DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and myh11b

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_017210292.1 Gene:myh11b / 566080 ZFINID:ZDB-GENE-101124-2 Length:2005 Species:Danio rerio


Alignment Length:1952 Identity:525/1952 - (26%)
Similarity:879/1952 - (45%) Gaps:408/1952 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|:|.....::||:::|   :....:.:..|:|:    |:.....|:..: ||.......|:..|
Zfish    35 VWIPSERDGFQSASIKE---ETGNEVVVELDNGQ----KVTVSKDDIQKM-NPPKFNKVEDMAAL 91

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..||||||.|:.. .:||||.|:..|.||||..:|:|...||..|:|....::.|||:::
Zfish    92 TCLNEASVLHNLRERYFS-GLIYTYSGLFCVVINPYKMLPIYSEKIIEMYKGKKRHEVPPHIYSV 155

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE-------SET---------- 191
            .:.||..:.:|..:.||:.:||||||||.:.|..::|.|.|..|.       |:|          
Zfish   156 TDNAYRNMLQEREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKEATSDTSSSAPNKQQK 220

  Fly   192 -------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLE 249
                   ::|:::|.::||:||||||||.:||||||||||.|:.|.|   ..::.||.:.|||||
Zfish   221 GSQLAFGELEKQLLQANPILEAFGNAKTIKNDNSSRFGKFIKINFDN---TGYIVGANIETYLLE 282

  Fly   250 KSRVVYQAQGERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQ 312
            |||.:.||:.||::||||.:.| |:.|. .||:|:....::|| :.|..:::...|.|...||::
Zfish   283 KSRCIRQAKIERSFHIFYYMVAGAKDKMREELLLEDFANYRFL-VAGHVQVQNQQDDEMLEETLE 346

  Fly   313 AMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVS 377
            ||.||||:.::...:.||.:.:|.||||:...:.|:  |:.............|||      .::
Zfish   347 AMEVLGFNEEERIGMFKICSTVLQLGNIEFKAEKNQ--EQASMPDNTAAQKVCHLQ------GIN 403

  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CS 441
            ..|..:.:|..||:...|.|....:.|.|..|.:||||.:|.:||::|:|.:||:|:...:| .|
Zfish   404 VTDFTKAMLTPKIKVGRELVQKAQTKEQADFAVEALAKAMYDRLFRWILGRVNKALDKTKRQGAS 468

  Fly   442 FIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPC 505
            |||:|||.|||.||.|||||.||||.||||||.||..:|.||||||.||||.|:.||| .|.|||
Zfish   469 FIGILDIAGFEIFEDNSFEQLCINYTNEKLQQLFNHTMFILEQEEYKKEGIEWSFIDFGLDLQPC 533

  Fly   506 IDLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDT 565
            |:|||   :..|:|.||||||..||.:|.|:..||....:....|.||:  ...|.|.::|::..
Zfish   534 IELIERPNNPPGILALLDEECWFPKATDVSFVEKLTNTHSSHCKFSKPKNLKEKTFFTVQHYAGK 598

  Fly   566 VEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRK 630
            |:|:...:|.||.|.::..:|.:||.|:.:..:.:.  :::|              |||      
Zfish   599 VDYNAMSWLTKNMDPLNDNVTALLSNSSSAFIQDIW--KDVD--------------RVV------ 641

  Fly   631 QQGNDTRRRVVPS-----------KQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684
              |.:|..::..|           |...:|||..::|||..|::|||.|.|::||||.||.:|.|
Zfish   642 --GLETMAKMAKSDSSAPAASKSKKGMFRTVGQLYKESLGKLMTTLHNTQPNFVRCIIPNHEKRA 704

  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIV 747
            .|.:...::.||...||||.:||...|||:|.::.:|..||::|...| :.|.  |.|.||..::
Zfish   705 GKIDAHLVLDQLSCNGVLEGIRICRQGFPNRIVFHEFRQRYEVLAAGS-IPKGFMDGKQSCTLMI 768

  Fly   748 MKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGI 812
            .....|.:.||.|.::||||.|.:|.||:.|.                       |::..:|...
Zfish   769 KHLDLDPNLYRIGLSKIFFRTGVLAQLEEERD-----------------------LKLTDIIIAF 810

  Fly   813 QKHARGYLARER-TQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAM 876
            |..|||:|.|:. :.|.::..|..:|.:....:|..|.:...|     :.|..:.:|        
Zfish   811 QAQARGFLGRKAFSNKQKQLTAMKVLQRNCAVYLTLRNWQWWR-----LFTKVKPLL-------- 862

  Fly   877 RDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGL 941
                   |:.|           |:...|.|  :..:::  |:...::.:.|.|.|:...::.:..
Zfish   863 -------QVTR-----------QEEEMNQI--EEELQK--AKEIAQKSETELKEITQKHDQVVEE 905

  Fly   942 ENKIISMQQRIDELNRDNS----NLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEA 1002
            .||:.:..|...||..::.    .|:.|..|:..:..::|.:  ||.|.:..:|..|:|..|.:.
Zfish   906 RNKLQAKLQEEAELYAESEEVRIRLETKKQELEEVLHEMEAR--LEEEEERSQAFQQEKGNLQQK 968

  Fly  1003 LNKQLE---AERD---EKMQL-----------LEENGHAQEEWISQKQTWRQENEELRRQIDEII 1050
            | |:||   ||:|   :|:||           |||:....|:   ||...::|.::|..::.:..
Zfish   969 L-KELENHLAEQDATRQKLQLESGAADGKIKKLEEDVLIMED---QKNKLQKEKQQLEERLADFS 1029

