Protein Alignment didum and myhz1.2

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_005171981.1
• Gene: myhz1.2 / 799300
• ZFINID: ZDB-GENE-070705-73
• Length: 1937
• Species: Danio rerio
• Alignment Length: 1926
• Identity: 495/1926 - (25%)
• Similarity: 846/1926 - (43%)
• Gaps: 478/1926 - (24%)

  Fly    29 EESYRKGAGFLKICTDSGKLKEVKLK------ADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||.  :| ..|.||:..:.|.      |...|:.|: ||.......|:..:::|:||.||
Zfish    44 KELYVKGT--IK-SRDGGKVTVITLDTKEERVAKEDDVHPM-NPPKFDKIEDMAMMTHLNEPSVL 104

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:. ..:||||.|:....:|||..:|:|...::.||||....:..||||::::.||..:.
Zfish   105 YNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFML 168

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSESETQ---------VERKVLASSPIMEA 206
            .:..|.|::::|||||||||:.|..::|||  ||.|.|.:.:         :|.:::|::|::||
Zfish   169 TDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQAAGKMQGSLEDQIIAANPLLEA 233

  Fly   207 FGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA 271
            :|||||.|||||||||||.::.|.....   |..|.:.|||||||||.:|...||.||||||:..
Zfish   234 YGNAKTVRNDNSSRFGKFIRIHFGTSGK---LASADIETYLLEKSRVTFQLPDERGYHIFYQMMT 295

  Fly   272 ARSKYPELV---LDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
              :..|||:   |...:.:.| :...|...:..:.|.|:...|..|:.:|||:.::...|.|...
Zfish   296 --NHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTG 358

  Fly   333 GILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIE 391
            .:||.||::..:|..|      |:||.|.              ...||.:::.|:.:.|...:::
Zfish   359 AVLHHGNMKFKQKQREEQAEPDGTEEADK--------------IGYLLGLNSADMLKALCYPRVK 409

  Fly   392 SVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEV 456
            ..||:|....::.....:..||:|.||.::|.::|..:|:.|:...::..|||||||.|||.|:.
Zfish   410 VGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDF 474

  Fly   457 NSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLD 520
            ||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..||:..:|:
Zfish   475 NSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILE 539

  Fly   521 EECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFGTTS--FFIKHFSDTVEYDVNGFLEKNRD 579
            |||..||.:|.|:..||    :||||.|.. .||..|...  |.:.|::.||:|:::|:|:||:|
Zfish   540 EECMFPKATDTSFKNKLYDQHLGKCNAFQK-PKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKD 603

  Fly   580 TVSKELTQVLSESNMSLAKQVM--TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP 642
            .:::.:.|:..:|::.|...:.  .:||            |.||:   ..|:|:.|:
Zfish   604 PLNESVVQLYQKSSVKLLATLYPPVVEE------------TGGGK---KGGKKKGGS-------- 645

  Fly   643 SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRI 707
                .:||.|||:|:|..|::.|.:|.||:|||:.||:.|.....|...:|.|||..||||.:||
Zfish   646 ----MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRI 706

  Fly   708 SAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAG 769
            ...|||||.||.||..||::| ..|.:.:.   |.|.:...::.....:.|:||||:|::||:||
Zfish   707 CRKGFPSRILYADFKQRYKVL-NASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAG 770

  Fly   770 QVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAG 834
            .:..||::|.......:|:.|::.|.::.||:|:                       ||.|.|..
Zfish   771 LLGTLEEMRDEKLASLVTMTQALCRAYLMRREFV-----------------------KMTERRDA 812

  Fly   835 LILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQ 899
            :...:|.     .|.::.::|                 :..|:.:|:   |:..::.|...:...
Zfish   813 IYTIQYN-----VRSFMNVKH-----------------WPWMKVYYK---IKPLLKSAETEKELA 852

  Fly   900 KRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKH 964
            ..:.:.:.|:..:           .|||||.        ..||.|::::
Zfish   853 TMKEDFVKCKEDL-----------AKAEAKK--------KELEEKMVAL---------------- 882

  Fly   965 KTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK---QLEAERDEKMQLLEENGHAQE 1026
                   |:.|.:|:..:.:|.:|:    .|.::..|.|.|   ||||:..|..:.||:......
Zfish   883 -------LQEKNDLQLAVASESENL----SDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINA 936

