Protein Alignment didum and myo7ab

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_073791404.1
• Gene: myo7ab / 556141
• ZFINID: ZDB-GENE-091110-4
• Length: 2204
• Species: Danio rerio
• Alignment Length: 1635
• Identity: 466/1635 - (28%)
• Similarity: 754/1635 - (46%)
• Gaps: 278/1635 - (17%)

  Fly    20 DLVWESATLEESY--RKGA-------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDL 75
            |.||.....:..:  ..||       |.:::..|.||.:::.|: :.:::.|: :|..:.|..|:
Zfish     8 DYVWLDLRTDHEFDVPVGAVVKFCDSGQIQVLDDEGKEQQISLQ-NATNIKPM-HPTSIHGVEDM 70

  Fly    76 TTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHI 140
            ..|..|:|.|:|.||.:|:.:| :||||.|.||||:|||..:|:|.|..||.|....:|::.|||
Zfish    71 IRLGDLNEAGILRNLLIRYNDR-VIYTYTGSILVAVNPYQLLPIYTPDQIRLYTNKKIGEMPPHI 134

  Fly   141 FALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIME 205
            |.:|:..|..::|...:...|:|||||||||.|.|..:::.||:.|..|  .:|::||.::||:|
Zfish   135 FGIADNCYFSMQRNKKDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQQVLEANPILE 197

  Fly   206 AFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC 270
            |||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||..||||||||.:.
Zfish   198 AFGNAKTIRNDNSSRFGKYVDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQAADERNYHIFYCML 259

  Fly   271 AARS--KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAG 333
            |..|  :..:|.|.....:.:|.||.....|...|.::::..:.||.:|.|:..:..:|.|:||.
Zfish   260 AGMSPDQKTKLGLGRATDYTYLTMGNCTVCEGRDDMKEYSSILSAMKILMFTETEYWEISKLLAA 324

  Fly   334 ILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVL 398
            |||:||::.     |...:.:.|:|.:..:. .|...|.||.|...|:...|..|.:.:..|.|.
Zfish   325 ILHMGNLRF-----EARTQRNLDTCVVVRSP-DLANAASLLEVDPQDVMMCLTTRTLITRGESVS 383

  Fly   399 IPNSIEAAQAARDALAKHIYAKLFQYIVGVLN------KSLNNGSKQCSFIGVLDIYGFETFEVN 457
            .|.|:|.....|||..|.||.:||.:||..:|      .|..|.:.:.| ||:|||:|||.|.||
Zfish   384 TPLSVEQGLDVRDAFVKGIYGRLFVWIVDKINATIFRAPSTENRTVRRS-IGLLDIFGFENFTVN 447

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDE 521
            ||||.|||:|||.|||.|..||||||||||..|.|.|..|:|.|||..:|:|..: :.::.|:||
Zfish   448 SFEQLCINFANENLQQFFVHHVFKLEQEEYNLEDINWQDIEFTDNQDALDMIAIKPMNIISLIDE 512

  Fly   522 ECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585
            |.:.|||:|.:...||..:.....::..|:.. .|.|.|:||:..|.|:..||||||||::..::
Zfish   513 ESKFPKGTDATMLNKLNSQHKLNTNYIPPKHSHETQFGIQHFAGVVHYETKGFLEKNRDSLHSDI 577

  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTV 650
            .|::..|.....||:...:....||.....::||           |:|.:||:|       ..|:
Zfish   578 IQLVHSSKNKFIKQIFQADVAMFLCGYMEPTATL-----------QKGMETRKR-------SPTL 624

  Fly   651 GSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSR 715
            .|||:.||..|:.||....|.:|||||||:.|....::....::|||..|::||:||..||:|.|
Zfish   625 SSQFKRSLELLMRTLSVCQPFFVRCIKPNELKKPMMFDRGLCVRQLRYSGMMETIRIRRAGYPIR 689

  Fly   716 WLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVR 778
            :.:.:|..||::|:  .:....:.|::.:|:.||:..:..:|.::.|.|:||.:......||..
Zfish   690 YTFAEFVDRYRVLMPGVKPAHKQEDLRGTCQRIVVSVLLRDDDWQIGKTKIFLKDHHDMLLEME- 753

  Fly   779 ANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARG 843
               |.|.||                  .|||. |||..||  .:|||:.::..||.:::.:..||
Zfish   754 ---RDKVIT------------------DKVIL-IQKTVRG--MKERTKFLKVRRAVMLIQRIWRG 794

