DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and XID

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_180882.2	Gene:	XID / 817886	AraportID:	AT2G33240	Length:	1770	Species:	Arabidopsis thaliana

Alignment Length:	1944	Identity:	553/1944 - (28%)
Similarity:	861/1944 - (44%)	Gaps:	419/1944 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GAKIWVPHADLVWESATLEESYRKGAGFLKIC---TDSGKLKEVKLKADGSDLPPLRNPAILVGQ 72
            |:::||...|..|....:.|:  .|......|   |...|:..|..|  ..:.|.|       |.
plant    27 GSQVWVEDPDEAWLDGEVVEA--NGQEIKVNCQTKTVVAKVNAVHPK--DPEFPEL-------GV 80

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGDL 136
            :|:|.|:||||||||.||:.|:...: ||||.|.||:|:||:..:| |||..|:..|:|...|:|
plant    81 DDMTKLAYLHEPGVLLNLKARYNANE-IYTYTGNILIAVNPFKRLPHLYGNEIMEQYKGTDFGEL 144

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG-SESE-TQVERKVLA 199
            .||.||:|:.||.|:..|..:.:|:||||||||||.|.|..|:|.|.:|| :||| ..||::||.
plant   145 SPHPFAVADSAYRKMINEGVSQAILVSGESGAGKTESTKMLMQYLAYMGGKAESEGRSVEQQVLE 209

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.||:||||||||.::.| |.||  .:.||.:.|||||:|||...:..|||||
plant   210 SNPVLEAFGNAKTVRNNNSSRFGKFVEIQF-NHMG--RISGAAIRTYLLERSRVCQVSDPERNYH 271

  Fly   265 IFYQLCAARSKYPE-LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIV 328
            .||.||||..:..| ..|.....|.:||......::.:.|::::..|.:||.|:|.|.::...|.
plant   272 CFYMLCAAPEQETERYQLGKPSTFHYLNQSNCHALDAIDDSKEYLATRKAMDVVGISPEEQDAIF 336

  Fly   329 KILAGILHLGNIQVSK-KFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            :::|.|||||||:.:| :.::|:|.:|..|      ..||::.|.|.......|...|..|.:.:
plant   337 RVVAAILHLGNIEFAKSEESDGAEPKDDKS------RFHLKVAAKLFMCDEKALENSLCNRVMVT 395

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN 457
            ..|.:..|....:|..:||||||.:|:|||.::|..:|.|:...|.....||||||||||:|:.|
plant   396 RGESITKPLDPGSAALSRDALAKIVYSKLFDWLVTKINNSIGQDSSSKYIIGVLDIYGFESFKTN 460

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLDLLDE 521
            ||||||||..||||||.|||||||:|||||.||.|.|:.|:|.|||..:||||.:. |::.||||
plant   461 SFEQFCINLTNEKLQQHFNQHVFKMEQEEYTKEEIDWSYIEFIDNQDVLDLIEKKPGGIIALLDE 525

  Fly   522 ECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELT 586
            .|..|:.:.::.|.||.........|.||:...|.|.|.|::..|.|....||:||:|.|..|..
plant   526 ACMFPRSTHDTLAEKLYQTFGSHKRFTKPKLARTDFTICHYAGDVTYQTELFLDKNKDYVVGEHQ 590

  Fly   587 QVLSESNMSLAKQVM--TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKT 649
            .:::.|:.|....:.  :.||       |:|||..                            .:
plant   591 SLMNSSDCSFVSSLFPKSREE-------SSKSSKF----------------------------SS 620

  Fly   650 VGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPS 714
            :||||::.|.||:.||:.|.|||:||:|||:......:|...::.|||..||:|.:|||.||:|:
plant   621 IGSQFKQQLQSLLETLNTTEPHYIRCVKPNNVLKPEIFENVNVLHQLRCGGVMEAIRISCAGYPT 685

  Fly   715 RWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRA 779
            |..:.:|..|:::|...:.....|...:|:.::.:  .|...::.|.|::|.||||:|.|:..||
plant   686 RKPFNEFLTRFRILAPEATERSFDEVDACKKLLAR--VDLKGFQIGKTKVFLRAGQMAELDAHRA 748

  Fly   780 NLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGW 844
            .:......|:|..|..::.|:::|.:|.....||...||::||.:.:..|...|.:.:.|.||.:
plant   749 EVLGHSARIIQRKVITYLSRKKYLLLQSASTEIQAFCRGHIARVQFKATRREAASVRIQKQARTY 813

  Fly   845 LCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQ 909
            :|:..:.:|..|...||:..|.|.||.:|........|:.||..:|..|.||.|.:.::..|..|
plant   814 ICQTAFKKLCASAISIQSGLRAMAARVEFQYRTKRKAAIIIQSQIRRCLCRRRYLRTKKAAITTQ 878

  Fly   910 AAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKM 974
            ...|..:|.|:.:::|..||....:::....||                        .|:..|..
plant   879 CGWRVKVAHRELRKLKMAAKETGALQDAKTKLE------------------------KEVEELTS 919

  Fly   975 KLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWI---SQKQTWR 1036
            .|||:|.:..|.:.||.  |:.:.|..|||       |.|:||.|......||.:   |..|..:
plant   920 CLELEKQMRMELEQVKT--QEVEDLRSALN-------DMKLQLGETQVTKSEEILKLQSALQDMQ 975

  Fly  1037 QENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEEL 1101
            .|.|||.::::...|:|.                                      ||..||:.:
plant   976 LEFEELAKELEMTNDLAA--------------------------------------ENEQLKDLV 1002

