DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XIJ

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001319790.1	Gene:	XIJ / 824985	AraportID:	AT3G58160	Length:	1242	Species:	Arabidopsis thaliana

Alignment Length:	1424	Identity:	432/1424 - (30%)
Similarity:	680/1424 - (47%)	Gaps:	254/1424 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSD-------LPPLRNPAILVG 71
            :||...:..|....:          |.|   .|:..|:|.. ||.|       |.|....|...|
plant    11 VWVEDPERAWIDGVV----------LNI---KGEEAEIKTN-DGRDVIANLSRLYPKDTEAPSEG 61

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGD 135
            ..|:|.|||||||.||.||..|: |...||||.|.||:|:||:..:| ||...::..|:.....:
plant    62 VEDMTRLSYLHEPAVLDNLATRY-ELNEIYTYTGNILIAVNPFQGLPHLYDAEVMEKYKEAYFKE 125

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS---ESETQVERKV 197
            |.||:||:...||.::..|..|..|:||||||:|||.:.|..|||.|..||.   |..| ||.:|
plant   126 LNPHVFAIGGIAYREMINEGRNKCILVSGESGSGKTETTKMLMRYLAYFGGHTAVEGRT-VENQV 189

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.|:|::||||||||.:|:||||||||.::.|.:   |..:.||.:.|||||:|||...:..|||
plant   190 LESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDD---VGRISGAAIRTYLLERSRVCQVSDPERN 251

  Fly   263 YHIFYQLCAARSKYPELV----LDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQ 323
            ||.||.||||.   ||.|    |.....|::||.....:::.|:|||::..|.:||.|:|.|.::
plant   252 YHCFYLLCAAP---PEDVERFKLGDPKSFRYLNQSSCYKLDGVNDAEEYLATRRAMDVVGISEKE 313

  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388
            ...|.:::|.|||||||:.||     .|:.||.|.....:..|||:|::||......|...|..|
plant   314 QDAIFRVVASILHLGNIEFSK-----GEDADSSSVKDEQSMFHLQMTSELLMCDPHSLEDALCKR 373

  Fly   389 KIESVNEYVLIPNSIE--AAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            .:.:..|  :|..|::  .|..:||.|||.||::||.::|..:|.|:...|.....|||||||||
plant   374 MMVTPEE--VIKRSLDPLGAAVSRDGLAKTIYSRLFDWLVNKINISIGQDSHSRRLIGVLDIYGF 436

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GV 515
            |:|:.||||||||||.||||||.|||||||:||.||.||.|.|:.::|.||:..:||||.:. |:
plant   437 ESFKTNSFEQFCINYTNEKLQQHFNQHVFKMEQGEYQKEEIDWSYVEFVDNKDVVDLIEKKPGGI 501

  Fly   516 LDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            :.||||.|.:||.:.|:::.||.........|.||:...:.|.:.|::..|:|..:.||:||:|.
plant   502 IALLDEACMLPKSTPETFSEKLYHTFKDHKRFMKPKLTRSDFTLVHYAGDVQYQSDQFLDKNKDY 566

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            |..|...:|:.|..|.         :..|.....|.|                         ||.
plant   567 VVAEHQDLLNASKCSF---------VSGLFPPLPKES-------------------------SKS 597

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
            ...::|::|:..|..|:.||::|.|||:||:|||:......::.|.::.|||:.||||.:|:..|
plant   598 KFSSIGARFKLQLQQLMETLNSTEPHYIRCVKPNNLLQPTVFDNANVLHQLRSGGVLEAIRVKCA 662

  Fly   711 GFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDE---DKYRFGNTQIFFRAGQVA 772
            |:|:...:.:|..|:.:|.......:.:.:::|     |||.::   ..|:.|.:::|.||||:|
plant   663 GYPTNRTFIEFLNRFLILAPEILKGEYEAEVAC-----KWILEKKGLTGYQIGKSKVFLRAGQMA 722

