Protein Alignment didum and myh10

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_009300420.1
• Gene: myh10 / 555454
• ZFINID: ZDB-GENE-030616-162
• Length: 2014
• Species: Danio rerio
• Alignment Length: 2028
• Identity: 546/2028 - (26%)
• Similarity: 886/2028 - (43%)
• Gaps: 487/2028 - (24%)

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|:|::.|  .:|...|....::||    |...:..|:..: ||.......|:..|
Zfish    39 VWVPSERHGFEAASIRE--ERGEEVLVELAENGK----KAMVNKDDIQKM-NPPKFSKVEDMAEL 96

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|..:||..|||....::.|||:|:
Zfish    97 TCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAI 160

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-----------ESET------ 191
            :|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|           ||..
Zfish   161 SESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPPESPKAVKLQN 225

  Fly   192 ------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250
                  ::||::|.::||:|:||||||.:||||||||||.::.| :..|  ::.||.:.||||||
Zfish   226 GILFYGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEK 287

  Fly   251 SRVVYQAQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313
            ||.:.||:.||.:|:||||.|...::  .:|:|:..:.::||:.|..| |....|.:.|.||::|
Zfish   288 SRAIRQAKDERTFHVFYQLLAGAGEHLRSDLLLEGFNSYRFLSNGNIP-IPGQQDKDNFQETMEA 351

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFN--EGSEEEDSDSCDIFHNDIHLQITADLLRV 376
            |.::.|:.::|..::|:::.:|..|||...|:.|  :.|..|::.:..:.|          ||.:
Zfish   352 MHIMSFNHEEILSMLKVVSAVLQFGNIVFKKERNTDQASMPENTAAQKLCH----------LLGM 406

  Fly   377 SADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-C 440
            :..:..|.:|..:|:...:||....:.|.|..|.:||||..|.:||:::|..:||:|:...:| .
Zfish   407 NVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGA 471

  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQP 504
            ||||:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:|||.|:.||| .|.||
Zfish   472 SFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQP 536

  Fly   505 CIDLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSD 564
            ||||||   :..|||.||||||..||.:|:::..||:.:......|:|||  .....|.|.|::.
Zfish   537 CIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQGTHGKFQKPRQLKDKADFCIIHYAG 601

  Fly   565 TVEYDVNGFLEKNRDTVSKELTQVLSESNMSLA-----KQVMTLEEIDTLCVDSAKSSTLGGRVV 624
            .|:|..:.:|.||.|.::..:..:|.:|.....     .::...:......|.|...|.  |.|.
Zfish   602 RVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELWKDEIQNFQRASFYDVSSLHESP--GEVD 664

  Fly   625 ISAGRKQQG--NDTR--RRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAF 685
            ...|..|..  |:|.  ......|...:|||..::|||..|::||..|.|::||||.||.:|.|.
Zfish   665 RIVGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAG 729

  Fly   686 KWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVM 748
            |.|...::.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.
Zfish   730 KLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACERMIR 793

  Fly   749 KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQ 813
            ....|.:.||.|.::||||.|.:|.||:.|.                       |:|..:|...|
Zfish   794 ALELDPNLYRIGQSKIFFRTGVLAHLEEERD-----------------------LKITDIIIYFQ 835

  Fly   814 KHARGYLARERTQKMREARAGL-ILSKYARGWLCRRRYLRLRH-----------SISGIQTYARG 866
            ...||||||:...|.::..:.| :|.:....      ||:|||           .:..:......
Zfish   836 SVCRGYLARKAFAKKQQQLSALKVLQRNCAA------YLKLRHWQWWRLFTKVKPLLQVTRQEEE 894

  Fly   867 MLARNKFHAMRDHYRAVQIQRFVRGALARRAYQK--RRRNIII--CQAAIRRFL----ARRKFKR 923
            |.|::: ..::...|.|:::..:  ....|.:|:  ..:||:.  .||....|.    .|.:...
Zfish   895 MQAKDE-ELIKVKERQVKVENEL--VEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLVA 956

  Fly   924 MKAEAKTISH--------MENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK 980
            .|.|.:.|.|        .|.:...|:|:...||..|.:       |:.:..|....:.||:|:|
Zfish   957 KKQELEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQD-------LEEQLDEEEAARQKLQLEK 1014

  Fly   981 -TLEAEFKNVK---AACQDKD-------KLIE----ALNKQLEAERDEKMQLLEENGHAQ----- 1025
             |.||:.|.::   ...:|::       ||:|    .:..|| ||.:||.:.|.:..:.|
Zfish  1015 VTAEAKIKKMEEDILLLEDQNSKFLKEKKLLEDRVGEMTSQL-AEEEEKAKNLGKVKNKQEMMMV 1078

