Protein Alignment didum and Myh10

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_017453033.1
• Gene: Myh10 / 79433
• RGDID: 71000
• Length: 2007
• Species: Rattus norvegicus
• Alignment Length: 2074
• Identity: 543/2074 - (26%)
• Similarity: 892/2074 - (43%)
• Gaps: 506/2074 - (24%)

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|:|.....:|:|:::|  .:|...:....::||    |...:..|:..: ||.......|:..|
  Rat    36 VWIPSERHGFEAASIKE--ERGDEVMVELAENGK----KAMVNKDDIQKM-NPPKFSKVEDMAEL 93

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|..:||..|||....::.|||:|:
  Rat    94 TCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAI 157

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-----------------ESET 191
            :|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|                 :.:.
  Rat   158 SESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKPVKPQG 222

  Fly   192 QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQ 256
            ::||::|.::||:|:||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.|.|
  Rat   223 ELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAVRQ 284

  Fly   257 AQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF 319
            |:.||.:||||||.:...::  .:|:|:..:.::||:.|..| |....|.:.|.||::||.::||
  Rat   285 AKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEAMHIMGF 348

  Fly   320 SIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRW 384
            |.::|..::|:::.:|..|||...|       |.::|...:..|.: .|....||.::..:..|.
  Rat   349 SHEEILSMLKVVSSVLQFGNISFKK-------ERNTDQASMPENTV-AQKLCHLLGMNVMEFTRA 405

  Fly   385 LLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDI 448
            :|..:|:...:||....:.|.|..|.:||||..|.:||:::|..:||:|:...:| .||||:|||
  Rat   406 ILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDI 470

  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE-- 510
            .|||.||:|||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||
  Rat   471 AGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERP 535

  Fly   511 -SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNG 572
             :..|||.||||||..||.:|:::..||:.:......|:|||  .....|.|.|::..|:|..:.
  Rat   536 ANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADE 600

  Fly   573 FLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLG------GRVVISAGRKQ 631
            :|.||.|.::..:..:|.:|:.....::.. :||..:...|...|..|      .|:|   |..|
  Rat   601 WLMKNMDPLNDNVATLLHQSSDRFVAELWK-DEIQNIQRASFYDSVSGLHEPPVDRIV---GLDQ 661

  Fly   632 QGNDTRRRVVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKI 692
            ....|......:.:.:|    |||..::|||..|::||..|.|::||||.||.:|.|.|.:...:
  Rat   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDED 755
            :.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:
  Rat   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACERMIRALELDPN 790

  Fly   756 KYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYL 820
            .||.|.::||||||.:|.||:.|.                       |:|..:|...|...||||
  Rat   791 LYRIGQSKIFFRAGVLAHLEEERD-----------------------LKITDIIIFFQAVCRGYL 832

  Fly   821 ARERTQKMREARAGL-ILSKYARGWLCRRRYLRLRH-----SISGIQTYARGMLARNKFHAMRDH 879
            ||:...|.::..:.| :|.:....      ||:|||     ..:.::...:......:..|..:.
  Rat   833 ARKAFAKKQQQLSALKVLQRNCAA------YLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEE 891

  Fly   880 YRAV-QIQRFVRGAL--ARRAYQK--RRRNIII--CQAAIRRFL----ARRKFKRMKAEAKTISH 933
            ...| :.|..|.|.|  ..|.:|:  ..:||:.  .||....|.    .|.:....|.|.:.|.|
  Rat   892 LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 956

  Fly   934 ---------------MENKYMGLENKIISMQQRIDELN--RDNSNLKHKTSEISVLKMKLELKKT 981
                           ::|:...::..|..:::::||..  |....|:..|:|..:.||:.|:...
  Rat   957 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLL 1021

  Fly   982 LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWIS-------QKQTWRQEN 1039
            .:...|.:|.....:|::.|. :.|| ||.:||.:.|.:..:.||..||       :::..|||.
  Rat  1022 EDQNSKFIKEKKLMEDRIAEC-SSQL-AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1084

  Fly  1040 EELRRQID-EIIDMAKN-AEVNQRNQEDRMLAEIDNRELNEAYQRAIK--DKEVIENENFM---- 1096
            |:.:|::| |..|:... ||:  :.|.|.:..::..:|  |..|.|:.  |.|.:...|.:
  Rat  1085 EKAKRKLDGETTDLQDQIAEL--QAQVDELKVQLTKKE--EELQGALARGDDETLHKNNALKVAR 1145