  Fly   844 WLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIIC 908
            ::.|:.|..:|.....:|...|......::.|.|  .|...:|.:.||.|.||.:.||...::..
Zfish   795 YITRKHYAVMRVGFLRLQALYRSRKLHQEYQATR--IRVTLLQAWCRGLLVRRTFSKRFHAVLTI 857

  Fly   909 QAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLK 973
            ||..|..:|||:.||::.|.             :.::.:.:||:.|..|
Zfish   858 QAYARGMIARRQCKRLRLER-------------DRRLEAERQRLAEEER---------------- 893

  Fly   974 MKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQE 1038
                ||..:.|.....:||.:.:::|     .||:.|::|: :|.|.|           :|.|
Zfish   894 ----LKNQMTARRARAEAARKHQERL-----AQLDREQEER-ELAERN-----------ETRR-- 935

  Fly  1039 NEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDN-RELNEAYQRAIKDKEVIENENFMLKEELS 1102
                ::::.|.::..|...||..:..|:|...:.| ..|......|.:..|.:||.....||.:.
Zfish   936 ----KKELLEQMEREKKEPVNDSDMVDKMFGFLGNANSLPNLEGEAPEGFEDLENAPKQFKEVID 996

  Fly  1103 RLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE 1167
                       ........:.||...|..||           .:..|...::|.:.|  |..|::
Zfish   997 -----------EPLPLPDDEEEDLSEYKFAK-----------FAATYFQGNATHMYV--RRPLKQ 1037

  Fly  1168 EKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYD----QLRTSIKHGVE-INELNA 1227
            ....|:                ::..:::.|.|....||...|    :...||..|.| |..:..
Zfish  1038 PLLFHE----------------DEGDQLAALAVWITVLRFMGDLPEPKYHISISDGSEKIPVMTK 1086

  Fly  1228 QHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESE 1292
            .:..|.:...:|..:.:|:.    ::...:.|.:..:|.....|:.:.....|  ||::..|:.:
Zfish  1087 IYETLGKRTYKRELQALQVD----EEKHEVHSKDTYTLSSSTTDIQKRNSVRH--KLVSLTLKKK 1145

  Fly  1293 LKAITEEHNSKLVEMTQEI-------ERLNNEKDELQKVMFESI------DEFEDSNVDTLRQND 1344
            .| :|||...:|.:....:       :|..:..::|..::...|      ||........|.||.
Zfish  1146 SK-LTEEVTRRLTDSDYSLQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQICKQLSQNA 1209

  Fly  1345 RYLRRE-----LQKAVAQFLLVQEELKLANAKLKAYRQDG--GQLEHKIEEEMIRNKSNGTSADV 1402
            ......     |...|..|...::.:|.    |:.:...|  |...: .||.:.|..:|.|....
Zfish  1210 SKSSHARGWILLSLCVGCFAPSEKFVKY----LRTFINSGPPGYAPY-CEERLRRTFANKTRTQP 1269

  Fly  1403 GANVTKQ--KSQNP--------QGLMKFHSSDLDKILQRLLSALTPRTVVGLLP--GFPAYLIFM 1455
            .:.:..|  ||:.|        .|..|...:|.....:.|.:||:.:  :||..  ||..| |.:
Zfish  1270 PSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAEELCNALSDK--IGLKDRFGFSLY-IAL 1331

  Fly  1456 CIRYTDLTNADDDVRELLSK----------------FVIQIKKMHRTP--HPIENRVIWLVNSIT 1502
            ..:.:.|.:..|.|.:.:|:                :.:..:|...||  :|.|:.|
Zfish  1332 FDKVSSLGSGKDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHNPAEDGV-------- 1388

  Fly  1503 LLNLMKQYGDVDEYVKFN----------TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQ 1557
            ..||:  |..:...|||.          .|..:||...::.    ..::.:.:::|.|:.|.
Zfish  1389 ATNLI--YQQIVRGVKFGEYRCDREEDLAELASQQYYVDYG----PEILPERLLSLIQSYIP--- 1444

  Fly  1558 GLLDPKIVPA 1567
               |.:|.|:
Zfish  1445 ---DREITPS 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	273/694 (39%)
		IQ	900..922	CDD:197470	8/21 (38%)
		SMC_prok_B	<942..1365	CDD:274008	80/446 (18%)
		Myo5_CBD	1424..1792	CDD:271254	35/174 (20%)
myo7ab	XP_073791404.1	None