DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH7B

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_016883475.1 Gene:MYH7B / 57644 HGNCID:15906 Length:2003 Species:Homo sapiens


Alignment Length:2022 Identity:539/2022 - (26%)
Similarity:879/2022 - (43%) Gaps:439/2022 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KIWVPHADLVWESATLEESYRKGA--GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDL 75
            ::|||..    :.|.:|...:..|  |.:.:.|...|:..|:    .::|.|: ||.......|:
Human    76 RVWVPDE----QDAYVEAEVKSEATGGRVTVETKDQKVLMVR----EAELQPM-NPPRFDLLEDM 131

  Fly    76 TTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHI 140
            ..:::|:|..||||||.|:. |.:||||.|:..|.||||..:|:|..|::.||:|....|..|||
Human   132 AMMTHLNEASVLHNLRQRYA-RWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHI 195

  Fly   141 FALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG----GSESETQ--------- 192
            :|:|:.||..:.|...|.|::::|||||||||:.|..::|||.|.    |...:.|         
Human   196 YAVADNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGT 260

  Fly   193 VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQA 257
            :|.:::.::|.|||||||||.|||||||||||.::.| ...|.  |..|.:.:||||||||::|.
Human   261 LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHF-GPSGK--LASADIDSYLLEKSRVIFQL 322

  Fly   258 QGERNYHIFYQLCAARSKYPELVLDHQDKFQFLNMG---------GAPEIERVSDAEQFNETVQA 313
            .|||:||::||:.:.|.  |||    ||.. .|:|.         |...::.::|.|:...|..|
Human   323 PGERSYHVYYQILSGRK--PEL----QDML-LLSMNPYDYHFCSQGVITVDNMNDGEELIATDHA 380

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEED-SDSCDIFHNDIHLQITADLLRVS 377
            |.:||||:.:.....||:..:||.||::..:|..|...|.| ::|.|         ..|.|:.||
Human   381 MDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESAD---------KAAYLMGVS 436

  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSF 442
            :.||.:.||..::...||||....|:|....|..||||..|.:||:::|..:|::|:....:..|
Human   437 SGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFF 501

  Fly   443 IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCI 506
            ||||||.|||.||.|||||.|||:.||||||.||||:|.||||||.:|||.|..||| .|.||||
Human   502 IGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCI 566

  Fly   507 DLIE--------------------SRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKP 550
            ||||                    ..||:|.:|:|||..||.||.|:..||. ....|.|:|::|
Human   567 DLIEKVRRLRLSDVGGPHSYSFCSQPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQP 631

  Fly   551 RFG-----TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLC 610
            |..     ...|.:.|::..|.|.:.|:||||:|.:::.:..:..:|...|         :.||.
Human   632 RPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRL---------LATLY 687

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
            .:.|.|        .|....:.|...:|:...|.|   ||....:|:|..|::.|.||.||:|||
Human   688 ENYAGS--------CSTEPPKSGVKEKRKKAASFQ---TVSQLHKENLNKLMTNLRATQPHFVRC 741

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMK 740
            |.||::|.....:...::.|||..||||.:||...|||:|.||.||..||::|  ......:|..
Human   742 IVPNENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRIL--NPSAIPDDTF 804

  Fly   741 LSCRNIVMKWI----QDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQ 801
            :..|....|.:    .|..:|:||:|::||:||.:..||::|..                     
Human   805 MDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQ--------------------- 848

  Fly   802 FLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISG 859
              |:.||:..:|..:||.|.|...|::...|..|...::       .:.|...:.:.:::..:..
Human   849 --RLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRS 911

  Fly   860 IQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAI---RRFLARRKF 921
            .|       |..:..|:|...|.      :|||||  |.:.:|:.:.....:|   :..||    
Human   912 AQ-------AEEELAALRAELRG------LRGALA--AAEAKRQELEETHVSITQEKNDLA---- 957

  Fly   922 KRMKAEAKTISHMENK-------YMGLENKIISMQQRI---DELNRDNSNLKHKTS--------- 967
            .:::||...::..|.:       .:.||.|:..:.:|:   :|:|.|.:..:.|..         
Human   958 LQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD 1022

  Fly   968 ----EISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQ--------------LEAERDEK 1014
                |:::.|.:.| |:..|.:.||:.......|:.:..|.|:              |:||.|..
Human  1023 IDDLELTLAKAEKE-KQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRV 1086

