Protein Alignment didum and myo10l1

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_001924041.3
• Gene: myo10l1 / 566674
• ZFINID: ZDB-GENE-080425-1
• Length: 2041
• Species: Danio rerio
• Alignment Length: 2013
• Identity: 501/2013 - (24%)
• Similarity: 819/2013 - (40%)
• Gaps: 530/2013 - (26%)

  Fly     5 EMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAIL 69
            |..:|:|:::||.|.|.:..| |:...   |.|.|.:.||.|::..::......:.....:.:.:
Zfish     2 ETFFAEGSRVWVNHKDQLLPS-TVNSC---GDGNLVLTTDYGEVVYLQQAEVNREKVSAMHQSSI 62

  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAM 133
            .|..|::||:.|||..::|||..|: ::..|||..|.||.|:|||.::. ||..|.:..|..|.:
Zfish    63 DGVEDMSTLAELHEAAIMHNLHQRY-QKDNIYTNIGSILAAVNPYKQIKGLYDLSAVELYSQHHL 126

  Fly   134 GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF-------AAVGGSESET 191
            |:|.|||||:|.|.|..|.:.:.:..:::|||||||||.|.|..:::.       |....:|..|
Zfish   127 GELPPHIFAIANECYRCLWKRHDSQCVLISGESGAGKTESTKLLLQFLSVMSQNSAGTPPTEKST 191

  Fly   192 QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQ 256
            :||:.::.|||||||||||||..|:||||||||.:|.| :|.|  .:||..:..|||||:|||.|
Zfish   192 RVEQAIVQSSPIMEAFGNAKTVYNNNSSRFGKFIQLHF-SQSG--NIQGGCIVDYLLEKNRVVRQ 253

  Fly   257 AQGERNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLG 318
            ..|||||||||.|.|..||..:   .:.|..:.|.:|:..|..:...:.|.:.|::.::|:.|:.
Zfish   254 NPGERNYHIFYALLAGASKSEKETYFLEDSPELFHYLSQSGCVKDRSLDDKKLFDDVMEALKVME 318

  Fly   319 FSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQIT--------ADLLR 375
            |:.::|.|:.|:|:|:|.|||::                   |......|||        ::||.
Zfish   319 FTEEEIRDMFKLLSGVLQLGNVE-------------------FMTAGGAQITTKQVVTNVSELLG 364

  Fly   376 VSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQC 440
            :....|...|..|.:....|.:..|.::|.|..:||::|..:|::.|.:|:..:|:.: .|....
Zfish   365 LDCFQLSEVLTQRSMILRGEEICSPLTVEQAIDSRDSVAMALYSQCFSWIIMRINQKI-KGKDNF 428

  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPC 505
            ..||:|||:|||.||||.||||.|||||||||:.||:|:|.|||.||.:|||.|..||:.||..|
Zfish   429 KSIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYNREGIHWEAIDWMDNAEC 493

  Fly   506 IDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDV 570
            :||||.:||:|.|::||.|.|||:|.:...||.|:.:..|::.|||.....|.|||::..|.|||
Zfish   494 LDLIEKKLGMLALVNEESRFPKGTDFTLLEKLHGRHSTNPYYVKPRLADHQFGIKHYAGEVLYDV 558

  Fly   571 NGFLEKNRDTVSKELTQVLSESNM----SLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQ 631
            .|.|||||||...::..:|.:|.:    .|.:||.:....:||.:.:|:.
Zfish   559 RGILEKNRDTFRDDILNMLKDSRLDFIYDLFEQVSSRNNEETLKMGTARK--------------- 608

  Fly   632 QGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQL 696
                           :.||.|||::||.||::||..:.|.:|||||||.||...|::...::.||
Zfish   609 ---------------KPTVSSQFRDSLHSLMATLSVSNPFFVRCIKPNMDKTPNKFDPEVVLNQL 658

