Protein Alignment didum and MYO15A

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Alignment Length: 799
• Identity: 307/799 - (38%)
• Similarity: 447/799 - (55%)
• Gaps: 63/799 - (7%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|:|.|..|.|..||.||::|| ||.:||||.|.|||::|||....:|||..::.|.|.|:|:
Human  1223 GVEDMTQLEDLQETTVLSNLKIRF-ERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYNGRALGE 1286

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
            ..||:||:|..|:.|:.....|..||:|||||:|||.:.|..:||.||:.......|...::|.:
Human  1287 NPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQVIQILEA 1351

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :|::|:||||||.|||||||||||.::....  ||  :.||....|||||||:|:||:.||||||
Human  1352 TPLLESFGNAKTVRNDNSSRFGKFVEIFLEG--GV--ISGAITSQYLLEKSRIVFQAKNERNYHI 1412

  Fly   266 FYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325
            ||:|.|.     |..:.   |...:.:.:||.||..||...|||:.|...:.||.|||||.:...
Human  1413 FYELLAGLPAQLRQAFS---LQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSEDQD 1474

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
            .|.:|||.||||||:...|      .|.|:.......:...:|..|:||::|.:.|::.:..:..
Human  1475 SIFRILASILHLGNVYFEK------YETDAQEVASVVSAREIQAVAELLQISPEGLQKAITFKVT 1533

  Fly   391 ESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFE 455
            |::.|.:..|.::|:|..||||:||.:||.||.:::..:| :|.:..:....|.:|||||||...
Human  1534 ETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVN-ALVSPRQDTLSIAILDIYGFEDLS 1597

  Fly   456 VNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLL 519
            .|||||.|||||||.||..||:.||:.|||||::|.|.|..|.|.||||||:||..: .|:|.:|
Human  1598 FNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLKPYGILRIL 1662

  Fly   520 DEECRMPKGSDESWAGKLIGKCNKF----PHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            |::|..|:.:|.::    :.||:..    |.:.||:.....|.|||::..|.|.|:.||:||.|.
Human  1663 DDQCCFPQATDHTF----LQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQ 1723

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            |.:::..:...|...:...:.:............|||::                ||.    .|.
Human  1724 VRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSV----------------TRL----YKA 1768

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
            |  ||.::||:||..|:..:....|.::||:|||..|....:|...::.|||..||||||||...
Human  1769 H--TVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKE 1831

  Fly   711 GFPSRWLYPDFYMRYQLLV-YRSKLDKN-DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            |||.|..:..|..||..|| .:..|..| ||.:|..:.:.|.:  .:.||.|.:::|.:......
Human  1832 GFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSRLCKVM--PNMYRVGVSKLFLKEHLYQL 1894

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            ||.:|.::.......:|..:|.|..:|:|..::..|..:|..|||||||:|.|:||.:     |.
Human  1895 LESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRS-----LV 1954

  Fly   839 KY---ARGWLCRRRYLRLR 854
            |:   ...::.|||||:||
Human  1955 KFRSLVHAYVSRRRYLKLR 1973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	271/694 (39%)
		IQ	900..922	CDD:197470
		SMC_prok_B	<942..1365	CDD:274008
		Myo5_CBD	1424..1792	CDD:271254
MYO15A	XP_016880204.1	SGP	<320..364	CDD:435798
		PHA03247	<723..1144	CDD:223021
		MYSc_Myo15	1236..1888	CDD:276838	271/694 (39%)
		IQ	1926..1947	CDD:197470	10/20 (50%)
		MyTH4	2066..2218	CDD:214535
		PHA03247	<2433..2673	CDD:223021
		SH3_MYO15A	2872..2951	CDD:213000
		MyTH4	3051..3205	CDD:214535
		FERM_M	3300..3420	CDD:459788
		FERM_C_MyoXV	3416..3517	CDD:270022