DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XI-I

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001328260.1	Gene:	XI-I / 829456	AraportID:	AT4G33200	Length:	1523	Species:	Arabidopsis thaliana

Alignment Length:	1857	Identity:	535/1857 - (28%)
Similarity:	815/1857 - (43%)	Gaps:	424/1857 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGK----LKEVKLKADGSDLPPLRN 65
            |:...:|.|:||...||.|.:|.:.:|:...   |.:.|.:||    ..|...:.|..|  ...|
plant     8 ELNLRKGDKVWVEDKDLAWIAADVLDSFDNK---LHVETSTGKKVFVSPEKLFRRDPDD--EEHN 67

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYR 129
                 |.:|:|.|:||||.|||:||:.|:.... ||||.|.||:|:||:.::| ||...::..|.
plant    68 -----GVDDMTKLTYLHEAGVLYNLQRRYALND-IYTYTGSILIAVNPFKKLPHLYNGHMMEQYM 126

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG--SESETQ 192
            |...|:|.||:||:::.||..:..::.:.||:||||||||||.:.|..|:|...|||  ::.:..
plant   127 GAPFGELSPHVFAVSDVAYRAMIDDSRSQSILVSGESGAGKTETTKLIMQYLTFVGGRATDDDRS 191

  Fly   193 VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQA 257
            ||::||.|:|::||||||||.|||||||||||.::.|.....:   .||.:.|||||:||||...
plant   192 VEQQVLESNPLLEAFGNAKTVRNDNSSRFGKFVEIQFDTNGRI---SGAAIRTYLLERSRVVRIT 253

  Fly   258 QGERNYHIFYQLCAARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ..|||||.||||||:.:...:..|.:..:|.:||.....|:|.||.||::..|.:||.::|.|..
plant   254 DPERNYHCFYQLCASGNDAEKYKLSNPRQFHYLNQSKTYELEGVSSAEEYKNTRRAMDIVGISQD 318

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :...|.:.||.||||||::    |:.|.|.:.|...|. .:..|||:.|||.:..|:.|...|..
plant   319 EQEGIFRTLAAILHLGNVE----FSSGREHDSSVVKDP-ESRHHLQMAADLFKCDANLLLASLCT 378

  Fly   388 RKI---ESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIY 449
            |.|   |.:....|.||   ||..:||.|||.:||.||.::|..:|||:....:....|||||||
plant   379 RSILTREGIIIKALDPN---AAVTSRDTLAKTVYAHLFDWLVDKINKSVGQDPESRFQIGVLDIY 440

  Fly   450 GFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-L 513
            |||.|:.|||||||||:|||||||.||:||||:||:||.||.|.|:.|:|.|||..:||||.: :
plant   441 GFECFKNNSFEQFCINFANEKLQQHFNEHVFKMEQDEYRKEEINWSYIEFIDNQDVLDLIEKKPI 505

  Fly   514 GVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNR 578
            ||:.||||.|..|:.:.||::.||.......|..|||:|..|.|.:.|::..|.|....||:|||
plant   506 GVIALLDEACMFPRSTHESFSMKLFQNFRFHPRLEKPKFSETDFTLSHYAGKVTYQTEAFLDKNR 570

  Fly   579 DTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPS 643
            |....|...:||                      |:|...:.|                  :.||
plant   571 DYTIVEHCNLLS----------------------SSKCPFVAG------------------IFPS 595

  Fly   644 KQHRKT--------VGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700
            .....|        |.|:|::.|.:|:.||..|.||||||:|||......|:|:..::.|||..|
plant   596 APEESTRSSYKFSSVSSRFKQQLQALMETLSKTEPHYVRCVKPNSLNRPQKFESLSVLHQLRCGG 660

  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIF 765
            |||.||||.||:|:|..|.||..|:.||......:.||.:.....|:.|  .....|:.|.|::|
plant   661 VLEAVRISLAGYPTRRNYSDFVDRFGLLAPEFMDESNDEQALTEKILSK--LGLGNYQLGRTKVF 723

  Fly   766 FRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMRE 830
            .||||:..|:..||.:......::|..:|.||..:.|:..:.....||.:.||.|:|......|.
plant   724 LRAGQIGILDSRRAEVLDASARLIQRRLRTFVTHQNFISARASAISIQAYCRGCLSRNAYATRRN 788

  Fly   831 ARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALAR 895
            |.|.:::.|:.|.||.|..:::|..:...:|:..|....|.||...::|..|..||...|....|
plant   789 AAAAVLVQKHVRRWLSRCAFVKLVSAAIVLQSCIRADSTRLKFSHQKEHRAASLIQAHWRIHKFR 853

