DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH14

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_011525622.1 Gene:MYH14 / 79784 HGNCID:23212 Length:2043 Species:Homo sapiens


Alignment Length:1915 Identity:520/1915 - (27%)
Similarity:848/1915 - (44%) Gaps:441/1915 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR------NPAILVGQ 72
            :|||.....:|:|.|.:...:.|             ||:|...|..|...|      ||......
Human    96 VWVPSELHGFEAAALRDEGEEEA-------------EVELAESGRRLRLPRDQIQRMNPPKFSKA 147

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            .|:..|:.|:|..||||||.|:.. .:||||.|:..|.||||.::|:|..:|:..|||....::.
Human   148 EDMAELTCLNEASVLHNLRERYYS-GLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVP 211

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE-------------- 188
            ||::|:.|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.              
Human   212 PHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPASVST 276

  Fly   189 -SETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252
             |..::||::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||
Human   277 VSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVAG--YIVGANIETYLLEKSR 338

  Fly   253 VVYQAQGERNYHIFYQLC--AARSKYPELVLDHQDKFQFLNMG--GAPEIERVSDAEQFNETVQA 313
            .:.||:.|.::||||||.  |......:|:|:....::||..|  .:|..||    |.|.||:::
Human   339 AIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQER----ELFQETLES 399

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378
            :.|||||.::|..::::::.:|..|||.:.:       |.::|...:..|.. .|....||.:..
Human   400 LRVLGFSHEEIISMLRMVSAVLQFGNIALKR-------ERNTDQATMPDNTA-AQKLCRLLGLGV 456

  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSF 442
            .|..|.||..:|:...:||....:.|.|..|.:||||..|.:||:::|..||::|:...:| .||
Human   457 TDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASF 521

  Fly   443 IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCI 506
            :|:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:|||.||.:|| .|.||||
Human   522 LGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCI 586

  Fly   507 DLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRF--GTTSFFIKHFSDTV 566
            ||||   :..|:|.||||||..||.:|:|:..|:..:....|.|::||.  ....|.:.|::..|
Human   587 DLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKV 651

  Fly   567 EYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQ 631
            :|..|.:|.||.|.::..:..:|.:|...|..::.  ::::.:         :|...|.|.|...
Human   652 DYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIW--KDVEGI---------VGLEQVSSLGDGP 705

  Fly   632 QGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQL 696
            .|...||.:.      :|||..::|||:.|::||..|.|.:||||.||.:|.|.|.|...::.||
Human   706 PGGRPRRGMF------RTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQL 764

  Fly   697 RACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRF 759
            |..||||.:||...|||:|.|:.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.
Human   765 RCNGVLEGIRICRQGFPNRILFQEFRQRYEILT-PNAIPKGFMDGKQACEKMIQALELDPNLYRV 828

  Fly   760 GNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER 824
            |.::||||||.:|.||:.|.                       |::..:|...|..|||||||..
Human   829 GQSKIFFRAGVLAQLEEERD-----------------------LKVTDIIVSFQAAARGYLARRA 870

  Fly   825 TQKMREARAGL-ILSKYARGWLCRRRYLRLRH-SISGIQTYARGMLARNKFHAMRDHY---RAVQ 884
            .||.::.::.| ::.:....      ||:||| ....:.|..:.:|...:    :|..   ||.:
Human   871 FQKRQQQQSALRVMQRNCAA------YLKLRHWQWWRLFTKVKPLLQVTR----QDEVLQARAQE 925

  Fly   885 IQRF-------------VRGALAR------RAYQKRRRNIIICQAA--IRRFLARRKFKR----M 924
            :|:.             ::|.:|:      |..::.|....:|..|  .|..||.||.:.    .
Human   926 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVS 990

  Fly   925 KAEAKTISHME-NKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFK 987
            :.||:.....| ::.|..|.|  .:||.|.||.      .|..:|... :.||:|:| |.||:.|
Human   991 ELEARVGEEEECSRQMQTEKK--RLQQHIQELE------AHLEAEEGA-RQKLQLEKVTTEAKMK 1046

  Fly   988 NVK---AACQDKDKLIEALNKQLE----------AERDEKMQLL-------EENGHAQEEWISQK 1032
            ..:   ...:|::..:....|.||          ||.:||::.|       |......|:.:.::
Human  1047 KFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKE 1111