  Fly  1097 -LKEELSRLTAGSFSLHARKASNASSQN----------------EDDVGYASAKNTLDINRPPDL 1144
             |:.:::.|..   ...:.|||...::.                ||.:...:|:..|...|..::
  Rat  1146 ELQAQIAELQE---DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1207

  Fly  1145 LSKNYSYNDST---------------SLVVKLRSILEE--------EKQKH-------------K 1173
            .....:..|.|               :.:.:|...||:        ||.|.             |
  Rat  1208 AELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1272

  Fly  1174 VLQEQYIKLSSRHKPTE---------------DSFRVSELEVENEKLRSEYDQLRTSIKH----- 1218
            |||:  :|..|.||..:               |..|| ||..:..||::|.|.:.|.::.
  Rat  1273 VLQQ--VKAESEHKRKKLDAQVQELHAKVSEGDRLRV-ELAEKANKLQNELDNVSTLLEEAEKKG 1334

  Fly  1219 --------GVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPE--SLQMRGNDVN 1273
                    |:| ::|......||||.|::           |..|..:|.||.|  |||.:..:..
  Rat  1335 MKFAKDAAGLE-SQLQDTQELLQEETRQK-----------LNLSSRIRQLEEEKNSLQEQQEEEE 1387

  Fly  1274 ELMEAFHSQKL--------INRQLESELKAI--TEEHNSKLVEMTQEIERLNNEK----DELQKV 1324
            |..:....|.|        ..::::.:|..|  .||...||::..:.:.:...||    |:|:|.
  Rat  1388 EARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKT 1452

  Fly  1325 MFESIDEFEDSNVDTLRQN-------------DRYLRRE-------------------------- 1350
            ......|.:|..||...|.             |:.|..|
  Rat  1453 KNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKAL 1517

  Fly  1351 -LQKAVAQFLLVQEELKLANAKLKA-------YRQDGGQLEHKIEE---------EMIRNKSNGT 1398
             |.:|:.:.|..:||.:..|.:|:|       .:.|.|:..|::|:         |.:|.:....
  Rat  1518 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1582

  Fly  1399 SADVGA----------NVTKQKSQNPQGLM------------------KFHSSDLDKILQRLLSA 1435
            ..::.|          |:...|:|..:.|.                  :..:...|:..||.|:.
  Rat  1583 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAV 1647

  Fly  1436 LTPRTVVGLLPGFPAYLIFMCIRYTDL-------TNADDDVRELLSKFVIQIKKMHRTPHPIENR 1493
            .:.:.              |.|...||       ..|.|:|.:.|.|...|:|...|
  Rat  1648 ASKKK--------------MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-------- 1690

  Fly  1494 VIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQG 1558
                       .|.:.....||.  |...|:::::||:.                 :|.|:|:|
  Rat  1691 -----------ELEEARASRDEI--FAQSKESEKKLKSL-----------------EAEILQLQ- 1724

  Fly  1559 LLDPKIVPAILNNDEIQRGRQA--HGMRSR---ATSIGASSSPEHGGGPAWKQL---IGQLEHFY 1615
                         :|:....:|  |..:.|   |..|..|:|.:.......::|   |.|||...
  Rat  1725 -------------EELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEEL 1776

  Fly  1616 KQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSN 1680
            ::.|.                                            |:..:.|..|...:..
  Rat  1777 EEEQS--------------------------------------------NMELLNDRFRKTTLQV 1797

  Fly  1681 DVL-TALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVF---- 1740
            |.| |.||.....:|...:.:.:.:.|.              |.:|: ||.:.|..:.:.|
  Rat  1798 DTLNTELAAERSAAQKSDNARQQLERQN--------------KELKA-KLQELEGAVKSKFKATI 1847

  Fly  1741 ------LEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVF-------RYSDIKLEDIE 1786
                  :.:|.|:|.....:::.:::..  ::..:..|.:|       |::|...|.:|
  Rat  1848 SALEAKIGQLEEQLEQEAKERAAANKLV--RRTEKKLKEIFMQVEDERRHADQYKEQME 1904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	278/720 (39%)
		IQ	900..922	CDD:197470	6/29 (21%)
		SMC_prok_B	<942..1365	CDD:274008	123/576 (21%)
		Myo5_CBD	1424..1792	CDD:271254	66/396 (17%)
Myh10	XP_017453033.1	Myosin_N	31..76	CDD:460670	9/45 (20%)
		MYSc_Myh10	99..802	CDD:276952	278/720 (39%)
		Myosin_tail_1	879..1959	CDD:460256	223/1177 (19%)