  Fly   773 FLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLIL 837
            .|:..|..:..:...::|..||..:.|.:|:.:::....||.:.||.:||:.:::||...|.:.:
plant   723 ELDAHRTRVLGESARMIQGQVRTRLTRERFVLMRRASVNIQANWRGNIARKISKEMRREEAAIKI 787

  Fly   838 SKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRR 902
            .|..|..:.::.|.:.:.|...:|:..|.|.||::|........|..||.:.||..|...|:|.:
plant   788 QKNLRRQIAKKDYGKTKSSALTLQSGVRTMAARHEFRYKLTTRAATVIQAYWRGYSAISDYKKLK 852

  Fly   903 RNIIICQAAIRRFLARRKFKRMK-AEAKTISHMENKYMGLENK---IISMQQRIDELNRDNSNLK 963
            |..::|::.:|..:||::..:.| |:.|..:..|.| :.|.|:   .:.|...:.....|::...
plant   853 RVSLLCKSNLRGRIARKQLGQSKQADRKEETEKERK-VELSNRAEEAVDMSFVLHSEQSDDAESG 916

  Fly   964 HKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEW 1028
            |..      |.||.::.....:..:|..:.|..|       ::|..||..|:.:..|:||:.:
plant   917 HGR------KAKLSIESEDGLDKSSVLHSEQSDD-------EELGHERKTKLSIESEDGHSDQ-- 966

  Fly  1029 ISQKQTWRQENEEL--RRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIE 1091
                    .::||:  .|:....|......|.:.....|    :.|:.|:  .::|  |.|..|:
plant   967 --------SDDEEIEHERKTKHCIQAEDGIEKSYVMHSD----QSDDEEI--GHKR--KTKHSIQ 1015

  Fly  1092 NENFMLKEELSRLTAGSFSLHARKASNASSQNED-DVGYASAKNTLDINRPPDLLSKNYSYNDST 1155
            .|:.:.|         ||.:|       |.|::| ::|:
plant  1016 AEDGIEK---------SFVVH-------SDQSDDEEIGH-------------------------- 1038

  Fly  1156 SLVVKLRSILEEEKQKHKV-----LQEQYIKLSSRHKPTEDSFRVSEL-----EVENEKLRSEYD 1210
                       |.|.||.:     :|:.::..|  .||......||::     :.|.|.|.:|.:
plant  1039 -----------ERKTKHAIQVEDGIQKSFVTCS--EKPYNTFSVVSQITSPIRDTEIESLTAEVE 1090

  Fly  1211 QLRTSI---KHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDV 1272
            .|:..:   |...:|:|.....|....|.||:|.|..:.:...||.|                 :
plant  1091 MLKALLQVEKQRADISERKCAEARELGERRRKRLEETERRVYQLQDS-----------------L 1138

  Fly  1273 NELMEAFHSQKLINRQLESELKAITEEHN-------------SKLVEMTQEIERLNNEKDELQKV 1324
            |.|:.:...|       .|:||:|....:             ..|.:.::..|..:::.|.....
plant  1139 NRLLYSMSDQ-------FSQLKSILRSPSMSASTMASAPVVRDDLADSSENSEASSSDSDFTFPA 1196

  Fly  1325 MFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAK-LKAYRQD--GG 1380
            ...|.|.|...|.:.|:                  ::.::|....|| .::|..|  ||
plant  1197 PSPSSDNFSTFNPNQLQ------------------VIVQDLSTTEAKGTESYDSDKEGG 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	288/726 (40%)
		MYSc_Myo5	84..767	CDD:276831	272/696 (39%)
		IQ	900..922	CDD:197470	6/21 (29%)
		GBP_C	<971..1086	CDD:303769	22/116 (19%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	26/116 (22%)
		Myo5_CBD	1424..1792	CDD:271254
XIJ	NP_001319790.1	Myosin_N	9..46	CDD:397036	11/48 (23%)
		MYSc_Myo11	74..717	CDD:276835	272/696 (39%)
		IQ	829..849	CDD:197470	6/19 (32%)
		DUF460	<1081..>1142	CDD:421465	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830