DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh15

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001159682.1 Gene:Myh15 / 667772 MGIID:3643515 Length:1925 Species:Mus musculus


Alignment Length:1991 Identity:503/1991 - (25%)
Similarity:872/1991 - (43%) Gaps:425/1991 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTT 77
            |.|||.....:..|.::||...|...::  |..|::..:|     .|.....||..|....||:.
Mouse    32 KCWVPDGKNAYIEAEVKESGDDGQVIVE--TRDGEIMRIK-----EDKLQQMNPEELEMIEDLSM 89

  Fly    78 LSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFA 142
            |.||:|..|||.||.|: :..:||||.||..||||||..:|:|...::.||:.....::.|||||
Mouse    90 LLYLNEASVLHTLRRRY-DHWMIYTYSGIFCVAINPYKWLPVYQKEVMAAYKRKRRSEVPPHIFA 153

  Fly   143 LAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG-SESETQ---VERKVLASSPI 203
            :|..|:..:.|...|.||:.:||||:||||:.|..::|||.:.. ||.:.:   :|.:::..:|:
Mouse   154 VANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATMAAISEPKKKLGNLEDQIVKMNPL 218

  Fly   204 MEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQ 268
            :||||||||.:|||||||||..::.|..:..:.|   |.:..|.|||||||||..||||||||||
Mouse   219 LEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSF---ADIQIYFLEKSRVVYQQPGERNYHIFYQ 280

  Fly   269 LCAARSKYPELVLDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            :.:...:...::|...:...| :...|...:|.:.||::|..|.:|:.||||...:.....|::.
Mouse   281 ILSGNQELRNMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATEKAIDVLGFLPDEKFGCYKLVG 345

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            .|:|.||::..:...|  |:.::|..:      :....|.|:.:.|.:|.:.|:..:|:..||||
Mouse   346 AIMHFGNLKFKRNLRE--EQLEADGTE------NADKAAFLMGIHASELLKGLIYPRIKVGNEYV 402

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQF 462
            ....:::....|..||::.||.::||::|..:|:.|:.......|:|:||..|||..:.||.||.
Mouse   403 TRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLTSHFFVGILDTTGFEILDYNSLEQL 467

  Fly   463 CINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMP 526
            |||:.||||||.|||.:|.||||||.|||:.|..||: .|.|.|||.||..:|:..:|:|||.:|
Mouse   468 CINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDFIEKPMGIFSILEEECMLP 532

  Fly   527 KGSDESWAGKLIGKCNKFPHFEKPRFGTTSFF---------------IKHFSDTVEYDVNGFLEK 576
            |.:|:.:..||      |.|    .||.:::|               :.|::..|.|:::|::.|
Mouse   533 KATDQMFKTKL------FDH----HFGKSAYFQTPTSPEKNFEVHFELAHYAGVVPYNISGWIGK 587

  Fly   577 NRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVV 641
            |:..:::.:..:|.:|:..:...:.|.:                   :|:....|.|        
Mouse   588 NKGLLNETVVALLQKSSNKVLANLFTKD-------------------IIAGSASQFG-------- 625

  Fly   642 PSKQHRKTVGSQF-------QESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRAC 699
             .|.|:|  |:.|       :|::..|::.|.:|.||:||||.||.:|:....:...::||||..
Mouse   626 -EKTHKK--GTSFHLITSLHKENINKLMTDLKSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCN 687

  Fly   700 GVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNI---VMKWIQ-DEDKYRFG 760
            ||||.:|:....|||..||.||..||.:|  ..::......:|.|..   |:.::: |...|:.|
Mouse   688 GVLEGIRVCCEAFPSWMLYDDFKQRYWIL--NPRIFSKSKFVSSRKATEEVLDFLEIDHPHYQCG 750

  Fly   761 NTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERT 825
            .|::||:|..:..||:                       |:..:|.||....|..|||.|.|...
Mouse   751 VTKVFFKAFILDQLEE-----------------------RRDEKISKVFTLFQARARGKLMRITF 792

  Fly   826 QKMREARAGL-ILSKYARGWLCRRR--YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQR 887
            ||:.|.|..| ::.:..|.::..:.  ::.|...|..:   |:.:.|..:...:::  ...|:|:
Mouse   793 QKILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPL---AKSVGAGEEIAGLKE--ECAQLQK 852

  Fly   888 FVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRI 952
            .:..:.::|...|.::..::.:....|.       :::||.:|:::.|.:...|....:.::.:|
Mouse   853 ALESSESQREELKTKQVSLVQEKNDLRL-------QLQAEQETLANSEEQCESLIKSKVELEVKI 910

  Fly   953 DELNRDNSNLKHKTSEISVLKMKL-----ELKK---TLEAEF-KNVKAACQDKDKL------IEA 1002
            .||:|.....:...||::....||     ||||   .|||.. |:.|..|..:.|:      :.:
Mouse   911 KELSRQVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKGKCAAEHKVRNLTEEVHS 975

  Fly  1003 LNKQLE------AERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEII-DMAKNAEVNQ 1060
            ||:::.      .:..|..|..:|..|.:||.:|...   :.|.:|.:|||.:. |:       :
Mouse   976 LNEEVSKLSRVVKDAQETQQQTQEQLHIEEEKLSNMS---KANLKLAQQIDVLEGDL-------E 1030

