DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XIH

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_194600.2	Gene:	XIH / 828991	AraportID:	AT4G28710	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1859	Identity:	526/1859 - (28%)
Similarity:	797/1859 - (42%)	Gaps:	433/1859 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDL 75
            |:.:||...::.|....:.|.  ||:.....|| |||...:|:    |...|....|...|.:|:
plant     9 GSCVWVEDPEVAWIDGEVIEV--KGSDIKVKCT-SGKTVAIKV----SSAYPKDVEAPASGVDDM 66

  Fly    76 TTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGDLEPH 139
            |.|:||||||||.|::.|| :...||||.|.||:|:||:..:| ||...:::.|:|...|:|.||
plant    67 TRLAYLHEPGVLQNMKSRF-DINEIYTYTGNILIAVNPFRRLPHLYNNHMMQQYKGAGFGELSPH 130

  Fly   140 IFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---SESETQVERKVLASS 201
            .||:|:.||.:::.:..:.||:||||||||||.:.|..|:|.|.:||   ||..| ||:|||.|:
plant   131 PFAVADAAYRQMKNQGISQSILVSGESGAGKTETTKLLMQYLADMGGRAVSEGRT-VEKKVLESN 194

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIF 266
            |::||||||||.||:||||||||.::.| :|.|  .:.||.:.|||||:|||...:..|||||.|
plant   195 PVLEAFGNAKTVRNNNSSRFGKFVEIQF-DQRG--RISGAAIRTYLLERSRVCQVSDPERNYHCF 256

  Fly   267 YQLCAARSKYPELV----LDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |.||||.   ||.:    |....||.:||.....|:||:.||:::.||.:||.|:|.:.::...|
plant   257 YMLCAAP---PEDIKKWKLADPRKFHYLNQSQCIELERMDDAKEYRETRKAMDVVGINSEEQEAI 318

  Fly   328 VKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            .:::|.||||||::    |.:|.|.:.|...|...| .||:..|:|.......|...|..|.|.:
plant   319 FQVVAAILHLGNVE----FGKGKEADSSAPKDDTSN-YHLKTAAELFMCDEQALEDSLCKRVIVT 378

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN 457
            ..|.:......|:|..:||||||.:|::||.:||..:|.|:.........||||||||||:|:.|
plant   379 RGETITKCLDQESAALSRDALAKTVYSRLFDWIVNKINDSIGQDPDSEYLIGVLDIYGFESFKTN 443

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLDLLDE 521
            ||||||||..||||||.|||||||:||:||.||.|.|:.|:|.|||..:||||.:. |::.||:|
plant   444 SFEQFCINLTNEKLQQHFNQHVFKMEQDEYNKEEIDWSYIEFVDNQEILDLIEKKAGGIISLLNE 508

  Fly   522 ECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELT 586
            .|..|:.:.|::|.|:........||.||:...|.|.|.|::..|.|....|||||:|.|..|..
plant   509 ACMFPRATHETFAEKMYQTFKDHKHFSKPKLSRTDFTICHYAGDVTYQTEQFLEKNKDYVVAEHQ 573

  Fly   587 QVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVG 651
            .:|:.|..:....:..|     |..|:.|.|..                            .::.
plant   574 TLLNASRCAFVASLFPL-----LAEDANKKSKF----------------------------SSIS 605

  Fly   652 SQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRW 716
            |:|::.|.:|:.||..|.|||:||:|||:......:|...::||||..||:|.:|||.||||:|.
plant   606 SRFKQQLVTLLETLSTTEPHYIRCVKPNNLLKPLIFENQNVLQQLRCGGVMEAIRISCAGFPTRK 670

  Fly   717 LYPDFYMRYQLLVYRSKLDK--------NDMKLSCRNIVMK-WIQDEDKYRFGNTQIFFRAGQVA 772
            .:.:|..|:.:|. ...|||        :...::|:.::.| .:|.   |:.|.|::|.||||:|
plant   671 KFEEFLERFSVLA-PEVLDKSTDGWPLSSTDDVACKKLLEKVALQG---YQIGKTKVFLRAGQMA 731

  Fly   773 FLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLIL 837
            .|:..|..:..:..:.:|...|.::.|:.||.::||...:|...||.|:|...:.:|...|.|.:
plant   732 DLDARRNEVLGRAASRIQRKFRSYLSRKTFLMLRKVATNMQAVCRGQLSRLIFEGLRRDAAVLEI 796

  Fly   838 SKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRR 902
            .:..|..|.|:.|..|..:...||...|||.:|.:....|....|:.||...|..||:..||:.:
plant   797 QRDIRMHLARKSYKELYFAAVSIQLGIRGMASRGRLRFQRQDKAAIMIQSHCRKFLAQLHYQRLK 861

  Fly   903 RNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTS 967
            :..|..|:|.|..|||::.:::|..||                                   :|.
plant   862 KAAITTQSAWRARLARKELRKLKMAAK-----------------------------------ETG 891

