Protein Alignment didum and Myh15

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001159682.1
• Gene: Myh15 / 667772
• MGIID: 3643515
• Length: 1925
• Species: Mus musculus
• Alignment Length: 1991
• Identity: 503/1991 - (25%)
• Similarity: 872/1991 - (43%)
• Gaps: 425/1991 - (21%)

  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTT 77
            |.|||.....:..|.::||...|...::  |..|::..:|     .|.....||..|....||:.
Mouse    32 KCWVPDGKNAYIEAEVKESGDDGQVIVE--TRDGEIMRIK-----EDKLQQMNPEELEMIEDLSM 89

  Fly    78 LSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFA 142
            |.||:|..|||.||.|: :..:||||.||..||||||..:|:|...::.||:.....::.|||||
Mouse    90 LLYLNEASVLHTLRRRY-DHWMIYTYSGIFCVAINPYKWLPVYQKEVMAAYKRKRRSEVPPHIFA 153

  Fly   143 LAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG-SESETQ---VERKVLASSPI 203
            :|..|:..:.|...|.||:.:||||:||||:.|..::|||.:.. ||.:.:   :|.:::..:|:
Mouse   154 VANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATMAAISEPKKKLGNLEDQIVKMNPL 218

  Fly   204 MEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQ 268
            :||||||||.:|||||||||..::.|..:..:.|   |.:..|.|||||||||..||||||||||
Mouse   219 LEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSF---ADIQIYFLEKSRVVYQQPGERNYHIFYQ 280

  Fly   269 LCAARSKYPELVLDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            :.:...:...::|...:...| :...|...:|.:.||::|..|.:|:.||||...:.....|::.
Mouse   281 ILSGNQELRNMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATEKAIDVLGFLPDEKFGCYKLVG 345

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            .|:|.||::..:...|  |:.::|..:      :....|.|:.:.|.:|.:.|:..:|:..||||
Mouse   346 AIMHFGNLKFKRNLRE--EQLEADGTE------NADKAAFLMGIHASELLKGLIYPRIKVGNEYV 402

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQF 462
            ....:::....|..||::.||.::||::|..:|:.|:.......|:|:||..|||..:.||.||.
Mouse   403 TRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLTSHFFVGILDTTGFEILDYNSLEQL 467

  Fly   463 CINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMP 526
            |||:.||||||.|||.:|.||||||.|||:.|..||: .|.|.|||.||..:|:..:|:|||.:|
Mouse   468 CINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDFIEKPMGIFSILEEECMLP 532

  Fly   527 KGSDESWAGKLIGKCNKFPHFEKPRFGTTSFF---------------IKHFSDTVEYDVNGFLEK 576
            |.:|:.:..||      |.|    .||.:::|               :.|::..|.|:::|::.|
Mouse   533 KATDQMFKTKL------FDH----HFGKSAYFQTPTSPEKNFEVHFELAHYAGVVPYNISGWIGK 587

  Fly   577 NRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVV 641
            |:..:::.:..:|.:|:..:...:.|.:                   :|:....|.|
Mouse   588 NKGLLNETVVALLQKSSNKVLANLFTKD-------------------IIAGSASQFG-------- 625

  Fly   642 PSKQHRKTVGSQF-------QESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRAC 699
             .|.|:|  |:.|       :|::..|::.|.:|.||:||||.||.:|:....:...::||||..
Mouse   626 -EKTHKK--GTSFHLITSLHKENINKLMTDLKSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCN 687

  Fly   700 GVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNI---VMKWIQ-DEDKYRFG 760
            ||||.:|:....|||..||.||..||.:|  ..::......:|.|..   |:.::: |...|:.|
Mouse   688 GVLEGIRVCCEAFPSWMLYDDFKQRYWIL--NPRIFSKSKFVSSRKATEEVLDFLEIDHPHYQCG 750

  Fly   761 NTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERT 825
            .|::||:|..:..||:                       |:..:|.||....|..|||.|.|...
Mouse   751 VTKVFFKAFILDQLEE-----------------------RRDEKISKVFTLFQARARGKLMRITF 792

  Fly   826 QKMREARAGL-ILSKYARGWLCRRR--YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQR 887
            ||:.|.|..| ::.:..|.::..:.  ::.|...|..:   |:.:.|..:...:::  ...|:|:
Mouse   793 QKILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPL---AKSVGAGEEIAGLKE--ECAQLQK 852

  Fly   888 FVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRI 952
            .:..:.::|...|.::..::.:....|.       :::||.:|:::.|.:...|....:.::.:|
Mouse   853 ALESSESQREELKTKQVSLVQEKNDLRL-------QLQAEQETLANSEEQCESLIKSKVELEVKI 910

  Fly   953 DELNRDNSNLKHKTSEISVLKMKL-----ELKK---TLEAEF-KNVKAACQDKDKL------IEA 1002
            .||:|.....:...||::....||     ||||   .|||.. |:.|..|..:.|:      :.:
Mouse   911 KELSRQVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKGKCAAEHKVRNLTEEVHS 975

  Fly  1003 LNKQLE------AERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEII-DMAKNAEVNQ 1060
            ||:::.      .:..|..|..:|..|.:||.:|...   :.|.:|.:|||.:. |:       :
Mouse   976 LNEEVSKLSRVVKDAQETQQQTQEQLHIEEEKLSNMS---KANLKLAQQIDVLEGDL-------E 1030

