DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh14

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_009290471.1 Gene:myh14 / 563011 ZFINID:ZDB-GENE-100921-1 Length:2065 Species:Danio rerio


Alignment Length:2018 Identity:544/2018 - (26%)
Similarity:891/2018 - (44%) Gaps:490/2018 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR-- 64
            :|.:..:|....:|||.....:|||::.|             :.|...||:|...|..|..||  
Zfish    31 ASSQADWAAKRLVWVPSEKHGFESASIRE-------------ERGDEVEVELTDSGRKLTLLREE 82

  Fly    65 ----NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
                ||.......|:..|:.|:|..||||||.|:.. .:||||.|:..|.||||..:|:|..|||
Zfish    83 LQRMNPPRFSKVEDMADLTCLNEASVLHNLRERYYS-GLIYTYSGLFCVVINPYKNLPIYTESII 146

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-ES 189
            ..|||....::.|||:|::|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..| :|
Zfish   147 EMYRGKKRHEMPPHIYAISEAAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS 211

  Fly   190 ET-------------------------------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGK 223
            .|                               ::||::|.::||:||||||||.:|||||||||
Zfish   212 GTLGRPKDTVVQMDGTRSLGRGSSAVNRTVQYGELERQLLQANPILEAFGNAKTVKNDNSSRFGK 276

  Fly   224 FTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC--AARSKYPELVLDHQDK 286
            |.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||||.  |..:...||:|...|:
Zfish   277 FIRINF-DVAG--YIVGANIETYLLEKSRAIRQAKDERTFHIFYQLLSGATEAMRKELLLGGADQ 338

  Fly   287 FQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFN--EG 349
            ::|| .||:..:...||:|.|.:|:.:||::||:.::...::|:::.:|..|||...|:.|  :.
Zfish   339 YRFL-CGGSLPVPGQSDSENFTQTMDSMTIMGFTQEESTSMLKVISSVLQFGNITFHKEKNTDQA 402

  Fly   350 SEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALA 414
            |..:|:.:..:.|          ||.:|..:..|.:|..:|:...|||....:.:.|..|.:|||
Zfish   403 SMPDDTAAQKLCH----------LLGISVLEFSRAILTPRIKVGREYVQKAQTKQQADFAVEALA 457

  Fly   415 KHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQH 478
            |..|.:||:::|..:|::|:...:| .||||:|||.|||.|::|||||.||||.||||||.||..
Zfish   458 KATYERLFRWLVHRINRALDRRQRQGASFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHT 522

  Fly   479 VFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEECRMPKGSDESWAGKLIG 539
            :|.||||||.:|||.|..||| .|.||||||||...   |||.||||||..|:.:|.|:..||..
Zfish   523 MFVLEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAHPPGVLALLDEECWFPRATDRSFVDKLSA 587

  Fly   540 KCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQ--- 599
            :......|.:||  .....|.|.|::..|:|....:|.||.|.::..:..:|.:|:.....:   
Zfish   588 EQGSHSKFMRPRQLKEEADFSIIHYAGKVDYKAKEWLVKNMDPLNDNVASLLHQSSDPFISELWR 652

  Fly   600 --VMTLEEI--------------DTLC---------VDSAKSSTLGGRVVISAGRKQQGNDTRRR 639
              :.||..:              |:.|         :|...|....|.|...|.    |..|::.
Zfish   653 EDIQTLPRVYFFDSYATLQTNGCDSSCDVMLERIVGLDQVSSGENSGPVSFGAA----GLKTKKG 713

  Fly   640 VVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLET 704
            :.      :|||..::|||..|::||..|.|:::|||.||.:|.|.|.....::.|||..||||.
Zfish   714 MF------RTVGQLYKESLTKLMATLRNTNPNFLRCIIPNHEKRAGKLSPHLVLDQLRCNGVLEG 772