  Fly   968 EISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQK 1032
            .:...|.|||                    |.:|.|..:|:.|:..:..:.|..
plant   892 VLEAAKSKLE--------------------KQVEELTWKLQLEKRMRTDMEESK----------- 925

  Fly  1033 QTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFML 1097
               .|||.:||..::|:                               |...|:.:
plant   926 ---TQENAKLRSALEEM-------------------------------QLQFKETK--------- 947

  Fly  1098 KEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLR 1162
                        :||.::...|....|          |:
plant   948 ------------ALHLQEVEAAKKMAE----------TV-------------------------- 964

  Fly  1163 SILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNA 1227
                      .||||         .|..|:..|.:|..|||||:|....|...|
plant   965 ----------PVLQE---------VPVVDTELVEKLTSENEKLKSLVSSLDQKI----------- 999

  Fly  1228 QHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESE 1292
                  :|..::.||               ||
plant  1000 ------DETEKKFEE---------------RS--------------------------------- 1010

  Fly  1293 LKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQ 1357
              .|.||...:.:|....|..|.....|||    |.|.:.|..|                |.:.|
plant  1011 --KINEERLKQAIEAETTIVNLKTAVHELQ----EKILDVESEN----------------KILRQ 1053

  Fly  1358 FLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHS 1422
            ..|:|....|....:|     |.|..|...:|   :..||:..:..|...:|:|.  ....::|
plant  1054 KSLIQASGHLPPTPVK-----GSQNGHFSSKE---SPFNGSEIETLARTQEQESD--AKTRRYH- 1107

  Fly  1423 SDLDKILQRLLSALTPRTV--VGLLPGFP--AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKM 1483
              ||:..:. :.||....|  :|...|.|  |:.|:.|:.:.....|:.  ..:..:.|..|...
plant  1108 --LDRQREN-IGALINCVVNNIGFNQGKPVAAFTIYKCLLHWKSFEAER--TSVFDRLVQMIGSA 1167

  Fly  1484 HRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLF-----EYR----- 1538
            .:.....|:...||.|:.|||.:::|      .:|.....|.:..:.. :||     .:|
plant  1168 IKDEGDNEHLAYWLSNTSTLLFMIQQ------SLKPGATPQQKTPVST-SLFGRMAMGFRSAPSS 1225

  Fly  1539 -----------RVILDLIVNLYQALI--MQIQGLLDPKIVPAILNN--DEIQ------------- 1575
                       ..::..:|....||:  .|:...:: ||...|.:|  :|:|
plant  1226 AETSAAAEAAAAAVIRPVVAKDPALLFKQQLTAYVE-KIFGMIRDNLKNELQTLLSLCIQAPRTS 1289

  Fly  1576 RGRQAHGMRSRATSIGASSSP-EHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFI 1639
            .||.....||..|.  .::|| :|     |..:...|.......|...:.....:.||.|...||
plant  1290 TGRSLRSFRSSKTM--RNNSPLDH-----WNGIYDGLNAILSTLQENFVPPVLIQNIFIQTFSFI 1347

  Fly  1640 CAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVR--SKKMSNDVLTALAPLNQVSQLL----QS 1698
            .....|.|:||.:.|.:..|..::..:..:|:|..  :::.:......|..:.|....:    :.
plant  1348 NVQLFNSLLLRRECCTFSNGEFVKSGLALLEEWCNETTEEYAGSSWDELKHIRQAVGFMVIHKKY 1412

  Fly  1699 RKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESE------ITNVFLEKLTEKLNARQMQKSN 1757
            |.|..|:..  |||..||..|:.::...|..|.|.:.      |.|:.: .:||..|     .::
plant  1413 RISYDDIAH--DLCPILSVQQLYRICTLYWDDSYNTRSVSQDVIANMRV-LMTEDSN-----NAD 1469

  Fly  1758 SDEFTIDQKFIQPFKVVFRYSDIKLEDI-ELPSHLNLDE 1795
            |..|.:|:....||......|.:|.:|. |:.....|:|
plant  1470 SSAFLLDEDSSIPFSADDLSSSMKEKDFAEMKPAEELEE 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	300/730 (41%)
		MYSc_Myo5	84..767	CDD:276831	285/700 (41%)
		IQ	900..922	CDD:197470	7/21 (33%)
		GBP_C	<971..1086	CDD:303769	17/114 (15%)
		coiled coil	1049..1068	CDD:293879	0/18 (0%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	17/108 (16%)
		Myo5_CBD	1424..1792	CDD:271254	89/423 (21%)
XIH	NP_194600.2	Myosin_N	12..47	CDD:280832	11/37 (30%)
		MYSc	56..738	CDD:214580	300/731 (41%)
		MYSc_Myo11	75..726	CDD:276835	285/700 (41%)
		Apolipoprotein	893..1041	CDD:279749	54/359 (15%)
		DUF4355	893..1011	CDD:290964	44/325 (14%)
		Ax_dynein_light	<978..1023	CDD:287215	18/111 (16%)
		MyosinXI_CBD	1109..1486	CDD:271259	84/402 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830