DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and si:dkey-110c1.10

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_021329161.1	Gene:	si:dkey-110c1.10 / 568760	ZFINID:	ZDB-GENE-050208-429	Length:	1665	Species:	Danio rerio

Alignment Length:	1862	Identity:	657/1862 - (35%)
Similarity:	983/1862 - (52%)	Gaps:	259/1862 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |::.| ||.:||.:|||..:.||.||.|...|..|...:.|....|:..|..: ...:.||||.|
Zfish     1 MATTE-LYTKGACVWVPDPEAVWVSAQLLRDYSPGDQQISIQLPDGREMEYPV-LPPAGLPPLGN 63

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRG 130
            |.||.|:||||.|::||||.|||||||||.:...|||||||:|||:|||..:|:||..:|.||.|
Zfish    64 PDILEGENDLTALTFLHEPAVLHNLRVRFLDYSSIYTYCGIVLVALNPYEPLPIYGEEVIDAYSG 128

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195
            ..|.|:|||||::|||||..:.||..|.|||:|||||:|||||||:.|||||.|||:..:|.||.
Zfish   129 QDMADMEPHIFSVAEEAYRTMIREEKNQSIIISGESGSGKTVSAKFTMRYFAVVGGAAQQTSVEE 193

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            |||||:|||||.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||..|
Zfish   194 KVLASNPIMEAIGNAKTTRNDNSSRFGKYIEIGFGCKGDII---GANMRTYLLEKSRVVFQAADE 255

  Fly   261 RNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            |||||||||||:|. .||   |.||..:.|.:.|.|....|....|..:...|..|.|:||....
Zfish   256 RNYHIFYQLCASRD-LPELRTLRLDSAENFHYTNQGQDVHISGTDDVVELERTRNAFTILGVQTD 319

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            |..:|.:|||.||||||:.:......|      |...|..:|..|.:.|.||||....:.:||..
Zfish   320 QQMEIFRILAAILHLGNVNIQASGRGG------DRSYIDGDDRSLAVFAKLLRVEGAQMAQWLCH 378

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN-NGSKQCSFIGVLDIYGF 451
            |::....|.::.|.:.:.|..||||||||:|.:||.:.|..||.||. :..|..||.||||||||
Zfish   379 RRLAVGGEMLVKPMTGQQANEARDALAKHVYEQLFTWTVQRLNSSLRAHREKPKSFTGVLDIYGF 443

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVL 516
            |||:.||||||||||||||||||||:|||:|||||||:|.:.|..|:|.||||||.|||.:||:|
Zfish   444 ETFDRNSFEQFCINYANEKLQQQFNRHVFQLEQEEYLREELPWNRIEFSDNQPCIALIEGQLGLL 508

  Fly   517 DLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            ||||||||||||||::||.||..: .|..|||.|||...::|.|.||:|.|:|:.:|||:|||||
Zfish   509 DLLDEECRMPKGSDDNWARKLYDQHLNHSPHFLKPRMSNSAFIIVHFADKVQYECDGFLDKNRDT 573

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            |.:|...:|..|...|..::...|.... |:   .:|||....|.|..|..            ::
Zfish   574 VFEEPINILRASQSELVAELFQKESAGG-CL---PNSTLANGSVRSGKRAH------------RE 622

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
            |:.|||.||::||..|:.||::||||||||||.||.|..|.::..:.:|||||||||||::||||
Zfish   623 HKLTVGFQFRQSLQLLMDTLNSTTPHYVRCIKSNDLKKPFLFDPKRAVQQLRACGVLETIQISAA 687

  Fly   711 GFP-----------SRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQI 764
            |:|           |||.|.:|:.||::|: :..:.::|::.||::.:...|.|.::|.||.|::
Zfish   688 GYPSRQVYLLLQPNSRWTYEEFFARYRVLL-QGFVSQDDVRHSCQSTLPDLIPDPEQYCFGKTKV 751

  Fly   765 FFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMR 829
            ||||||||.||::|.:.......::||.||.:..||.:.|:::..:.:|::.||.|||.....:|
Zfish   752 FFRAGQVAVLEKLRGDRLHAAGVLIQSWVRGWQQRRHYQRLRQATSILQRYTRGTLARRLAWTLR 816

  Fly   830 EARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALA 894
            ..||.||:.|..|....|:.||.:|.:...||.:.||..||..:..|......|.:|..|||.||
Zfish   817 YTRAALIIQKTYRMLAVRQLYLTIRGATIKIQAFIRGTKARRIYSQMLTERAVVILQARVRGWLA 881

  Fly   895 RRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDN 959
            |.:|::.|..:::.|..:||..|||:..|::|:|:::........|:|.|::.:|.|.|:..|::
Zfish   882 RSSYRRIRGAVVLMQCCVRRRAARRELLRLRADARSVEKYRELNKGMEVKLMQLQLRADQQARES 946

  Fly   960 SNLKH--------KTSEI-----SVLKMKLELKKTL----------EAEFKNVKAACQDK----D 997
            ::|:.        .|||:     |:||::.:||:::          |.|::..:...:.:    .
Zfish   947 ASLRETLQTERDAHTSELENLHSSLLKLQNQLKESINTAPLVSQKQEEEWRRAEEKAKQEILQLT 1011

