DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Myo28B1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster


Alignment Length:1382 Identity:402/1382 - (29%)
Similarity:644/1382 - (46%) Gaps:250/1382 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QGAKIWVPHADLVWESATLEESYRKGAGFLK-------ICTDSGK---------LKEVKLKADGS 58
            :|..:||..     ::.|.|.:...||..::       :|.|..|         ||.:.:.:. .
  Fly     9 KGEYVWVKP-----QNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQ-E 67

  Fly    59 DLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPS 123
            |:            .|:.||..|.|..:|.||:.|:. :|:||||.|.:|||||||..:|:|...
  Fly    68 DV------------EDMITLGDLQEYTILRNLQNRYA-KQLIYTYTGSMLVAINPYQILPIYTNR 119

  Fly   124 IIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE 188
            .|:.||..::.:|.|||||:::.|:.:|:|...|..:::|||||||||.|.|..::|.||:.|..
  Fly   120 EIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH 184

  Fly   189 SETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRV 253
            |  .:|::::.::|||||||||||.||||||||||:.::.|..|..:   |||.:..|||||||:
  Fly   185 S--WIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAI---QGARIQQYLLEKSRI 244

  Fly   254 VYQAQGERNYHIFYQLCAARS--KYPELVLDHQ--DKFQFLNMGGAPEIERVSDAEQFNETVQAM 314
            |:|::.||||||||.:.|..|  :...|.|..|  .::.:|..||...:....||:.|.:...||
  Fly   245 VFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAM 309

  Fly   315 TVLGFSIQQIADIVKILAGILHLGNIQ--VSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVS 377
            .||.|..:::..|:.:||.||||||::  .::..|..:.|.|...        :||..|.||.:.
  Fly   310 KVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTP--------NLQRVAQLLGIP 366

  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CS 441
            ...|...|..|.|....|:|....|.|||...|||..|.:|..:|..||..:|:::|....| .:
  Fly   367 ISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMN 431

  Fly   442 FIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCI 506
            .||||||:|||.|:.|||||.|||||||.|||.|..|:||:||:||..|.|.|..|:|.|||..:
  Fly   432 SIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQIL 496

  Fly   507 DLIESR-LGVLDLLDEECRMPKGSDESWAGKL-IGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYD 569
            |||..: :.::.|:|||.:.|||:|::...|| :...|:..:.:.....|:.|.|:|::..|.|:
  Fly   497 DLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYN 561

  Fly   570 VNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGN 634
            ..||||||||:.|.:|..::..|.......:...|    :.:|:||.                  
  Fly   562 PLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHE----MPMDTAKK------------------ 604

  Fly   635 DTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRAC 699
                        :.|:..:|:.||..|:.||....|:::||||||:.|....::....::|||..
  Fly   605 ------------QPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYS 657

  Fly   700 GVLETVRISAAGFPSRWLYPDFYMRYQLLVYR-SKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQ 763
            |::||.||..||:|.|..|..|..||:|||.. ..|::.|.:...|.|....:..:...::|.|:
  Fly   658 GMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQYGKTK 722

  Fly   764 IFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKM 828
            :|.|....|.||..|:.|..|.|..:|..:||.::||...|.::.|..:|::.||.|.|.:.|.|
  Fly   723 LFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVM 787

  Fly   829 REARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGAL 893
            |:.                  :.||...|:..|       ...||..:|  .|.:::|...||.|
  Fly   788 RQG------------------FHRLGACIAAQQ-------LTTKFTMVR--CRTIKLQALSRGYL 825

  Fly   894 ARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE-----AKTISHMENKYMGLENKIISMQQRID 953
            .|:.:||             :.|.|||..::|.|     ||         |....:::.:||..:
  Fly   826 VRKDFQK-------------KLLERRKQNQLKKEELLKLAK---------MKEAEELLRLQQLKE 868

  Fly   954 ELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKN--VKAACQDKDKLIEALNKQLEAERDEKMQ 1016
            :..|:....:.|       :::.|.:...||..:|  ..||.|.|.:     .|.::.|..:...
  Fly   869 QKEREQREQQEK-------RLQEEQRLKAEAAARNALAMAAVQQKRR-----TKPVKQEAPKAPT 921

  Fly  1017 LLEENG---------------HAQEEWISQKQTWRQ-----ENEELRRQIDEIIDMAKNAEVNQR 1061
            |...|.               ......:::..|..:     :.|..::.:|::....       .
  Fly   922 LQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFL-------N 979

  Fly  1062 NQEDRMLAEIDNRELNEAYQRAIKDKEVIENENF-MLKEELSRLTAGSFSLHARKASNAS-SQNE 1124
            ::.|..|.:::|....:..:........|:..:| .||...:....|:.:.|.||....| .::|
  Fly   980 DEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHE 1044

  Fly  1125 DDVGYASAKNT-LDINR----PPDLLSK-NYSYNDSTSLVVKLRSILE-EEKQKHKVLQEQYIKL 1182
            ..:...::|.. |.|.|    .||::|. .....|:.:|:..|.|:|. .:..|.::    :::.
  Fly  1045 HPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRL----FVRQ 1105

  Fly  1183 SSRHKPTEDSFRVSELEVENEKLRSEY------------DQLRTSIKHGVEINELNAQHAALQEE 1235
            |.|        |:.:.....||...|:            :::...|.||:..|.|          
  Fly  1106 SQR--------RIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSL---------- 1152

  Fly  1236 VRRRREECIQ--LKAVLLQQSQSMRSLEPESLQMRGNDVNEL-MEAFHSQKLINRQLESELKAIT 1297
                |:|.:.  .|.:.|..|:|..|        ||..:..| :..|...|    :.|..|::..
  Fly  1153 ----RDEILAQICKQLYLNPSRSSYS--------RGWLLLSLCLSCFPPSK----EFEPHLRSFM 1201

  Fly  1298 EEHNSKLVEMTQEIERL 1314
            ::..::| :.|..::||
  Fly  1202 KQGTAQL-QATPSLQRL 1217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 272/722 (38%)
MYSc_Myo5 84..767 CDD:276831 263/692 (38%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 18/136 (13%)
coiled coil 1049..1068 CDD:293879 1/18 (6%)
coiled coil 1077..1086 CDD:293879 0/8 (0%)
JAKMIP_CC3 <1190..1299 CDD:292653 23/123 (19%)
Myo5_CBD 1424..1792 CDD:271254
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 273/735 (37%)
MYSc_Myo7 81..726 CDD:276832 263/692 (38%)
IQ 765..785 CDD:197470 6/19 (32%)
DUF4355 827..>887 CDD:290964 17/88 (19%)
MyTH4 1031..1239 CDD:295320 47/226 (21%)
B41 1248..1429 CDD:214604
FERM_N 1248..>1288 CDD:286467
FERM_B-lobe 1342..1429 CDD:271216
PH-like 1454..1547 CDD:302622
MyTH4 1674..1819 CDD:214535
B41 1827..2032 CDD:214604
FERM_N 1829..>1877 CDD:286467
FERM_M 1936..2032 CDD:278785
FERM_C2_MyoVII 2028..2121 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466252
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.850

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