  Fly  1026 --EEWISQKQTWRQENE------------------ELRRQIDEI-IDMAK------------NAE 1057
              ||.:.:::..|||.|                  ||:.||||: |.:||            :.|
Zfish  1079 DLEERLKKEEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDEE 1143

  Fly  1058 VNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQ 1122
            |.|:|...:.|.|: ..:|.| .|..::.::...|:...||.:||.      .|.|.|     ::
Zfish  1144 VAQKNNALKQLREL-QAQLAE-LQEDLESEKAARNKAEKLKRDLSE------ELEALK-----TE 1195

  Fly  1123 NEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRH- 1186
            .||.:...:|:..|...|..:              |.:|:..:::|.:.|   :.|..::..||
Zfish  1196 LEDTLDTTAAQQELRSKREQE--------------VAELKKAIDDETRNH---ESQIQEMRQRHG 1243

  Fly  1187 -------KPTEDSFRV-SELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREEC 1243
                   :..|.:.|| ..||...:.|.|:..:|...:|        :.|.|..:.|.:|::.|.
Zfish  1244 TALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNEVK--------SLQQAKSESEHKRKKLEA 1300

  Fly  1244 IQLKAVLLQQSQSMR---------------------------------SLEPESLQMRGNDVNEL 1275
             ||:.|:.:.|:..:                                 :.:..||:.:..|..||
Zfish  1301 -QLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGIKLTKDVSSLESQLQDTQEL 1364

  Fly  1276 MEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE-RLNNEKD--ELQKVMFESIDEFED--S 1335
            ::....|||   .|.|.::.:.||.|:.|.:..:|.| |.|.||.  .||..:.|:..:.||  .
Zfish  1365 LQEETRQKL---NLSSRIRQLEEEKNNLLEQQEEEEESRKNLEKQLATLQAQLVETKKKLEDDVG 1426

  Fly  1336 NVDTLRQNDRYLRREL--------QKAVAQFLL------VQEELKLANAKLKAYRQDGGQLEHK- 1385
            .::.|.:..|.|::::        :||:|...|      :|:||......|...||....||.|
Zfish  1427 ALEGLEEVKRKLQKDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDDLMVDLDHQRQIVSNLEKKQ 1491

  Fly  1386 -------IEEEMI----RNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKIL------QRLL 1433
                   .||:.|    ..:.:...|:.....||..|.         :..||:.|      :||.
Zfish  1492 KKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSM---------ARALDEALEAKEEFERLN 1547

  Fly  1434 SALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLV 1498
            ..|.                   ....||.::.|||    .|.|.:::|..||   :|.:|
Zfish  1548 KQLR-------------------AEMEDLISSKDDV----GKNVHELEKSKRT---LEQQV---- 1582

  Fly  1499 NSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPK 1563
                 ..:..|..::::      |.|..:..|           |.|.||: ||:..|    .|..
Zfish  1583 -----EEMRTQLEELED------ELQATEDAK-----------LRLEVNM-QAMKAQ----FDRD 1620

  Fly  1564 IVPAILNNDEIQRG--RQAHGM--------RSRATSIGASSSPE----------HGGGPAWKQLI 1608
            :......|:|.:|.  :|...|        :.||.::.|....|          .....|..:.|
Zfish  1621 LQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKKLEMDLKDVEAQIEAANKARDEAI 1685

  Fly  1609 GQLEHFYKQFQHFGLD----NCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCI 1669
            .||.....|.:.:..:    ....::||.|
Zfish  1686 KQLRKLQAQMKDYQRELEEARTSRDEIFTQ----------------------------------- 1715

  Fly  1670 EDWVRSKKMSNDVLTALAPLNQVSQLLQS-----RKSEQDVQTICDLCTSLSTAQVLKVMKSYKL 1729
                 ||:....:.:..|.:.|:.:.|.|     |.:||:...:.|..::.::.:...:.:..:|
Zfish  1716 -----SKENEKKLKSLEAEILQLQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRL 1775

  Fly  1730 --------DDYESEITNVFL------------EKLTEKL-----------NAR-QMQKSNSD--- 1759
                    ::.|.|.:|:.|            :.|..:|           ||| |:::.|.|
Zfish  1776 EARIAQLEEELEEEQSNMELLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKS 1840

  Fly  1760 -----EFTIDQKF 1767
                 |.::..||
Zfish  1841 KLQELEGSVKSKF 1853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	276/727 (38%)
		IQ	900..922	CDD:197470	6/29 (21%)
		SMC_prok_B	<942..1365	CDD:274008	121/536 (23%)
		Myo5_CBD	1424..1792	CDD:271254	73/419 (17%)
myh10	XP_009300420.1	Myosin_N	34..79	CDD:460670	11/45 (24%)
		MYSc_Myh10	102..812	CDD:276952	276/727 (38%)
		Myosin_tail_1	889..1969	CDD:460256	227/1124 (20%)