  Fly  1027 EWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RNQEDRMLAEIDN--------REL 1076
            |..::|:....|..||::.||::      ::..|:|..|: :|..:.|.|:.::        :.|
Zfish   937 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKAL 1001

  Fly  1077 NEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRP 1141
            .||:|:.:.|.:..|       ::::.||         |:.....|..||:     :.:|:..:
Zfish  1002 QEAHQQTLDDLQAEE-------DKVNTLT---------KSKTKLEQQVDDL-----EGSLEQEK- 1044

  Fly  1142 PDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKLSSRHKPTED-----SFRVSE 1197
                              |||..||..|:|    .|:.||..:.|.:..:.:|:     .|..|:
Zfish  1045 ------------------KLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQ 1091

  Fly  1198 L--EVENE-----KLRSEYDQLRTSIKHGVEINELNAQHAALQ-------------EEVRRRREE 1242
            |  ::|:|     :|:.:..:|:..|:...|  |:.|:.||..             ||:..|.||
Zfish  1092 LLSKIEDEQSLGAQLQKKIKELQARIEELEE--EIEAERAARAKVEKQRADLSRELEEISERLEE 1154

  Fly  1243 CIQLKAVLLQQSQS--------MRSLEPESLQ----------MRGNDVNELMEAFHSQKLINRQL 1289
            .....|..::.::.        .|.||..:||          .:.:.|.||.|...:.:.:.::|
Zfish  1155 AGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKL 1219

  Fly  1290 ESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV---MFESIDEFEDSNVDTLRQ-NDRYLRR- 1349
            |.|    ..|:..::.:::..:|.:...|..|:|:   :.:.:.|.:..|.:.||| ||...:|
Zfish  1220 EKE----KSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQLNDLSAQRA 1280

  Fly  1350 --------------ELQKAVAQFL---------------LVQEELKLANA---KLKAYRQDGGQL 1382
                          |.:..|:|..               .::||:|..||   .:::.|.|...|
Zfish  1281 RLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLL 1345

  Fly  1383 EHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI--LQRLLSALTPRTVVGLL 1445
            ..:.|||      ....|::...::|..|:..|...|:.:..:.:.  |:.....|..|
Zfish  1346 REQFEEE------QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQR------ 1398

  Fly  1446 PGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL-LNLMKQ 1509
                            |..|::.:..:.||.....|...|....:|:.:|.:..:..| .||.|:
Zfish  1399 ----------------LQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKK 1447

  Fly  1510 YGDVDEYVKFNTEK--QNQQQLKNFNLFEYRRVILDL--IVNLYQALIMQIQGL------LDPKI 1564
            ..:.|:.:....:|  :.|.:|:.... |.|.:..:|  :.|.|:..:.|::.|      |..:|
Zfish  1448 QRNFDKVLAEWKQKYEEGQAELEGAQK-EARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEI 1511

  Fly  1565 VPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAE 1629
              :.|.....:.|:..|.:.....::....:...   .|.::..|.|||
Zfish  1512 --SDLTEQIGETGKSIHELEKSKKAVETEKAEIQ---TALEEAEGTLEH---------------- 1555

  Fly  1630 QIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQ 1694
                                       |...|:|..:                     .||||..
Zfish  1556 ---------------------------EESKILRVQL---------------------ELNQVKS 1572

  Fly  1695 LLQSRKSEQD---------VQTICDLCTSLSTAQV------LKVMKSYKLDDYESEITNVFLEKL 1744
            .:..:.:|:|         .|.|.|...|...::|      |::.|                 |:
Zfish  1573 EIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKK-----------------KM 1620

  Fly  1745 TEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784
            ...||..::|.|:::....: ||.::..:...:.:.:.|:|
Zfish  1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDD 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	268/715 (37%)
		IQ	900..922	CDD:197470	1/21 (5%)
		SMC_prok_B	<942..1365	CDD:274008	104/521 (20%)
		Myo5_CBD	1424..1792	CDD:271254	61/390 (16%)
myhz1.2	XP_005171981.1	Myosin_N	33..78	CDD:460670	10/36 (28%)
		MYSc_class_II	101..768	CDD:276951	268/715 (37%)
		Myosin_tail_1	848..1925	CDD:460256	187/1021 (18%)