DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and MYO5C

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_061198.2	Gene:	MYO5C / 55930	HGNCID:	7604	Length:	1742	Species:	Homo sapiens

Alignment Length:	1886	Identity:	715/1886 - (37%)
Similarity:	1069/1886 - (56%)	Gaps:	241/1886 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVG 71
            ||.|..::|:|..:.||:||.:.:.||.|...|::..:.|  .|:....:...|||||||.||||
Human     6 LYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDG--TELDYSVNPESLPPLRNPDILVG 68

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136
            :||||.|||||||.||||||:||.|.::||||.||||||:|||.::|:||.:||.||.|..|||:
Human    69 ENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDM 133

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201
            :|||||:|||||.::.|.|.|.||||||||||||||||:|||||||.|..|.|...||.|||||:
Human   134 DPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASN 198

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIF 266
            ||.||.||||||||||||||||:|::.|..|..::   ||.|.||||||||||:|::.|||||||
Human   199 PITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQII---GANMSTYLLEKSRVVFQSENERNYHIF 260

  Fly   267 YQLCAA--RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVK 329
            |||||:  :|::..|.|...::|.:..|||...||.|:|..:..||.:..|:|||......|:.|
Human   261 YQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFK 325

  Fly   330 ILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVN 394
            |||.||||||:|::...||.|...:.||        ||::..:||.:.:..:.:||..|||.:.:
Human   326 ILAAILHLGNVQITAVGNERSSVSEDDS--------HLKVFCELLGLESGRVAQWLCNRKIVTSS 382

  Fly   395 EYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSF 459
            |.|:.|.:...|..|||||||.|||.||.:||..:|::|....||.:|||||||||||||:||||
Human   383 ETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSF 447

  Fly   460 EQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECR 524
            |||||||||||||||||.||||||||||:||.|.||:||||||||.|||||:::|:|:||||||.
Human   448 EQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECL 512

  Fly   525 MPKGSDESWAGKLIGK-CNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQV 588
            :|.|:||:|..||... .|:.|.|||||...|||.|:||:|.|||...||||||||||...|.::
Human   513 LPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEI 577

  Fly   589 LSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH-RKTVGS 652
            |..|...|....  .:|..|      ..|..|..:.:.:.::.        :.|:.:| |.||||
Human   578 LRASKFHLCANF--FQENPT------PPSPFGSMITVKSAKQV--------IKPNSKHFRTTVGS 626

  Fly   653 QFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWL 717
            :|:.||..|:.||:||||||||||||||:|:.|::::.:|:|||||||||||:||||..:||||.
Human   627 KFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWT 691

  Fly   718 YPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLR 782
            |.:||.||.:|:.:.:|..:|.|..|:.::.:.|||.::|:||.|:|||||||||:||::|.:..
Human   692 YIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKL 756

  Fly   783 KKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK------MREARAGLILSKYA 841
            ::...:||..:|.::.|::|||.::....||::.||   ::..:|      ::||.|.:|:.|:.
Human   757 RQSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRG---QQTVRKAITAVALKEAWAAIIIQKHC 818

  Fly   842 RGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNII 906
            ||:|.|..|..:|.:...:|.|:||.|||.::..|.:.::||.:|::.|..||||.:|..||.::
Human   819 RGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVL 883

  Fly   907 ICQAAIR-----------------------RFLARR-----KFKRMKAE-AKTISHMEN------ 936
            ..|...|                       ...|.|     |.::::|| .|..:|..|
Human   884 NIQLTYRVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGK 948

  Fly   937 KYM-GLENKIISMQQRIDELNRDNS----NLKHKTSEISVLKMKLE-LKKTLEAEF--------- 986
            :|. .:|.|:..:|:...||.....    .|:.||.|   ||.|:: |.|.|..:.
Human   949 RYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEE---LKEKMDNLTKQLFDDVQKEERQRML 1010

  Fly   987 --KNVKAACQDKDKLIEALNKQLEAERDEKMQL--LEENGHAQEEWISQKQTWRQENEELRRQID 1047
              |:.:...||.:|.|::|.::::|.:||||||  |.|..|...:.:      :.|...|.:|:.
Human  1011 LEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHVTSDGL------KAEVARLSKQVK 1069

  Fly  1048 EIIDMAKNAEVNQRNQED-RMLAEIDNRELNEAYQRAIKDKEVIEN--ENFMLKEELSRLTAGSF 1109
            .|.:..|..|:.|..:.| ....:...||:.|      |..|:.:.  |::.:::..|||:
Human  1070 TISEFEKEIELLQAQKIDVEKHVQSQKREMRE------KMSEITKQLLESYDIEDVRSRLS---- 1124

  Fly  1110 SLHARKASNASSQNEDD---VGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK 1171
                  ..:....|||.   ..|...|                          |...:||...|.
Human  1125 ------VEDLEHLNEDGELWFAYEGLK--------------------------KATRVLESHFQS 1157

