Protein Alignment didum and MYO1G

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 1064
• Identity: 325/1064 - (30%)
• Similarity: 494/1064 - (46%)
• Gaps: 233/1064 - (21%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |:.|...|..:.....:.||::|| |:..||||.|.:||::|||.|:|||||..|..|:|..:.:
Human    10 GKPDFVLLDQVTMEDFMRNLQLRF-EKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYE 73

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER---KV 197
            ..||::|:|..||..::..:.:..|::|||||||||.::|:.|:|.|||.......:|||   .:
Human    74 RPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVL 138

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.|:.::||||||:|.||.|||||||:..:.|..:...:   |..:|:||||||||:.|..||||
Human   139 LKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPI---GGHIHSYLLEKSRVLKQHVGERN 200

  Fly   263 YHIFYQLC--AARSKYPELVLDHQDK-FQF------LNMGGAPEIERVSDAEQFNETVQAMTVLG 318
            :|.||||.  :...:..||.|:.... :.|      |||.....::  ||.:......:||.|:|
Human   201 FHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALD--SDEQSHQAVTEAMRVIG 263

  Fly   319 FSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEED---SDSCDIFHNDIHLQITADLLRVSADD 380
            ||.:::..:.:|||.|||||||:..:....|.::|.   ::...:.|       .|:|.....|.
Human   264 FSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDH-------VAELTATPRDL 321

  Fly   381 LRRWLLMRKIESVNEYVLIPNSIEAAQA--ARDALAKHIYAKLFQYIVGVLNKSLNNGSK----- 438
            :.|.||.|.:.|... .||.....||:|  ||||.||.:|.:||:::|..:|..:....:
Human   322 VLRSLLARTVASGGR-ELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRD 385

  Fly   439 -QCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDN 502
             :.:.||||||||||.|.|||||||||||.||||||.|.|.:.|.|||||.:|||||..:::::|
Human   386 GKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNN 450

  Fly   503 QPCIDLIE-SRLGVLDLLDEECRMPKGSDESWAGKLIGK---------------------CNKFP 545
            ...:||:| ...|:|.:|||.|        |.||.:..:                     |   |
Human   451 ATIVDLVERPHRGILAVLDEAC--------SSAGTITDRIFLQTLDMHHRHHLHYTSRQLC---P 504

  Fly   546 HFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLC 610
            ..:...|| ..|.|||::..|.|.|.||::||||.:.::..::|..|.
Human   505 TDKTMEFG-RDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNST----------------- 551

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
                 ..||  |.:...|::.....|:|.:        |.|:.|:.|:.:|:..|.:..|.||||
Human   552 -----DPTL--RAMWPDGQQDITEVTKRPL--------TAGTLFKNSMVALVENLASKEPFYVRC 601

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMK 740
            ||||:||||.|.:......|:...|:||.||:..|||.||..|..|.:||              |
Human   602 IKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRY--------------K 652

  Fly   741 LSCRNIVMKWIQDEDK---------------YRFGNTQIFFRAGQ-VAFLEQVRANLRKKYITIV 789
            ::|.......:...||               ..||::::|.|:.: :..|||.||.|....:.::
Human   653 MTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLL 717

  Fly   790 QSVVRRFVYR---RQFLRIQKVINGIQKH-ARGYLA--RERTQKMRE------------------ 830
            |...|..:.|   |:...|..::...::| .|.:||  :.|.|..|:
Human   718 QKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQ 782

  Fly   831 --------------ARAGL----------ILSKYA---------RGWLCRRRYLRLRHSISGIQT 862
                          ||..:          |.:|.|         :.|.|||.:.|...|.:....
Human   783 PFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNP 847

  Fly   863 YARGMLA-RNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKA 926
            .|..:.| |.|....:|.:.||.....||  ...|.::.|.|.:::....:.:....|:::.|:|
Human   848 TASSLFAQRLKTLQDKDGFGAVLFSSHVR--KVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRA 910

  Fly   927 ---EAKTISHMENKYMGLE-----NKIISMQQRIDE-----LNRDNSNLKHKTSE-ISVLKMKLE 977
               ||.|         ||.     ::::.:..|..:     |:|....|.::..| :.||
Human   911 VPLEAVT---------GLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVL----- 961

  Fly   978 LKKTLEAEFKNVKAACQDKDKLIE 1001
                        .|.||.:.:.:|
Human   962 ------------AAHCQGEGRTLE 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	261/742 (35%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	11/71 (15%)
		Myo5_CBD	1424..1792	CDD:271254
MYO1G	NP_149043.2	MYSc_Myo1	23..694	CDD:276829	261/742 (35%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		10/21 (48%)
		Myosin_TH1	815..980	CDD:461801	39/187 (21%)