  Fly  1051 DMAKNAEVNQRN------QEDRMLAEIDNRELNE--AYQRAIKDKEVIENENFMLKEELSRLTAG 1107
            ......|...:|      :.:.|:::::.|...|  :.|...|.|..:|.|:..|:|::..|...
Zfish  1030 SNLAEEEEKSKNLTKLKAKHESMISDLEVRMKKEEKSRQDVEKAKRKLETEHSDLQEQMKNLQTL 1094

  Fly  1108 SFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEE---- 1168
            ...|..::|     ::|.::....|....:..:..:.|.|   .::...|:.:|:..||.|    
Zfish  1095 IAELKTQQA-----RSEMEIQELQASVEAESTQKSNALKK---IHEMEGLLSELQDELEAEQGAG 1151

  Fly  1169 KQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIK---------HGVEINE 1224
            ::..|..:|...:||:.....|||...:.::   ::||::.:|....:|         |..:::|
Zfish  1152 RKSEKARKELEEELSALRTELEDSLDTTAVQ---QELRAKREQEVAMLKKLIEDEGRSHEAQVHE 1213

  Fly  1225 LNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPE------SLQMRGNDVNELMEAFHSQK 1283
            |..:||...:|:.::.::..:.||.|   .::.::||.|      :|:..||...:|.:   .:|
Zfish  1214 LKQKHAQAVDELSQQLDQSKRAKATL---EKAKQALEKEVGDLNGNLRSLGNAKQDLEQ---KKK 1272

  Fly  1284 LINRQL--------ESELK-------------------AITEEHNSKLVEMTQEIERLNNEKDEL 1321
            .:..||        |||.|                   :|..|..||.:::::::..||::..:.
Zfish  1273 KVETQLADLQTRFNESERKREELGDAVSKLNTEYNNVNSILNEAESKNIKLSKDVVSLNSQLQDA 1337

  Fly  1322 QKVMFES----------IDEFEDSNVDTLRQNDR--YLRRELQKAVAQFLLVQEELKLANAKLKA 1374
            |:::.|.          :.:.||.....|.|.|.  ..||.:::.|:.   :..:|..|..:|..
Zfish  1338 QELLAEETRQKLNFSTRLRQMEDERNGLLEQIDEETEARRNVERHVSS---LNTQLSEAKKRLDE 1399

  Fly  1375 YRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFH-SSDLDKIL------QRL 1432
            |..:...|     ||..:.......|..|....|..|.:.....|.| ..:||.:|      ::|
Zfish  1400 YSSNFQML-----EESKKRLQRDLEATKGELEEKTASYDKSEKTKNHLQQELDDVLLDLDNQRQL 1459

  Fly  1433 LSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWL 1497
            :|.:..:.                 |..|...||:  :.|.||:..:...........|.:.:.|
Zfish  1460 VSNMEKKQ-----------------RKFDQMLADE--KTLSSKYSQERDCAEAEAREKETKCLAL 1505

  Fly  1498 VNSITLLNLMKQYGDVDEYVKFN-TEKQNQQQL------KNFNLFEYRRVILDLIVNLYQALIMQ 1555
            ..:     |.:..|.:.|..|.| |.:.:.:.|      ||.:..|..:..|:..|   :.:.:|
Zfish  1506 TRA-----LEECQGSLRELEKLNKTLRTDMEDLISSKDNKNAHELEKTKRALEAQV---EEMTIQ 1562

  Fly  1556 IQGLLDPKIVPAILNNDEIQRGRQAH-----GMRSRATSI-----GASSSPEHGGGPAWKQLIGQ 1610
            ::.|           .||:|....|.     .|::....|     |.....|.    ..|||:.|
Zfish  1563 MEEL-----------EDELQAAEDAKLHLEVNMQALKVQIQRDIQGREEQSEE----KRKQLLKQ 1612

  Fly  1611 LEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRS 1675
            :.....:.:.        ||.....|    |.|..  .|.||             :..:||.|..
Zfish  1613 VRELEAELED--------EQKMRTSL----AAAKK--KLEGD-------------LQDLEDQVDV 1650

  Fly  1676 KKMSNDVLTALAPLNQVS--------QLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDY 1732
            ...:.|  .|:..|.::.        :|..:|.|.::|  :.|...|...|:.:           
Zfish  1651 NSRARD--EAVKQLRKIQTQMKDYQRELEDARASHKEV--LSDARESERKARAM----------- 1700

  Fly  1733 ESEITNVFLEKLTEKLNARQMQKSNSDEF-------------TIDQKFIQPFKVVFRYSDIKLED 1784
            |:||.::. |:|.....||:..:...||.             |.|:|         |..:.|::.
Zfish  1701 EAEILHLH-EELASAEKARKHAERERDEIAGEMASGSFGKSGTSDEK---------RRLESKIQH 1755

  Fly  1785 IE 1786
            :|
Zfish  1756 LE 1757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 293/758 (39%)
MYSc_Myo5 84..767 CDD:276831 281/728 (39%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 32/139 (23%)
coiled coil 1049..1068 CDD:293879 2/24 (8%)
coiled coil 1077..1086 CDD:293879 2/10 (20%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/150 (21%)
Myo5_CBD 1424..1792 CDD:271254 76/407 (19%)
myh11bXP_017210292.1 Myosin_N 33..70 CDD:280832 8/41 (20%)
Myosin_head 85..788 CDD:278492 285/740 (39%)
MYSc_class_II 97..788 CDD:276951 281/728 (39%)
Myosin_tail_1 865..1943 CDD:279860 205/1033 (20%)
FAM76 <1020..1099 CDD:292665 14/78 (18%)
BAR <1156..>1305 CDD:299863 34/157 (22%)
RILP-like <1760..1872 CDD:304877
COG7 1824..>1943 CDD:287200
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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