  Fly   697 RACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSK----LDKNDMKLSCRNIVMKWIQDEDK- 756
            |..|:||||:|..||||.|..:.||:.||::::...:    ....|.|....:::.  |.|:.|
Zfish   659 RYSGMLETVKIRRAGFPVRRTFKDFFTRYKIILKEKEKAAVASNGDDKKKSTDLLT--IHDKTKK 721

  Fly   757 -YRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYL 820
             ::||.|::|.:......||:.|..:|.|...|:::.:.|::.|:.|.:..:.|..|||:.|.:|
Zfish   722 EWQFGKTKVFLKETLEQKLEKQRDEVRSKAGLIIRAYLLRYIARKDFKKALESIVTIQKNYRTHL 786

  Fly   821 ARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQI 885
            .|.|.|:.|.  |.|:|.|:.||.:                  |||
Zfish   787 YRRRFQRKRS--AALVLQKHRRGQV------------------ARG------------------- 812

  Fly   886 QRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQ 950
                                 :|:
Zfish   813 ---------------------VCR----------------------------------------- 815

  Fly   951 RIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKM 1015
                                  |::.|.||..|.|.|..           |...|:.|.:|::|.
Zfish   816 ----------------------KLRDEKKKREEEERKKK-----------EEQEKKTEGDREKKN 847

  Fly  1016 QLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRM--LAEIDNRELNE 1078
               ||...|:..         :..||..||::||:.:.:..|:.|:.:||.:  |.|...:||
Zfish   848 ---EEEDEAESP---------RTVEEDTRQMEEILRLEREIEILQKKREDSVSTLCESSKQEL-- 898

  Fly  1079 AYQRAIKDKEVIENENFMLKEELSRLTAGSFSL--------------HARKASNASSQNEDDVGY 1129
               |..:|.||:..     |:..||:......|              .|...|..:::.|.|.|:
Zfish   899 ---RLRRDAEVLRQ-----KKAASRVATEFLELLDTGGPEVIPGDPKQAASRSATATEEEVDEGF 955

  Fly  1130 ASAKNTLDI-------NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRH- 1186
            .:.:..:.:       ..|.|                  :.||...........|..:..|:.:
Zfish   956 HAEEECIPLPEFPPPAEGPVD------------------QEILATLPPPPAAFAEGTVAPSAPNV 1002

  Fly  1187 -------------KPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRR 1238
                         .|.....:..|.:.|..|...|.|    ..|.|.:::..:...||
Zfish  1003 PPGAPPPPSPPPPPPLPGETKKEEGKPEEAKTDKEVD----GKKEGEDVDRTSRLTAA------- 1056

  Fly  1239 RREECIQLKAVLLQQSQSMRSLEPESLQMRGN-----DVNELMEAFHSQKLINRQLESELKAITE 1298
                            :|:...|.....:.|:     |.::|.:.           :|.:.|...
Zfish  1057 ----------------ESLPDTEEPIYSVPGDGESDYDQDDLEDG-----------QSSIAATDG 1094

  Fly  1299 EHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDT-----------LRQND-------R 1345
            ||..|........|..|...|...    ||.|| .|..|||           |..|.       .
Zfish  1095 EHARKSTCTNASQESYNRSSDSYA----ESDDE-HDGYVDTDEEVSNGKVNILNGNGPPYFHSYL 1154

  Fly  1346 YLRREL------------QKAVAQFLLVQEELK-------------------------LANAKLK 1373
            |::..|            .:....|...||.||                         |.::||.
Zfish  1155 YMKAGLMIPWRRRWCVLKDETFMWFRSKQESLKSGWLYKKGGGLSTLSRRNWKMRWFVLRDSKLM 1219

  Fly  1374 AYRQDG-----GQLEHKIEEEMIRNKSNGTSADVGANVTKQK-----SQNPQG-------LMKFH 1421
            .:..|.     |.::.:..:|::.|.....:.::   ||.::     :::|:.       |.:.|
Zfish  1220 YFENDSEEKLKGTIDIRAAKEIVDNHEKENALNI---VTDERTYQVFAESPEDASGWFTMLSRVH 1281

