DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myo7bb

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_021322881.3 Gene:myo7bb / 566034 ZFINID:ZDB-GENE-070912-482 Length:2160 Species:Danio rerio


Alignment Length:2174 Identity:547/2174 - (25%)
Similarity:894/2174 - (41%) Gaps:607/2174 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEES-------YRK--GAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAIL 69
            :.:...|.||    :|.|       |.|  |:|...:..|.||...:. :.|.:.|.|: :|..:
Zfish     2 VMLKKGDHVW----IESSIGVPIGGYVKISGSGQYCLIDDEGKEHSIP-EGDRAALKPM-HPTSV 60

  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134
            .|.:|:..|..|.|.|:|.||.:|. ::.|||||.|.:|||:|||..:|:|....::.|.|..:|
Zfish    61 EGVDDMICLGDLSEAGLLRNLFLRH-KQGIIYTYIGSVLVAMNPYEMLPIYTADQVQQYHGRKLG 124

  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLA 199
            :|.|||||:|:..|..:.|...|...|:|||||||||.|.|..:::.|||.|..|  .:|::::.
Zfish   125 ELPPHIFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAVSGQHS--WIEQQIIQ 187

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            ::||:||||||||.||||||||||:.::.| |:.||  ::||.|..||||||||.:||..|||||
Zfish   188 ANPILEAFGNAKTIRNDNSSRFGKYVEIFF-NKAGV--IEGAHMEQYLLEKSRVCHQALQERNYH 249

  Fly   265 IFY-QLCAARSKYPE-LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            ||| .|...:|.:.: |.|....:|.:|..|.....:...||::|.....|:.||.|:.:...:|
Zfish   250 IFYCMLAGMQSDHKKTLSLGDASEFNYLTEGDCLTCDGRDDADEFARIRSALKVLTFTDRDCWEI 314

  Fly   328 VKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            .|:||.|||:|||..     :.:...:.||||:..:. |..:.|.||.|....|.:.|..|...:
Zfish   315 FKLLAAILHMGNIDF-----QSTIMNNMDSCDVLSSS-HFSVIAKLLEVDDAALDKSLTHRSFMT 373

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNN-GSKQCSF----IGVLDIYGFE 452
            ..|.|..|.|.|.|...|||.||.:|.:||.::...:|.:::. .:.:.|:    ||:|||:|||
Zfish   374 NREMVTKPLSSEQATDIRDAFAKALYGRLFVWMFTKINSAIHKPQTDEPSYTRQSIGLLDIFGFE 438

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVL 516
            .|..|||||.|||:|||.|||.|.:|||||||:||.||||:|..|.|.|||..:||:..: |.:|
Zfish   439 NFPQNSFEQLCINFANEHLQQFFVRHVFKLEQDEYTKEGISWKRIAFNDNQKTLDLLALKPLNIL 503

  Fly   517 DLLDEECRMPKGSDESWAGKLI--GKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRD 579
            .|:|||...|||:|.:...||.  .|.||. :..........|.::||:..|.||..||||||||
Zfish   504 ALIDEESHFPKGTDATMLNKLSQEHKGNKL-YISSRGDHRIHFGVQHFAGLVYYDCEGFLEKNRD 567

  Fly   580 TVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRK-QQGNDTRRRVVPS 643
            |||.::.:::.:|:..|.||:...|    :.|:|.|:|....:.|::.... :|.|::||::   
Zfish   568 TVSMDILELIRKSSNKLLKQIFEKE----INVNSVKNSNKMNKAVMTPKNSLRQVNESRRQI--- 625

  Fly   644 KQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRIS 708
                .|:..||::||.||:..|....|.::||.||||.|:...:.....:||||..|:|||:||.
Zfish   626 ----STLSGQFRQSLDSLMKALSLCQPFFIRCFKPNDKKLPMVFNRELCMQQLRYSGMLETIRIR 686

  Fly   709 AAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLS--CRNIVMKWIQDEDKYRFGNTQIFFRAGQV 771
            ..|:|.|..:.||..||:.|:.....|.|....:  |..|....|:||:.::.|.|::|.|....
Zfish   687 KLGYPIRHTFKDFLHRYRALLKSIDCDPNTEPAAKCCAAICRTLIKDEEDWKIGKTKVFLRGHHD 751