  Fly   896 RAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRID-ELNRDN 959
            .|::.|:.:||..|...|:.||:|:|:::|..|.....:......||.::..::.|:. |.....
plant   854 SAFRHRQSSIIAIQCRWRQKLAKREFRKLKQVANEAGALRLAKTKLEKRLEDLEWRLQLEKRLRT 918

  Fly   960 SNLKHKTSEISVLKMKLELKKTLEAEFKNVKAA-------CQDKDKLIEALNKQLEAERDEKMQL 1017
            |..:.|:||||      :|:||||:....:.||       | :|:.::|   |||:....||..:
plant   919 SGEEAKSSEIS------KLQKTLESFSLKLDAARLATINEC-NKNAVLE---KQLDISMKEKSAV 973

  Fly  1018 LEE-NGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDN-----REL 1076
            ..| ||..:         .:::|..|:..::.:       |...|..|..:|....|     ::|
plant   974 ERELNGMVE---------LKKDNALLKNSMNSL-------EKKNRVLEKELLNAKTNCNNTLQKL 1022

  Fly  1077 NEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRP 1141
            .||.:|..:.:..:::    |:|:||.|                 :||:.|   ..:.|| |..|
plant  1023 KEAEKRCSELQTSVQS----LEEKLSHL-----------------ENENQV---LMQKTL-ITSP 1062

  Fly  1142 PDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDS----FRVSELEVEN 1202
            .                 ::..||.|:|....|:..|..:.|....||...    |..|..|...
plant  1063 E-----------------RIGQILGEQKHSSAVVPAQNDRRSVFETPTPSKHIMPFSHSLSESRR 1110

  Fly  1203 EKLRSE-----YDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEP 1262
            .||.:|     |:.|...||..:..|:.....|            |:..|.:|
plant  1111 SKLTAERNLENYELLSRCIKENLGFNDDKPLAA------------CVIYKCLL------------ 1151

  Fly  1263 ESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFE 1327
                             |.     |..|||..||.                         .::.|
plant  1152 -----------------HW-----RAFESESTAIF-------------------------NIIIE 1169

  Fly  1328 SIDEFEDSNVDTLRQNDR--YLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEM 1390
            .|:|       .|:..|.  .|...|..|.|...|:|..|: :|:.|.|..|..|:..:.::...
plant  1170 GINE-------ALKGGDENGVLPYWLSNASALLCLLQRNLR-SNSFLNASAQRSGRAAYGVKSPF 1226

  Fly  1391 IRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFM 1455
               |.:|  .|.||:..:.:                                     :||.|.
plant  1227 ---KLHG--PDDGASHIEAR-------------------------------------YPALLF-- 1247

  Fly  1456 CIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN 1520
                          ::.|:..|.:|                             ||    .::.|
plant  1248 --------------KQQLTACVEKI-----------------------------YG----LIRDN 1265

  Fly  1521 TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRS 1585
            .:|:                                   |.|      |....||..:.:.|:..
plant  1266 LKKE-----------------------------------LSP------LLGSCIQAPKASRGIAG 1289

  Fly  1586 RATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLR 1650
            ::.|.|  ..|:......|:.::..|:....:.:...:.:.:..::..|:..||.....|.|:||
plant  1290 KSRSPG--GVPQQSPSSQWESILKFLDSLMSRLRENHVPSFFIRKLVTQVFSFINLSLFNSLLLR 1352

  Fly  1651 GDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLL-------QSRKSEQDVQTI 1708
            .:.|.:..|..::..|..:|.|:.:.| .....|:...||.:.|.:       :.:||..:::.
plant  1353 RECCTFSNGEYVKSGISELEKWIANAK-EEFAGTSWHELNYIRQAVGFLVIHQKKKKSLDEIRQ- 1415

  Fly  1709 CDLCTSLSTAQVLKVMKSYKLDDY-----ESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFI 1768
             |||..|:..|:.::...|..|.|     .||:.:. :..|.:|.|    ||..|:.|.:|....
plant  1416 -DLCPVLTIRQIYRISTMYWDDKYGTQSVSSEVVSQ-MRVLVDKDN----QKQTSNSFLLDDDMS 1474

  Fly  1769 QPFKVVFRYSDIKLEDIEL------PSHLNLDEFLTK 1799
            .||..         |||:.      ||.:...:|:::
plant  1475 IPFSA---------EDIDKAIPVLDPSEIEPPKFVSE 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	303/727 (42%)
		MYSc_Myo5	84..767	CDD:276831	289/697 (41%)
		IQ	900..922	CDD:197470	8/21 (38%)
		GBP_C	<971..1086	CDD:303769	29/127 (23%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	22/117 (19%)
		Myo5_CBD	1424..1792	CDD:271254	65/385 (17%)
XI-I	NP_001328260.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830