Protein Alignment didum and Myh7b

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_017174700.1
• Gene: Myh7b / 668940
• MGIID: 3710243
• Length: 1947
• Species: Mus musculus
• Alignment Length: 2016
• Identity: 545/2016 - (27%)
• Similarity: 875/2016 - (43%)
• Gaps: 447/2016 - (22%)

  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTT 77
            ::|||..    :.|.:|...:..|...|:..::...|.:.::.  :::.|: ||.......|:..
Mouse    34 RVWVPDE----QDAYVEAEVKTEATGGKVTVETKDQKVLTVRE--TEMQPM-NPPRFDLLEDMAM 91

  Fly    78 LSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFA 142
            :::|:|..||||||.|:. |.:||||.|:..|.||||..:|:|..:::.||:|....:..|||:|
Mouse    92 MTHLNEAAVLHNLRQRYA-RWMIYTYSGLFCVTINPYKWLPVYTAAVVAAYKGKRRSEAPPHIYA 155

  Fly   143 LAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG----GSESETQ---------VE 194
            :|:.||..:.|...|.|::::|||||||||:.|..::|||.|.    |...:.|         :|
Mouse   156 VADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLE 220

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            .:::.::|.|||||||||.|||||||||||.::.| ...|.  |..|.:.:||||||||::|..|
Mouse   221 DQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHF-GPTGK--LASADIDSYLLEKSRVIFQLPG 282

  Fly   260 ERNYHIFYQLCAARSKYPELVLDHQDKFQFLNMG---------GAPEIERVSDAEQFNETVQAMT 315
            ||.||::||:.:  .|.|||    ||.. .|:|.         |...::.:.|.|:...|..||.
Mouse   283 ERGYHVYYQILS--GKKPEL----QDML-LLSMNPYDYHFCSQGVTTVDNMDDGEELIATDHAMD 340

  Fly   316 VLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEED-SDSCDIFHNDIHLQITADLLRVSAD 379
            :||||:.:.....||:..:||.||::..:|..|...|.| ::|.|         ..|.|:.||:.
Mouse   341 ILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESAD---------KAAYLMGVSSG 396

  Fly   380 DLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIG 444
            ||.:.||..::...||||....|:|....|..||||..|.:||:::|..:|::|:....:..|||
Mouse   397 DLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIG 461

  Fly   445 VLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDL 508
            ||||.|||.||.|||||.|||:.||||||.||||:|.||||||.:|||.|..||| .|.||||||
Mouse   462 VLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDL 526

  Fly   509 IESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKPRFG-----TTSFFIKHFSDTVE 567
            ||..||:|.:|:|||..||.||.|:..||. ....|.|:|::||..     ...|.:.|::..|.
Mouse   527 IEKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVP 591

  Fly   568 YDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQ 632
            |.:.|:||||:|.:::.:..:..:|...|         :.||..:.|.|        .|....:.
Mouse   592 YSIVGWLEKNKDPLNETVVPIFQKSQNRL---------LATLYENYAGS--------CSTEPPKS 639

  Fly   633 GNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLR 697
            |...:|:...|.|   ||....:|:|..|::.|.||.||:||||.||::|.....::..::.|||
Mouse   640 GVKEKRKKAASFQ---TVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSFLVLHQLR 701

  Fly   698 ACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQ----DEDKYR 758
            ..||||.:||...|||:|.||.||..||::|  ......:|..:..|....|.:.    |..:|:
Mouse   702 CNGVLEGIRICRQGFPNRLLYADFRQRYRIL--NPSAIPDDTFVDSRKATEKLLGSLDIDHTQYQ 764

  Fly   759 FGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARE 823
            ||:|::||:||.:..||::|..                       |:.||:..:|..:||.|.|.
Mouse   765 FGHTKVFFKAGLLGILEELRDQ-----------------------RLAKVLTLLQARSRGRLMRL 806

  Fly   824 RTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYR 881
            ..|:|...|..|...::       .:.|...:.:.:::..:...|       |..:..|:|...|
Mouse   807 EYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQ-------AEEELAALRAELR 864

  Fly   882 AVQIQRFVRGALARRAYQKRRRNIIICQAAI---RRFLARRKFKRMKAEAKTISHMENK------ 937
            .      :|||||  ..:.:|:.:...|.::   :..||    .:::||...::..|.:
Mouse   865 G------LRGALA--TAEAKRQELEETQVSVTQEKNDLA----LQLQAEQDNLADAEERCHLLIK 917

  Fly   938 -YMGLENKIISMQQRI---DELNRDNSNLKHKTS-------------EISVLKMKLELKKTLEAE 985
             .:.||.|:..:.:|:   :|:|.|.:..:.|..             |:::.|.:.| |:..|.:
Mouse   918 SKVQLEAKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKE-KQATENK 981

  Fly   986 FKNVKAACQDKDKLIEALNKQ--------------LEAERDEKMQL------LEENGHAQEEWIS 1030
            .||:.......|:.:..|.|:              |:||.|....|      ||:.....|..:.
Mouse   982 VKNLTEEMAALDEAVVRLTKEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVEDLECSLE 1046