  Fly   772 AFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLA-RERTQKMREARAGL 835
            .:||..||               :.:||:..: ||:|:          || ::|...:.:.:|.|
Zfish   752 TYLELERA---------------QELYRKALI-IQRVM----------LAHKDRKNFINKRKAAL 790

  Fly   836 ILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHA--MRDHYRAVQIQRFVRGALARRAY 898
            :|.|..||:..:|.:..::...:.:|...|.    .|.|.  ||....|:.:|...||.|||:..
Zfish   791 VLQKNWRGYKEKRDFCTVKQGFARLQAKVRS----RKLHEEYMRRRAAAIVLQTQTRGLLARKEL 851

  Fly   899 QKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLK 963
            :.::..:|:.||..|..|||:..||||:| :.::..|.:  ..|...:.:|||::||.|.|....
Zfish   852 KSKKEAVILLQAQTRGLLARKSLKRMKSE-EFLTAQEKQ--AQELAALELQQRLEELLRKNEETA 913

  Fly   964 HKTS------------------------------EISVLKMKLELKKTLEAEFKNVKAACQDKDK 998
            ...:                              |......|||..:.:|:.....|.....:..
Zfish   914 KSQNNEDEEMVENIFNFLPTAIAGQEGPAPEGFEEFEAEPAKLEEVELIESPVVETKVMSIPESS 978

  Fly   999 LIEALNKQLEAERDE-----KMQLLEENGHAQEEWISQK------------------QTW----- 1035
            ....:.::.|.|.|:     |...|...|.:...:|.|:                  ..|     
Zfish   979 EDHQVKEEEEEEEDDEFSFSKFASLHFQGASTHSYIQQRLRQPLLYHEDEGDTLACLTVWWIILR 1043

  Fly  1036 --------RQE-------------NEELRRQIDEIIDM-----------------AKNAEVNQRN 1062
                    :||             .:...|::..::.:                 .|::.:.:..
Zfish  1044 FMGDLPEPKQERVSAMADPIQRNLGQRQARRLSNLVGLDQKFLRKKMKQQKGGGKRKHSAIPEEE 1108

  Fly  1063 QE------------------------DRMLAEIDNRELNEAY---QRAIKD-------KEVIENE 1093
            .|                        ||.:..::...:...|   :..|:|       |::..|:
Zfish  1109 PEEEPKSQMEAVQEEQVVLFGEGPTFDRPMTPLEKLHIIVGYAIVRPDIRDEIYCQICKQLTGNK 1173

  Fly  1094 N-----------------FMLKEELS-------RLTAGSFSLHA-----RKASNA---------- 1119
            |                 |...|.|:       |.....:|.:.     |..:|.          
Zfish  1174 NRKSVNRGWILLSICLGIFSPTERLTKYLQSFIRCGPSEYSAYCAERLRRTLANGERNEPPCWVE 1238

  Fly  1120 --SSQNEDDVGYA--------------SAKNTLDINRPPDLLSKNYSYNDS------TSLVVKLR 1162
              |.:|::.:|.|              ||..:.::   ...:|:|.:..||      .::..|:.
Zfish  1239 LQSVENKNPIGVAVGLMDGRNISLTVDSASTSAEV---CTAISQNTNLQDSFGFSLYAAMYEKMW 1300

  Fly  1163 S-------ILE-----EEKQKHKVLQEQYIKLSSRHKPTEDSFRVSEL-----EVENEKLRSE-- 1208
            |       ||:     |:::|.:..:||       |.|....|| .|:     :..::::.:|  
Zfish  1301 SLGSGSQHILDAVSMCEQEEKRQGREEQ-------HAPWRLYFR-KEIFTPWHDCSSDQISTELI 1357

  Fly  1209 YDQLRTSIKHGVEINELN---AQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGN 1270
            |.|:...:|:|..:::..   .|.||....|:...|..:::...:::...:|..:|.:||.    
Zfish  1358 YRQIIHGLKNGEYLSDKEDDYVQLAAKHYYVQHGSESSLEIAQKIVRDCMNMTIIENKSLV---- 1418