  Fly   705 VRISAAGFPSRWLYPDFYMRYQLL----VYRSKLD---KNDMKLSCRNIVMKWIQDEDKYRFGNT 762
            :||...|||:|..:.:|..||::|    :.|:.:|   .:::.:|...:      |::.:|.|.:
Zfish   773 IRICRQGFPNRIPFQEFRQRYEILTPNAIPRTFMDGKHASELMISALEL------DKNLFRVGQS 831

  Fly   763 QIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK 827
            ::|||||.:|.||:.|.      :.|..:::|                 .|..|||||||:...|
Zfish   832 KVFFRAGVLAHLEEERD------LKITDTIIR-----------------FQSAARGYLARKAFHK 873

  Fly   828 MREARAGL-ILSKYARGWLCRR--RYLRLRHSISGIQTYARGMLARNKFHAMRD---HYRAVQIQ 886
            .::..:.| ::.:....:|..|  ::.||...:..:....|           :|   ..|..|:|
Zfish   874 KQQQLSALRVMQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR-----------QDEEIQAREAQLQ 927

  Fly   887 RFVRGALAR-----RAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHME-------NKYM 939
            : .:..|::     ....|:.:.:|..::.:.        .:::|||:..:..|       |:..
Zfish   928 K-AKDKLSKLELDFTELDKKNQQLIEEKSVLT--------DQLQAEAELFAEAEEMRARLANRKQ 983

  Fly   940 GLENKIISMQQRIDE--------------LNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNV 989
            .||:.:..::.|::|              :.:...:|:.:..|....:.:|:|:| |||::.|::
Zfish   984 ELEDVLGELESRLEEEEERTVQLTNEKKRIQQHVQDLEEQLEEEEGTRQRLQLEKVTLESKVKSL 1048

  Fly   990 KA----ACQDKDKLIEALNKQLE----------AERDEKMQLLEENGHAQ-------EEWISQKQ 1033
            :|    ..:.:|:|.:. .||||          .|.:||::.|.:..:.|       ||.:.:::
Zfish  1049 EAETLTLAEQRDRLSKE-KKQLEERLNEVTDQLTEEEEKVKSLNKLKNKQEAVIADIEERLKREE 1112

  Fly  1034 TWRQENEELRRQI--------DEIIDMA-----KNAEVNQRNQEDRML---AEIDNRELNEAYQR 1082
            ..|.|.|:.:|::        :::.||:     ....::||.:|...|   .|.:.....|| ||
Zfish  1113 QGRLEQEKWKRRMEGEAVEAQEQLSDMSLLVTELRGSLSQREKEITTLQTRLEEEGARRTEA-QR 1176

  Fly  1083 AIKD--------KEVIENENFM----------LKEELSRLTAGSFSLHARKASNASSQNEDDVGY 1129
            |:::        ||.:|||..|          |.|||..|               .::.||.:..
Zfish  1177 ALREAMSQVSELKEEVENERGMRERAEKQRRDLGEELEAL---------------RTELEDTLDT 1226

  Fly  1130 ASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV---------------LQEQY 1179
            .:|:..|...|..:|              .:|:..||||.::|:.               ||||.
Zfish  1227 TAAQQELRSRREAEL--------------GELQRCLEEETRRHEAQLSELRIKHTAAIDSLQEQL 1277

  Fly  1180 IKLSSRHKPTEDSFRVSELE----------VENEKLRSEYDQLRTSIKHGVEINELNAQHAALQE 1234
            .......:..|.:..|.|.|          ::..|:.||..:.|..    .::.||||:.:..:.
Zfish  1278 DNAKRSRQSLEKAKAVLEEERLNLSAELKTLQGGKMESERGRKRAE----GQLQELNARLSQAER 1338

  Fly  1235 EVRRRREECIQLKAVLLQQSQSMRS---------LEPESLQMRGNDVNELMEAFHSQKLI----N 1286
            |...|.|...:|::.|...|.|:.|         .|..||:.:.:||.||::....|||.    .
Zfish  1339 EREEREERLGKLQSELESLSSSLSSSDSKSHRLHKEVSSLESQLHDVQELLQEETRQKLALGSRV 1403