  Fly  1031 QKQTWRQENEELRRQIDEIIDMA--------------------KNAEVNQRN--QEDRMLAEIDN 1073
            |::..|.:.|..:|:::..:.:.                    |::|::|.|  .||..|..:.
Mouse  1047 QEKKLRMDTERAKRKLEGDLKLTQETVTDTTQDKQQLEEKLKKKDSELSQLNLRVEDEQLVGVQ- 1110

  Fly  1074 RELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNAS-----SQNEDDVGYASA- 1132
                  .|:.||:.:....|   |:|||....|....:..::|..|.     |:..::.|.|||
Mouse  1111 ------LQKKIKELQARAEE---LEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAG 1166

  Fly  1133 ------KNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTED 1191
                  |...::.|                    ||..|||     .||:.:....:.|.|..:.
Mouse  1167 QREGCRKREAELGR--------------------LRRELEE-----AVLRHEATVAALRRKQADS 1206

  Fly  1192 SFRVSE-----------LEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECI- 1244
            :..:||           ||.|..:||.|.|.|..|:       |..|:..|..|::.|..|:.:
Mouse  1207 AAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASV-------ETLARGKASAEKLCRTYEDQLS 1264

  Fly  1245 --QLKAVLLQQSQSMRSLEPESLQMRGNDVNELME---------------AFHSQKLINRQLESE 1292
              ::|...||:..:..|.:...||....::..|:|               |..|.:.:.||||.|
Mouse  1265 EAKIKVEELQRQLADASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRRQLEEE 1329

  Fly  1293 LKA-----------------ITEEHNSKLVEMTQEIERL-------------NNEKDELQKVMFE 1327
            .||                 :.|:|..: .|...|::||             ..|.|.:|:.
Mouse  1330 SKAKGALAHAVQALRHDCDLLREQHEEE-SEAQAELQRLLSKANAEVAQWRSKYEADAIQRT--- 1390

  Fly  1328 SIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR 1392
              :|.|::.        :.|...||:|       :|.::.||||..:..:...:|:.: .|::..
Mouse  1391 --EELEEAK--------KKLALRLQEA-------EEGVEAANAKCSSLEKAKLRLQTE-SEDVTL 1437

  Fly  1393 NKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCI 1457
            .....|||  .|.:.|::....:.|.:....:.:  :||.|.| ..|...||  |...:
Mouse  1438 ELERATSA--AAALDKKQRHLERALEERRRQEEE--MQRELEA-AQREARGL--GTELF------ 1489

  Fly  1458 RYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQ--YGDVDEYVKFN 1520
               .|.::.::..|.|.....:.|.:......:.::|.....||..|...|:  .|:..|.....
Mouse  1490 ---RLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSELQAAL 1551

  Fly  1521 TEKQNQQQLKNFNLFEYRRVILDL-----------------IVNL---YQALIMQIQGLLD---- 1561
            .|.:...:|:.....   |:.|:|                 ..||   :|..:..:|..||
Mouse  1552 EEAEGALELEETKTL---RIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQASLDAETR 1613

  Fly  1562 --------PKIVPAILNNDEIQRG---RQAHGMRSRATSIGASSSPEHGG--------------G 1601
                    .|.:...||:.|:|.|   |||...::....:.|....|..|              |
Mouse  1614 ARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGRDEEQRLAAELREQG 1678

  Fly  1602 PAWKQ----LIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMII 1662
            .|.::    |..:||......:........|||   :||.  ....||.|..:      .||::
Mouse  1679 QALERRAALLAAELEELRAALEQGERSRRLAEQ---ELLE--ATERLNLLHSQ------NTGLL- 1731

  Fly  1663 RYNIGCIEDWVRSKKMSNDVLTALAPLN-QVSQLLQSRK--SEQDVQTICDLCTSLSTAQVLKVM 1724
                      .:.||:..|    ||.|: :|.:..|.|:  .|:..:.|.|      .|.:.:.:
Mouse  1732 ----------NQKKKLEVD----LAQLSGEVEEAAQERREAEEKAKKAITD------AAMMAEEL 1776

  Fly  1725 KSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPS 1789
            |..:......|.....||:...:|.|| ::::........:|.:|..:...|..:.:| |.|...
Mouse  1777 KKEQDTSAHLERMKKTLEQTVRELQAR-LEEAEQAALRGGKKQVQKLEAKVRELEAEL-DAEQKK 1839

  Fly  1790 H 1790
            |
Mouse  1840 H 1840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	285/716 (40%)
		IQ	900..922	CDD:197470	4/24 (17%)
		SMC_prok_B	<942..1365	CDD:274008	113/551 (21%)
		Myo5_CBD	1424..1792	CDD:271254	84/425 (20%)
Myh7b	XP_017174700.1	Myosin_N	30..74	CDD:460670	8/45 (18%)
		MYSc_Myh7b	98..773	CDD:276953	285/716 (40%)
		Myosin_tail_1	853..1930	CDD:460256	225/1118 (20%)