  Fly  1061 RNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSR--LTAGSFSLHARKASNASSQN 1123
            |.::.||..|.:.|:|.:..:...:..|.:|:....|.|:|.:  ...|..:.......|..||.
Mouse  1031 RERKARMKCEREKRKLQDELKMNQEGAENLESSRQKLAEQLRKKEFEMGQMNSKVENEKNQVSQL 1095

  Fly  1124 EDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEK----QKHKVLQEQY----- 1179
            :..|   ....|..:|...:|.|:.           .:|:.:|.||    |..:.|.|:.     
Mouse  1096 QKMV---KELQTHILNLKEELESER-----------TIRAKVEREKGDLVQDLEDLNERLEEAGG 1146

  Fly  1180 IKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIK--HGVEINELNAQHAALQEEVRRRREE 1242
            ..|:......:...|..:|..:.|:....::....|:|  |...:.||..|...|| :||     
Mouse  1147 TSLAQMEITKQQEARFQKLHHDMEETTRHFEATSASLKKRHAENLAELEGQVEHLQ-QVR----- 1205

  Fly  1243 CIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEA-FHSQK---LINRQLESELKAITEEHNSK 1303
                  ::|:|.:|...|:.:.|.   |.|:::..| .:::|   |..|:|        .|.|:|
Mouse  1206 ------LVLEQDKSDLQLQVDDLL---NRVDQMARAKANAEKLCGLYERRL--------NEANTK 1253

  Fly  1304 LVEMTQEIERLNNEKDELQK---VMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEEL 1365
            |.|:||....|..:|.:||.   ..|:.::| :::.:..|.:......|::::..||   ::||.
Mouse  1254 LDEVTQLAHDLTTQKTKLQSESGEFFKRLEE-KEALISQLSREKSNFTRQVEELRAQ---LEEES 1314

  Fly  1366 KLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKF------H 1421
            :..:|   .|::.:.|...|..:.|||      ....|::...::|...:..|...|:      .
Mouse  1315 RSQSALSHALQSAKHDYDLLREQYEEE------QEVKAELHRALSKGNKETVQWRAKYEHDAMQR 1373

  Fly  1422 SSDLDKILQRL-----------------------------------LSALTPRTVVGLLPGFPAY 1451
            :.||::..::|                                   ||.|.....|....|... 
Mouse  1374 TEDLEEAKKKLAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQ- 1437

  Fly  1452 LIFMCIRYTD--LTNAD---DDVREL----------LSKFVIQIKK-----------MHRTPHPI 1490
                  :::|  ||:..   |:.:||          ||..|:..::           :.|....:
Mouse  1438 ------QHSDKALTSWKQKLDETQELLQASQKETRALSSEVLTFRQACEESTEAQETLKRQNQDL 1496

  Fly  1491 ENRVIWLVNSITLLNLMKQYGDVDEYVKF----NTEKQ------------NQQQLKNFNL----- 1534
            :.::..|.|.:.  ..:|...:|::..|.    .||.|            |:.::..|.|     
Mouse  1497 QEQICSLTNQVR--EGIKNLAEVEKAKKLIEQEKTEVQVRLEETEGALERNESKILRFQLELSEA 1559

  Fly  1535 -FEYRRVI------LDLIVNLYQALIMQIQGLLD------------PKIVPAILNNDEIQ---RG 1577
             .|..|.:      .:.:...:|..:..:|..||            .|.:...|...|||   ..
Mouse  1560 KAELERKLSEKEEEAERLREKHQQAMGSLQSNLDLEASSRIEATRLRKKMEGDLKEMEIQLCAAN 1624

  Fly  1578 RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAV 1642
            ||...| :||..                ||.||::..::|..    |:.|..:...:      .|
Mouse  1625 RQVSQM-TRALG----------------QLQGQMKDLHQQLD----DSIYQNKDLKE------QV 1662

  Fly  1643 AL---NCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMS-NDVLTALAPLN-----QVSQLLQS 1698
            ||   ..::|:.::....|         ..|...|.:|:: .::|.|...:|     ..|.|.|.
Mouse  1663 ALAEQRTVLLQSELEELRT---------LQEQTERGRKLAEKELLEATERINLFHTQNTSLLSQK 1718

  Fly  1699 RKSEQDVQTI----------CDLC------TSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEK 1747
            :|.|.||..:          |...      |:...|.:.:.:|       :.:.||..||::.:.
Mouse  1719 KKLEADVAQVQKEAGEMLQACQKAEEKAKKTAAEAANMSEELK-------KEQDTNAHLERMRKN 1776

  Fly  1748 L--NARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIE 1786
            :  ..:.:|| ..||  .:|..:...|...:..:.::.|:|
Mouse  1777 MEQTIKDLQK-RLDE--AEQTAVLGSKKQIQKLESRVRDLE 1814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 258/744 (35%)
MYSc_Myo5 84..767 CDD:276831 245/714 (34%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 34/136 (25%)
coiled coil 1049..1068 CDD:293879 3/19 (16%)
coiled coil 1077..1086 CDD:293879 0/8 (0%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/114 (22%)
Myo5_CBD 1424..1792 CDD:271254 86/494 (17%)
Myh15NP_001159682.1 Myosin_N 31..69 CDD:280832 10/38 (26%)
Myosin_head 84..757 CDD:278492 251/726 (35%)
MYSc_Myh15_mammals 96..757 CDD:276892 245/714 (34%)
Myosin_tail_1 838..1914 CDD:279860 213/1098 (19%)
NBP1 <1004..>1136 CDD:285709 34/155 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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