DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myhz1.1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001108561.1 Gene:myhz1.1 / 58142 ZFINID:ZDB-GENE-000322-5 Length:1937 Species:Danio rerio


Alignment Length:1928 Identity:498/1928 - (25%)
Similarity:848/1928 - (43%) Gaps:482/1928 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKGAGFLKICTDSGKL-------KEVK-LKADGSDLPPLRNPAILVGQNDLTTLSYLHEPG 85
            :|.|.||....|   |.||:       ||.| :|.|  |:.|: ||.......|:..:::|:||.
Zfish    44 KELYVKGTIKSK---DGGKVTVITLDTKEEKVVKED--DVHPM-NPPKFDKIEDMAMMTHLNEPS 102

  Fly    86 VLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTK 150
            ||:||:.|:. ..:||||.|:....:|||..:|:|...::.||||....:..||||::::.||..
Zfish   103 VLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQF 166

  Fly   151 LERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSESETQ---------VERKVLASSPIM 204
            :..:..|.|::::|||||||||:.|..::|||  ||.|.|.:.:         :|.:::|::|::
Zfish   167 MLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLL 231

  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269
            ||:|||||.|||||||||||.::.|.....   |..|.:.|||||||||.:|...||.||||||:
Zfish   232 EAYGNAKTVRNDNSSRFGKFIRIHFGTSGK---LASADIETYLLEKSRVTFQLPDERGYHIFYQM 293

  Fly   270 CAARSKYPELV---LDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            ..  :..|||:   |...:.:.| :...|...:..:.|.|:...|..|:.:|||:.::...|.|.
Zfish   294 MT--NHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGFNNEEKMGIYKF 356

  Fly   331 LAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRK 389
            ...:||.||::..:|..|      |:||.|.              ...||.:::.|:.:.|...:
Zfish   357 TGAVLHHGNMKFKQKQREEQAEPDGTEEADK--------------IGYLLGLNSADMLKALCYPR 407

  Fly   390 IESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETF 454
            ::..||:|....::.....:..||:|.||.::|.::|..:|:.|:...::..|||||||.|||.|
Zfish   408 VKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIF 472

  Fly   455 EVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDL 518
            :.||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..||:..:
Zfish   473 DFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSI 537

  Fly   519 LDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFGTTS--FFIKHFSDTVEYDVNGFLEKN 577
            |:|||..||.:|.|:..||    :||||.|.. .||..|...  |.:.|::.||:|:::|:|:||
Zfish   538 LEEECMFPKATDTSFKNKLYDQHLGKCNAFQK-PKPAKGKAEAHFSLVHYAGTVDYNISGWLDKN 601

  Fly   578 RDTVSKELTQVLSESNMSLAKQVM--TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRV 640
            :|.:::.:.|:..:|::.|...:.  .:||            |.||:   ..|:|:.|:      
Zfish   602 KDPLNESVVQLYQKSSVKLLATLYPPVVEE------------TGGGK---KGGKKKGGS------ 645

  Fly   641 VPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETV 705
                  .:||.|||:|:|..|::.|.:|.||:|||:.||:.|.....|...:|.|||..||||.:
Zfish   646 ------MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGI 704

  Fly   706 RISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFR 767
            ||...|||||.||.||..||::| ..|.:.:.   |.|.:...::.....:.|:||||:|::||:
Zfish   705 RICRKGFPSRILYADFKQRYKVL-NASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768

  Fly   768 AGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREAR 832
            ||.:..||::|.......:|:.|::.|.::.||:|:                       ||.|.|
Zfish   769 AGLLGTLEEMRDEKLASLVTMTQALCRAYLMRREFV-----------------------KMMERR 810

  Fly   833 AGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRA 897
            ..:...:|.     .|.::.::|                 :..|:.:|:   |:..::.|...:.
Zfish   811 DAIYTIQYN-----VRSFMNVKH-----------------WPWMKVYYK---IKPLLKSAETEKE 850

  Fly   898 YQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNL 962
            ....:.:.:.|:..:           .|||||.        ..||.|::::              
Zfish   851 LATMKEDFVKCKEDL-----------AKAEAKK--------KELEEKMVAL-------------- 882

  Fly   963 KHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK---QLEAERDEKMQLLEENGHA 1024
                     |:.|.:|:..:.:|.:|:    .|.::..|.|.|   ||||:..|..:.||:....
Zfish   883 ---------LQEKNDLQLAVASESENL----SDAEERCEGLIKSKIQLEAKLKETTERLEDEEEI 934

