DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh11a

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_021332550.1 Gene:myh11a / 554168 ZFINID:ZDB-GENE-050531-1 Length:1983 Species:Danio rerio


Alignment Length:2058 Identity:551/2058 - (26%)
Similarity:893/2058 - (43%) Gaps:517/2058 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|||:::|.:  |...|....|:||    |:..:..|:..: ||.......|:..|
Zfish    35 VWVPSEKHGFESASIKEEH--GDEVLVELMDNGK----KITVNKDDIQKM-NPPKFSKVEDMAEL 92

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..||||||.|:.. .:||||.|:..|.:|||..:|:|...||..|:|....::.|||:::
Zfish    93 TCLNEASVLHNLRERYYS-GLIYTYSGLFCVVVNPYKMLPIYSEKIIEMYKGKKRHEVPPHIYSI 156

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE---------------SETQV 193
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.               :..::
Zfish   157 TDNAYRNMMQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDMSAQQSGQQFAYGEL 221

  Fly   194 ERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQ 258
            |:::|.::||:||||||||.:||||||||||.::.| :..|  |:.||.:.||||||||.:.||:
Zfish   222 EKQLLQANPILEAFGNAKTIKNDNSSRFGKFIRINF-DVTG--FIVGANIETYLLEKSRCIRQAK 283

  Fly   259 GERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321
            .||.:||||.:.| .:.|. .||:|::.:.::||:.|.. :|....|.|.::||::||.::|||:
Zfish   284 TERAFHIFYYMVAGTKDKLREELLLENFNNYRFLSAGHV-QIPGNQDDEMYDETMEAMEIMGFSV 347

  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386
            ::.||::|:::.:|.||||:..|:.|:  |:.............|||      .::..|..|.:|
Zfish   348 EERADVLKVVSTVLQLGNIEFKKERNQ--EQATMPDNTAAQKVCHLQ------GINVTDFTRAIL 404

  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYG 450
            ..:|:...|.|....:.|.|..|.:||||.:|.:||::|:..:||:|:...:| .||:|:|||.|
Zfish   405 TPRIKVGREVVQKAQTKEQADFAIEALAKAMYERLFRWILLRVNKALDKTKRQGASFLGILDIAG 469

  Fly   451 FETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---S 511
            ||.||.|||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||:|||   :
Zfish   470 FEIFENNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNN 534

  Fly   512 RLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPH---FEKPR--FGTTSFFIKHFSDTVEYDVN 571
            ..|:|.||||||..||.:|.|:..||   ||...:   |.||:  ...|.|.::|::..|:|:..
Zfish   535 PPGILALLDEECWFPKATDVSFVEKL---CNTHANHTKFAKPKQLKDKTEFSVQHYAGRVDYNAV 596

  Fly   572 GFLEKNRDTVSKELTQVLSESNMSL-------AKQVMTLEEI----DTLCVDSAKSSTLGGRVVI 625
            .:|.||.|.::..:|.:|:.|:...       |.:|:.||.|    |:|...::|:         
Zfish   597 AWLTKNMDPLNDNVTALLNNSSNPFVQDLWKDADRVVGLETIAKMSDSLAPSASKT--------- 652

  Fly   626 SAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETA 690
                             .|...:|||..::||||.|::|||.|.|::||||.||.:|.|.|.:..
Zfish   653 -----------------KKGMFRTVGQLYKESLAKLMTTLHNTQPNFVRCIIPNHEKRAGKLDAH 700

  Fly   691 KIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQD 753
            .:::|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|
Zfish   701 LVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA-ANAIPKGFMDGKQACCLMIKHLDID 764

  Fly   754 EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIV----QSVVRRFVYRRQFLRIQKVING--- 811
            .:.||.|.::||||.|.:|.||:.| :|:   ||::    ||..|.|:.|:.|.:.|:.:..   
Zfish   765 PNLYRIGQSKIFFRTGVLAQLEEER-DLK---ITVIIIAFQSQARGFLARKAFAKRQQQLTAMKV 825

  Fly   812 IQKHARGY-----------------------------LARERTQKMREARAGLILSKYARGWLCR 847
            ||::...|                             |..|..||.:|:         |:.:...
Zfish   826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMSLKEEELQKAKES---------AQKFEIE 881

  Fly   848 RRYLRLRHS-------------ISGIQTYA-----RGMLARNK------FHAM-------RDHYR 881
            .:.:.|:|:             .:..:.||     |..||..|      .|.|       .|...
Zfish   882 LKDIALKHTQLMDERNQLQEKLQAETELYAEAEEMRVRLASKKQELEEILHEMEARLEEEEDRGA 946

  Fly   882 AVQIQRFVRGALAR----------RAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMEN 936
            |:|:::.......:          .|.||.:...:.|.|         |.|:::.:...:....|
Zfish   947 ALQMEKKKMHEQIKDLEEHLEEEEDARQKLQLEKVTCDA---------KIKKLEDDILIMDDQNN 1002

  Fly   937 KYMG----LENKIISMQQRIDELNRDNSNL-----KHKT--SEISV--------------LKMKL 976
            |...    ||.:|......:.|....:.||     ||::  ||:.|              .|.||
Zfish  1003 KLQKERKILEERIADFSSNLAEEEEKSKNLTKLKNKHESMISELEVRLKKEEKTRQELDKAKRKL 1067

  Fly   977 ELKKT--------LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLL----EENGHAQ--EE 1027
            |.:..        |:|:..::||....|::.::|...:||.|..:|...|    |..||..  :|
Zfish  1068 EAESNDLQEQIADLQAQIADLKAQLAKKEEELQAALARLEDETGQKNNALKKIRELEGHISDLQE 1132

