Protein Alignment didum and Myo18b

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_083177.2
• Gene: Myo18b / 74376
• MGIID: 1921626
• Length: 2605
• Species: Mus musculus
• Alignment Length: 1602
• Identity: 376/1602 - (23%)
• Similarity: 657/1602 - (41%)
• Gaps: 316/1602 - (19%)

  Fly     4 EEMLYAQGAKIWVPHADLVWESATL---EESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |:..| :..|:|:...|....:..|   |.:....||.:::|.|:.:   ..::.|...:.| .|
Mouse   547 EDRWY-EAQKVWLVQKDGFTLATVLKPDEGTADPPAGRVRLCIDADR---TVIEVDEEQVHP-AN 606

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRG 130
            |:.|....||.:|..::|..|::.|..|: ..|:.||..|..|:.:.|.....   ||..:..||
Mouse   607 PSELDQAEDLASLVSVNESSVMNTLLQRY-RAQLPYTCSGPDLITLQPQTTTV---PSSGKVPRG 667

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-ESETQVE 194
            ...| |..|:.:||:.||..|..:..:.||:..|.||||||...:..:.:...:.|| :....||
Mouse   668 RQDG-LPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGSVDGRVSVE 731

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
             |:.|:..::.|||...|..:..::||.....|.| |..|  .:..|.:.|.|||.|||..|.||
Mouse   732 -KLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDF-NATG--RVTAAQLQTVLLENSRVARQPQG 792

  Fly   260 ERNYHIFYQLCAAR--SKYPELVLDHQDKFQFLNMG--GAPEIERVSDAEQFNETVQAMTVLGFS 320
            |.|:.:|.||.|..  ....||.|....:.....||  ..|| ::...|..|::...||.:||.|
Mouse   793 EGNFEVFSQLLAGMDVDLRTELNLHQMAESSAFGMGLWSKPE-DKQKAATAFSQLRGAMELLGIS 856

  Fly   321 IQQIADIVKILAGILHLGNIQVSK-------KFNEGSEEEDSDSCDIFHNDI-------HL---- 367
            ..:...|.::||.|.|||.....|       :|...:...::..||  :.::       ||
Mouse   857 EGEQQAIWRVLAAIYHLGAAGACKVGRKQFMRFEWANHAAEALGCD--YEELNTATFKHHLRQII 919

  Fly   368 -QITADLLRVSADDLR--RWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVL 429
             |:|:...|....|..  ..|.|..:|.|                 :.:|..:|.:||..:|.::
Mouse   920 EQMTSGPQRQGLQDNEACSGLKMTGVECV-----------------EGMASGLYQELFVAVVSLI 967

  Fly   430 NKSLNNGSKQCSFIGVLDIYGFET------FEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYL 488
            |:|.::.....:.|.|:|..||:.      ....:||:.|.|||.|:||..|....|....|.|.
Mouse   968 NRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLFYHRTFVSTLERYK 1032

  Fly   489 KEGI-------------TWTMIDFYDNQ---PCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL 537
            :|||             |..::|...:|   |.....|...|:..:||||.|:...||.:...:|
Mouse  1033 EEGIPVPFDLPESSPGTTVAVVDQNPSQVHLPAGRGAEDAGGLFWVLDEEVRVQGSSDSTVLERL 1097

  Fly   538 IGKCNKFPHF---EKPRFGT------TSFFIKHFSDTVEYDVNGFLEKNRDTVSK-ELTQVLSES 592
            .....|....   |.|...|      ...|.:...|.|.||:.|:|.:.:..::. |..|:|.:|
Mouse  1098 RAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVRYDLTGWLRRAKPNLAALEAPQILQQS 1162

  Fly   593 NMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP-------SKQHRKTV 650
            ..         ||:.:|....||...:...|....|..||... |.|||.       :...||..
Mouse  1163 KR---------EELQSLFQARAKLPPVCRAVAGLEGTSQQALH-RSRVVRRAFASSLAAVKRKAP 1217

  Fly   651 GSQFQESLASLISTLHATTPHYVRCI-----------------KPNDDKVAFKWETAKIIQ---- 694
            .:|.:..:.:|||.|..:..|::.|:                 :|:.|:......||..|.
Mouse  1218 CAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPSQPSGDQGVANEPTALDIPALRV 1282

  Fly   695 QLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL--VYRSKLDKNDMKLSCRNIV---MKWIQDE 754
            ||....:||.:|:..||:........|..|:|:|  ....|||....:|..|.:|   :|.:..|
Mouse  1283 QLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLDLTSEELDERKVVEELLKTLDLE 1347

