Protein Alignment didum and Myo1e

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_011241116.1
• Gene: Myo1e / 71602
• MGIID: 106621
• Length: 1119
• Species: Mus musculus
• Alignment Length: 993
• Identity: 310/993 - (31%)
• Similarity: 508/993 - (51%)
• Gaps: 193/993 - (19%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |.:|:..||.:.|..::.||:.|:.: ..|:||.|.:|:::||:.:||.:|...:..|:|.|..:
Mouse    32 GVDDMVLLSKITESSIVENLKKRYMD-DYIFTYIGSVLISVNPFKQMPYFGEKEVEMYQGAAQYE 95

  Fly   136 LEPHIFALAEEAYTK--LEREN-CNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ-VERK 196
            ..|||:|||:..|..  ::||| |   :|:||||||||||:|||.|.|.:.|.|...:.| |:..
Mouse    96 NPPHIYALADSMYRNMIIDRENQC---VIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDI 157

  Fly   197 VLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGER 261
            :|.|:|::||||||||.||:|||||||:.::.| :..|..  .|..:..:||||||||.:..|||
Mouse   158 ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SPGGEP--DGGKISNFLLEKSRVVMRNPGER 219

  Fly   262 NYHIFYQLCAARSKYPE----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ::||||||....|  ||    |.:...|.:.:|::.|:.:::.:.|...|.||:.||.|:|...:
Mouse   220 SFHIFYQLIEGAS--PEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSE 282

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :...:::|:|||||||||...:..|..:.|.:.          .|...|.||.::.|.|:..|..
Mouse   283 EQTLVLQIVAGILHLGNISFKEVGNYAAVESEE----------FLAFPAYLLGINQDRLKEKLTS 337

  Fly   388 RKIES----VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDI 448
            |:::|    .:|.:.:..::|.|...||||||.::|::|.::|..:||::....::.: ||||||
Mouse   338 RQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYN-IGVLDI 401

  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL 513
            ||||.|:.|.|||||||:.||||||.|.:...|.|||||::|||.||.|::::|:...|||||::
Mouse   402 YGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKV 466

  Fly   514 ---GVLDLLDEEC----RMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVN 571
               |::.:||:.|    .:.:|:|::...||..:.....||.....|   |.|.|::..|.||::
Mouse   467 NPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQG---FIIHHYAGKVSYDMD 528

  Fly   572 GFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVD-SAKSSTLGGRVVISAGRKQQGND 635
            ||.|:|||.:..:|.:::..|.:...|.:..    :.|..| ..:.:|.|.::      |:|.||
Mouse   529 GFCERNRDVLFMDLIELMQSSELPFIKSLFP----ENLQADKKGRPTTAGSKI------KKQAND 583

  Fly   636 TRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700
                                     |:|||...||||:||||||:.|....||.:::..|:...|
Mouse   584 -------------------------LVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLG 623

  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLL------VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRF 759
            :.|.:|:..||:..|.::..|..||.:|      |:|     .|.|....:::.....|.|:::.
Mouse   624 LKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWR-----GDEKQGVLHLLQSVNMDSDQFQL 683

  Fly   760 GNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARE 823
            |.:::|.:|.:..| ||::|......|..::|...|:||.|::::
Mouse   684 GRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYV-------------------- 728

  Fly   824 RTQKMREARAGLILSKYARGWLCRRRYLRLRHSISG--IQTYARGMLARNKFHAMRDHYRAVQIQ 886
               :|||..:.|:|:|..          |.|:||:.  |..|. ||..|            .::|
Mouse   729 ---QMREEASDLLLNKKE----------RRRNSINRNFIGDYI-GMEER------------PELQ 767

  Fly   887 RFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE-AKTISHMENKYMGLENKIISMQQ 950
            :||.                               ||.|.: |.|::..:.::.|::..::...:
Mouse   768 QFVG-------------------------------KREKIDFADTVTKYDRRFKGVKRDLLLTPK 801

  Fly   951 RIDELNR-------DNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAAC-----QDKDKLIEAL 1003
            .:..:.|       |...:|      .|||.::|:::.|......::...     |:.|.|:|::
Mouse   802 CLYLIGREKVKQGPDKGVVK------EVLKRRIEVERILSVSLSTMQDDIFILHEQEYDSLLESV 860

  Fly  1004 NK----QLEAER-DEKMQ 1016
            .|    .|.|:| :||.|
Mouse   861 FKTEFLSLLAKRYEEKTQ 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	251/708 (35%)
		IQ	900..922	CDD:197470	0/21 (0%)
		SMC_prok_B	<942..1365	CDD:274008	19/92 (21%)
		Myo5_CBD	1424..1792	CDD:271254
Myo1e	XP_011241116.1	MYSc_Myo1	45..691	CDD:276829	251/708 (35%)
		Myosin_TH1	731..932	CDD:461801	42/208 (20%)
		SH3_MyoIe_If_like	1067..1118	CDD:212761