  Fly  1287 RQLESE---LKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLR 1348
            |.||.|   |....||...|..|:|::|:....:..:|:: ..|.::...::..:|.|:    ::
Zfish  1404 RALEEEKAGLMERLEEEEEKTRELTRQIQNHTQQLADLKR-QTEEVNSAVEAGEETRRK----MQ 1463

  Fly  1349 RELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMI---RNKSNGTSAD--------- 1401
            |:|:.|      ||.|......|.:..||. .:|..:||:..|   |.:.|.|:.:         
Zfish  1464 RDLENA------VQREKSKEEEKERIERQK-ERLREEIEDMTIALQRERQNCTALEKRQKKFDQC 1521

  Fly  1402 ------VGANVTKQK----SQNPQGLMKFHSSDLDKILQRLLSALT------PRTVVGLLPGFPA 1450
                  |.|.:.:::    :::.:...:|.|      |.|.|...|      .||...|.     
Zfish  1522 LAEEKAVSARLQEERDRAEAESREKETRFLS------LSRALQEATEQRDELERTNKQLR----- 1575

  Fly  1451 YLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDE 1515
                  :....|.||.|||.:       .:.::.|:...:|...                     
Zfish  1576 ------LEMEQLVNAQDDVGK-------NVHELERSRRALETEA--------------------- 1606

  Fly  1516 YVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQA 1580
                .:.|:..|:|:: .|.|.....|.|.|.| |||..|.:..:..|       .::.:..|:|
Zfish  1607 ----QSLKEQTQELED-ELGEAENARLRLEVTL-QALRAQFEREISTK-------EEKGEEKRRA 1658

  Fly  1581 --HGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVA 1643
              ..:|...|.:....:.........|||..:|:....|.:   ..|...|:.|.|         
Zfish  1659 LNKQVRELETMLEEEKTQRAQALTVKKQLETELQEAEAQVE---AANRGREEAFRQ--------- 1711

  Fly  1644 LNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQT- 1707
                |.|....|.|   :||.        :...|::.|.:.|           ||:.||:.:|| 
Zfish  1712 ----MKRLQTQMKE---LIRE--------LDETKLARDEIVA-----------QSKDSEKRLQTL 1750

  Fly  1708 ---ICDLCTSLSTAQVLKVMKSYKLDDYESEITN-------VFLEKLTEKLNARQMQ------KS 1756
               :..|...||.::..|.....:.|:...||.|       :|.||...:....||:      :|
Zfish  1751 EAELLQLTEDLSVSERQKRQAQQERDEMADEIINNATGKSALFDEKRRLETRITQMEEELEEAQS 1815

  Fly  1757 NSD 1759
            |::
Zfish  1816 NAE 1818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 290/790 (37%)
MYSc_Myo5 84..767 CDD:276831 277/760 (36%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 37/152 (24%)
coiled coil 1049..1068 CDD:293879 5/23 (22%)
coiled coil 1077..1086 CDD:293879 5/8 (63%)
JAKMIP_CC3 <1190..1299 CDD:292653 35/134 (26%)
Myo5_CBD 1424..1792 CDD:271254 72/361 (20%)
myh14XP_009290471.1 Myosin_N 41..77 CDD:280832 12/48 (25%)
Myosin_head 94..836 CDD:278492 281/772 (36%)
Motor_domain 106..836 CDD:277568 277/760 (36%)
Myosin_tail_1 913..1993 CDD:279860 220/1069 (21%)
GBP_C <1067..1263 CDD:303769 50/225 (22%)
coiled coil 1232..1243 CDD:293879 3/24 (13%)
coiled coil 1252..1263 CDD:293879 1/10 (10%)
RILP-like <1552..1649 CDD:304877 30/154 (19%)
TTKRSYEDQ <1811..2011 CDD:287216 2/8 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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