  Fly   755 DK-YRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQF--LRIQKVIN-GIQKH 815
            .| ...|::|:|.:||.|:.||:.|..|..:.|.:.|:..|.|:.|:::  |:|:::.. .|||:
Mouse  1348 KKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGFLSRQEYKKLKIRRLATLCIQKN 1412

  Fly   816 AR-----------GYLARER--------TQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQ 861
            ..           |.||..|        |:::|.....|.|               ||..:...:
Mouse  1413 LAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTL---------------LRQKLQKSE 1462

  Fly   862 TYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKA 926
            . :|..|.:|           ..:.......|......:|.:..:.|||     |...:.:|::|
Mouse  1463 N-SRSELRQN-----------TDLLESKITDLTSELADERFKGDVACQA-----LESERAERLQA 1510

  Fly   927 EAKTISHMENKYMGLENKIISMQQRIDELNR--DNSNLKHK-TSEISVLKMKLELKKTLEAEFKN 988
             .:.:..::.||..:::.:..:|::::|..:  ..:||:.| .......:|:|:..: :|.:|..
Mouse  1511 -LREVQELKTKYQQVQDALGEVQKQLEEAQQRIQGANLEEKPAGGADEWQMRLDCAQ-MENDFLR 1573

  Fly   989 VKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQ------------TWRQENEE 1041
                     |.::...::|::|...:.:|.::.|..|..:...|:            ||  :.|:
Mouse  1574 ---------KRLQQCEERLDSEMKARTELEQKLGELQSAYEEAKKMAHQLKRKCHHLTW--DLED 1627

  Fly  1042 LRRQIDEIIDMAKNAEVNQRNQE-DRMLAEIDNRELNEA-YQRAIKDK----------------- 1087
            .|..::.  ..::|.|:.:|.:: |..||:    .|.|: :::::::|
Mouse  1628 TRVLLEN--QQSRNHELEKRQKKFDLQLAQ----ALGESMFEKSLREKVSQENNGVRWELGQLQQ 1686

  Fly  1088 --EVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKN---TLDINRPPDLLSK 1147
              |..|.|...||:|:.|       |..:|....|..:..|.|.||.|.   .|:.|    .|.:
Mouse  1687 QLEQKEQEASKLKQEVER-------LQGQKRELLSCASVGDQGVASLKERVWELETN----ALEQ 1740

  Fly  1148 NYSYNDSTSLVVKLRSI-------LEEEKQKH-KVLQEQYIKLSSRHKPTEDSFRVSELEVENEK 1204
            ...::...:.:.:|..:       :|..||.| |..::|..:|....:..:...|..|:::|
Mouse  1741 QKIHSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLE--- 1802

  Fly  1205 LRSEYDQLRTSI--KHGVE--INELNAQ--HAALQEEVRRRRE--------ECIQLKAVLLQQSQ 1255
              .||::.:.::  ||.:|  |..|..|  |.....|.|.||:        ..:||....::.|:
Mouse  1803 --QEYEEKQVALHEKHDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLLATIEDSK 1865

  Fly  1256 ---SMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLE---SELKAITEEHNSKLVEMTQEIERL 1314
               |...||....|:..::. :..:|..:||::...||   |||:.:|  .:..||:  :::.||
Mouse  1866 TSISKEELEKVHSQLEQSEA-KCEDALKTQKVLTADLENMHSELENVT--RSKSLVD--EQLYRL 1925

  Fly  1315 NNEKDELQKVMFESIDEFED---SNVDTLRQND------RYLRRELQKAVAQFLLVQEELKLANA 1370
            ..|:.:|.|.:.|...:..|   .:.|.:.|:.      :.|:.:|::...:...::|:|.:|..
Mouse  1926 QFERADLLKRIDEDQGDLNDLMQKHKDLIAQSAADIGQIQELQLQLEETKKEKQKLREQLHMAQL 1990

  Fly  1371 KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQ 1412
            :::       .||....|..|.::......|:......||.|
Mouse  1991 RIQ-------YLEQSTVERAIVSRQEAIICDLENKTEFQKVQ 2025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	205/774 (26%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	101/498 (20%)
		Myo5_CBD	1424..1792	CDD:271254
Myo18b	NP_083177.2	PHA03247	<55..472	CDD:223021
		COG5022	606..2126	CDD:227355	363/1538 (24%)
		MYSc_Myo18	625..1361	CDD:276837	205/774 (26%)