DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and myo5aa

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_017207607.1	Gene:	myo5aa / 562188	ZFINID:	ZDB-GENE-041027-2	Length:	1854	Species:	Danio rerio

Alignment Length:	1942	Identity:	767/1942 - (39%)
Similarity:	1134/1942 - (58%)	Gaps:	230/1942 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSE-EMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR 64
            |:.| :.::.:.|::|:|..:.||.||.|.:.||:|.|.|::..:.||..|.||....::||.||
Zfish     1 MNQELDFMFIKYARVWIPDDEEVWRSAELTKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLPHLR 65

  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYR 129
            ||.||||:||||.|||||||.|||||:|||.:.::|||||||:|||||||..:|:||..||.||.
Zfish    66 NPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLPIYGADIINAYS 130

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVE 194
            |..|||::|||||:|||||.::.|:..|.||||||||||||||||||||||||.|.||.||..||
Zfish   131 GQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVE 195

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            .|||||:||||:.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||..
Zfish   196 EKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHII---GANMRTYLLEKSRVVFQADE 257

  Fly   260 ERNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321
            ||||||||||||: :..||   |.|...:.|.:...|..|.|:.|.||::.:.|..|..:||.:.
Zfish   258 ERNYHIFYQLCAS-AHLPEFKALKLGKANDFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINE 321

  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386
            .....:.:|||.||||||:.|        ::.||||..|..|:.||.:..:|:.|:..|:..||.
Zfish   322 SYQMGLFQILASILHLGNVDV--------KDRDSDSSIIPPNNGHLSVFCELMGVTYQDMSHWLC 378

  Fly   387 MRKIESVNEYVLIPNSIEAAQA--ARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIY 449
            .:|:::..|..:.|  |...||  ||||||||||||||.:||..:||:|::..||.|||||||||
Zfish   379 HKKLKTATETYIKP--IPKLQAINARDALAKHIYAKLFNWIVDHVNKALHSTVKQHSFIGVLDIY 441

  Fly   450 GFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLG 514
            ||||||:||||||||||||||||||||.||||||||||:||.|.||:||||||||||:|||:::|
Zfish   442 GFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMG 506

  Fly   515 VLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLE 575
            :||||||||:||||||:|||.||    :..|   ..|||||....:|.|:||:|.|||..:||||
Zfish   507 ILDLLDEECKMPKGSDDSWAQKLYNTHLKTC---ALFEKPRMSNKAFIIQHFADKVEYQCDGFLE 568

  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRV 640
            ||:|||::|...||..|...|..::...||..|....:|...  |||..:|. :..:|..::
Zfish   569 KNKDTVNEEQINVLKASKFDLLVELFHDEEKATSPTGAAPGP--GGRTRLSV-KPDKGKSSQ--- 627

  Fly   641 VPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETV 705
             .||:|:||||.||:.||..|:.||:||||||||||||||.|.||.::..:.:|||||||||||:
Zfish   628 -ASKEHKKTVGLQFRNSLQLLMETLNATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETI 691

  Fly   706 RISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQ 770
            |||||||||||.|.:|:.||::|: :.|....|.|::|:|::.|.:||.|||:||.|:|||||||
Zfish   692 RISAAGFPSRWTYQEFFSRYRVLM-KQKDVLTDKKMTCKNVLEKLVQDPDKYQFGKTKIFFRAGQ 755

  Fly   771 VAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGL 835
            ||:||::||:..:.....:|..:|.::.|:::||::.....||:..|||.||...:.:|..||.:
Zfish   756 VAYLEKLRADKLRAACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAI 820

  Fly   836 ILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQK 900
            |:.||.|.::.:..|.|.:.:...:|...|..:||..:.|:...::||.||:.|||.|||:.:::
Zfish   821 IIQKYQRMYIQKTCYKRKQAAALAMQCILRAYMARQLYKALLREHKAVIIQKMVRGWLARQWFKR 885

  Fly   901 RRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK 965
            ..:.|:..|..|||..|:|:.|::|.||:::.|.:...:|:||||:.:|:|||:.|::|.::..:
Zfish   886 SLKAIVYLQCCIRRMRAKRELKKLKIEARSVEHFKKLNIGMENKIMQLQRRIDDQNKENRSMSER 950

  Fly   966 TSEISVL------KMKLELKKTLEAEFKNVKAACQDKDKL------IEALNKQLEAERDEKMQLL 1018
            .:.:...      :|:.|:.:...||    :.|..:.:|:      :|.|.|.|:..:.||
Zfish   951 LNTLETSHAVESERMRAEVTRLRGAE----EDAKNNANKVTSLLEELERLRKDLQNTQKEK---- 1007

  Fly  1019 EENGHAQEEWISQKQTWRQENE----ELRRQIDEIIDMAKNAEVNQRNQE------DRM------ 1067
                .|.|:|   .||::.|.|    ||:.| ::::...|| .:||..||      |:|
Zfish  1008 ----KAIEDW---AQTYQDEMEKMISELKEQ-NQLLKTEKN-NLNQLIQEQSQQWTDKMQRALKE 1063

  Fly  1068 -LAEIDNRELNE---AYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG 1128
             ..:::| :|||   .||..:.:...:|.:...||||:: |.........|:..:..|.||.:..
Zfish  1064 ETQQLEN-DLNEERSRYQNLLTEHLRLEEKYDDLKEEIT-LAVNVPKPGHRRTDSTHSSNESECT 1126

