DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and myo15aa

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_021330383.1 Gene:myo15aa / 560592 ZFINID:ZDB-GENE-080425-2 Length:2394 Species:Danio rerio


Alignment Length:1247 Identity:374/1247 - (29%)
Similarity:586/1247 - (46%) Gaps:227/1247 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|:|.|..|||..||.||:.|| ||.:||||.|.|||::|||....:||..::..::|||:|:
Zfish    20 GVEDMTQLEELHEGAVLLNLKKRF-ERNLIYTYIGSILVSVNPYKMFNIYGTDMVLQHKGHALGE 83

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
            ..||:||:|..:|||:.....|..||:|||||:|||.:.|..:||.||:...::.||   ::|.:
Zfish    84 NPPHLFAIANASYTKMMDAKENQCIIISGESGSGKTETTKLVLRYLAAIHHKQNITQ---QILEA 145

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :|::|:||||||.||||||||||:.::..  :.||  :.||....|||||||:|:||:.||||||
Zfish   146 TPLLESFGNAKTVRNDNSSRFGKYMEIFM--EEGV--ISGAITSQYLLEKSRIVFQAKDERNYHI 206

  Fly   266 FYQLCAA--RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIV 328
            ||::.|.  ..:.....|...:.:.:||.||...|...||.|.|...:.||.:|.||.:..:.|.
Zfish   207 FYEMLAGLPSQQKQSFYLQDAETYYYLNQGGDCVIVGKSDGEDFRRLLSAMEILHFSAEDQSGIF 271

  Fly   329 KILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESV 393
            ::|:.||||||:     |.|..|.|..:...:.... .:::.|:||::|.:.|::.:..:..|::
Zfish   272 RVLSSILHLGNV-----FFERYETESQEVASVVSAQ-EIRVVAELLQISPEGLQKSITFKVTETM 330

  Fly   394 NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNS 458
            .|.:..|.::|:|..||||:||.:|:.||.::...:||.:...::..| |.:|||||||....||
Zfish   331 REKIYTPLTVESAIDARDAVAKILYSLLFSWLTDRINKQVYPRNEALS-ISILDIYGFEDLTFNS 394

  Fly   459 FEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDEE 522
            |||.|||||||.||..||:.:||.||:||.:|.|.|..:.|.|||.|||||.:: .|:|.:||::
Zfish   395 FEQLCINYANEYLQFFFNRVIFKEEQDEYNREQIIWEEVPFSDNQACIDLIAAKPHGILRILDDQ 459

  Fly   523 CRMPKGSDESWAGKLIGKCN----KFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSK 583
            ...|:.:|.::    :.||:    ..|.:.||:.....|.|||::..|.|.|:.||:||.|.|.:
Zfish   460 SGFPQATDHTF----LQKCHYHHGNNPLYSKPKMPLPEFTIKHYAGKVSYQVHKFLDKNYDQVRQ 520

  Fly   584 ELTQVLSES-NMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHR 647
            ::..:..:| |..:|...|...|                  .::..|.|.|.::   .|..:...
Zfish   521 DVLDLFIQSKNKMVAYLFMNYAE------------------ALNQQRSQIGKNS---TVTRRHQA 564

  Fly   648 KTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGF 712
            .||.::||:||..||..:....|::|||||||.:|....::...:..||...|:||||||...|:
Zfish   565 STVAAKFQQSLLELIEKMERANPYFVRCIKPNQNKEPAVFDMELVSAQLCYSGILETVRIRREGY 629

  Fly   713 PSRWLYPDFYMRYQ-LLVYRSKLDKNDMKLSCRNIVMKWIQ-DEDKYRFGNTQIFFRAGQVAFLE 775
            |.|..:..|..||: ||..:.....|..  :|..::.|... ....::.|.|::|.:......||
Zfish   630 PIRMPFDVFLFRYKSLLGLKQPPPANGE--NCVIMLRKLCPVRPGAFQVGVTKLFMKEEIYFLLE 692

