KLRSEYD 1210
            |||::        ||:.|.:| |::.:|.|....|    |.||..   |..||..:: .|..|::
plant  1081 VKLKTAMQRLEEKILDMEAEK-KIMHQQTISTPVRTNLGHPPTAP---VKNLENGHQTNLEKEFN 1141

  Fly  1211 QLR-TSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVL--LQQSQSMRSLEPESLQMRGNDV 1272
            :.. |:...|      .|..:|.:.::       :.:.|::  ::.:....:.:|
plant  1142 EAEFTTPVDG------KAGKSAAERQI-------MNVDALIDCVKDNIGFSNGKP---------- 1183

  Fly  1273 NELMEAFHSQKLIN--RQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDS 1335
               :.||...|.:.  :..||              |.|...:||      :|  |..|..|.||.
plant  1184 ---VAAFTIYKCLLHWKCFES--------------EKTNVFDRL------IQ--MIGSAIENEDD 1223

  Fly  1336 NVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSA 1400
            |        .:|...|....|...|:|:.|                            |:||:.|
plant  1224 N--------SHLAYWLTSTSALLFLLQKSL----------------------------KTNGSGA 1252

  Fly  1401 DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNA 1465
            ..........|...:..|.|.||.....|.....|.....|..:...:||.|.
plant  1253 TQSKKPPASTSLFGRMAMSFRSSPASGNLAAAAEAAALAVVRPVEAKYPALLF------------ 1305

  Fly  1466 DDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLK 1530
                ::.|:.:|                             .|.:|.|.:
plant  1306 ----KQQLAAYV-----------------------------EKMFGMVRD--------------- 1322

  Fly  1531 NFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAH-GMRSRATSIGASS 1594
              ||......:|.|.                            ||..|.:. ||.....|.|..|
plant  1323 --NLKRELSTLLSLC----------------------------IQAPRSSKGGMLRSGRSFGKDS 1357

  Fly  1595 SPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETG 1659
            ...|     |:.:|..|.......:...:.....::|:.|...:|.....|.|:||.:.|.:..|
plant  1358 PAVH-----WQSIIDGLNSLLVTLKENHVPLVLIQKIYSQTFSYINVQLFNSLLLRKECCTFSNG 1417

  Fly  1660 MIIRYNIGCIEDW-VRSKKMSNDVLTALAPLNQVSQLL----QSRKSEQDVQTICDLCTSLSTAQ 1719
            ..::..:..:|.| .::|:.|......|..:.|....|    :.|.|..::..  |||..||..|
plant  1418 EFVKSGLAELELWCCQAKEYSGPSWEELKHIRQAVGFLVIHQKYRISYDEIAN--DLCPVLSVQQ 1480

  Fly  1720 VLKVMKSYKLDDYES-----EITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKV 1773
            :.::...|..|.|.:     |:.:.....:||:.|     .::||.|.:|.....||.:
plant  1481 LYRICTLYWDDSYNTRSVSQEVISSMRTLMTEESN-----DADSDSFLLDDDSSIPFSI 1534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	280/701 (40%)
		IQ	900..922	CDD:197470	7/21 (33%)
		SMC_prok_B	<942..1365	CDD:274008	86/443 (19%)
		Myo5_CBD	1424..1792	CDD:271254	64/361 (18%)
MYA2	NP_001190465.1	Myosin_N	68..108	CDD:460670	10/40 (25%)
		MYSc_Myo11	136..779	CDD:276835	280/701 (40%)
		IQ	889..911	CDD:197470	9/21 (43%)
		Myosin_tail_1	<935..>1111	CDD:460256	52/269 (19%)
		MyosinXI_CBD	1159..1535	CDD:271259	97/556 (17%)