DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh9b

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_001920098.4 Gene:myh9b / 561431 ZFINID:ZDB-GENE-030131-998 Length:1698 Species:Danio rerio


Alignment Length:1608 Identity:461/1608 - (28%)
Similarity:768/1608 - (47%) Gaps:276/1608 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||...|.:|:.:|:|.:  |...:....||||    |::.:..|:..: ||.......|:..|
Zfish    30 VWVPSERLGFEAGSLKEEH--GDEVVVELADSGK----KIRVNKDDIQKM-NPPKFSKVEDMAEL 87

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
Zfish    88 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAI 151

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE-----------SETQVERKV 197
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.           |..::|:::
Zfish   152 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTKKDQSSSVLSHGELEKQL 216

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.
Zfish   217 LQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERT 278

  Fly   263 YHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            :|:||.:...     ||   ||.|:..:|::||:.|.. .|....|.:.:.|||:||.::|||.:
Zfish   279 FHMFYYMLTGVGDKLRS---ELCLEGYNKYRFLSNGNV-TIPGQQDRDMYVETVEAMRIMGFSEE 339

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :...::::::.:|.|||:...|       |..||...: .:|...|....|:.::..|..|.:|.
Zfish   340 EHVGLLRVISSVLQLGNMSFKK-------ERHSDQASM-PDDTAAQKVCHLMGMNVTDFTRAILS 396

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGF 451
            .:|:...:||....:.|.|:.|.:||||..|.::|:::|..:||:|:...:| .||||:|||.||
Zfish   397 PRIKVGRDYVQKAQTQEQAEFAVEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDIAGF 461

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---SR 512
            |.||:|||||.||||.||||||.||..:|.||||||.:|||.|:.||| .|.||||||||   |.
Zfish   462 EIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPASP 526

  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLE 575
            .|:|.||||||..||.:|:|:..|::.:....|.|.||:  .....|.|.|::..|:|..:.:|.
Zfish   527 PGILALLDEECWFPKATDKSFVEKVLQEQGTHPKFHKPKKLKDEADFCIIHYAGKVDYKADEWLM 591

  Fly   576 KNRDTVSKELTQVLSESN----MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636
            ||.|.::..:..:|::|.    ..|.|.|..:..:|.:    |..|.|.|..           .|
Zfish   592 KNMDPLNDNVATLLNQSTDRFVSELWKDVDRIVGLDKV----AGMSELPGAF-----------KT 641

  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701
            |:.:.      :|||..::|.|:.|::||..|.|::||||.||.:|.|.|.:...::.|||..||
Zfish   642 RKGMF------RTVGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGV 700

  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQI 764
            ||.:||...|||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::
Zfish   701 LEGIRICRQGFPNRIVFQEFRQRYEILTPNS-IPKGFMDGKQACMLMIRALELDPNLYRIGQSKV 764

  Fly   765 FFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING---IQKHARGYLARERTQ 826
            |||||.:|.||:.|.......|...|:..|.:|.|:.|.:.|:.:..   ||::...||.....|
Zfish   765 FFRAGVLAHLEEERDMKITDVIINFQAWCRGYVARKAFAKRQQQLTAMRVIQRNCAAYLKLRNWQ 829

  Fly   827 KMR---EARAGLILSKYARGWLCRRRYL-RLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQR 887
            ..|   :.:..|.:|:.......:...| ::|..    |..|...|...:....:.:...:.:|.
Zfish   830 WWRLFTKVKPLLQVSRQEEEMQAKEEELSKVREK----QQVAEQQLVEMEVKQQQLNAEKMALQE 890

  Fly   888 FVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRI 952
            .::..:...|.....||.::.:......:......|::.|.:..:|::.:...::..|..::|::
Zfish   891 QLQAEMDLCAEADEMRNRLVAKKQELEEILHDLEARVEEEEERANHLQAEKKKMQQNIADLEQQL 955

  Fly   953 DELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVK---AACQDKDKLIEALNKQLE------ 1008
            ||            .|.:..|::|| |.|:||:.|..:   ....|::..:....|.:|      
Zfish   956 DE------------EEAARQKLQLE-KVTMEAKLKKTEEEVMVLDDQNNKLSKEKKLMEERIAEF 1007