  Fly  1102 SRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILE 1166
            |.|        .||...:.|:.|:                                    .|.|.
plant  1003 SSL--------QRKIDESDSKYEE------------------------------------TSKLS 1023

  Fly  1167 EEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSI-----KHGVEINELN 1226
            ||:.|.:|             |..|...:.:||.||:||::....|...|     ||.|..:.::
plant  1024 EERVKQEV-------------PVIDQGVIIKLEAENQKLKALVSTLEKKIDSLDRKHDVTSSNIS 1075

  Fly  1227 AQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGND-VNELMEAFHSQKLINRQLE 1290
            .|   |:|......|....|.|...:....:.|||.|:.:..||| .||..|   ..:::..::.
plant  1076 DQ---LKESASSDYEMLSNLAAENERLKALVSSLENENYENDGNDSPNEQKE---GPQMLKEEIL 1134

  Fly  1291 SELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSN----------VDTLRQNDR 1345
            :|..:|.:|..:||....:::..|   .|.|::.:.|:..::|:::          |||.::.:.
plant  1135 AEDFSIDDEMTNKLAAENKDLYDL---VDLLERKIDETEKKYEEASKLCEERLKQVVDTEKKYEE 1196

  Fly  1346 YLR--RELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKI-----EEEMIRNKSNGTSADVG 1403
            ..|  .|..|.|     |..|.||...|....|     ||.|:     |::::|.::...||  .
plant  1197 ASRLCEERLKQV-----VDTETKLIELKTSMQR-----LEEKVSDMEAEDKILRQQALRNSA--S 1249

  Fly  1404 ANVTKQKSQN----------------------PQ---GLMKFHSSDLD----KILQRLLSALTPR 1439
            ..::.|||.:                      |.   |.|.|..|.::    :.:..||..::..
plant  1250 RKMSPQKSLDLFVFMYLFQPVENGHHESFAPIPSRRFGAMSFRRSQIEQQPHEFVDVLLKCVSKN 1314

  Fly  1440 TVVGLLPGFP--AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSIT 1502
              ||...|.|  |:.|:.|:.:..|..|:.  ..:..:.|.........|....|...||.|:.|
plant  1315 --VGFSHGKPVAAFTIYKCLIHWKLFEAEK--TSVFDRIVPIFGSAIENPEDDSNLAYWLTNTST 1375

  Fly  1503 LLNLMKQ-------------------------------------YGDVDEYVK-------FNTEK 1523
            ||.|:::                                     .|||.:.|.       |
plant  1376 LLFLLQRSLKSHSTTGASPKKPPQPTSFFGRMTQGFRSPSSASLSGDVVQQVDARYPALLF---- 1436

  Fly  1524 QNQQQLKNFNLFEYRRVILDLIVNLYQALIMQ---------IQGLLD------------------ 1561
              :|||..:         ::.|..::|..:.:         ||||.|
plant  1437 --KQQLTAY---------IETIYGIFQENVKRKLAPVLSSCIQGLKDSSHEFSAETLSAESSEQN 1490

  Fly  1562 ----------PKIV-----------------------PAILNNDEIQRGRQAHGMRSRATSIGAS 1593
                      |:.:                       ||..:.:..|........:::.::..:.
plant  1491 SPEKPSEENPPEKLSEDNSSGKLSEDYLAAKPSEDNSPAKPSEENSQAKLSEVNPQAKPSAENSL 1555

  Fly  1594 SSPEHGGGP--AWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMW 1656
            :.|.....|  .|:.:||.|.......:...:....|::||.|....|.....|.|:.| :.|.:
plant  1556 AKPSEENSPTETWQDVIGLLNQLLGTLKKNYVPLFLAQKIFCQTFQDINVQLFNSLLQR-ECCTF 1619

  Fly  1657 ETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQ-------DVQTICDLCTS 1714
            ..|..:...:..:|.|. |:...:.|.::...|....|.|....:||       |:.|  :||.:
plant  1620 IMGKKVNVWLNELESWC-SQATEDFVGSSWDELKNTRQALVLLVTEQKSTITYDDLTT--NLCPA 1681

  Fly  1715 LSTAQVLKVMKSYKLDDYESE------ITNVFLEKLTEKLNARQ--MQKSNSDEFTIDQ 1765
            |||.|:.::....|:||:|.:      |:|:.|....|..::|.  :..::|..|..|:
plant  1682 LSTQQLYRICTLCKIDDHEDQNVSPDVISNLKLLVTDEDEDSRSFLLDNNSSIPFAADE 1740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	295/720 (41%)
		MYSc_Myo5	84..767	CDD:276831	281/690 (41%)
		IQ	900..922	CDD:197470	5/21 (24%)
		GBP_C	<971..1086	CDD:303769	28/117 (24%)
		coiled coil	1049..1068	CDD:293879	2/18 (11%)
		coiled coil	1077..1086	CDD:293879	0/8 (0%)
		JAKMIP_CC3	<1190..1299	CDD:292653	30/114 (26%)
		Myo5_CBD	1424..1792	CDD:271254	85/469 (18%)
XID	NP_180882.2	Myosin_N	28..64	CDD:280832	8/37 (22%)
		MYSc	76..744	CDD:214580	296/721 (41%)
		MYSc_Myo11	92..736	CDD:276835	281/690 (41%)
		Tropomyosin_1	926..1068	CDD:289488	50/245 (20%)
		PRKG1_interact	937..1023	CDD:292521	31/174 (18%)
		MIS13	987..1241	CDD:285420	74/367 (20%)
		MyosinXI_CBD	1298..1739	CDD:271259	84/463 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm2587
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830