  Fly  1422 SSDLDKILQRLLSALTPRTVVGLL-------------PGFPAYLIFMCIRYTDLTNADDDVRELL 1473
            ::..:::|:.......|:..||.|             |..|.  .|:.|....:.:.:.|:.|.:
Zfish  1282 NASPEQLLEMSHEQANPKNAVGTLDVGLIDSVCASDNPDRPN--SFVIITANRVIHCNSDLPEEM 1344

  Fly  1474 SKFVIQIKKMHRTPHPIENRVI---WLVNSI------TLLNLMKQ-----YGDVDEY-------V 1517
            ..::..::|............:   ||...:      :.|.|.|:     :..:|.|       .
Zfish  1345 HHWISLLQKPKGDSKSDGQEFLVRGWLHKEMKAGAKSSALKLKKRWFVLTHNSLDYYKSSERNAS 1409

  Fly  1518 KFNTEKQN------QQQLKNFNLFEYRRVIL----------DLIVNLYQALIMQIQGLLDPKIVP 1566
            |..|...|      |.:.|.|....|..:|:          ..::|.....:..|||::|.| ||
Zfish  1410 KMGTLVLNSLCSVVQPEEKKFKETGYWNIIVHGRKHSYRLYTKLLNEAMRWVSAIQGVIDNK-VP 1473

  Fly  1567 AILNNDEIQRGRQAHGMRSRATS--------IGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGL 1623
            ......::.|..:.:.:.|.|..        :..:..|.|  .|......|::....::.:.:|.
Zfish  1474 IETPTQQLIRDIKENSVNSEAVEQMYRRNPILRYTQHPLH--SPLLPLPYGEVSDSLRKEKGYGS 1536

  Fly  1624 DNCYAEQIFHQL---------LYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMS 1679
            ....|.:||:.|         :..|..:...|..||.          :|..:.|     :..|.:
Zfish  1537 LQDEAVKIFNSLQEMEIVSDPVAIIQGILQTCHDLRP----------LRDEVYC-----QLIKQT 1586

  Fly  1680 NDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKL 1744
            |.|....:|.|:....|.:          |..||.|.:..:|:.:: :.|...........:||.
Zfish  1587 NHVPQPNSPANRAHWHLLT----------CMSCTFLPSRAILRYLR-FHLKRVRERYPGTEIEKY 1640

  Fly  1745 TEKLNARQMQKSNSDEFTIDQKFIQPFKV-------VFRYSDIKLEDIELPSHLNLDEFLTKI 1800
            ...: ...::|:.:.|:...|:.|....:       |:.:.....: |.:.||....|.:.|:
Zfish  1641 AHFI-GESLKKTKAREYVPSQEEIAALLIRQEMTTTVYCHGGGSCK-ISINSHTTAGEVVEKL 1701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	273/711 (38%)
		IQ	900..922	CDD:197470	1/21 (5%)
		SMC_prok_B	<942..1365	CDD:274008	86/494 (17%)
		Myo5_CBD	1424..1792	CDD:271254	75/441 (17%)
myo10l1	XP_001924041.3	SH3_19	7..58	CDD:465815	13/54 (24%)
		MYSc_Myo10	77..733	CDD:276840	273/711 (38%)
		MYO10_CC	861..911	CDD:465249	17/59 (29%)
		PH-like	1153..>1184	CDD:473070	3/30 (10%)
		PH2_MyoX	1187..1288	CDD:270108	13/103 (13%)
		PH3_MyoX-like	1353..1478	CDD:270109	24/125 (19%)
		MyTH4	1561..1665	CDD:459939	24/130 (18%)
		FERM_F1_Myosin-X	1669..1765	CDD:340726	6/34 (18%)
		B41	1676..1940	CDD:214604	6/27 (22%)
		FERM_C_MyoX	1936..2024	CDD:270023