  Fly  1009 ----AERDEKMQLLE--ENGHAQ-----EEWISQKQTWRQENEELRRQI--------DEIIDM-A 1053
                ||.:||.:.|:  :|.|..     |:.:.:::..|||.|:.||::        |:|.:: |
Zfish  1008 TTNLAEEEEKSKSLQKLKNKHEAMITDLEDRLRREEKQRQELEKNRRKLEGDSTELHDQIAELQA 1072

  Fly  1054 KNAEVN-QRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFM--LKE--ELSRLTAGSFSLHA 1113
            :.||:. |..:::..|.|...|...||.|:.:..|::.|.|:.:  |:|  ||.|........|.
Zfish  1073 QIAELKAQLAKKEEELQEALARIEEEAAQKNLAQKKIRELESQLSELQEDLELERAARTKAEKHR 1137

  Fly  1114 R----KASNASSQNEDDVGYASAKNTLDINRPPDLL----------------------------- 1145
            |    :.....::.||.:...:|:..|...|..::.                             
Zfish  1138 RDLGEELEALKTELEDTLDSTAAQQELRTKRETEVAQLKKALEEDAKVHEQVMAEIRQKHSQAFD 1202

  Fly  1146 ------------------SKNYSYNDSTSLVVKLRSILE---EEKQKHKVLQEQYIKLSSRHKPT 1189
                              ||....::...|.::|:::::   |.:.:.|..:.|..:|..:|  |
Zfish  1203 ELNEQLEQVKRNKVSVEKSKQALESERNELQIELQTLMQGKGESEHRRKKAEAQLQELQVKH--T 1265

  Fly  1190 EDSFRVSELEVENEKLRSEYDQLRT--------SIKHGVEINELNAQ----HAALQEEVRRR--- 1239
            |...:..||.....|:::|.|.:.|        |||...:.:.:.:|    ...||||.|::   
Zfish  1266 ESERQRIELAERLTKMQAELDNVNTLLSDAEGKSIKASKDCSTVESQLQDVQEVLQEETRQKLAL 1330

  Fly  1240 -------REECIQLKAVLLQQSQSMRSLEPE--SLQMRGNDVNELME--------AFHSQKLINR 1287
                   .:|...|:..|.::.::.|:||.:  ::|.:..|:.:.||        |..|:|.:.|
Zfish  1331 NTRLRQLEDEQHSLREQLEEEEEAKRNLEKQIGTMQAQLVDMKKKMEQESGSLECAEESRKRVQR 1395

  Fly  1288 QLESELKAITEEHNSKLVEMTQEIERLNNEKDEL-----------------QKVMFESIDEFEDS 1335
            .||:..:.: :|.|:...::.:...||..|.|::                 ||...:.:.|.:..
Zfish  1396 DLEAVSQRL-DERNAAFDKLDKTKTRLQQELDDMLVDQDHLRQIVSNLEKKQKKFDQMLAEEKSI 1459

  Fly  1336 NVDTLRQNDR-------------YLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIE 1387
            :.....:.||             .|.|||:....    ::|||...|..|:|..:|         
Zfish  1460 SARYAEERDRAEAEAREKETRMLALARELETLTD----MKEELDRTNKLLRAEMED--------- 1511

  Fly  1388 EEMIRNKSNGTSADVGANV---TKQKSQNPQGL--MKFHSSDLDKILQ 1430
              ::.:|.     |||.:|   .|.|....|.|  ||....:|:..||
Zfish  1512 --LVSSKD-----DVGKSVHDLEKSKRAMEQQLEEMKTQLEELEDELQ 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 284/741 (38%)
MYSc_Myo5 84..767 CDD:276831 271/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 37/144 (26%)
coiled coil 1049..1068 CDD:293879 5/20 (25%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/140 (23%)
Myo5_CBD 1424..1792 CDD:271254 3/7 (43%)
myh9bXP_001920098.4 Myosin_N 28..66 CDD:280832 13/41 (32%)
Myosin_head 81..767 CDD:278492 275/723 (38%)
Motor_domain 93..767 CDD:277568 271/711 (38%)
KASH_CCD 937..1120 CDD:291334 45/195 (23%)
Sec1 <943..>1076 CDD:301618 33/145 (23%)
Dor1 1018..>1175 CDD:302817 37/156 (24%)
Filament 1034..1341 CDD:278467 60/308 (19%)
Rab5-bind 1306..1606 CDD:286404 58/268 (22%)
GrpE 1532..>1640 CDD:295646 7/21 (33%)
GBP_C <1596..1689 CDD:303769
coiled coil 1660..1669 CDD:293879
coiled coil 1678..1689 CDD:293879
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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