DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo19

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_079690.2	Gene:	Myo19 / 66196	MGIID:	1913446	Length:	963	Species:	Mus musculus

Alignment Length:	884	Identity:	295/884 - (33%)
Similarity:	437/884 - (49%)	Gaps:	180/884 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LKAD-----GSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAIN 112
            ||.|     |.::|       |...:|||.::.:....||..|:.|:.| .|.||..|..|||:|
Mouse    20 LKGDLREFLGGEIP-------LHQLDDLTKVNPVTLETVLRCLQARYTE-DIFYTNAGCTLVALN 76

  Fly   113 PYAEMP-LYGPSIIRAYRGHAMGD---LEPHIFALAEEAYTKLER--ENCNLSIIVSGESGAGKT 171
            |:..:| ||.|.:::.|  ||...   |:||||.:.|:.|..::.  |..|.||:||||||||||
Mouse    77 PFKHVPQLYAPELMQEY--HAAPQPQKLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKT 139

  Fly   172 VSAKYAMRYFAAVGGSESETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKL-L 228
            .:::..|:::|.|..|.:..:       :|:::|.|:|:|||||||.|.||.||||||||.:| |
Mouse   140 WTSRCLMKFYAVVAASPTSCENHKIAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQL 204

  Fly   229 FRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV--LDHQDKFQFLN 291
            .|.|.    :.||.:.||||||:||..||..|||:|||||:|...:|...|.  |.....|.:|
Mouse   205 NRAQQ----MTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGATKDERLQWHLPEGTAFSWL- 264

  Fly   292 MGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSD 356
                |..|...:.:.|..|.:||..||.......:|.|:|||:|||||:...      ..|:::.
Mouse   265 ----PNPESSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFV------DSEDEAL 319

  Fly   357 SCDIFHN-DIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLI--PNSIEAAQAARDALAKHIY 418
            .|.:..: .:.::.:|.||::....|...:.:|.|::..:..:.  |.|.......||.|||.||
Mouse   320 PCQVMDDTKVSVRTSALLLQLPEKMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIY 384

  Fly   419 AKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKL 482
            |:||.::|.|:|.|:...||. .:|||:||:||||:|..||.||.|||||||||||.|..|..:.
Mouse   385 ARLFDWLVSVINSSICADSKSWTAFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRA 449

  Fly   483 EQEEYLKEGITWTMIDFYDNQPCIDLIE-SRLGVLDLLDEECRMPKGS---------DESWAGK- 536
            :||||..||:.|:.:::.|||.|:||:| |.:.:..|::||||:.:.|         :.:.||:
Mouse   450 QQEEYEVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRP 514

  Fly   537 LIG--KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQ 599
            .:|  |.::.|          ||.:.||:..|.|...|.:|||:|.|..|||::|.:|...|...
Mouse   515 CLGHNKLSREP----------SFVVVHFAGPVRYHTAGLVEKNKDPVPPELTELLQQSQDPLLTM 569

  Fly   600 VM-------TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQES 657
            :.       |.||             |.|:                    |:....||.|:|:.|
Mouse   570 LFPANPEEKTQEE-------------LSGQ--------------------SRAPALTVVSKFKAS 601

  Fly   658 LASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFY 722
            |..|:..||.|||||:||||||.......:...:::.||.|||::||:.|||||||.|..:.:|.
Mouse   602 LEQLLQVLHNTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFI 666

  Fly   723 MRYQLLVYRSKL---------------DKNDMKLSCRNIVMK-WIQD---------------EDK 756
            .||:||   .:|               ..::..|..:...:: .:||               .|.
Mouse   667 ERYKLL---RRLGPRMSSGLGGLEPAEGSSEQPLCAKEATLQPLLQDILHALPALIQTAATPSDP 728

  Fly   757 YR-------FGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814
            .:       .|.|:||.....:..||..||.:.::....:|...||.       |:||
Mouse   729 AKNTQIPLYCGRTKIFMTDSMLELLECGRAQMLEQCARCIQCGWRRH-------RLQK------- 779

  Fly   815 HARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRL 853
                        :.::.||.:::....|.||.|:...||
Mouse   780 ------------QEKQRRAAVLIQAAFRSWLTRKHIRRL 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	274/790 (35%)
		MYSc_Myo5	84..767	CDD:276831	268/760 (35%)
		IQ	900..922	CDD:197470
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	268/760 (35%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	602..624		14/21 (67%)
		IQ	784..804	CDD:366194	6/19 (32%)
		MyMOMA region. /evidence=ECO:0000250\|UniProtKB:Q96H55	829..963
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820