  Fly  1015 MQL------LEENGHAQEEWISQKQTWRQENEELRRQI--------DEIIDMAKNAE--VNQRNQ 1063
            ..|      ||:.....|..:.|::..|.:.|..:|::        :.:.|.|::.:  ..:..:
Human  1087 SALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK 1151

  Fly  1064 EDRMLAEI-----DNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNAS--- 1120
            :|..|:::     |.:.|....|:.||:.:....|   |:|||....|....:..::|..|.   
Human  1152 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEE---LEEELEAERAARARVEKQRAEAARELE 1213

  Fly  1121 --SQNEDDVGYASA-------KNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQ 1176
              |:..::.|.|||       |...::.|                    ||..|||...:|:.  
Human  1214 ELSERLEEAGGASAGQREGCRKREAELGR--------------------LRRELEEAALRHEA-- 1256

  Fly  1177 EQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQLRTSIKHGVEINELNAQHA 1230
               ...:.|.|..|.:..:.|           ||.|..:||.|.|.|..::       |...:..
Human  1257 ---TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANV-------ETLTRAK 1311

  Fly  1231 ALQEEVRRRREECI---QLKAVLLQQSQSMRSLEPESLQMRGNDVNELME-------------AF 1279
            |..|::.|..|:.:   ::|...||:..:..|.:...||....:::.|:|             |.
Human  1312 ASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKAL 1376

  Fly  1280 HSQKL--INRQLESELKA-----------------ITEEHNSKLVEMTQEIERL----------- 1314
            .:|.|  :.||||.|.||                 :.|:|..: .|...|::||           
Human  1377 AAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEE-AEAQAELQRLLSKANAEVAQW 1440

  Fly  1315 --NNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQ 1377
              ..|.|.:|:.     :|.|::.        :.|...||:|       :|.::.||||..:..:
Human  1441 RSKYEADAIQRT-----EELEEAK--------KKLALRLQEA-------EEGVEAANAKCSSLEK 1485

  Fly  1378 DGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRT-- 1440
            ...:|:.: .|::.......|||  .|.:.|::....:.|.:....:.:  :||.|.|....:  
Human  1486 AKLRLQTE-SEDVTLELERATSA--AAALDKKQRHLERALEERRRQEEE--MQRELEAAQRESRG 1545

  Fly  1441 ----VVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVI---QIKKMHRTPHPIENR----- 1493
                :..|..|....|..:.....:..|..:::.:|..:..:   .|:::.:|...:|..     
Human  1546 LGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1610

  Fly  1494 --------VIWLVNSITL---LNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVN 1547
                    .:.|..:.||   |.|.:...:||..:     .:..::..|... .::|.:..|..:
Human  1611 AALEEAEGALELEETKTLRIQLELSQVKAEVDRKL-----AEKDEECANLRR-NHQRAVESLQAS 1669

  Fly  1548 LYQALIMQIQGLLDPKIVPAILNNDEIQRG---RQAHGMRSRATSIGASSSPEHGGGPAWKQ--- 1606
            |......:.:.|...|.:...||:.|:|.|   |||...::....:.|....|..|....::   
Human  1670 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAA 1734

  Fly  1607 ---------------LIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMW 1656
                           |..:||......:........|||   :||.  ....||.|..:      
Human  1735 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQ---ELLE--ATERLNLLHSQ------ 1788

  Fly  1657 ETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLN-QVSQLLQSRK--SEQDVQTICDLCTSLSTA 1718
            .||::           .:.||:..|    ||.|: :|.:..|.|:  .|:..:.|.|      .|
Human  1789 NTGLL-----------NQKKKLEAD----LAQLSGEVEEAAQERREAEEKAKKAITD------AA 1832

  Fly  1719 QVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLE 1783
            .:.:.:|..:......|.....||:...:|.|| ::::........:|.:|..:...|..:.:| 
Human  1833 MMAEELKKEQDTSAHLERMKKTLEQTVRELQAR-LEEAEQAALRGGKKQVQKLEAKVRELEAEL- 1895

  Fly  1784 DIELPSH 1790
            |.|...|
Human  1896 DAEQKKH 1902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 297/766 (39%)
MYSc_Myo5 84..767 CDD:276831 287/736 (39%)
IQ 900..922 CDD:197470 4/24 (17%)
GBP_C <971..1086 CDD:303769 29/149 (19%)
coiled coil 1049..1068 CDD:293879 3/20 (15%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/154 (21%)
Myo5_CBD 1424..1792 CDD:271254 76/416 (18%)
MYH7BXP_016883475.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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