  Fly  1172 HKVLQEQYIKLSSRHKPTEDSFRVSELEVE---NEKLRSEYDQLRTSIKHGVEINELNAQHAALQ 1233
            .|...|:.|:..        :|:|..|..|   .:||..|.:.:..||:|  |:..|.:::..:.
Human  1158 QKDCYEKEIEAL--------NFKVVHLSQEINHLQKLFREENDINESIRH--EVTRLTSENMMIP 1212

  Fly  1234 E------EVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESE 1292
            :      |:.:::::   |:..|.:|::.|:.    .|:...|.::...|...:|:   :.||::
Human  1213 DFKQQISELEKQKQD---LEIRLNEQAEKMKG----KLEELSNQLHRSQEEEGTQR---KALEAQ 1267

  Fly  1293 LKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQ 1357
            .:..|:| ..||::..||::..:   |.|:| .||:..|.:.:           .|:|..:...:
Human  1268 NEIHTKE-KEKLIDKIQEMQEAS---DHLKK-QFETESEVKCN-----------FRQEASRLTLE 1316

  Fly  1358 FLLVQEELKLANAKLKAYRQDGGQLEHKIEEEM-IRNKSNGTSADVGANVTKQKSQNPQ---GLM 1418
            ...::|||.:.:..:|           |::::: ..:|:.|.:.||      ..|..|:   |::
Human  1317 NRDLEEELDMKDRVIK-----------KLQDQVKTLSKTIGKANDV------HSSSGPKEYLGML 1364

  Fly  1419 KFHSSDLDKILQRLLSALTPR-TVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK 1482
            ::...|..|::|.|:..|.|| .||.::||.||:::|||:||.|..|..:.::.|::..:..||:
Human  1365 QYKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLKSLMNSTINGIKQ 1429

  Fly  1483 MHRTP-HPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIV 1546
            :.:.. ...|....||.|:...||.:|||...:|::|.|:.:||:..|.||:|.|||:::.|:.:
Human  1430 VVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAI 1494

  Fly  1547 NLYQALIMQIQGLLDPKIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIG 1609
            .:|...|:.::..:.|.|||.:|..:.:|  .|.:..|.|.|::||      :...|.....::.
Human  1495 RIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSI------DDTDGYTMTSVLQ 1553

  Fly  1610 QLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVR 1674
            ||.:||......|||.....|...||.:.|.||.||.|.||.|:|....||.||.||..:|:|::
Human  1554 QLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLK 1618

  Fly  1675 SKKMSNDVL-TALAPLNQVSQLLQSRK-SEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEI 1736
            .|.:.|.:. ..|.||:|.:.|||.:| ::.|.:.|.:.|||||..|::|::.|| .:||:|..:
Human  1619 DKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRV 1683

  Fly  1737 TNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRY--SDIKLEDIELPSHLNLDEFLTK 1799
            |..|:.|:...||:|:    :|.:..:|.|::  |:|.|.:  |...||.|::||...|. ||.:
Human  1684 TPSFVRKVQALLNSRE----DSSQLMLDTKYL--FQVTFPFTPSPHALEMIQIPSSFKLG-FLNR 1741

  Fly  1800 I 1800
            :
Human  1742 L 1742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	399/716 (56%)
		MYSc_Myo5	84..767	CDD:276831	374/686 (55%)
		IQ	900..922	CDD:197470	7/49 (14%)
		GBP_C	<971..1086	CDD:303769	33/129 (26%)
		coiled coil	1049..1068	CDD:293879	5/19 (26%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	24/117 (21%)
		Myo5_CBD	1424..1792	CDD:271254	130/376 (35%)
MYO5C	NP_061198.2	Myosin_N	12..48	CDD:280832	11/37 (30%)
		MYSc	62..752	CDD:214580	399/716 (56%)
		MYSc_Myo5	81..741	CDD:276831	374/686 (55%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	632..654		16/21 (76%)
		IQ	810..828	CDD:197470	7/17 (41%)
		COG1340	890..1150	CDD:224259	64/310 (21%)
		P-loop_NTPase	<910..>1163	CDD:304359	67/303 (22%)
		GBP_C	<927..1030	CDD:303769	26/105 (25%)
		coiled coil	997..1010	CDD:293879	1/12 (8%)
		coiled coil	1019..1030	CDD:293879	4/10 (40%)
		Rab5-bind	1020..1345	CDD:286404	87/419 (21%)
		DUF3585	1160..1326	CDD:304905	42/201 (21%)
		Myo5c_CBD	1369..1736	CDD:271260	130/378 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	766	1.000	Domainoid score	I83
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1254	1.000	Inparanoid score	I175
Isobase	1	0.950	-	0	Normalized mean entropy	S1278
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41050
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790