  Fly  1025 QEEWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RNQEDRMLAEIDN--------R 1074
            ..|..::|:....|..||::.||::      ::..|:|..|: :|..:.|.|:.::        :
Zfish   935 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKK 999

  Fly  1075 ELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDIN 1139
            .|.||:|:.:.|.:..|       ::::.||         |:.....|..||:     :.:|:..
Zfish  1000 ALQEAHQQTLDDLQAEE-------DKVNTLT---------KSKTKLEQQVDDL-----EGSLEQE 1043

  Fly  1140 RPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKLSSRHKPTED-----SFRV 1195
            :                   |||..||..|:|    .|:.||..:.|.:..:.:|:     .|..
Zfish  1044 K-------------------KLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFET 1089

  Fly  1196 SEL--EVENE-----KLRSEYDQLRTSIKHGVEINELNAQHAALQ-------------EEVRRRR 1240
            |:|  ::|:|     :|:.:..:|:..|:...|  |:.|:.||..             ||:..|.
Zfish  1090 SQLLSKIEDEQSLGAQLQKKIKELQARIEELEE--EIEAERAARAKVEKQRADLSRELEEISERL 1152

  Fly  1241 EECIQLKAVLLQQSQS--------MRSLEPESLQ----------MRGNDVNELMEAFHSQKLINR 1287
            ||.....|..::.::.        .|.||..:||          .:.:.|.||.|...:.:.:.:
Zfish  1153 EEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQ 1217

  Fly  1288 QLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV---MFESIDEFEDSNVDTLRQ-NDRYLR 1348
            :||.|    ..|:..::.:::..:|.:...|..|:|:   :.:.:.|.:..|.:.||| ||...:
Zfish  1218 KLEKE----KSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQ 1278

  Fly  1349 R---------------ELQKAVAQFL---------------LVQEELKLANA---KLKAYRQDGG 1380
            |               |.:..|:|..               .::||:|..||   .:::.|.|..
Zfish  1279 RARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCD 1343

  Fly  1381 QLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI--LQRLLSALTPRTVVG 1443
            .|..:.|||      ....|::...::|..|:..|...|:.:..:.:.  |:.....|..|    
Zfish  1344 LLREQFEEE------QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQR---- 1398

  Fly  1444 LLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL-LNLM 1507
                              |..|::.:..:.||.....|...|....:|:.:|.:..:..| .||.
Zfish  1399 ------------------LQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLD 1445

  Fly  1508 KQYGDVDEYVKFNTEK--QNQQQLKNFNLFEYRRVILDL--IVNLYQALIMQIQGL------LDP 1562
            |:..:.|:.:....:|  :.|.:|:.... |.|.:..:|  :.|.|:..:.|::.|      |..
Zfish  1446 KKQRNFDKVLAEWKQKYEEGQAELEGAQK-EARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1509

  Fly  1563 KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCY 1627
            :|  :.|.....:.|:..|.:.....::....:...   .|.::..|.|||              
Zfish  1510 EI--SDLTEQLGETGKSIHELEKSKKAVETEKAEIQ---TALEEAEGTLEH-------------- 1555

  Fly  1628 AEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQV 1692
                                         |...|:|..:                     .||||
Zfish  1556 -----------------------------EESKILRVQL---------------------ELNQV 1570

  Fly  1693 SQLLQSRKSEQD---------VQTICDLCTSLSTAQV------LKVMKSYKLDDYESEITNVFLE 1742
            ...:..:.:|:|         .|.|.|...|...::|      |::.|                 
Zfish  1571 KSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKK----------------- 1618

  Fly  1743 KLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784
            |:...||..::|.|:::....: ||.::..:...:.:.:.|:|
Zfish  1619 KMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDD 1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 278/745 (37%)
MYSc_Myo5 84..767 CDD:276831 268/715 (37%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 33/132 (25%)
coiled coil 1049..1068 CDD:293879 4/25 (16%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/151 (21%)
Myo5_CBD 1424..1792 CDD:271254 61/390 (16%)
myhz1.1NP_001108561.1 Myosin_N 36..74 CDD:280832 11/32 (34%)
Myosin_head 89..768 CDD:278492 271/727 (37%)
MYSc_class_II 101..768 CDD:276951 268/715 (37%)
Myosin_tail_1 848..1925 CDD:279860 187/1021 (18%)
SPEC 881..1043 CDD:295325 42/209 (20%)
MIT_CorA-like <1297..>1409 CDD:294313 23/139 (17%)
TMPIT 1473..>1583 CDD:285135 25/179 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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