  Fly  1028 WISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEV--- 1089
            .:..::..|.:.|:.:|.:.|.::..|:      ..||.:......:||     ||.:::||   
Zfish  1133 DLESERAARNKAEKTKRDLGEELEALKS------ELEDTLDTTATQQEL-----RAKREQEVTLL 1186

  Fly  1090 ---IENENFMLKEELSRLTAGSFSLHARKASNASSQNEDD----VGYASAKNTLDINRPPDLLSK 1147
               ||:|:.:.:.::..:.    ..|.:.....:.|.|..    |....||..|:          
Zfish  1187 KRAIEDESRVHEAQVQEMR----QKHTQALEELTEQLEQSKRVKVNLEKAKQALE---------- 1237

  Fly  1148 NYSYNDSTSLVVKLRSIL---EEEKQKHKVLQEQYIKL------SSRHKPTEDSFRVSELEVENE 1203
                .:::.|.|:|||:.   ::.:.|.|.|:.|...|      |.||| .|...|||::.||.|
Zfish  1238 ----KETSELHVELRSLTQGKQDVEHKKKKLEGQLADLQSRFNDSERHK-AELGDRVSKITVELE 1297

  Fly  1204 KLRSEYDQLR-TSIKHGVEINELNAQ----HAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPE 1263
            .:.:..::.. .:||...::..|::|    ...|.||.|::           ||.|..:|.:|  
Zfish  1298 SVTNLLNEAEGKNIKLSKDVASLSSQVQDTQELLAEETRQK-----------LQLSTKLRQIE-- 1349

  Fly  1264 SLQMRGNDVNELMEAFHSQKLINRQLE---SELKAITEEHNSKLVEMTQEIERLNNEKDELQKVM 1325
                  :|.|.|.|....:....|.:|   |.|.....:...||.|||..:|.|...|..||:.:
Zfish  1350 ------DDRNALQEQLDEEAEAKRNVERHVSTLNIQLSDFKKKLEEMTGNVELLEEGKKRLQRDL 1408

  Fly  1326 FESIDEFEDSNV-----------------DTLR--QNDRYLRRELQKAVAQF--LLVQEE----- 1364
            ..:..:||:...                 |||.  .|.|.|...|:|...:|  :|.:|:     
Zfish  1409 EAANTQFEEKAAAYDKLEKTKNRLQQELEDTLMDLDNQRQLVSNLEKKQKKFDQMLAEEKSISSK 1473

  Fly  1365 -------------------LKLANAKLKAY--RQDGGQLEHKIE---EEMIRNKSNGTSADVGAN 1405
                               |.||.|..:|.  |::..:....:.   |:::.:|.     |||.|
Zfish  1474 YADERDRAEAEAREKETKALSLARALEEAQEAREEFERANKALRAEMEDLVSSKD-----DVGKN 1533

  Fly  1406 VTK-QKSQNPQGL------MKFHSSDLDKILQ-------------RLLSALTPRTVVGLLPGFPA 1450
            |.: :||:  :||      ||....:|:..||             :.|.|...|           
Zfish  1534 VHELEKSK--RGLEAQVEEMKTQLEELEDELQAAEDAKLRLEVNMQALKAQFER----------- 1585

  Fly  1451 YLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLL--NLMKQYGDV 1513
                      ||...|:...|...:.|.|::::.........:...|..|...|  :|....|.:
Zfish  1586 ----------DLQGRDEQGEEKKRQLVKQVRELETELEDERKQRTALAASKKKLEGDLKDLEGQI 1640

  Fly  1514 DEYVKFNTE-----KQNQQQLKNF-----NLFEYRRVIL------DLIVNLYQALIMQIQGLLDP 1562
            :...|...|     ::.|.|:|:|     :....|..:|      :......:|.::|:|.  |.
Zfish  1641 ETSNKGRDEAIKQLRKLQAQMKDFQRELDDAHAAREEVLSSAKENERKAKTLEAELLQLQE--DL 1703

  Fly  1563 KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCY 1627
            ..........|.:|...|..:.|.|:...|.|..:.......:||..:||.              
Zfish  1704 AAAERAKKQVEAERDELADELASNASGKSALSDEKRRLEAKIQQLEEELEE-------------- 1754

  Fly  1628 AEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQV 1692
                                         |.|     |:..:.|.:|......|.||     |::
Zfish  1755 -----------------------------EQG-----NMEMLNDRLRKSAQQVDQLT-----NEL 1780

  Fly  1693 -SQLLQSRKSEQDVQTICDLCTSLSTAQVL----KVMKSYKLDDYESEITNVF----------LE 1742
             ::...|:|:|             |..|::    |.:|: ||.:.|:::.:.|          :.
Zfish  1781 QAERTTSQKNE-------------SARQLMERQNKELKA-KLQEMENQVKSKFKSSISALEAKVA 1831

  Fly  1743 KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDI 1785
            :|.|:|......|.|:.:             ..|..|.||:::
Zfish  1832 QLEEQLEQESRDKQNTAK-------------AVRQKDKKLKEM 1861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 289/752 (38%)
MYSc_Myo5 84..767 CDD:276831 277/722 (38%)
IQ 900..922 CDD:197470 4/21 (19%)
GBP_C <971..1086 CDD:303769 31/142 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/116 (24%)
Myo5_CBD 1424..1792 CDD:271254 69/408 (17%)
myh11aXP_021332550.1 Myosin_N 32..71 CDD:308391 13/41 (32%)
MYSc_class_II 98..778 CDD:276951 277/722 (38%)
Myosin_tail_1 855..1935 CDD:307627 234/1184 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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