  Fly  1061 RNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSR--LTAGSFSLHARKASNASSQN 1123
            |.::.||..|.:.|:|.:..:...:..|.:|:....|.|:|.:  ...|..:.......|..||.
Mouse  1031 RERKARMKCEREKRKLQDELKMNQEGAENLESSRQKLAEQLRKKEFEMGQMNSKVENEKNQVSQL 1095

  Fly  1124 EDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEK----QKHKVLQEQY----- 1179
            :..|   ....|..:|...:|.|:.           .:|:.:|.||    |..:.|.|:.
Mouse  1096 QKMV---KELQTHILNLKEELESER-----------TIRAKVEREKGDLVQDLEDLNERLEEAGG 1146

  Fly  1180 IKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIK--HGVEINELNAQHAALQEEVRRRREE 1242
            ..|:......:...|..:|..:.|:....::....|:|  |...:.||..|...|| :||
Mouse  1147 TSLAQMEITKQQEARFQKLHHDMEETTRHFEATSASLKKRHAENLAELEGQVEHLQ-QVR----- 1205

  Fly  1243 CIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEA-FHSQK---LINRQLESELKAITEEHNSK 1303
                  ::|:|.:|...|:.:.|.   |.|:::..| .:::|   |..|:|        .|.|:|
Mouse  1206 ------LVLEQDKSDLQLQVDDLL---NRVDQMARAKANAEKLCGLYERRL--------NEANTK 1253

  Fly  1304 LVEMTQEIERLNNEKDELQK---VMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEEL 1365
            |.|:||....|..:|.:||.   ..|:.::| :::.:..|.:......|::::..||   ::||.
Mouse  1254 LDEVTQLAHDLTTQKTKLQSESGEFFKRLEE-KEALISQLSREKSNFTRQVEELRAQ---LEEES 1314

  Fly  1366 KLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKF------H 1421
            :..:|   .|::.:.|...|..:.|||      ....|::...::|...:..|...|:      .
Mouse  1315 RSQSALSHALQSAKHDYDLLREQYEEE------QEVKAELHRALSKGNKETVQWRAKYEHDAMQR 1373

  Fly  1422 SSDLDKILQRL-----------------------------------LSALTPRTVVGLLPGFPAY 1451
            :.||::..::|                                   ||.|.....|....|...
Mouse  1374 TEDLEEAKKKLAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQ- 1437

  Fly  1452 LIFMCIRYTD--LTNAD---DDVREL----------LSKFVIQIKK-----------MHRTPHPI 1490
                  :::|  ||:..   |:.:||          ||..|:..::           :.|....:
Mouse  1438 ------QHSDKALTSWKQKLDETQELLQASQKETRALSSEVLTFRQACEESTEAQETLKRQNQDL 1496

  Fly  1491 ENRVIWLVNSITLLNLMKQYGDVDEYVKF----NTEKQ------------NQQQLKNFNL----- 1534
            :.::..|.|.:.  ..:|...:|::..|.    .||.|            |:.::..|.|
Mouse  1497 QEQICSLTNQVR--EGIKNLAEVEKAKKLIEQEKTEVQVRLEETEGALERNESKILRFQLELSEA 1559

  Fly  1535 -FEYRRVI------LDLIVNLYQALIMQIQGLLD------------PKIVPAILNNDEIQ---RG 1577
             .|..|.:      .:.:...:|..:..:|..||            .|.:...|...|||   ..
Mouse  1560 KAELERKLSEKEEEAERLREKHQQAMGSLQSNLDLEASSRIEATRLRKKMEGDLKEMEIQLCAAN 1624

  Fly  1578 RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAV 1642
            ||...| :||..                ||.||::..::|..    |:.|..:...:      .|
Mouse  1625 RQVSQM-TRALG----------------QLQGQMKDLHQQLD----DSIYQNKDLKE------QV 1662

  Fly  1643 AL---NCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMS-NDVLTALAPLN-----QVSQLLQS 1698
            ||   ..::|:.::....|         ..|...|.:|:: .::|.|...:|     ..|.|.|.
Mouse  1663 ALAEQRTVLLQSELEELRT---------LQEQTERGRKLAEKELLEATERINLFHTQNTSLLSQK 1718

  Fly  1699 RKSEQDVQTI----------CDLC------TSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEK 1747
            :|.|.||..:          |...      |:...|.:.:.:|       :.:.||..||::.:.
Mouse  1719 KKLEADVAQVQKEAGEMLQACQKAEEKAKKTAAEAANMSEELK-------KEQDTNAHLERMRKN 1776

  Fly  1748 L--NARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIE 1786
            :  ..:.:|| ..||  .:|..:...|...:..:.::.|:|
Mouse  1777 MEQTIKDLQK-RLDE--AEQTAVLGSKKQIQKLESRVRDLE 1814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	245/714 (34%)
		IQ	900..922	CDD:197470	2/21 (10%)
		SMC_prok_B	<942..1365	CDD:274008	105/464 (23%)
		Myo5_CBD	1424..1792	CDD:271254	86/494 (17%)
Myh15	NP_001159682.1	Myosin_N	28..73	CDD:460670	12/47 (26%)
		MYSc_Myh15_mammals	96..757	CDD:276892	245/714 (34%)
		Myosin_tail_1	838..1914	CDD:460256	213/1098 (19%)