DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and myo19

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_021332051.1	Gene:	myo19 / 562279	-ID:	-	Length:	978	Species:	Danio rerio

Alignment Length:	858	Identity:	313/858 - (36%)
Similarity:	456/858 - (53%)	Gaps:	121/858 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KLKEVKLKADG----------SDLPP-LRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQII 100
            |:..||.||:|          .||.. |.|.|.|...:|||.::.:....||..|:.|: ..::.
Zfish    39 KVNGVKNKANGLGKSLNDSLEGDLRDFLINEAELHTYDDLTKVNPVTPSTVLKCLQARY-SAKVF 102

  Fly   101 YTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAM-GDLEPHIFALAEEAYTKLER--ENCNLSII 161
            ||:.|..|||:||:..:| ||...::|.|..... .:.:||||.:|||||..::.  |..|.|::
Zfish   103 YTHAGCTLVALNPFQPIPHLYSLDVMREYHSAPQPQEFKPHIFIVAEEAYRNVQGQVEPMNQSLV 167

  Fly   162 VSGESGAGKTVSAKYAMRYFAAVGGSESETQ-----VERKVLASSPIMEAFGNAKTTRNDNSSRF 221
            ||||||||||.:::..|:|:|.|..|....|     :|::||.|:|:|||||||.|.||:|||||
Zfish   168 VSGESGAGKTWTSRCLMKYYATVATSSQRCQDTVERIEKRVLDSNPVMEAFGNACTLRNNNSSRF 232

  Fly   222 GKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC--AARSKYPELVLDHQ 284
            ||:.:|...:.   ..|.||::.||||||:||.:||..|||:|||||:.  |...:..|.:|..:
Zfish   233 GKYIQLQLNSS---QLLVGASVQTYLLEKTRVAFQAPNERNFHIFYQMMKGATEQQRLEWMLPLE 294

  Fly   285 DKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEG 349
            ..|.:|     |..|:..:.:...|||:||..||....:.|.|.|||||:|.|||:..|
Zfish   295 QDFVWL-----PHAEKTLEEDCLQETVEAMISLGIDEGKRAQIFKILAGLLQLGNVDFS------ 348

  Fly   350 SEEEDSDSCDIF-HNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDAL 413
            ...|::..||:. .:...||..||||:||.|:|:..|::|.:.:..:.:|.|.|.......||.|
Zfish   349 PAPEEAQPCDLSGQSKGFLQKAADLLQVSLDELQSCLIVRTLRAGKQNILKPCSQSECGIRRDCL 413

  Fly   414 AKHIYAKLFQYIVGVLNKSLN-NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQ 477
            ||.|||:||.::|..:|.|:: :.|..|:|||:||:||||.|.:|:.||.|||||||||||.|..
Zfish   414 AKVIYAQLFDWLVTFINNSMSADSSMWCNFIGLLDVYGFECFLLNNLEQLCINYANEKLQQHFVA 478

  Fly   478 HVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIE-SRLGVLDLLDEECRMPKGSDE---------- 531
            |..|.:||||:.||:.|:.|.:.|||.|:|||| |...::.||:||||:.:.||.
Zfish   479 HYLKAQQEEYVSEGLQWSFIRYQDNQGCLDLIEGSPSSIISLLNEECRLNRASDAKKFRVRLEKE 543

  Fly   532 -------SWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVL 589
                   ||     .|.:|.|||.          :.|::..|.|.:.|.:|||:|.|..||..:|
Zfish   544 LSDNANISW-----DKFSKEPHFT----------VAHYAGRVSYQIEGMMEKNKDPVPPELICLL 593

  Fly   590 SESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQF 654
            .:|..||         :::|..|              ..|:.:|:....:||       ||.|:|
Zfish   594 QKSQDSL---------LNSLFAD--------------GDRESEGSRGHSKVV-------TVVSKF 628

  Fly   655 QESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYP 719
            :.||.||:..||:|||||.||||||.|.....::..::|.||.|||::||:.|||||||.|....
Zfish   629 KNSLESLMKILHSTTPHYTRCIKPNPDCRPLTFQKEEVIAQLEACGIVETINISAAGFPIRIPND 693

  Fly   720 DFYMRYQLLV---YRSKLDKNDMKLSCRNIVMKWIQ------------DEDKYRFGNTQIFFRAG 769
            .|:.||.|:.   ..:|....:|.....:::...|:            :.:....|.|::|....
Zfish   694 SFFQRYGLIANNRLAAKKKSPEMGSVVEDVLSVVIKKHSPNSTFSPDDNNNMVHCGRTKVFLTHS 758

  Fly   770 QVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAG 834
            .:..||:.|..:|.:....:|...||...|::|||.| ....||...|.:..|...:|..:| ..
Zfish   759 LLEILEEHRNRVRSQKAFSIQCCWRRHQQRQRFLRTQ-AATCIQAGVRSWRVRREIKKWHKA-VS 821

  Fly   835 LILSKYA--RGWL 845
            :|.:|:.  |.|:
Zfish   822 VIQTKWRRWRAWM 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	284/758 (37%)
		MYSc_Myo5	84..767	CDD:276831	276/728 (38%)
		IQ	900..922	CDD:197470
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
myo19	XP_021332051.1	Motor_domain	87..756	CDD:328930	276/728 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010