DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and myo15ab

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_021331574.1	Gene:	myo15ab / 570113	ZFINID:	ZDB-GENE-090312-149	Length:	4355	Species:	Danio rerio

Alignment Length:	1132	Identity:	344/1132 - (30%)
Similarity:	537/1132 - (47%)	Gaps:	233/1132 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WVPHA---------DLVWESATLEE-SYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAIL 69
            |||..         |.::...:|.. |||                 ||.|.||::
Zfish  1925 WVPDREGEPRGTWYDKMYSIRSLPTVSYR-----------------VKRKGDGTE---------- 1962

  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134
                |:|.:..|.||.||.||::|| ::::||||.|.|||::|||....:||..::..|.||||.
Zfish  1963 ----DMTQMEQLTEPAVLINLKIRF-DQELIYTYIGSILVSVNPYQLFNIYGTDMVLQYEGHAMA 2022

  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLA 199
            |..||:||:|..|||.:.....|..||:|||||:|||.:.|..:||..|:....:.|| :.::|.
Zfish  2023 DNPPHLFAIANVAYTTMMDIKQNQCIIISGESGSGKTEATKLVLRYLTAIHHKRNITQ-QIEILE 2086

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            ::|::|:||||||.|||||||||||.::..  :.||  :.||....|||||||:|:||:.|||||
Zfish  2087 ATPLLESFGNAKTVRNDNSSRFGKFVEIFL--EEGV--ISGAITSQYLLEKSRIVFQAKDERNYH 2147

  Fly   265 IFYQLCAARSKYPE--LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |||::.|....:.:  ..|...:.:.:||.||...|....|.|.|.....||.:|.||.:..:.|
Zfish  2148 IFYEMLAGLPSHTKRAFYLQEAETYYYLNQGGNCGITGKDDGEDFRRLQSAMDILHFSTEDQSSI 2212

  Fly   328 VKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            .::|:.||||||:     |....|.|..::..:.... .::..||||::|.:.|::.:..:..|:
Zfish  2213 FRVLSSILHLGNV-----FFHRVETEVQETAGVVSTQ-EIRAVADLLQISPEGLQKAITFKVTEA 2271

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN 457
            :.|.:..|.|:|:|..||||:||.:|:.||.::...:|..:...::..| |.:|||||||:...|
Zfish  2272 MREKIYTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVYPRNEALS-ISLLDIYGFESLVFN 2335

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDE 521
            ||||.|||||||.||..|::.:||.|||||::|.|.|..:.|.|||.|||||.:: .|:|.:||:
Zfish  2336 SFEQLCINYANETLQFFFSKIIFKQEQEEYIREQINWKELTFTDNQACIDLISAKPHGLLRILDD 2400

  Fly   522 ECRMPKGSDESWAGKLIGKCN----KFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            :...|:.:|.::    :.||:    ..|.:.||:.....|.:.|::..|.|.|:.||:||.|.|.
Zfish  2401 QSCFPQATDNTF----LQKCHYHHGNNPLYSKPKMPLPEFTVYHYAGRVTYQVHKFLDKNFDQVR 2461

  Fly   583 KELTQVLSES-NMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            :|:..:..:| |.:::...:...|:    ::..|            |...:.:...||..||
Zfish  2462 QEVLDLFMQSQNRTVSNLFIKHSEM----LNQQK------------GAMNRSSTVTRRYQPS--- 2507

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
              ||.::||:||..|:..:....|.:|||||||::|....::...:..|||..|:|:|:||...|
Zfish  2508 --TVAAKFQQSLQELLDKMERCNPFFVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEG 2570

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQ----DEDKYRFGNTQIFFRAGQVA 772
            :|.|..:..|..||:.|:...|...:|..    |.||...:    ::..|:.|.:::|.:.....
Zfish  2571 YPIRVPFHKFLNRYKALLGMKKPPPSDGD----NCVMMLTKLCPINKGDYQVGVSKLFLKEEVYQ 2631

  Fly   773 FLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMR------EA 831
            .||..|..:.......:|..||.|..||:||:.:..:..:|.|.:|::||:|..:||      .|
Zfish  2632 LLESKRDRVMHIAALTLQRYVRMFFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRA 2696

  Fly   832 RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVR------ 890
            ...||::        |:||:|:           ..:|||.    ..:..|.::::|..|
Zfish  2697 MIRLIVN--------RKRYIRI-----------NVLLARR----AEEERRRLELERISREVVNVT 2738

  Fly   891 --------GALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTI------SHMENKYM-- 939
                    |.|.:.....|.|: ..|.|.::.       .|::.:.:..      :|:..||:
Zfish  2739 QLVIPAELGGLLQATAGGRERH-SDCLALVQA-------PRIQTDPQLTLPLDINNHLMTKYIRT 2795

  Fly   940 ------------GLENKIISM-----QQRID------------ELNRDNSNL------------- 962
                        .|||.:..:     |..:|            .||....||
Zfish  2796 HFRELLFGMLTAPLENSLTRLEDDLKQDAVDVFILILRFMGDPNLNGAQENLFGNYIIQRGLATP 2860

  Fly   963 ------------------KHKTSEISVLKM-----------KLE---LKKTLEAEFKNVKAACQD 995
                              ..:.:|...|.|           |:|   ||...:......||.||
Zfish  2861 PIRDEILAQIANQVWRNENSRNAERGWLLMAACLSSFAPSEKMEKYLLKFVSDYALNGFKALCQ- 2924

  Fly   996 KDKLIEALNKQL---EAERDEKMQLLE 1019
             .||::|:.|..   ||.|.....|||
Zfish  2925 -HKLLQAMQKSYLVPEASRTYPPSLLE 2950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	261/724 (36%)
		MYSc_Myo5	84..767	CDD:276831	255/694 (37%)
		IQ	900..922	CDD:197470	4/21 (19%)
		GBP_C	<971..1086	CDD:303769	20/66 (30%)
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
myo15ab	XP_021331574.1	Atrophin-1	<546..799	CDD:331285
		Atrophin-1	<719..1317	CDD:331285
		FtsK	<1119..>1705	CDD:332908
		Motor_domain	1974..2626	CDD:328930	254/693 (37%)
		MyTH4	2808..2955	CDD:214535	30/145 (21%)
		SH3	3686..3765	CDD:327375
		MyTH4	3875..4028	CDD:214535
		FERM_B-lobe	4137..4234	CDD:271216
		FERM_C_MyoXV	4240..4341	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900