DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh10

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_009300420.1 Gene:myh10 / 555454 ZFINID:ZDB-GENE-030616-162 Length:2014 Species:Danio rerio


Alignment Length:2028 Identity:546/2028 - (26%)
Similarity:886/2028 - (43%) Gaps:487/2028 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|:|::.|  .:|...|....::||    |...:..|:..: ||.......|:..|
Zfish    39 VWVPSERHGFEAASIRE--ERGEEVLVELAENGK----KAMVNKDDIQKM-NPPKFSKVEDMAEL 96

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|..:||..|||....::.|||:|:
Zfish    97 TCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAI 160

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-----------ESET------ 191
            :|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|           ||..      
Zfish   161 SESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPPESPKAVKLQN 225

  Fly   192 ------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250
                  ::||::|.::||:|:||||||.:||||||||||.::.| :..|  ::.||.:.||||||
Zfish   226 GILFYGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEK 287

  Fly   251 SRVVYQAQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313
            ||.:.||:.||.:|:||||.|...::  .:|:|:..:.::||:.|..| |....|.:.|.||::|
Zfish   288 SRAIRQAKDERTFHVFYQLLAGAGEHLRSDLLLEGFNSYRFLSNGNIP-IPGQQDKDNFQETMEA 351

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFN--EGSEEEDSDSCDIFHNDIHLQITADLLRV 376
            |.::.|:.::|..::|:::.:|..|||...|:.|  :.|..|::.:..:.|          ||.:
Zfish   352 MHIMSFNHEEILSMLKVVSAVLQFGNIVFKKERNTDQASMPENTAAQKLCH----------LLGM 406

  Fly   377 SADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-C 440
            :..:..|.:|..:|:...:||....:.|.|..|.:||||..|.:||:::|..:||:|:...:| .
Zfish   407 NVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGA 471

  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQP 504
            ||||:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:|||.|:.||| .|.||
Zfish   472 SFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQP 536

  Fly   505 CIDLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSD 564
            ||||||   :..|||.||||||..||.:|:::..||:.:......|:|||  .....|.|.|::.
Zfish   537 CIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQGTHGKFQKPRQLKDKADFCIIHYAG 601

  Fly   565 TVEYDVNGFLEKNRDTVSKELTQVLSESNMSLA-----KQVMTLEEIDTLCVDSAKSSTLGGRVV 624
            .|:|..:.:|.||.|.::..:..:|.:|.....     .::...:......|.|...|.  |.|.
Zfish   602 RVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELWKDEIQNFQRASFYDVSSLHESP--GEVD 664

  Fly   625 ISAGRKQQG--NDTR--RRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAF 685
            ...|..|..  |:|.  ......|...:|||..::|||..|::||..|.|::||||.||.:|.|.
Zfish   665 RIVGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAG 729

  Fly   686 KWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVM 748
            |.|...::.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.
Zfish   730 KLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACERMIR 793

  Fly   749 KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQ 813
            ....|.:.||.|.::||||.|.:|.||:.|.                       |:|..:|...|
Zfish   794 ALELDPNLYRIGQSKIFFRTGVLAHLEEERD-----------------------LKITDIIIYFQ 835

  Fly   814 KHARGYLARERTQKMREARAGL-ILSKYARGWLCRRRYLRLRH-----------SISGIQTYARG 866
            ...||||||:...|.::..:.| :|.:....      ||:|||           .:..:......
Zfish   836 SVCRGYLARKAFAKKQQQLSALKVLQRNCAA------YLKLRHWQWWRLFTKVKPLLQVTRQEEE 894

  Fly   867 MLARNKFHAMRDHYRAVQIQRFVRGALARRAYQK--RRRNIII--CQAAIRRFL----ARRKFKR 923
            |.|::: ..::...|.|:::..:  ....|.:|:  ..:||:.  .||....|.    .|.:...
Zfish   895 MQAKDE-ELIKVKERQVKVENEL--VEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLVA 956

  Fly   924 MKAEAKTISH--------MENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK 980
            .|.|.:.|.|        .|.:...|:|:...||..|.:       |:.:..|....:.||:|:|
Zfish   957 KKQELEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQD-------LEEQLDEEEAARQKLQLEK 1014

  Fly   981 -TLEAEFKNVK---AACQDKD-------KLIE----ALNKQLEAERDEKMQLLEENGHAQ----- 1025
             |.||:.|.::   ...:|::       ||:|    .:..|| ||.:||.:.|.:..:.|     
Zfish  1015 VTAEAKIKKMEEDILLLEDQNSKFLKEKKLLEDRVGEMTSQL-AEEEEKAKNLGKVKNKQEMMMV 1078

  Fly  1026 --EEWISQKQTWRQENE------------------ELRRQIDEI-IDMAK------------NAE 1057
              ||.:.:::..|||.|                  ||:.||||: |.:||            :.|
Zfish  1079 DLEERLKKEEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDEE 1143