  Fly  1129 YAS---------------AKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQ-- 1176
            |.|               :|:.||:                 ||.:||:..:.|.:|:.:.||
Zfish  1127 YNSEFAESEEGSRVGEDVSKSILDM-----------------SLFLKLQKRVSELEQEKQSLQNE 1174

  Fly  1177 -----EQYIKLSSR----HKPTE------DSFRVSELEVENEKLRSEYDQLRTSIKHGVE----- 1221
                 ||:.:..:|    ||...      :|.:..|||.||:||:.:.:|:|.|::..||
Zfish  1175 LDRREEQFQRARARDDEEHKKARGAELEYESLKRQELESENKKLKHDLNQMRQSLRGSVEAGSGA 1239

  Fly  1222 ---------INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMR-------SLEP----ESLQ 1266
                     :::|||.:    ||:..|:||.:.|::.|:.|.::|:       ..||    |.:|
Zfish  1240 PGSPAYTVLLDQLNASN----EELEVRKEEVLILRSQLVSQKEAMQHKDEKTTMTEPLPYIEDVQ 1300

  Fly  1267 M--------------------------RGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLV 1305
            .                          :.|:..||...:...|..||.|||:|:|....|::::.
Zfish  1301 KLTDAKEISQAYMGLKDTNRSPFPDYHKLNEDGELWLVYEGLKETNRLLESQLQAQRRSHDNEVE 1365

  Fly  1306 EMTQEIERLNNEKDELQKVMFESIDEFEDSNVDT--------LRQNDRYLRRELQKAVAQFLLVQ 1362
            .:..|:..|..|.:..|:::.:::....::.::.        |...:..|..:|:|.......::
Zfish  1366 VLRGELHSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLDLMEQLEKQDKTVRKLK 1430

  Fly  1363 EELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTK--QKSQNPQGLMKFHSSDL 1425
            ::||:...|:...  :|||::          .|.|.:||...:...  ::.::.||::::...|.
Zfish  1431 KQLKVFAKKINDL--EGGQMD----------VSPGQTADEPVHPVNIPRREKDFQGMLEYKKEDE 1483

  Fly  1426 DKILQRLLSALTPRTV-VGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPH 1488
            .|:::.::..|.||.| |.|:||.|||::|||:|:.|..|.|..||.||:..:..||| :.:...
Zfish  1484 LKLVKNIILELKPRGVAVNLIPGLPAYILFMCLRHADYINDDQKVRSLLTSVINSIKKILKKRGD 1548

  Fly  1489 PIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALI 1553
            ..|....||.|:...|:.:|||...::::|.|:.|||:..|.||:|.|||:|:.||.:.:||.||
Zfish  1549 DFETVSFWLANTCRFLHCLKQYSGDEQFMKHNSPKQNEHCLSNFDLAEYRQVLSDLAIQIYQQLI 1613

  Fly  1554 MQIQGLLDPKIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYK 1616
            ..::.:|.|.||..:|.::.||  .|.:..|:|.|.:||...      |......:|.||..|:.
Zfish  1614 KCMENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADE------GTYTLDSIIRQLNTFHS 1672

  Fly  1617 QFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKK-MSN 1680
            ...|.|.|....:|:..|..|.|.||.||.|:||.|:|.|..||.||||:..:|:|:|.|. |:.
Zfish  1673 IMCHHGTDPELIKQVVKQQFYIIGAVTLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMTC 1737

  Fly  1681 DVLTALAPLNQVSQLLQ-SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEK 1743
            .....|.||.|.:|||| .:|:::|.:.||.:|.:|||||::||:..| .::.:|..::.:|:..
Zfish  1738 GAKETLEPLIQAAQLLQVKKKTDEDAEAICSMCNALSTAQIVKVLNLYTPVNAFEERVSVLFIRT 1802

  Fly  1744 LTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800
            :..:|..|:    .|.:..:|.|.|.|....|..|.:.||.|::||.||| .|||::
Zfish  1803 IQTRLRDRK----ESPQLLMDTKLIYPVTFPFNPSSLALETIQIPSSLNL-AFLTRV 1854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	414/721 (57%)
		MYSc_Myo5	84..767	CDD:276831	389/691 (56%)
		IQ	900..922	CDD:197470	7/21 (33%)
		GBP_C	<971..1086	CDD:303769	36/146 (25%)
		coiled coil	1049..1068	CDD:293879	8/31 (26%)
		coiled coil	1077..1086	CDD:293879	4/11 (36%)
		JAKMIP_CC3	<1190..1299	CDD:292653	40/165 (24%)
		Myo5_CBD	1424..1792	CDD:271254	137/374 (37%)
myo5aa	XP_017207607.1	MYSc_Myo5	85..752	CDD:276831	389/691 (56%)
		IQ	766..787	CDD:197470	3/20 (15%)
		IQ	789..811	CDD:197470	8/21 (38%)
		SMC_N	<920..1279	CDD:330553	99/398 (25%)
		SMC_N	<1156..>1445	CDD:330553	63/294 (21%)
		Myo5a_CBD	1480..1854	CDD:271262	143/384 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	762	1.000	Domainoid score	I82
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20100
Inparanoid	1	1.050	1236	1.000	Inparanoid score	I177
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24904
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4210
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010