DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo15a

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_008766109.1	Gene:	Myo15a / 501699	RGDID:	1561873	Length:	3512	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	306/801 - (38%)
Similarity:	449/801 - (56%)	Gaps:	68/801 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|:|.|..|.|..||.||:.|| ||.:||||.|.|||::|||....:|||..::.|.|.|:|:
  Rat  1212 GVEDMTQLEDLQETTVLTNLKTRF-ERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGE 1275

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
            ..||:||:|..|:.|:.....|..:|:|||||:|||.:.|..:|..||: ....:...:.|:|.:
  Rat  1276 NPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLRCLAAM-NQRRDVMQQIKILEA 1339

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :|::||||||||.|||||||||||.::....  ||  :.||....|||||||:|:||:.||||||
  Rat  1340 TPLLEAFGNAKTVRNDNSSRFGKFVEIFLEG--GV--ICGAITSQYLLEKSRIVFQAKNERNYHI 1400

  Fly   266 FYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325
            ||:|.|.     |..:.   |...:.:.:||.||..||...|||:.|...:.||.||||:.:...
  Rat  1401 FYELLAGLPAQLRQAFS---LQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQD 1462

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
            .|.:|||.||||||:...|      .|.|:.......:...:|..|:||:||.:.|::.:..:..
  Rat  1463 SIFRILASILHLGNVYFEK------HETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVT 1521

  Fly   391 ESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFE 455
            |::.|.:..|.::|:|..||||:||.:||.||.:::..:| :|.:..:....|.:|||||||...
  Rat  1522 ETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVN-ALVSPKQDTLSIAILDIYGFEDLS 1585

  Fly   456 VNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLL 519
            .|||||.|||||||.||..||:.||:.|||||::|.:.|..|.|.||||||:||..: .|:|.:|
  Rat  1586 FNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRIL 1650

  Fly   520 DEECRMPKGSDESWAGKLIGKCNKF----PHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            |::|..|:.:|.::    :.||:..    |.:.||:.....|.|||::..|.|.|:.||:||.|.
  Rat  1651 DDQCCFPQATDHTF----LQKCHYHHGANPLYCKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQ 1711

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            |.:::..:...|...:...:.:.....|......|||::                ||.    .|.
  Rat  1712 VRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSI----------------TRL----YKA 1756

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
            |  ||.::||:||..|:..:....|.:|||:|||..|....:|...::.|||..||||||||...
  Rat  1757 H--TVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKE 1819

  Fly   711 GFPSRWLYPDFYMRYQLLVYRSKLD---KNDMKLSCRNIVMKWIQ-DEDKYRFGNTQIFFRAGQV 771
            |||.|..:..|..||:.|| ..||:   ..||   |.:::.:... ..|.||.|.:::|.:....
  Rat  1820 GFPVRLPFQVFIDRYRCLV-ALKLNVPADGDM---CVSLLSRLCTVTPDMYRVGVSKLFLKEHLH 1880

  Fly   772 AFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLI 836
            ..||.:|..:..:....:|..:|.|..:|:|..:::.|..:|..|||:|||:|.|:||::
  Rat  1881 QLLESMRERVLNRAALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQS----- 1940

  Fly   837 LSKY---ARGWLCRRRYLRLR 854
            |.|:   ...::.|||||:||
  Rat  1941 LLKFRSLVHTYVNRRRYLKLR 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	279/720 (39%)
		MYSc_Myo5	84..767	CDD:276831	271/696 (39%)
		IQ	900..922	CDD:197470
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo15a	XP_008766109.1	MYSc	1206..1888	CDD:214580	279/721 (39%)
		MYSc_Myo15	1225..1876	CDD:276838	271/696 (39%)
		MyTH4	2054..2200	CDD:214535
		SH3	2853..2932	CDD:302595
		MyTH4	3032..3186	CDD:214535
		B41	3196..3401	CDD:214604
		FERM_B-lobe	3291..3391	CDD:271216
		FERM_C_MyoXV	3397..3498	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810