  Fly  1033 QTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNR--ELNEAYQRAIKDK-----EVI 1090
            :..|||.|:|:|::|......:...|.|:.:.:.:.|::..:  ||..|..|| :|:     :::
Human  1112 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA-EDEGGARAQLL 1175

  Fly  1091 ENENFMLKEELSRLTAGSFSLHARKASNASSQNE-DDVG------YASAKNTLD-INRPPDLLSK 1147
            ::    |:|..:.|......|.:.:.:...::.: .|:|      ....::||| .|...:|.||
Human  1176 KS----LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1236

  Fly  1148 NYSYNDSTSLVVKLRSILEEEKQKHK-VLQE-------------QYIKLSSRHKPTEDSFRVSEL 1198
            .      ...|.:|:..||||.:.|: .:||             :.::.:.|.|...:..|:: |
Human  1237 R------EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLA-L 1294

  Fly  1199 EVENEKLRSEYDQLRTSIKHG--------VEINELNAQ-------HAALQEEVRRRREECIQLKA 1248
            |.|..:||:|...|:|:.:.|        :::.|:..:       .|...|:::|.:.|...:..
Human  1295 EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1359

  Fly  1249 VLLQ-QSQSMR-SLEPESLQMRGNDVNELMEAFHSQKL---------------INRQLESELKA- 1295
            .|.: :|:::| |.|..|.:.:.:|..||::.....||               :..|||.|..| 
Human  1360 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1424

  Fly  1296 ----------------------------------------ITEEHNSKLVEMTQEIERLNNEKDE 1320
                                                    ..|....:|.|.|:.::||...:..
Human  1425 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR 1489

  Fly  1321 LQKVMFESIDEFEDSN--VDTL----RQNDRYLRRE---------------------------LQ 1352
            ||:.:.::..:.|...  |.||    |:.|:.|..|                           |.
Human  1490 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1554

  Fly  1353 KAVAQFLLVQEELKLANAKLKA-------YRQDGGQLEHKIEE--EMIRNKSNGTSADVGANVTK 1408
            :|:.:....:|||:..|..|:|       .:.|.|:..|::|.  .:....:|    |:.|.||:
Human  1555 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN----DLRAQVTE 1615

  Fly  1409 QKSQ-------------NPQGLMKFHSSDL--------------------------DKILQRLLS 1434
            .:.:             ..|.|...|..||                          ::..||.|:
Human  1616 LEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1680

  Fly  1435 ALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPI--------- 1490
            ....:.:.|.|....|.:       .......::..:.|.|...|:|::.|.....         
Human  1681 VAARKKLEGELEELKAQM-------ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1738

  Fly  1491 -----ENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQ-------QLKNFNL-----FEYR 1538
                 |.|:..|  ...:|.|.::....|     ...:|.||       ::.|.||     .|.:
Human  1739 QNRESEKRLKGL--EAEVLRLQEELAASD-----RARRQAQQDRDEMADEVANGNLSKAAILEEK 1796

  Fly  1539 RVI-----------------LDLIVNLYQALIMQIQGLLD----PKIVPAILNNDEIQRGRQAHG 1582
            |.:                 .:|:.:.|:.|::|::.|..    .:...|...:...|..||...
Human  1797 RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1861

  Fly  1583 MRSRATSIGASSSPEHGGGPAWKQLIGQLE 1612
            :|.|.....|.:...|      |..|..||
Human  1862 LRGRLGEEDAGARARH------KMTIAALE 1885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 288/740 (39%)
MYSc_Myo5 84..767 CDD:276831 275/710 (39%)
IQ 900..922 CDD:197470 8/23 (35%)
GBP_C <971..1086 CDD:303769 34/137 (25%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/181 (17%)
Myo5_CBD 1424..1792 CDD:271254 44/262 (17%)
MYH14XP_011525622.1 Myosin_head 148..836 CDD:278492 279/721 (39%)
MYSc_Myh14_mammals 159..836 CDD:276893 275/710 (39%)
Myosin_tail_1 913..1993 CDD:279860 198/1022 (19%)
GBP_C <1661..1761 CDD:303769 16/108 (15%)
coiled coil 1729..1746 CDD:293879 1/16 (6%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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