DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and myo5ab

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_009296049.3 Gene:myo5ab / 565267 ZFINID:ZDB-GENE-050411-72 Length:1800 Species:Danio rerio


Alignment Length:1903 Identity:756/1903 - (39%)
Similarity:1099/1903 - (57%) Gaps:206/1903 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |::.| ||::.|::|:|....||.||.|...||.|...|.:..:.....|.||......||||||
Zfish     1 MAAPE-LYSKLARVWIPDPAEVWRSAELSRDYRPGDPVLHLLLEDETELEYKLDLKSGVLPPLRN 64

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRG 130
            |.||||:||||.|||||||.|||||||||.:.::|||||||||||||||..:|:||..||.||.|
Zfish    65 PDILVGENDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSG 129

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195
            ..|||::|||||::||||.::.|:..|.||||||||||||||||||||||||.|..|..:..||.
Zfish   130 QNMGDMDPHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESSDDASVEE 194

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            |||||:||||||||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||..|
Zfish   195 KVLASNPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHII---GANMRTYLLEKSRVVFQASEE 256

  Fly   261 RNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            |||||||||||. :..||   |.|...|.|.:.|.||:|.|..|:|.::...|.:|.::||.:..
Zfish   257 RNYHIFYQLCAC-AHLPEFKPLKLGSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEA 320

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            ....:.:||:.||||||::|        :|..|.||.|...:.||.:..||..||.:.:..||..
Zfish   321 HQMGLFQILSAILHLGNVEV--------KERGSSSCSISDENGHLDMFCDLTEVSNESMAHWLCH 377

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFE 452
            :|:::..|.:..|.:...|...|||||||||||||.:||..:||:|:..||..||||||||||||
Zfish   378 KKLKTATETLNKPVTRLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKPHSFIGVLDIYGFE 442

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLD 517
            |||:||||||||||||||||||||.||||||||||:||.|.||:||||||||||:|||:::|:||
Zfish   443 TFELNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMGLLD 507

  Fly   518 LLDEECRMPKGSDESWAGKLIG-KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            ||||||.||||||:|||.||.. ...|..||||||....:|.|.||:|.|||..:||||||:|||
Zfish   508 LLDEECTMPKGSDDSWAQKLYNTHLKKSSHFEKPRMSNKAFIILHFADKVEYQCDGFLEKNKDTV 572

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ::|...||..|..||..::...||           |........|:||.:.|..|:    ..::|
Zfish   573 NEEQINVLKASKFSLLLELFQDEE-----------SPAAPNTTASSGRAKFGRSTQ----SFREH 622

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
            :|:||.||:.||..|:.||:||||||||||||||.|..|..:..:.:|||||||||||:||||||
Zfish   623 KKSVGLQFRNSLHLLMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAG 687

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQ 776
            |||||.|.:|:.|||:|:.:.:: ..|.||:|::::.:.:|::|||:||.|:|||||||||:||:
Zfish   688 FPSRWTYQEFFSRYQVLMTKKEI-LLDRKLTCQSVLERLVQNKDKYQFGKTKIFFRAGQVAYLEK 751

  Fly   777 VRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYA 841
            :||:..:.....:|..:|.::.|:::|||::....:||:.||:.||...:.:|..||.::..|..
Zfish   752 LRADKLRTACIHIQKTIRCWLARKKYLRIRQAAITLQKYTRGHQARCLCKTLRRTRAAVVFQKNT 816

  Fly   842 RGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNII 906
            |.|..||:|||.:.:...||...||..||.::..:...::|:.|||:|||.|||..|::.:|.::
Zfish   817 RMWAARRQYLRQKTAAVLIQRILRGYTARLEYKRLVCEHKALLIQRWVRGFLARWRYRRIKRAVV 881

  Fly   907 ICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKT----- 966
            ..|..:||.||||:.|::|.||:::.|.:....|:||||:.:|:::||.:::|..|..:.     
Zfish   882 YLQCCVRRMLARRELKKLKIEARSVEHYKKLNYGMENKIMQLQRKLDEQHKENRELSEQIGAIES 946

  Fly   967 -SEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWIS 1030
             |.:.:.|:.::||...|||     ...:.::.|:.:|.::||..|.|    ||:|.....| ::
Zfish   947 HSVVELEKLHVQLKTLQEAE-----EEARHREDLVTSLQEELELVRRE----LEKNKEMVVE-LN 1001

  Fly  1031 QKQTW-RQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDK----EVI 1090
            :|.|. :.|.||:.|.|.|            :.|:.|..:|:.|.::.|..|..:.::    :.:
Zfish  1002 EKNTMLKSEKEEMNRLIQE------------QEQQIREKSEVTNEDVTENLQTQLNEERFRYQNL 1054

  Fly  1091 ENENFMLKEELSRL----------TAG------------SFSLHAR--KASNASSQNEDDVGYAS 1131
            ..|:..|:|..:.|          |||            |.|:|:.  ..|..||..::|....:
Zfish  1055 LTEHLKLEERYADLRSEKEAAEISTAGDSRADSGYSSSQSESIHSSMLTGSEVSSLEKEDAVQVA 1119