  Fly   776 QVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY 840
            ..|..:|......:|...|.|..|:::...:..|..:|.|.||:|.|:|..|||     :.|.|:
Zfish   693 SKRDRVRHVAALTLQRYTRMFFVRKRYTAFRMKIIRLQAHCRGFLTRKRYVKMR-----VSLVKF 752

  Fly   841 ---ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVR------------ 890
               ...::.|:||:|||:.            ||.|   ..:..|.::::...|            
Zfish   753 RSLVHMYVDRKRYIRLRYE------------ARRK---AEEEQRRIEMELSKREVVNVTHLVIPA 802

  Fly   891 --GALARRAYQKRRRN---IIICQA----------------------AIRRFLARRKFKRMKAEA 928
              |||.:.|...|..:   :.:.||                      .::......||..:.|..
Zfish   803 ELGALLQAAAGGRELHSDCLALVQAPTVQVETQLTLPLDINNYTISKLVQIHFKEPKFGMLTAPL 867

  Fly   929 KT-ISHMEN--------------KYMG-----------LENKIISMQQRIDELN-RDN------- 959
            || ::|:::              ::||           ..|.||  |:.:..|| ||.       
Zfish   868 KTPLTHVDDDLTHEALDVFVMILRFMGDPHLNGAQENLFGNYII--QKGLTNLNLRDEILCQIAN 930

  Fly   960 ---SNLKHKTSEISVLKM-----------KLE---LKKTLEAEFKNVKAACQDKDKLIEALNKQL 1007
               .|.....||...|.:           |:|   ||...:..:...||..|  .|||:|:.|.|
Zfish   931 QVWRNPNPDNSERGWLLLLACLSAFAPSAKVEKYLLKFVSDHAYNEFKAVGQ--HKLIQAMQKSL 993

  Fly  1008 ---EAERDEKMQLLEENGHAQE-------------EWISQKQTWRQENEELRRQIDE---IIDMA 1053
               |..|...:.|||...:.::             .::....:| ...|||...|.:   :.:..
Zfish   994 YGPETARTYPLSLLEWTANRKKANMVLQVHCFDGTSFLCPVHSW-TSGEELAGDILQHRGVTEAW 1057

  Fly  1054 KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIEN-----ENFMLKEE---LSRLTAG--- 1107
            |...|..:  |....||:..   ::.....|.|.|::.|     ..|::..|   .:|..||   
Zfish  1058 KGCSVIMK--EHGQWAELAG---HDYVMDLIADMELMRNFPKQKSYFIISAESPTRTRPNAGLAL 1117

  Fly  1108 ---------SFSLHARKASNASSQNEDDVGYASAKNT-------------LDINRPPDLLSKNYS 1150
                     ..||...:...:||..:.|..|:.|::.             ||....|.|...|..
Zfish  1118 FGSGFDSDDDSSLLLPQTMLSSSLPDSDGYYSHAESDFSEAPTQKGMDRYLDSLFDPVLSDGNGD 1182

  Fly  1151 YNDSTSLVVKLR 1162
            :..|:|:..:::
Zfish  1183 FEKSSSMSSRMK 1194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 266/716 (37%)
MYSc_Myo5 84..767 CDD:276831 257/692 (37%)
IQ 900..922 CDD:197470 4/46 (9%)
GBP_C <971..1086 CDD:303769 30/147 (20%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653
Myo5_CBD 1424..1792 CDD:271254
myo15aaXP_021330383.1 Motor_domain 34..684 CDD:328930 257/691 (37%)
IQ 723..742 CDD:279006 7/18 (39%)
MyTH4 866..1013 CDD:214535 35/150 (23%)
Atrophin-1 <1205..1505 CDD:331285
SH3_MYO15A 1716..1795 CDD:213000
MyTH4 1914..2068 CDD:214535
FERM_B-lobe 2176..2273 CDD:271216
FERM_C_MyoXV 2279..2380 CDD:270022
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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