  Fly  1271 DVNELMEAFHSQ-KLINR-----QLESELKAITEE----HNSKLVEMTQEIERLNNEKDEL---- 1321
            .:.:|:.:.|:| ..||.     :::||.....::    |.|||.| .|.|...:..:|:.    
Zfish  1419 KLVQLVNSAHTQGPYINTNTPVYKVKSETVEYAQQKWPIHFSKLYE-AQVISGPSVPQDQFVVVV 1482

  Fly  1322 --QKVMF--ESIDEF------EDSNVDTLRQNDR------------------YLRRELQKAVAQF 1358
              :.|.|  |:..||      |.|.::.:.: ||                  ...:||.:.|..|
Zfish  1483 NWKGVFFQDETEGEFLQLSYPEVSRIEIVSE-DRSGGLVCLTTPKGMYELKIVKGKELVELVNMF 1546

  Fly  1359 L-----------LVQEELKLANAKLKAYR--------QDGGQLEHKIEEEMIRNKSNGTSADVGA 1404
            :           .:|:..:..:..|.:||        :||   |:.:||..|:.::..|| ..||
Zfish  1547 ISGLKERSMYAVAIQDLSRQEDPTLLSYRRGDVLYIIKDG---EYSLEEGWIKARNERTS-QTGA 1607

  Fly  1405 NVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDV 1469
                              ..||.|  ::|..||                                
Zfish  1608 ------------------VSLDAI--QILPMLT-------------------------------- 1620

  Fly  1470 RELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNL----MKQYGDV-DEYVKFNTEKQNQQQL 1529
                              .|.|       .::.||||    .|....| .:..:.:||:.....|
Zfish  1621 ------------------RPTE-------ETLNLLNLSPARRKSVMPVLPQKEELSTERVAHMTL 1660

  Fly  1530 KNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASS 1594
            |.|: |:|.|                                |.:..||:..|.:.:..    ::
Zfish  1661 KEFS-FDYFR--------------------------------DPVNEGRRGKGGKEKLW----AN 1688

  Fly  1595 SPEHGGGPAWKQLIGQLE--HFYKQF------------------------QHFGLDNCYAE---Q 1630
            |.|....|..:.|.|..|  |.....                        |.||....:.|   :
Zfish  1689 SKEPLKQPLIRNLQGNSELCHLASDSFTAILKYMGDYPVKHVRTPIDLTNQIFGPATAHVELRDE 1753

  Fly  1631 IFHQLLYFICAVALNCLMLRGDICMW-------ETGMIIRYNIGCIEDWVRSKKMSNDVLTALAP 1688
            |:.|::..:........|.||...:|       .:.:::|:....:|...|..       .|.|.
Zfish  1754 IYCQIMKQMTNNRNGLSMERGWQLLWLCCGLFPPSQLLLRHAQRFLESRPREP-------LASAC 1811

  Fly  1689 LNQVSQLL--QSRK---SEQDVQTICDLCTSL--------STAQVLKVMKSYKLDDYESEIT--- 1737
            |.::..:|  :.||   .:.:|..|.:..|.:        .|:::.:|..:.::.|....|.   
Zfish  1812 LQRMQAMLSIEGRKLPPHQVEVDAIQNNSTQIFHKVHFPNDTSEIFEVTTTTRIKDLCRNIAKDL 1876

  Fly  1738 --------NVFLEKLTEKLNARQMQKSNSDEFTIDQ------------------KFIQPFKVVFR 1776
                    ::|::..|      :::..||:|:..|.                  ..|.|:.|:|.
Zfish  1877 RLSSPEGYSLFVKTST------KVESMNSEEYFFDNLRQLTDVTKKGKKVREATPTIVPYLVLFM 1935

  Fly  1777 ----YSDIKLEDI----------ELPSHL 1791
                ::.|..:||          |||.:|
Zfish  1936 RKLWFNVIPGKDITADLMFHFPQELPKYL 1964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 282/695 (41%)
IQ 900..922 CDD:197470 7/21 (33%)
SMC_prok_B <942..1365 CDD:274008 109/688 (16%)
Myo5_CBD 1424..1792 CDD:271254 76/465 (16%)
myo7bbXP_021322881.3 None

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