  Fly  1058 VNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQ 1122
            |.|:|...:.|.|: ..:|.| .|..::.::...|:...||.:||.      .|.|.|     ::
Zfish  1144 VAQKNNALKQLREL-QAQLAE-LQEDLESEKAARNKAEKLKRDLSE------ELEALK-----TE 1195

  Fly  1123 NEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRH- 1186
            .||.:...:|:..|...|..:              |.:|:..:::|.:.|   :.|..::..|| 
Zfish  1196 LEDTLDTTAAQQELRSKREQE--------------VAELKKAIDDETRNH---ESQIQEMRQRHG 1243

  Fly  1187 -------KPTEDSFRV-SELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREEC 1243
                   :..|.:.|| ..||...:.|.|:..:|...:|        :.|.|..:.|.:|::.|.
Zfish  1244 TALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNEVK--------SLQQAKSESEHKRKKLEA 1300

  Fly  1244 IQLKAVLLQQSQSMR---------------------------------SLEPESLQMRGNDVNEL 1275
             ||:.|:.:.|:..:                                 :.:..||:.:..|..||
Zfish  1301 -QLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGIKLTKDVSSLESQLQDTQEL 1364

  Fly  1276 MEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE-RLNNEKD--ELQKVMFESIDEFED--S 1335
            ::....|||   .|.|.::.:.||.|:.|.:..:|.| |.|.||.  .||..:.|:..:.||  .
Zfish  1365 LQEETRQKL---NLSSRIRQLEEEKNNLLEQQEEEEESRKNLEKQLATLQAQLVETKKKLEDDVG 1426

  Fly  1336 NVDTLRQNDRYLRREL--------QKAVAQFLL------VQEELKLANAKLKAYRQDGGQLEHK- 1385
            .::.|.:..|.|::::        :||:|...|      :|:||......|...||....||.| 
Zfish  1427 ALEGLEEVKRKLQKDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDDLMVDLDHQRQIVSNLEKKQ 1491

  Fly  1386 -------IEEEMI----RNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKIL------QRLL 1433
                   .||:.|    ..:.:...|:.....||..|.         :..||:.|      :||.
Zfish  1492 KKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSM---------ARALDEALEAKEEFERLN 1547

  Fly  1434 SALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLV 1498
            ..|.                   ....||.::.|||    .|.|.:::|..||   :|.:|    
Zfish  1548 KQLR-------------------AEMEDLISSKDDV----GKNVHELEKSKRT---LEQQV---- 1582

  Fly  1499 NSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPK 1563
                 ..:..|..::::      |.|..:..|           |.|.||: ||:..|    .|..
Zfish  1583 -----EEMRTQLEELED------ELQATEDAK-----------LRLEVNM-QAMKAQ----FDRD 1620

  Fly  1564 IVPAILNNDEIQRG--RQAHGM--------RSRATSIGASSSPE----------HGGGPAWKQLI 1608
            :......|:|.:|.  :|...|        :.||.::.|....|          .....|..:.|
Zfish  1621 LQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKKLEMDLKDVEAQIEAANKARDEAI 1685

  Fly  1609 GQLEHFYKQFQHFGLD----NCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCI 1669
            .||.....|.:.:..:    ....::||.|                                   
Zfish  1686 KQLRKLQAQMKDYQRELEEARTSRDEIFTQ----------------------------------- 1715

  Fly  1670 EDWVRSKKMSNDVLTALAPLNQVSQLLQS-----RKSEQDVQTICDLCTSLSTAQVLKVMKSYKL 1729
                 ||:....:.:..|.:.|:.:.|.|     |.:||:...:.|..::.::.:...:.:..:|
Zfish  1716 -----SKENEKKLKSLEAEILQLQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRL 1775

  Fly  1730 --------DDYESEITNVFL------------EKLTEKL-----------NAR-QMQKSNSD--- 1759
                    ::.|.|.:|:.|            :.|..:|           ||| |:::.|.|   
Zfish  1776 EARIAQLEEELEEEQSNMELLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKS 1840

  Fly  1760 -----EFTIDQKF 1767
                 |.::..||
Zfish  1841 KLQELEGSVKSKF 1853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 288/757 (38%)
MYSc_Myo5 84..767 CDD:276831 276/727 (38%)
IQ 900..922 CDD:197470 6/29 (21%)
GBP_C <971..1086 CDD:303769 44/167 (26%)
coiled coil 1049..1068 CDD:293879 7/31 (23%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/142 (20%)
Myo5_CBD 1424..1792 CDD:271254 73/419 (17%)
myh10XP_009300420.1 Myosin_N 37..75 CDD:280832 11/41 (27%)
Myosin_head 90..812 CDD:278492 280/739 (38%)
MYSc_Myh10 102..812 CDD:276952 276/727 (38%)
Myosin_tail_1 889..1969 CDD:279860 227/1124 (20%)
DUF342 <1085..1170 CDD:302792 22/86 (26%)
RILP-like <1528..1637 CDD:304877 34/174 (20%)
GBP_C <1641..1734 CDD:303769 17/132 (13%)
coiled coil 1705..1714 CDD:293879 1/8 (13%)
coiled coil 1723..1734 CDD:293879 2/10 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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