  Fly  1132 AKNTLDINRPPDLLSKNYSYNDSTSLVVKL-RSILEEEKQKHKVLQEQYIK----LSSRHKPTED 1191
            |                     ..||::|| |.:.|.||:...:..|...|    :..:.|..||
Zfish  1120 A---------------------DVSLLLKLQRRVAELEKENMDMQSEMDTKEEQLVLEKAKELED 1163

  Fly  1192 ------------SFRVSELEVENEKLRSEYDQLRTSIKHG--------------VEINELNAQHA 1230
                        :.:..|||.:|:||:.:..:||.|:..|              |.:.:||:.: 
Zfish  1164 CRKTLGAERDYEALKRQELESDNKKLKKDLQELRQSLSKGTGSKVTSPGGRAYNVILEQLNSTN- 1227

  Fly  1231 ALQEEVRRRREECIQLKAVLL--------------QQSQSMRSLEPESLQMRGNDVNELMEAFHS 1281
               ||:..|:||.:.|::.|:              ....|.||...:..::  |:..||..|:.|
Zfish  1228 ---EELEVRKEEVLILRSQLVSHEAFKHKELGTEGDSGDSSRSPTLDLTEL--NEDGELWMAYES 1287

  Fly  1282 QKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRY 1346
            .|..||.|.|:|:...|.|..:...:..|::.|..|.|:.|:::.:|::...|:.:..      .
Zfish  1288 LKETNRILVSQLQTQRESHEKETESLRAELQHLKAELDQQQQMLSQSLELPHDARIQA------S 1346

  Fly  1347 LRRELQKAVAQFLLVQEEL-------KLANAKLKAYRQ-----DGGQLEHKIEEEMIRNKSNGTS 1399
            |:.|:.:...|.:.:.|::       :....:||.|.:     :|...|....|.|:        
Zfish  1347 LQHEISRLTQQNMDLLEQMGKQDKMVRKLKKQLKIYMKKFGEPEGVHFEQSSPENML-------- 1403

  Fly  1400 ADVGANVT-KQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTV-VGLLPGFPAYLIFMCIRYTDL 1462
            |:.|..|: .:|.::.||::::...|.:|:.:.|::.|.||.| |.|:||.|||::|||:|:.|.
Zfish  1404 AESGRTVSIVRKERDFQGMLEYRREDENKLFKTLITDLKPRGVAVNLVPGLPAYILFMCLRHADY 1468

  Fly  1463 TNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQ 1527
            .|.|..|..||:..:..||...:.....|:...||.|:...|:.:|||...:.|.|.||.:||:.
Zfish  1469 ANDDLRVSTLLNTSINSIKNTLKKRGDFESISFWLANTCRFLHCLKQYSGEEGYSKHNTPRQNEH 1533

  Fly  1528 QLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ--RGRQAHGMRSRATSI 1590
            .|.||:|.|||:|:.||.:.:||.||..|:.:|.|.|.||:|..:.||  .|.:..|||.|.:|.
Zfish  1534 CLTNFDLSEYRQVLSDLAIQIYQQLIRVIENILQPMIAPAMLEQETIQGVMGVKPTGMRKRTSSF 1598

  Fly  1591 GASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICM 1655
            ...:|  |    :.:.::.||:.||......|.|.....|:..|..|.||:|.||.|:||.|:|.
Zfish  1599 HEENS--H----SLESILKQLDGFYFTLLQHGNDAEVVRQVIKQQFYVICSVTLNNLLLRKDMCS 1657

  Fly  1656 WETGMIIRYNIGCIEDWVRSKKM-SNDVLTALAPLNQVSQLLQ-SRKSEQDVQTICDLCTSLSTA 1718
            |..|:.||||:..:|:|:..|.: .:....:|.||.|.:|||| .:||:.|...||.:||:|:|.
Zfish  1658 WSKGLQIRYNVCQLEEWLLDKDLQGSGARESLEPLIQAAQLLQIKKKSQDDADAICTMCTALTTQ 1722

  Fly  1719 QVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKL 1782
            |::|::..| .::::|..::..|::.:...|..|:    .|.:..:|.|.|.|....|..|.:.|
Zfish  1723 QIVKILSLYTPVNEFEERVSISFIKTIQTLLKDRK----ESSQLLMDAKIIFPVTFPFNPSSVAL 1783

  Fly  1783 EDIELPSHLNLDEFLTKI 1800
            |.::|||.||| .|||::
Zfish  1784 ETLQLPSRLNL-SFLTRV 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 382/686 (56%)
IQ 900..922 CDD:197470 8/21 (38%)
SMC_prok_B <942..1365 CDD:274008 115/502 (23%)
Myo5_CBD 1424..1792 CDD:271254 135/373 (36%)
myo5abXP_009296049.3 None

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