  Fly   998 KLIEAL---NKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVN 1059
            :.|:||   ...|:.|||.....|::...||||               |||  :.:|.| :|.|.
Zfish  1012 QEIQALRVDRDSLQKERDSLAIRLQDQEKAQEE---------------RRQ--QSVDQA-DASVR 1058

  Fly  1060 QRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNE 1124
            ...:|:|           ..||..:::...:|.....|: ::|..|.                ||
Zfish  1059 AELEEER-----------RRYQSLLREFTRLEQRYDNLR-DMSLFTT----------------NE 1095

  Fly  1125 DDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPT 1189
            ...|:....:|:.: .||.|::..:|                                ||...|:
Zfish  1096 RARGHRRTDSTVSL-EPPSLVTSPFS--------------------------------SSPVFPS 1127

  Fly  1190 EDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQS 1254
            .:       :|....:.|..|:.|.|.:|.:.:         |.|::           :|....:
Zfish  1128 PE-------QVRRISVTSPSDRGRWSQEHPLSM---------LMEDM-----------SVAKDAA 1165

  Fly  1255 QSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKD 1319
            :.|:|             .:...|:.:.::.|:.||::|.       |:..:..|||..|.....
Zfish  1166 ERMKS-------------EDFRHAYDAVRVANKFLETQLL-------SQRAQWEQEISALRTNLQ 1210

  Fly  1320 ELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEH 1384
            :||       |.....:.|   :||         .:.|.::.::|......:||       :|:|
Zfish  1211 QLQ-------DRDTPGDPD---KND---------LLEQVMVREQECVRLRRELK-------ELKH 1249

  Fly  1385 KIEEEMIRNKSNGTSADV--GANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPG 1447
            .:....|.:.|....|:.  ..:.:.|::|...||::....|..|:::.|::.:...:|:...||
Zfish  1250 TVSLRRILSYSGLVVAESQDPTSPSSQRNQTITGLLECRKKDESKLIKHLITDVRAESVLSSSPG 1314

  Fly  1448 FPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIK---KMHRTPHPIENRVIWLVNSITLLNLMKQ 1509
            ..|.::|:|:|..|.:.....|:.|.|..|..||   |.|  .:.::...:||.||..|.:|:.|
Zfish  1315 LAARVLFLCVRQVDCSGDQARVKGLCSAVVTGIKTALKKH--GNDLDMTAVWLKNSYVLRDLLLQ 1377

  Fly  1510 YGDVDEYVKFNTEKQNQQQLKNF--NLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNND 1572
            :..       ..|.:..:.|...  ::.|:.|.:.||.:..||.|:...:..|.|.|:||:|.::
Zfish  1378 HSP-------RQESRGSEDLLPLVTDVQEFVRALSDLCIQSYQQLLSISESRLQPIIIPAMLESE 1435

  Fly  1573 EIQRGRQAHGMRSRATSIGASSSPEHGGGP---AWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQ 1634
            .|. |.....::..|....|.|.|...||.   :...::.:|...:.......|.:...||.|||
Zfish  1436 MIP-GLAGSSVKLSAARKRAGSDPRPPGGSEGVSMSSVLRELSALHTALSRQHLPSVLQEQAFHQ 1499

  Fly  1635 LLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKM-SNDVLTALAPLNQVSQLLQ- 1697
            |:|.:.|..||.|:||.|:|.|..|:.||||:..:|:|:|::.: :...:..|.||.|.:||||
Zfish  1500 LVYLLSASTLNSLLLRKDMCCWSRGLQIRYNVSVLEEWLRARSLQTGGAVGTLEPLIQAAQLLQM 1564

  Fly  1698 SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDEF 1761
            |:|:|.|.|.:...|::|:..|::|::..| ...|.|..:|..|:..:...|..|   .....:.
Zfish  1565 SKKTEADAQAMVQACSALTNQQMVKILSLYTPQSDLEERVTLNFIRLVQALLKGR---SEGPPQL 1626

  Fly  1762 TIDQKFIQPFKVVFRY---SDIKLEDIELPSHLNLDEFLTKI 1800
            .:|.:.:  |.|.|.:   :.:..|.:::|..|.:: ||.::
Zfish  1627 LLDVRRV--FPVTFPHDPPAQVTAEQMQIPEALKIN-FLRRV 1665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	379/728 (52%)
		MYSc_Myo5	84..767	CDD:276831	357/698 (51%)
		IQ	900..922	CDD:197470	7/21 (33%)
		GBP_C	<971..1086	CDD:303769	29/131 (22%)
		coiled coil	1049..1068	CDD:293879	6/18 (33%)
		coiled coil	1077..1086	CDD:293879	2/8 (25%)
		JAKMIP_CC3	<1190..1299	CDD:292653	16/108 (15%)
		Myo5_CBD	1424..1792	CDD:271254	105/381 (28%)
si:dkey-110c1.10	XP_021329161.1	Myosin_head	3..1621	CDD:332202	647/1811 (36%)
si:dkey-110c1.10	XP_021329161.1	MYSc_Myo5	82..754	CDD:276831	357/698 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010